Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,916 recruiting studies in this area right now.
By phase
- Not applicable4,936
- Phase 21,188
- Phase 1583
- Phase 3465
- Phase 1/Phase 2396
- Phase 4237
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer493
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma284
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer148
- Crohn Disease144
- Ulcerative Colitis140
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)107
- Liver Cancer101
- Lung Cancer99
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma89
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University91
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California461
- Arizona174
- Texas148
- Florida135
- Massachusetts127
- Alabama123
- New York123
- Maryland87
- Ohio80
- Pennsylvania72
Recruiting studies7,916 total
- NCT07618273Recruiting
Smart phone app for tracking stomach and digestive health
This study tests a smartphone app called ALEX that helps you track digestive symptoms like bloating, stomach pain, or changes in bowel habits over four weeks. Researchers want to see if the app makes it easier to notice patterns in your symptoms and understand your gut health better.
Jacksonville, FloridaAges 18–44 - NCT07619638Recruiting
Microbiome Supplement for Mild-to-Moderate Ulcerative Colitis
This trial tests a specially designed supplement that aims to restore healthy gut bacteria in people with mild-to-moderate ulcerative colitis. The goal is to reduce inflammation and improve symptoms like rectal bleeding and bowel urgency.
IzmirAges 18–75 - NCT07620210Recruiting
Swallowing Therapy and Pressure Ball Training After Stroke
This study tests whether a swallowing therapy program (CTAR) combined with a pressure ball exercise helps older adults who had a stroke recover their ability to swallow safely. Many stroke survivors struggle with swallowing, which can lead to serious health problems, so this research aims to find better ways to help.
Tainan, Tainan CityAges 65–90 - NCT07621783Recruiting
Blood protein levels and bowel disease activity in IBD
This study measures a blood protein called LRG and compares it to how active your inflammatory bowel disease (IBD) is during a planned scope procedure. The goal is to see if this blood test could help doctors assess disease activity more easily in the future.
BonheidenAges 16 years+ - NCT07623265Recruiting
Understanding Immunotherapy Response in Liver Cancer
This study collects tumor samples and medical information from patients with liver cancer to understand why some patients respond better to immunotherapy (immune-boosting drugs) than others. The goal is to improve treatment selection and outcomes for future patients.
AntwerpAges 18 years+ - NCT07627399Recruiting
Best Care Practices for Stroke in Regular Hospital Units
This study tests whether following best-practice guidelines for stroke care in regular hospital units (rather than specialized stroke centers) helps patients recover better. Researchers will track how well patients do when they receive standardized stroke care protocols.
Antequera, MálagaAges 18 years+ - NCT07627711RecruitingPhase 1/Phase 2
CAR-NK cells for advanced pancreatic cancer
This trial tests specially engineered immune cells (CAR-NK cells) designed to find and attack pancreatic cancer cells. The cells target specific proteins on cancer cells and may help people whose cancer has progressed despite prior treatment.
Shenzhen, GuangdongAges 18–75 - NCT07628751Recruiting
Standard care versus radiation therapy for early-stage liver cancer
This study compares two treatment approaches for early-stage liver cancer: standard treatments (like ablation or chemotherapy injected into blood vessels) versus a newer radiation therapy called SABR. The goal is to see which approach works better and is safer for patients with a single small tumor.
WaratahAges 18 years+ - NCT07628998Recruiting
Text Messages to Encourage Colorectal Cancer Screening
This study tests whether reminder text messages help people complete colorectal cancer screening. You would receive SMS messages encouraging you to schedule a screening test if you haven't done so after an initial invitation.
Sabadell, CataloniaAges 50–69 - NCT07629245RecruitingPhase 1/Phase 2
Cell therapy for Crohn's disease fistulas after prior treatment
This trial tests whether injecting your own fat-derived cells combined with a skin graft can heal anal fistulas (abnormal passages near the anus) that didn't respond to or came back after a previous cell therapy study. You must have already participated in the ADICROHN-2 study.
MarseilleAges 18 years+ - NCT07629609RecruitingPhase 2
New PET scan imaging for pancreatic and stomach cancers
This study tests a new type of PET scan (a detailed imaging test) called [68Ga]Ga-FAPI that may help doctors see cancer better and faster than standard scans. You'll receive this experimental scan to see if it improves cancer detection before surgery.
CopenhagenAges 18 years+ - NCT07629986Recruiting
How antibiotics work in cystic fibrosis patients on ETI therapy
This study measures how antibiotics are processed by the body in people with cystic fibrosis who are taking a combination drug called elexacaftor/tezacaftor/ivacaftor (ETI). Understanding this helps doctors prescribe the right antibiotic doses for patients on this newer treatment.
RoscoffAges 12 years+ - NCT07631000RecruitingPhase 2
Cadonilimab with chemotherapy for stomach cancer surgery
This trial tests a new immunotherapy drug called cadonilimab combined with chemotherapy before surgery for stomach or gastroesophageal junction cancer. The goal is to shrink the tumor and improve outcomes for patients who are candidates for surgery.
Basking Ridge, New JerseyAges 18 years+ - NCT07632118RecruitingPhase 3
Radiation and chemotherapy after pancreatic cancer surgery
This trial tests whether combining radiation therapy with chemotherapy (called the GX regimen) after pancreatic cancer surgery helps prevent cancer from returning in patients with high-risk features. The study aims to see if this combination treatment improves outcomes compared to standard care.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT07632196Recruiting
Nerve Stimulation to Improve Bowel Control After Rectal Cancer Surgery
This trial tests whether a small electrical device placed on the skin behind your ankle can help improve bowel control after surgery to remove rectal cancer. Many patients experience changes in bowel function after this surgery, and this treatment may help restore normal continence.
Manresa, BarcelonaAges 18 years+ - NCT07632573RecruitingPhase 1
Safety Study of BDHK-2009 Tablets in Healthy Adults
This is an early-stage safety study testing a new experimental tablet called BDHK-2009 in healthy volunteers with no major illnesses. Researchers want to make sure the drug is safe and well-tolerated before testing it in people with medical conditions.
Hangzhou, ZhejiangAges 18–55 - NCT07635394Recruiting
Pregabalin for Irritable Bowel Syndrome Relief
This study tests whether pregabalin, a nerve-pain medication, can help reduce irritable bowel syndrome (IBS) symptoms like abdominal pain and irregular bowel habits. Researchers want to see if it's safe and effective for people with mild-to-moderate IBS.
Beijing, Beijing MunicipalityAges 18–70 - NCT07635784Recruiting
Hemorrhoid Treatment Registry: Tracking Embolization Safety
This registry collects information about a minimally invasive procedure called hemorrhoidal artery embolization (HAE), which blocks blood vessels feeding internal hemorrhoids. It's for adults with persistent bleeding hemorrhoids that haven't improved with standard treatments like creams or medications.
Libertyville, IllinoisAges 18 years+ - NCT07635836Recruiting
Two surgical approaches for upper stomach cancer
This trial compares two different surgical techniques for removing upper stomach cancer. The study tests which reconstruction method—double-tract or tubular—leads to better outcomes and quality of life after surgery.
Jinan, ShandongAges 18–75 - NCT07636798RecruitingPhase 1/Phase 2
Chemotherapy and immunotherapy combination for advanced bile duct cancer
This trial tests a combination of three treatments—chemotherapy delivered directly to the liver, plus two immunotherapy drugs—for advanced bile duct cancer that cannot be surgically removed. The goal is to see if this combination works better than standard treatment and is safe for patients.
Chengdu, SichuanAges 18–75 - NCT07636824RecruitingPhase 2
Chemotherapy plus radiation after bile duct cancer surgery
This study tests whether combining chemotherapy and radiation therapy after surgery improves outcomes for patients with bile duct or gallbladder cancer. It's designed for patients whose surgery showed signs the cancer might come back.
BeijingAges 18–80 - NCT07638436RecruitingPhase 2
Immunotherapy with chemotherapy for advanced esophageal cancer
This trial tests whether combining a new immunotherapy drug (adebrelimab) with standard chemotherapy can help shrink borderline resectable esophageal squamous cell carcinoma before surgery. The goal is to make tumors easier to remove and improve survival.
Guangzhou, GuangdongAges 18–75 - NCT07639138RecruitingPhase 2
Lenalidomide with targeted therapy and immunotherapy for advanced liver cancer
This trial tests whether adding lenalidomide (a drug that boosts the immune system) to your current targeted therapy and immunotherapy can help advanced liver cancer that has progressed after previous treatments. You would be eligible if your cancer has already been treated with at least two prior drug combinations and initially responded before growing back.
Beijing, No. 1 Shuaifuyuan, Dongcheng District, Beijing, ChinaAges 18–75 - NCT07640230Recruiting
Cartoons and games to ease surgery anxiety in children
This study tests whether watching cartoons or playing mobile games can help reduce anxiety and fear in children ages 7–12 who need surgery for appendicitis (an inflamed appendix). The goal is to find simple, non-medication ways to calm children before their operation.
AnkaraAges 7–12
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,916 recruiting gastroenterology studies from the U.S. registry right now, out of 12,516 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.