Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT07199491Enrolling by invitation
Healthy lifestyle program for Hispanics with fatty liver disease
This trial tests a culturally tailored lifestyle program for Hispanic adults with fatty liver disease (MASLD). It aims to help improve liver health through diet and activity changes with support from a family member.
Houston, TexasAges 18 years+ - NCT06844604Recruiting
Comparing carbon footprint of robotic, laparoscopic, and open colorectal surgery
This study measures the environmental impact (carbon footprint) of different surgical techniques for removing part of the colon or rectum. It aims to find which approach is more sustainable without compromising patient care.
BaselAges 18 years+ - NCT07196735Recruiting
Body composition study for women with functional dyspepsia
This study uses a simple, painless test (bio-electrical impedance) to measure body composition in women with functional dyspepsia (stomach discomfort without a clear cause). It aims to better understand how body makeup relates to symptoms.
BrusselsAges 18–75 - NCT07198984Recruiting
Boosting gut bacteria to improve digestive health
This study tests whether boosting certain gut bacteria can improve your gut health. If you're a healthy adult who exercises regularly or eats a flexitarian diet, this trial may be for you.
Jouy-en-JosasAges 20–80 - NCT06845865Recruiting
Gut barrier test in ICU patients with organ failure
This study looks at how the gut barrier works in people with severe infections that cause organ failure. It measures intestinal permeability using a simple test, to see if a 'leaky gut' contributes to how sick patients get.
VincennesAges 18 years+ - NCT04804891RecruitingPhase 1
Personalized immune medicine plan after intestinal transplant
This Phase 1 study tests a way to lower (minimize) the immune-suppressing medicines after an intestinal transplant while still keeping the new organ safe. It uses blood tests that look at immune activity and “chimerism” to guide how strong the immune suppression needs to be.
New York, New YorkAges 18–65 - NCT07258771RecruitingPhase 4
Upadacitinib plus steroids vs steroids alone for severe ulcerative colitis
This trial tests if adding upadacitinib (a pill) to standard steroid treatment helps people with a severe flare of ulcerative colitis feel better faster. You may qualify if you are having frequent bloody stools and signs of serious inflammation, and you haven't tried upadacitinib before.
Ann Arbor, MichiganAges 18–75 - NCT07193836Enrolling by invitation
Lidocaine for easier recovery after laparoscopic surgery
This study tests whether giving lidocaine (a numbing medicine) through an IV can help you wake up more smoothly and with less discomfort after laparoscopic gallbladder or gynecologic surgery. If you are generally healthy and having one of these specific surgeries, you may be a good fit.
Yinchuan, NingxiaAges 18–70 - NCT06543979RecruitingPhase 1/Phase 2
Anorectal manometry for children with chronic constipation
This study is for children aged 4–16 who have long-term constipation that doesn't get better with standard laxatives. It uses a test called anorectal manometry to measure how well the muscles in the bottom work, which can help guide treatment.
CairoAges 4–16 - NCT06048445Recruiting
Preventing bile duct issues after children's liver transplant
This trial tests placing a temporary drainage stent during liver transplant surgery in children to see if it helps prevent bile duct complications. It might improve recovery for young transplant recipients.
Hangzhou, ZhejiangAges 1–6 - NCT07190495RecruitingPhase 4
Ginger to prevent nausea after gallbladder surgery
This trial tests if taking ginger can help prevent nausea and vomiting after gallbladder surgery. It might be an option for people who want a natural remedy to feel better after their operation.
Nabeul, Nabeul GovernorateAges 18 years+ - NCT06738550Enrolling by invitation
Agave inulin for constipation in new dialysis patients
This study tests whether a natural fiber supplement called agave inulin can help with constipation and improve quality of life for people who have just started peritoneal dialysis for kidney failure.
Metepec, State of MexicoAges 18 years+ - NCT05654649RecruitingPhase 1/Phase 2
Dexamethasone to prevent bowel blockage after C-section
This trial studies whether a medicine called dexamethasone can help prevent bowel “slow-down” (ileus) after a C-section done with spinal anesthesia. If you qualify, you may receive the study medicine to see if it helps you recover your bowel function faster.
AsyutAges 18–40 - NCT07188220Recruiting
Understanding patient views on fatty liver disease study
This study asks people with metabolic fatty liver disease and liver scarring about their experiences. It aims to learn what matters to you so doctors can improve care.
BarcelonaAges 18–75 - NCT07643298Recruiting
Lidocaine through feeding tube to reduce nausea after weight-loss surgery
This study tests whether delivering lidocaine (a numbing medication) through a feeding tube during weight-loss surgery can reduce nausea and vomiting afterward. You would receive this medication as part of the surgery procedure to see if it helps you feel better in recovery.
Yinchuan, NingxiaAges 18–65 - NCT07182565RecruitingPhase 1/Phase 2
Short radiation plus chemotheapy and immunotherapy before surgery for junction cancer
This trial tests a combination of shortened radiation therapy, immunotherapy, and chemotherapy given before surgery for cancer at the junction of the esophagus and stomach. The goal is to see if this approach is safe and improves outcomes.
Xiamen, FujianAges 18 years+ - NCT07182942RecruitingPhase 4
Study of Xiqing and Probiotics for Chronic Kidney Disease
This trial tests if taking Xiqing (a Chinese herbal product) and probiotics together can help people with chronic kidney disease (CKD) by improving gut health and making their medication work better. It is for patients with moderate to advanced CKD who do not need dialysis yet.
Wuhan, HubeiAges 18–75 - NCT06849193Recruiting
Predicting treatment outcomes in advanced bile duct cancer
This study looks at how well current chemotherapy and immunotherapy work for advanced bile duct or gallbladder cancers that cannot be removed by surgery. Researchers will collect data from multiple centers to build a model that helps predict how patients may respond to treatment.
Nanjing, JiangsuAges 18 years+ - NCT06813976RecruitingPhase 3
Chemotherapy after surgery for ampullary cancer
This trial compares two types of chemotherapy to see which works better after surgery for ampullary cancer. One treatment is a stronger combination (FOLFIRINOX), and the other is a single drug (capecitabine or gemcitabine). It is for people whose cancer was completely removed by surgery and who have no spread to other organs.
DijonAges 18 years+ - NCT07171593Enrolling by invitation
High protein drink for Crohn's with muscle loss
This trial tests if a high protein oral nutrition drink with HMB can help people with active Crohn's disease who also have muscle loss (sarcopenia). The goal is to see if it improves muscle strength and overall health.
Guangzhou, GuangdongAges 18–50 - NCT06549907Recruiting
Study of double immunotherapy plus anti-angiogenic therapy
This trial studies people with certain types of colorectal or other solid tumors that did not respond to a single immunotherapy drug. It tests whether adding a second immune checkpoint blocker and an anti-angiogenic drug can help control the cancer.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07161765Enrolling by invitation
Straining and bowel issues in bleeding hemorrhoids
This study looks at how problems with bowel movements and straining relate to bleeding hemorrhoids. It may help find better ways to treat these symptoms.
Ann Arbor, MichiganAges 18 years+ - NCT04707443Recruiting
Feeding support for newborns with a small-bowel stoma
This trial looks at how to provide nutrition by mouth or through a feeding tube (enteral feeding) for babies who have a small-bowel stoma (an opening made for stool to leave the body). It may help babies grow and get adequate nutrition while they recover.
Shanghai, Shanghai MunicipalityAges Up to 6 months - NCT04623580Recruiting
Hernia surgery registry for adults after groin hernia repair
This is a registry that collects health information from adults who have surgery for an inguinal or femoral groin hernia, whether planned or urgent, and whether it’s a first-time or recurrent hernia. It helps doctors better understand hernia care and outcomes for patients over time.
LeuvenAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.