Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,877 recruiting studies in this area right now.
By phase
- Not applicable4,908
- Phase 21,181
- Phase 1583
- Phase 3466
- Phase 1/Phase 2391
- Phase 4235
- Phase 2/Phase 3113
Top conditions
- Colorectal Cancer495
- Gastric Cancer297
- Pancreatic Cancer293
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer174
- Breast Cancer145
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer113
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)105
- Liver Cancer99
- Lung Cancer98
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas146
- Florida134
- Massachusetts128
- New York123
- Alabama121
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,877 total
- NCT06650332RecruitingPhase 1/Phase 2
Cadonilimab combo for first-line HER2-positive gastric cancer
This trial tests a new combination treatment (cadonilimab plus chemotherapy) as the first therapy for people with advanced gastric or gastroesophageal junction cancer that has a certain amount of HER2 protein. It aims to see if this combination can shrink tumors and help people live longer.
Hangzhou, ZhejiangAges 18–75 - NCT04982276RecruitingPhase 1/Phase 2
Test new cancer drugs for advanced stomach or esophagus cancer
This Phase 1/2 study tests the safety and effectiveness of two investigational drugs (AK109 and AK104) in people with advanced stomach (or lower esophagus/GEJ) cancer. It’s for cases where the cancer did not respond to first-line treatment that included anti–PD-1/PD-L1 therapy plus chemotherapy.
BeijingAges 18–75 - NCT06934538RecruitingPhase 1/Phase 2
Immunotherapy trial for advanced colorectal cancer
This trial tests a new immunotherapy drug (STC-1010) for people with colorectal cancer that cannot be removed by surgery or has spread. It aims to see if the drug can shrink tumors or slow the disease.
Baltimore, MarylandAges 18–75 - NCT06642883Recruiting
A supplement for gut health in ulcerative colitis remission
This study tests a supplement called ProLife 10 FORTE to see if it affects the natural balance of gut bacteria in people with ulcerative colitis (UC) that is in remission. If you have UC that is not active and you meet other health criteria, you may be able to join.
Padua, PaduaAges 18–75 - NCT06410443Recruiting
Steroid treatment for radiation-induced bowel injury
This trial tests if local steroids can help heal bowel damage caused by radiation therapy for cancer. It may reduce pain, bleeding, and urgency, and improve quality of life.
Shenyang, LiaoningAges 18 years+ - NCT07144111RecruitingPhase 1
Liver Function and Inavolisib Study
This study tests how the body processes the drug inavolisib when taken by people with moderate or severe liver problems compared to those with healthy livers. It helps doctors understand the right dose for patients with liver impairment.
Lake Forest, CaliforniaAges 18–80 - NCT07145151RecruitingPhase 2
Studying UBT251 for MASH liver disease
This trial tests a new medication called UBT251 for people with MASH, a type of liver disease linked to weight and metabolism. It aims to see if the medicine can reduce liver damage and scarring.
Beijing, Beijing MunicipalityAges 18–75 - NCT06633250Recruiting
Testing a rice-based formula for babies with cow's milk allergy
This trial tests a special formula made from hydrolyzed rice protein in babies with cow's milk protein allergy. The goal is to see if the formula supports healthy growth and is well-tolerated, while also improving quality of life.
BerlinAges Up to 8 months - NCT06979102Enrolling by invitation
Stoma care teaching for new ileostomy patients and caregivers
This trial tests a teaching method that uses a real patient to help new ileostomy patients and their unpaid caregivers learn stoma care and management. It aims to improve confidence and skills.
Ankara, TurkeyAges 18 years+ - NCT07589465Recruiting
Lactulose to Help Digestion Recover After Appendix Surgery
This study tests whether taking lactulose (a gentle laxative) after appendix removal helps your stomach and intestines work normally again. The trial compares lactulose to a placebo (inactive pill) to see which helps patients recover bowel function faster.
SichuanAges 18 years+ - NCT06786793Recruiting
AI in colonoscopy screening study
This study tests whether artificial intelligence can help doctors find polyps or other issues during a colonoscopy. It may lead to better detection and earlier treatment.
Krakow, Lesser PoladnAges 50–65 - NCT06075199Recruiting
Study of stomach lining changes for cancer risk
This study follows people with intestinal metaplasia (a change in the stomach lining) over time to better understand who might develop stomach cancer. It does not test a new treatment but aims to improve prediction and prevention.
SeoulAges 18 years+ - NCT07537673RecruitingPhase 2
Ear Stimulation Plus Steroid for Chemo Nausea Relief
This trial tests whether stimulating specific points on your ear combined with a steroid medication can reduce nausea and vomiting caused by trastuzumab deruxtecan, a breast cancer drug. The goal is to help you feel better during treatment.
HangzhouAges 18–85 - NCT06074679Recruiting
Single incision gallbladder surgery for acute cholecystitis
This study tests whether removing the gallbladder through a single small cut (single incision laparoscopic cholecystectomy) is safe and effective for people with acute cholecystitis (sudden gallbladder inflammation). It may mean less pain and faster recovery than traditional surgery.
Huangshan City, AnhuiAges 18–70 - NCT05786404RecruitingPhase 1
Fecal transplant study for people with active ulcerative colitis
This trial tests whether transplanting stool bacteria (called fecal microbiota transplantation, or FMT) can improve symptoms in people with active ulcerative colitis. You may be able to help test a new approach for restoring gut bacteria, while receiving standard ulcerative colitis care from your doctor.
Houston, TexasAges 18 years+ - NCT06070740RecruitingPhase 2
Durvalumab Plus Chemo for Advanced Gastrointestinal NEC
This trial tests a combination of durvalumab (an immunotherapy drug) plus a chemotherapy called XELOX as the first treatment for advanced gastrointestinal neuroendocrine carcinoma (NEC). It aims to see if the combination works better than chemo alone.
Beijing, Beijing MunicipalityAges 18–75 - NCT06074536Recruiting
Training doctors to share decisions in colorectal cancer screening
This study tests whether training doctors to better involve patients in decisions about colorectal cancer screening improves shared decision-making. If you are between 50 and 74 and due for screening, your GP might invite you to join.
Soisy-sous-MontmorencyAges 50–74 - NCT04891016RecruitingPhase 2
Immunotherapy with chemotherapy for locally advanced stomach cancer
This trial studies toripalimab (an immune system medicine) plus FLOT chemotherapy in people with stomach cancer that has grown locally but hasn’t spread to distant organs. It aims to improve control of the cancer and help more people have their tumors fully treated.
Zhengzhou, HenanAges 18–70 - NCT06996379Recruiting
Testing J-Tip for pain relief during belly fluid drainage
This trial tests a device called J-Tip that numbs the skin before a paracentesis (a procedure to drain fluid from your belly). It's for adults with cirrhosis and ascites in the emergency department or hospital, and aims to make the procedure less painful.
Chicago, IllinoisAges 18 years+ - NCT07054983Enrolling by invitation
Parent interviews on tube weaning experiences
This study interviews parents about their child's tube weaning process to understand what helps or makes it harder. Your insights could help improve support for other families.
Kansas City, MissouriAges 18 years+ - NCT06749990Recruiting
Alcohol relapse risk after liver transplant
This study looks at why some people with alcohol-related liver disease start drinking again after a liver transplant. It aims to find factors that increase or decrease that risk.
BolognaAges 18 years+ - NCT06626074Recruiting
MRI study for NASH diagnosis
This study looks at MRI scans to find better ways to diagnose NASH (a type of fatty liver disease with inflammation). If you are already scheduled for a liver biopsy for suspected NASH, an MRI might help researchers learn more about your condition.
Angers, FranceAges 18 years+ - NCT06423508Recruiting
Testing stool storage methods and gut bacteria differences
This trial will study how different storage methods affect stool samples for gut bacteria analysis. It aims to understand differences in gut bacteria between people over time. Participation involves providing stool samples.
Vienna, State of ViennaAges 18–70 - NCT06625957RecruitingPhase 3
NTCB02-1 trial for patients needing IV nutrition
This trial tests an investigational IV nutrition product called NTCB02-1 in patients who need nutrition through a vein (parenteral nutrition) for at least 3 days. It aims to see if it is safe and works well.
Gyeonggi-do, Goyang-siAges 19 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,877 recruiting gastroenterology studies from the U.S. registry right now, out of 12,321 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.