Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06646198RecruitingPhase 2
TIPS with half-dose Donafenib for liver cancer with portal hypertension
This trial tests a treatment that combines a procedure called TIPS with a targeted therapy drug (Donafenib) at half strength. It is for people with advanced liver cancer that has spread into the portal vein and caused high blood pressure in the liver (portal hypertension). The goal is to see if this combination can help control the cancer and reduce complications.
Guangzhou, GuangdongAges 18–75 - NCT06318949Recruiting
Albumin changes as early signs of chronic liver disease
This study is looking at whether changes in a protein called albumin can help find liver disease earlier. It is for people who have some liver scarring but no serious complications.
AngersAges 18 years+ - NCT06181409Recruiting
New scans to detect liver disease complications
This study uses two types of scans (MRI and ultrasound) to check for high pressure in the veins of your liver. It may help doctors find problems earlier without invasive tests.
Montreal, QuebecAges 18 years+ - NCT06324838Recruiting
Surgery study for Crohn's disease in the ileocecal area
This trial compares two surgical techniques for removing the affected part of the intestine in people with Crohn's disease. It aims to see if removing more tissue around the blood vessels leads to better outcomes.
OdenseAges 18 years+ - NCT06213441Recruiting
Stoma training via smartphone for first-timers
This trial tests whether a short, picture-based training session on a smartphone can help people with a new stoma feel better and manage daily tasks more easily.
AksarayAges 18 years+ - NCT06282445RecruitingPhase 2
Combination therapy for first-line metastatic colorectal cancer
This trial tests whether adding the immunotherapy drug adebrelimab to standard chemotherapy plus bevacizumab can help people with a specific type of metastatic colorectal cancer that cannot be removed by surgery. It is for patients whose tumors are microsatellite stable (MSS) or have normal mismatch repair (pMMR).
Jinhua, ZhejiangAges 18–75 - NCT06163729RecruitingPhase 2
Testing camrelizumab plus chemo and radiation before/after surgery for stomach-esophagus cancer
This trial tests combining the immunotherapy drug camrelizumab with chemotherapy and radiation before and after surgery for a specific type of stomach-esophagus cancer. It aims to see if this approach helps shrink the tumor and improve outcomes.
Beijing, Beijing MunicipalityAges 18–80 - NCT06159244Recruiting
Gut bacteria in severe alcoholic hepatitis
This trial looks at the gut bacteria (microbiome) in people with severe alcoholic hepatitis to understand how it affects the illness. It may help doctors find better ways to treat this condition.
Amiens, PicardieAges 18–75 - NCT06272500Recruiting
Betaine for high gastrin in autoimmune gastritis
This trial tests if betaine hydrochloride can lower high gastrin levels caused by autoimmune gastritis. It may help people with this condition by reducing stomach-related symptoms.
Zhengzhou, HenanAges Any age - NCT05963490RecruitingPhase 2
Regorafenib with or without targeted immunotherapy and radiation for spread colon cancer
This Phase 2 study tests whether taking regorafenib alone or with immunotherapy (toripalimab) and a lower-dose radiation plan can better control metastatic colon or rectal cancer that has MSS/pMMR. It may help by combining cancer-blocking medicine with immune activation and focused radiation to metastatic spots.
ShanghaiAges 18–70 - NCT06078709RecruitingPhase 2
Pre-surgery radiation and chemo for esophageal cancer
This trial tests a shorter course of radiation combined with chemotherapy (FOLFOX) before surgery for esophageal or stomach-junction cancer. It aims to reduce side effects and still improve outcomes.
Scottsdale, ArizonaAges 18 years+ - NCT06039917Recruiting
Automatic reminders for stomach precancer follow-up
This study tests whether an automatic reminder system can help more people with stomach precancerous changes get the follow-up checks they need after an upper endoscopy. The goal is to see if the system improves how often patients return for surveillance.
Quanzhou, FujianAges 18 years+ - NCT06121479Enrolling by invitationPhase 3
Testing oral amino acid supplements for advanced liver disease
This trial tests if taking branched-chain amino acids by mouth can help people with cirrhosis and ascites (fluid in the belly). It aims to improve nutrition and reduce complications.
Bangkok, BangkokAges 18–85 - NCT06001333Recruiting
Fecal transplant to clear superbugs from the gut
This study tests whether a fecal transplant (FMT) can remove certain antibiotic-resistant bacteria from your gut. It might help people who carry superbugs like CPE or VRE but aren't currently on antibiotics.
Chuncheon, Gangwon-doAges 20 years+ - NCT06044909Recruiting
Guiding liver surgery with combined images
This trial tests a new method that combines different medical images (CT, MRI, ultrasound) to help guide surgeons during laparoscopic (keyhole) liver surgery. It may make the surgery more precise and safer.
Saint-EtienneAges 18 years+ - NCT06080880Recruiting
Testing weekly vs every 3 weeks ondansetron for chemo nausea
This trial compares two schedules of ondansetron (a nausea prevention drug) in people getting cisplatin chemotherapy plus a PD-1 inhibitor. It aims to find which dosing schedule works best to prevent nausea and vomiting.
Wuhan, HubeiAges 18 years+ - NCT05923255Recruiting
Trial for surgery planning in right-side colon cancer
This trial studies how to treat cancers located near the right bend of the colon (hepatic flexure) or the first part of the transverse colon. It may help patients by testing a specific approach to surgery before and around the time of resection.
Bengbu, AnhuiAges 18–75 - NCT05990218Recruiting
AI for finding right-sided colon polyps
This trial tests whether artificial intelligence can help doctors find polyps on the right side of the colon during a colonoscopy, especially for doctors with different levels of experience.
Bangkok, BangkokAges 40–80 - NCT05926804Recruiting
Screening and treatment for Helicobacter pylori in teens
This trial checks teenagers for a long-lasting H. pylori stomach infection and then treats those who need it. It may help prevent ongoing stomach problems from the infection and compare outcomes between treated and non-treated groups.
CoyhaiqueAges 14–18 - NCT06120803RecruitingPhase 2
Esomeprazole for preventing radiation-induced esophagitis
This study tests whether a common heartburn medicine (esomeprazole) can help prevent or reduce painful swallowing caused by radiation for lung cancer. If you have stage 3 non-small cell lung cancer and are getting chemo and chest radiation, you may be able to join.
Chicago, IllinoisAges 18 years+ - NCT06038305Recruiting
Anemia and growth in kids with stomach bug
This study looks at how common anemia (low iron levels) is in children with acute gastroenteritis (stomach bug), and how their growth is affected. It helps doctors understand if more blood tests or growth checks are needed.
AsyutAges 1 month–2 years - NCT06058572RecruitingPhase 2
Rifaximin for gut bacteria after stem cell transplant in leukemia
This trial tests whether the antibiotic rifaximin can help protect the healthy bacteria in your gut after a stem cell transplant for acute leukemia. It may reduce infections and other complications during your recovery.
Navi Mumbai, MaharashtraAges 18–70 - NCT05992857Recruiting
Omentum wrap to prevent leaks after Whipple surgery
This trial tests if wrapping a flap of abdominal tissue (omentum) around the arteries during Whipple surgery (pancreaticoduodenectomy) can reduce the risk of a serious leak. It may help patients who have a higher fistula risk score (7 or more) during their open surgery.
ClichyAges 18 years+ - NCT05938439Recruiting
Testing a magnetic device for Candy Cane Syndrome
This trial studies how well a small magnetic device works to relieve problems caused by Candy Cane Syndrome, such as pain, nausea, vomiting, or reflux-like symptoms. It will also check whether the device is safe for your anatomy and overall health.
BrusselsAges 18–85
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.