Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT07288346Recruiting
Predicting success of double-balloon endoscopy
This trial uses a CT scan to predict how well a special endoscope can reach the entire small intestine. It may help doctors plan your procedure and improve results.
Dezhou, ShandongAges 18–80 - NCT07285096Recruiting
New quadruple therapy for H. pylori infection
This trial tests a combination of four medications to treat H. pylori, a bacteria that can cause stomach ulcers and other issues. The goal is to see if this newer therapy works well for people who are infected.
JinanAges 18–70 - NCT06809036Recruiting
Mobilisation and breathing exercises after abdominal surgery
This study tests whether a supervised program of moving and breathing exercises helps patients recover faster after open or robot-assisted abdominal surgery. It may reduce complications and speed up return to daily activities.
GothenburgAges 18 years+ - NCT06505395RecruitingPhase 2
Octreotide injection for advanced neuroendocrine tumors
This trial is testing an injectable medicine called octreotide for people with advanced neuroendocrine tumors of the digestive system or pancreas. It aims to see if the medicine can help control the tumor.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07280949Recruiting
Pain relief study for laparoscopic colon surgery
This study tests a new combination of pain blocks for people having laparoscopic (keyhole) colon or rectal surgery. The goal is to see if adding a back muscle block to the standard abdominal wall block provides better pain relief.
Cairo, GovernorateAges 18–90 - NCT04491929Recruiting
Radiation treatment for colon cancer in the liver using tiny beads
This trial studies a targeted liver radiation procedure that uses tiny radioactive beads to treat colon cancer spread mostly in the liver. It may help people whose liver tumors cannot be removed or treated with other common local treatments, but it has several safety and “screening” checks.
Aarhus N, DanmarkAges 18 years+ - NCT07592013Enrolling by invitation
Ancestry Supplements for Fatty Liver Disease
This study tests whether a special supplement (made from cacao, nopal, and crickets) can help improve fatty liver disease in people with excess body fat. Fatty liver disease happens when fat builds up in the liver, and this trial investigates whether these natural ingredients can reduce that buildup.
Guadalajara, GuadalajaraAges 18–60 - NCT07346066RecruitingPhase 3
A trial of IS-001 injection for robotic colorectal surgery
This trial tests an injection called IS-001 during robotic-assisted colorectal surgery. It may help surgeons see the ureters more clearly, which could reduce the risk of injury.
Newport Beach, CaliforniaAges 16–75 - NCT06506292RecruitingPhase 2
Study of adebrelimab plus chemo before and after stomach cancer surgery
This trial tests combining adebrelimab (an immunotherapy) with chemotherapy (XELOX) before and after surgery for stomach cancer that hasn't spread. The goal is to see if this approach helps shrink tumors and improves outcomes.
Tianjin, Tianjin MunicipalityAges 18–75 - NCT06825546RecruitingPhase 2
Icaritin plus chemo for advanced pancreatic cancer
This trial tests a new combination of a plant-based drug (icaritin) and two chemotherapy drugs (AG) for people with advanced pancreatic cancer who have not had treatment before. The goal is to see if the combination works better than chemotherapy alone.
Guangzhou, GuangdongAges 18–80 - NCT06963125Recruiting
Prune juice for constipation in older adults
This study tests whether drinking prune juice can improve bowel movements, reduce constipation symptoms, and enhance quality of life in older adults who have trouble going to the bathroom regularly.
Chiayi City, Chiayi CountyAges 65–100 - NCT07277946Recruiting
Testing a new mesh fixation system for laparoscopic hernia repair
This study is testing a new system (ECLIPSIUM) for fixing mesh during laparoscopic hernia repair. It aims to see if the system is safe and works well for people with a single midline hernia (ventral, umbilical, or incisional) that is small to medium size (1-5 cm). If you qualify, the study will help doctors repair your hernia with a special mesh that may reduce complications.
Loma Linda, CaliforniaAges 22 years+ - NCT05121025Recruiting
Study of stomach bacteria and gut microbes in Helicobacter infection
This study looks at how stomach bacteria (Helicobacter pylori) interact with the normal microbes in your gut. You may be asked to provide tissue, stool, and blood samples to help researchers understand infection and the body’s response.
Freiburg im Breisgau, Baden-WurttembergAges 18 years+ - NCT07276568Enrolling by invitationEarly Phase 1
Hepatocyte-like cell injection for small liver syndrome
This early-phase trial tests an injection of lab-grown liver cells into the stomach muscle to prevent or treat small-for-size syndrome, a condition where a partial liver graft is too small. It may also help people with acute or chronic liver failure.
Beijing, ProvinceAges Any age - NCT07175441RecruitingPhase 2
Testing a new drug combo for advanced liver cancer
This trial tests a new drug called RBS2418 added to two immunotherapy medicines (tremelimumab and durvalumab) for people with advanced liver cancer that cannot be removed by surgery. The goal is to see if the combination helps patients who are starting their first treatment for this stage of liver cancer.
Baltimore, MarylandAges 18 years+ - NCT07321470Recruiting
Nasogastric tube care after pancreas surgery
This trial compares two ways of managing nasogastric tubes after pancreas and bile duct surgery. One group gets a tube for a while, the other avoids one. It tests if skipping the tube helps recovery.
Taipei, Zhongzheng DistrictAges 20–75 - NCT07276100RecruitingPhase 2
Fecal transplant to help liver cancer that worsened on first treatment
This trial tests whether transplanting healthy stool bacteria into your gut can help your own immune system fight liver cancer that has stopped responding to the standard first combination treatment (atezolizumab + bevacizumab). It is for patients whose liver cancer has started growing quickly despite that treatment.
Bologna, BOAges 18 years+ - NCT06929962RecruitingPhase 4
VA dual sequential therapy for H. pylori gastritis
This trial tests a new two-step antibiotic treatment for adults with chronic gastritis caused by H. pylori bacteria. If you have not been treated for H. pylori before and are between 18 and 70, you may be able to join.
Nanjing, JiangsuAges 18–70 - NCT07275866Recruiting
Probiotic study for people with constipation
This study tests whether a multi-strain probiotic can help relieve constipation. You would stop other constipation treatments and track your symptoms with a daily diary.
LondonAges 18–70 - NCT07274579Enrolling by invitation
AI tool for gastric cancer protein testing
This trial tests an artificial intelligence model that helps doctors interpret a specific protein test (CLDN18.2) in stomach cancer tissue samples. It may help guide future treatment decisions.
Guangzhou, GuangdongAges 18 years+ - NCT07273331Enrolling by invitation
Nursing needs for people with cirrhosis
This study asks people with liver cirrhosis about their nursing needs. Your answers will help nurses better support others with the same condition.
ReykjavikAges Any age - NCT07272577Recruiting
Nerve block for pain after laparoscopic abdominal surgery
This study tests a nerve block (erector spinae plane block) to see if it helps reduce pain after laparoscopic abdominal surgery. If you're having keyhole surgery, you may receive the block along with standard anesthesia.
AsyutAges 18 years+ - NCT07272928Recruiting
Comparing surgery order for liver spread from colon cancer
This trial looks at whether removing the colon tumor or the liver tumors first affects recovery in patients having both removed at the same time. It helps doctors decide the best surgical approach.
Alessandria, PiedmontAges 18 years+ - NCT07179159Recruiting
14-day stomach infection treatment study
This study compares two treatments for an H. pylori stomach infection: taking two medicines (vonoprazan and amoxicillin) versus taking four medicines. Both treatments are given for 14 days.
Jinan, ShandongAges 18–70
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.