Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,607 recruiting studies in this area right now.
By phase
- Not applicable4,687
- Phase 21,190
- Phase 1566
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer480
- Pancreatic Cancer289
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer147
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Ovarian Cancer90
- Pancreas Cancer90
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis76
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California443
- Arizona189
- Texas140
- Alabama129
- Florida127
- Massachusetts120
- New York120
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,607 total
- NCT06599892Recruiting
Cystic fibrosis care with highly effective modulators
This study looks at how cystic fibrosis care is organized when patients take highly effective CFTR modulator drugs. It aims to understand if care needs change for those on modulators compared to those who cannot take them.
LyonAges 6 years+ - NCT05959577Recruiting
Compare hemorrhoid surgeries: standard removal vs stapling
This study compares two surgical treatments for severe hemorrhoids: traditional excision versus a stapling procedure. It may help you and your care team choose the approach that works best for symptoms in grade III–IV hemorrhoids.
TaipeiAges 25–75 - NCT06590259RecruitingPhase 2
Ablation plus drug therapy for colorectal cancer liver metastases
This trial tests a combination treatment that uses heat or cold (ablation) to destroy liver tumors along with medicines that boost your immune system to fight cancer. It is for people whose colorectal cancer has spread to the liver and who could not have surgery, or whose first treatment stopped working.
ShanghaiAges 18–75 - NCT05964530Recruiting
Testing local removal versus radical surgery for rectal cancer
This trial looks at whether removing the rectal tumor locally (through the anus) can work as well as a more extensive operation after scans show no remaining cancer. It may help some people avoid bigger surgery if the cancer truly appears gone after treatment.
TaipeiAges 18–75 - NCT06586983Recruiting
Hepatitis B care closer to home in Ethiopia
This trial tests a program to bring hepatitis B care to local clinics in Ethiopia, so you may not need to travel far for treatment. It is for adults who have tested positive for hepatitis B surface antigen (HBsAg), meaning they have a current hepatitis B infection.
Addis Ababa, Addis AbabaAges 18 years+ - NCT06587425RecruitingPhase 2
Combination therapy for CLDN18.2-positive advanced stomach cancer
This study tests a combination of three drugs (LM-302, Candonilimab, and Capecitabine) as the first treatment for advanced stomach cancer that has a specific protein (Claudin 18.2). It aims to see if the combination shrinks tumors and is safe.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06589388Recruiting
Using a blood test to predict rectal cancer treatment success
This trial is looking at whether a simple blood test (ctDNA monitoring) can help predict how well total neoadjuvant therapy (chemo and radiation before surgery) works for rectal cancer. It may help doctors tailor treatment to your specific needs.
Ho Chi Minh CityAges 18–80 - NCT06601231Recruiting
Better liver cancer screening with GAAD score and imaging
This study looks at whether adding a blood test (the GAAD score) to standard imaging can better detect liver cancer at an early stage in people with chronic liver disease. It may help you if you have cirrhosis or certain types of liver scarring.
Rotterdam, CAAges 18 years+ - NCT06608381RecruitingPhase 3
Comparing partial vs. total omentectomy in gastric cancer surgery
This trial compares removing part or all of the fatty lining of the stomach (omentum) during minimally invasive surgery for a certain stage of gastric cancer. The goal is to see if removing less tissue is as safe and effective.
SeoulAges 20–85 - NCT06603376RecruitingPhase 2
Drug combo for BRAF-mutated advanced colorectal cancer
This trial tests a combination of four drugs (irinotecan liposome, fluorouracil, folinic acid, vermofenib, and cetuximab) as a first treatment for people with advanced colorectal cancer that has a specific BRAF V600E mutation. It aims to see if this combination can shrink tumors or slow their growth.
ShanghaiAges 18–80 - NCT06603337Recruiting
Switching advanced meds for Crohn's or colitis
This trial looks at people with Crohn's disease or ulcerative colitis who have already tried and failed at least one advanced medication (like a biologic or small molecule drug). If you are starting a new advanced therapy, researchers will track how well it works for you.
RomaAges 18–70 - NCT06602843Recruiting
Chemoimmunotherapy before and after surgery for esophageal cancer
This trial tests a treatment plan that combines chemotherapy and immunotherapy before surgery, followed by radiation and immunotherapy after surgery for people with esophageal squamous cell cancer. It aims to see if this approach helps prevent the cancer from coming back.
HefeiAges 18–75 - NCT07749586RecruitingPhase 1/Phase 2
Study of ARV-6723 alone or with pembrolizumab for advanced solid tumors
This trial tests an experimental drug called ARV-6723, alone or with another drug called pembrolizumab, for people with advanced solid tumors that have not responded to other treatments. The goal is to see if these combinations can help shrink tumors or slow their growth.
New York, New YorkAges 18 years+ - NCT07748403RecruitingPhase 1/Phase 2
Gene therapy for Wilson disease
This trial is testing an experimental gene therapy called PM577 that aims to fix the faulty gene causing Wilson disease. It might offer a new treatment option that could reduce or replace the need for daily medications.
New Haven, ConnecticutAges 12 years+ - NCT07744425Enrolling by invitation
Surgical imaging device study
This study tests a new camera that helps surgeons see tissues more clearly during surgery. It may help improve surgical precision and safety.
Palo Alto, CaliforniaAges 18–90 - NCT07742735RecruitingPhase 3
Study of apraglutide for short bowel syndrome with intestinal failure
This study tests a new medicine called apraglutide, given as a shot, to see if it can help adults with short bowel syndrome and intestinal failure reduce their need for intravenous nutrition (parenteral support). The study compares apraglutide to a placebo (a shot with no medicine) to check if it is safe and effective.
Los Angeles, CaliforniaAges 18 years+ - NCT06606756Recruiting
Registry for children with inflammatory bowel disease
This registry collects information about children and teenagers with inflammatory bowel disease (IBD) to help doctors better understand and treat the condition. By joining, you'll help researchers learn more about IBD in young people.
GiessenAges Up to 18 years - NCT06609447RecruitingPhase 4
Probiotic with vedolizumab for moderate ulcerative colitis
This study tests whether adding a special probiotic (VSL#3) to vedolizumab helps people with moderate ulcerative colitis more than vedolizumab alone. You may qualify if you are already planning to start vedolizumab and haven't responded well enough to other treatments.
Beijing, Beijing MunicipalityAges 18–85 - NCT06609551RecruitingPhase 3
ctDNA-guided chemo choice for elderly colon cancer patients
This trial tests whether using a ctDNA blood test can help choose the best chemotherapy after colon cancer surgery for people aged 70–80. It aims to make treatment more personalized and reduce side effects.
Hangzhou, ZhejiangAges 70–80 - NCT07744672Recruiting
Comparing two surgeries for high anal fistula
This trial compares two surgical techniques to treat a complex type of anal fistula (an abnormal tunnel between the anal canal and skin). It aims to find which approach offers better healing and fewer risks.
CairoAges 16 years+ - NCT07744087Recruiting
Comparing two surgical methods for removing tumors near the pancreas
This trial compares two types of surgery to remove tumors that start near the pancreas but not in it. The goal is to see if a newer, less invasive method works as well as the standard approach, which may mean fewer cuts and a faster recovery.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07749092Recruiting
Kimchi powder for gut health in IBS
This study tests whether taking kimchi powder (a dried form of the fermented cabbage dish) can improve gut health and symptoms in people with diarrhea-predominant IBS. You'll avoid regular kimchi for about 2 months, then take the powder daily and track how you feel.
YangsanAges 20–70 - NCT07744230Enrolling by invitation
Preventing hernias after liver transplant with a mesh
This study tests whether placing a special mesh during a liver transplant can prevent hernias from forming later. It is for patients who have certain risk factors that make hernias more likely.
Rome, LazioAges 18 years+ - NCT07741435Recruiting
Simple blood, urine, and saliva test to find cancer early
This study tests a new way to find cancer by looking at DNA in blood, urine, and saliva. It may help detect cancer earlier and monitor how well treatment works.
Bogotá, Bogota D.C.Ages 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,607 recruiting gastroenterology studies from the U.S. registry right now, out of 11,926 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.