Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT03977779Recruiting
Stent to help prevent pancreatitis after endoscopy
This trial tests a temporary, biodegradable stent to lower the chance of getting pancreatitis after an ERCP endoscopy procedure. It may help people who are considered at higher risk, by trying to prevent this complication.
Marseille, Provence-Alpes-Côte d'Azur RegionAges 18 years+ - NCT04964869Recruiting
Epinephrine injection to prevent delayed bleeding after sphincterotomy
This trial tests whether a one-time epinephrine medicine injection can help prevent delayed bleeding after an ERCP procedure called sphincterotomy. You may be considered if you had only brief bleeding right after the procedure and you don’t have certain bleeding-risk conditions.
Taichung, North Dist.Ages 20 years+ - NCT04516681RecruitingPhase 3
Ascorbic acid plus immunotherapy for spread colorectal cancer
This trial tests whether intravenous vitamin C (ascorbic acid) combined with an immune treatment (adebrelimab) can slow or shrink metastatic colorectal cancer that can’t be removed with surgery. It focuses on tumors that strongly show a specific marker called GLUT3, and aims to see if the combination works better than standard approaches.
Shanhai, Shanghai MunicipalityAges 18–75 - NCT06533592Recruiting
Bile duct connection technique in liver transplant
This study compares two ways of connecting the bile duct during a liver transplant to see which leads to a smoother recovery. It is for adults having a planned first transplant from a deceased donor.
Warsaw, Masovian VoivodeshipAges 18–75 - NCT06611345Recruiting
Tumor-treating fields with immunotherapy and chemo for bile duct cancer
This trial is testing a new combination of treatments—a wearable device that sends electric fields to the tumor area (tumor-treating fields) plus immunotherapy (durvalumab) and chemotherapy (gemcitabine/cisplatin)—for people with advanced bile duct or gallbladder cancer. It may be an option if you haven't had chemotherapy for advanced disease before.
HefeiAges 18–75 - NCT04305769RecruitingPhase 2
Alanyl-glutamine to help treat C. difficile diarrhea
This study tests whether the supplement alanyl-glutamine, given along with standard treatment, can improve outcomes for adults being treated for C. difficile infection (a cause of diarrhea). It may help the body recover better after antibiotics that usually treat C. difficile.
Charlottesville, VirginiaAges 18–105 - NCT05851534Recruiting
Pre-surgery risk reduction for pancreatic surgery
This study helps people going for planned pancreatic cancer surgery (with or without chemo beforehand) by focusing on controllable risk factors before the operation. The goal is to improve safety and outcomes after surgery.
's-HertogenboschAges 18 years+ - NCT07686757Enrolling by invitationPhase 4
Study of mirikizumab for ulcerative colitis and Crohn's disease
This study tests a new medicine called mirikizumab for people with ulcerative colitis or Crohn's disease who have not responded well to other treatments. It aims to see if mirikizumab can help control symptoms and improve quality of life.
Sun City, ArizonaAges 21 years+ - NCT07685652Recruiting
Better prep for colonoscopy with video and booklet
This study tests if watching a short video and reading a booklet helps patients prepare better for a colonoscopy compared to just getting standard instructions. Good preparation makes the procedure safer and more effective.
Sibu, SarawakAges 18 years+ - NCT07687589Enrolling by invitation
Testing a gut hormone for nausea in healthy adults
This study tests whether a natural gut hormone called GIP can reduce nausea by increasing blood flow to the gut. Researchers want to see how this works in healthy people.
HellerupAges 18–60 - NCT07686406Recruiting
IBD biomarker discovery study
This study collects blood, stool, tissue, and health information from people with inflammatory bowel disease (IBD), their relatives, and healthy volunteers to find patterns that may help diagnose or treat IBD better in the future.
Guangzhou, GuangdongAges 14 years+ - NCT07684716Recruiting
Personalized non-drug help for colonoscopy prep
This study tests a personalized, non-drug method to improve bowel preparation for colonoscopy. If you are scheduled for a colonoscopy and need to take laxatives, this approach might help you get better results.
Shenyang, LiaoningAges 18 years+ - NCT07685938RecruitingPhase 2
Medicines to prevent heart damage from radiation
This trial tests whether common heart medicines (statins or ACE-inhibitors) can protect the heart during cancer radiation therapy. It is for adults who are about to start chest radiation and have not taken these drugs before.
Chapel Hill, North CarolinaAges 18 years+ - NCT07681128Recruiting
Studying a new surgical stitch to help stomach emptying after pancreas surgery
This trial is testing whether adding a special connection (Braun anastomosis) between two parts of the small intestine during pancreas surgery can reduce delayed stomach emptying, a common problem after the procedure.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07687628Recruiting
Camera test for breathing trouble in newborns with fistula
This study tests whether a camera-based scope can help doctors diagnose breathing problems in newborns who had surgery for a birth defect where the food tube and windpipe are connected. The goal is to avoid putting a breathing tube in the child during the exam.
Bergamo, ItalyAges birth–4 weeks - NCT07686640RecruitingPhase 3
Short course radiation plus chemo with or without immunotherapy for rectal cancer
This trial tests whether adding two immunotherapy drugs (iparomlimab and tuvonralimab) to standard short-course radiation and chemotherapy improves outcomes in people with a common type of locally advanced rectal cancer (pMMR/MSS). It is for those with stage II or III cancer that has at least one high-risk feature and is within 12 cm of the anal verge.
Jinan, ShandongAges 18–75 - NCT07686133Enrolling by invitation
Digital education for colon and rectal cancer patients
This trial tests a digital education program for patients with colon or rectal cancer who are scheduled for surgery. It aims to see if online learning helps people better prepare for their operation and recovery.
TorontoAges 18 years+ - NCT07687875RecruitingPhase 1
Virus therapy plus immunotherapy before surgery for rectal cancer
This trial tests a combination of a cancer-killing virus (oncolytic virotherapy) and an immunotherapy drug (pembrolizumab) given before surgery for a certain type of rectal cancer. It aims to see if this approach helps shrink the tumor and improve outcomes for patients whose tumors have a normal DNA repair system (pMMR).
Copenhagen, Captial RegionAges 18 years+ - NCT07684326RecruitingPhase 2/Phase 3
Can dapagliflozin help liver cirrhosis with fluid buildup? (Phase 2/3 randomized trial)
This trial tests a diabetes pill (dapagliflozin) to see if it helps people with liver cirrhosis and fluid buildup (ascites). The goal is to improve fluid balance and possibly reduce hospital stays.
GizaAges 18 years+ - NCT07687303Recruiting
Ventilator modes and stomach tube tolerance in ICU patients
This study looks at how different ventilator settings affect pressure in the belly and how well patients tolerate a feeding tube. It may help doctors choose the best ventilator mode for you.
DamanhūrAges 18–60 - NCT07681089RecruitingPhase 2
Foscenvivint for HIV/HCV cirrhosis with hemophilia
This trial tests a drug called foscenvivint for people with hemophilia and liver cirrhosis caused by both HIV and hepatitis C (already treated). The study aims to see if it can help improve liver health.
Sapporo, HokkaidoAges 18–79 - NCT07685353Recruiting
Genes and graft fat after liver transplant study
This study looks at how genetic differences between liver donors and recipients affect fat buildup in the new liver after transplantation. It may help doctors understand why some transplanted livers develop steatosis (fatty liver) after the surgery.
New DelhiAges 18 years+ - NCT07688044Recruiting
How food and bacteria cause belly pain in IBS
This study looks at how certain foods and gut bacteria might trigger abdominal pain in people with Irritable Bowel Syndrome (IBS). If you have IBS and frequent belly pain, you may help researchers understand the link between diet, bacteria, and pain.
Kingston, OntarioAges 18–70 - NCT07683221RecruitingPhase 2
Combination treatment for locally advanced pancreatic cancer
This trial tests a new combination of drugs with radiation therapy for people with locally advanced pancreatic cancer that cannot be removed with surgery. The treatment aims to shrink the tumor and improve outcomes.
Jinan, ShandongAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.