Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,606 recruiting studies in this area right now.
By phase
- Not applicable4,685
- Phase 21,189
- Phase 1568
- Phase 3457
- Phase 1/Phase 2368
- Phase 4229
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer479
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer90
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University100
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)50
- National Taiwan University Hospital45
Where studies are running
- California442
- Arizona190
- Texas140
- Alabama129
- Florida127
- New York120
- Massachusetts119
- Maryland88
- Ohio80
- Illinois69
Recruiting studies7,606 total
- NCT07665528Recruiting
Botox vs Botox with surgery for chronic anal fissure
This trial compares two treatments for a long-lasting anal fissure: Botox injections alone versus Botox combined with a small surgery (fissurectomy and anoplasty). It aims to see which works better and may help patients who have not healed with standard care.
Islamabad, FederalAges 18–65 - NCT07670611RecruitingPhase 4
Vitamin D2 alone or with calcitriol for children with liver disease
This trial compares two types of vitamin D—one is plain vitamin D2, the other is vitamin D2 plus a more active form (calcitriol)—to see which works better for children with liver problems and low vitamin D levels.
BangkokAges Up to 18 years - NCT07664397RecruitingPhase 1
Imaging study of a new tracer for cancer detection
This study tests a new imaging tracer called [89Zr]DFO-YS5 that may help detect certain cancers on a PET-CT scan. The goal is to see if this tracer is safe and works well for finding tumors, which could one day help doctors plan better treatments.
San Francisco, CaliforniaAges 18 years+ - NCT07670273RecruitingPhase 2
Drug combo for advanced HER2 bile duct cancer
This trial tests a combination of three drugs (trastuzumab rezetecan, adebrelimab, and lenvatinib) as a first treatment for people with advanced HER2-positive or HER2-low bile duct or gallbladder cancer. The goal is to see if this combination helps shrink or control the cancer.
BeijingAges 18–75 - NCT07667894Recruiting
Online mindfulness for emotional distress in GERD
This study tests an online mindfulness program called MIED to see if it can help reduce emotional distress for people with GERD (chronic acid reflux). It involves weekly online sessions and questionnaires over several weeks.
Beijing, Beijing MunicipalityAges 18–65 - NCT07663422RecruitingPhase 2
Treating immunotherapy-related liver inflammation with mycophenolate and prednisone
This trial tests a combination of two drugs, mycophenolate mofetil and prednisone, to treat moderate to severe liver inflammation caused by immunotherapy. The goal is to see if this treatment can help control the inflammation without needing long-term high-dose steroids.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07668453RecruitingPhase 2
Adebrelimab plus chemo for advanced bile duct cancer
This study tests adding the immunotherapy adebrelimab to standard chemotherapy (gemcitabine and nab-paclitaxel) as a first treatment for advanced biliary tract cancer that can't be removed by surgery. The goal is to see if this combination helps shrink tumors and improve outcomes.
Nanjing, JiangsuAges 18–75 - NCT07667049RecruitingPhase 1
Gut health study for preterm infants
This study looks at how the gut works in premature babies to better understand digestion and health. It may help improve care for newborns born early.
Baltimore, MarylandAges Up to 4 days - NCT07667166Recruiting
Measuring outcomes in acute cholangitis
This study looks at how well people recover from acute cholangitis, a serious bile duct infection. It will create a tool to track the impact of treatment, such as drainage procedures, to help doctors improve care.
Hyderabad, TelanganaAges 18–80 - NCT03409263Recruiting
Registry for people with TIPS for high portal pressure
This study is a registry, meaning it collects health information to better understand people who have a TIPS procedure for high pressure in the liver’s blood vessels. It may help doctors improve how TIPS is used and monitored over time.
Vienna, State of ViennaAges 18–99 - NCT05099939Recruiting
Monitoring sugar changes in adults with cystic fibrosis
This study uses continuous glucose monitoring (a sensor that checks blood sugar trends) to understand how sugar handling changes over time in people with cystic fibrosis. It may help doctors spot early “pre-diabetes” or abnormal sugar patterns sooner.
Montreal, QuebecAges 18 years+ - NCT06510348Recruiting
Feeding support for ventilated patients with gut issues
This trial tests a special approach to nutrition for patients on breathing machines who have trouble digesting food. It aims to see if the new method helps meet nutritional needs better.
BucharestAges 18 years+ - NCT03874026RecruitingPhase 2
Folfiri plus cetuximab for advanced, gene-matched colon cancer
This trial tests whether a combination chemotherapy (Folfiri) plus cetuximab works better for people with stage IV colorectal cancer that has specific tumor gene markers and a specific blood-gene type. It may help you shrink tumors or control the cancer if you match the study’s required lab and health criteria.
NaplesAges 18–75 - NCT05961059RecruitingPhase 1
Shigella vaccine safety study for healthy adults
This Phase 1 study tests a Shigella (gut infection) vaccine and additives to see how safe they are in healthy adults. If you qualify, you may help researchers understand whether the vaccine triggers any unwanted immune or stomach side effects.
LeidenAges 18–50 - NCT06520683RecruitingPhase 3
Immunotherapy after surgery for high-risk stage II colorectal cancer
This trial tests whether a drug called an immune checkpoint inhibitor (PD-1 blocker) can help lower the risk of cancer returning after surgery. It is for people with a specific type of colorectal cancer (dMMR or MSI-H) that had certain high-risk features.
Guangzhou, GuangdongAges 18–80 - NCT07660848RecruitingPhase 2
A study of two new injections for fatty liver disease with MASH
This trial tests two new injections (HRS-4729 and HRS-9531) for people with MASH, a type of fatty liver disease. The study aims to see if these drugs can help reduce liver fat and improve liver health.
Beijing, Beijing MunicipalityAges 18–75 - NCT07661641RecruitingPhase 1
Study of new radioactive treatments for GRPR-positive tumors
This early-phase study tests two new radioactive treatments (lutetium-177 and actinium-225) together with a guided imaging agent in people with GRPR-positive solid tumors (including prostate, breast, or colorectal cancers). The goal is to see if these treatments can shrink tumors that have stopped responding to standard therapies.
Melbourne N., VictoriaAges 18 years+ - NCT07660445Recruiting
Endoscopic stomach reshaping and duodenal procedure for obese type 2 diabetes
This trial tests a procedure that reshapes the stomach and treats the upper intestine to help control blood sugar and weight in people with obesity and type 2 diabetes. It may be an option if you have a moderate to high need for metabolic surgery.
ShatinAges 18–70 - NCT07656623Recruiting
Probiotics for IBS with stomach issues and stress
This trial tests whether a special probiotic blend can help people with irritable bowel syndrome (IBS) who also have stomach symptoms like heartburn, bloating, or nausea, and feel anxious, depressed, or stressed. It aims to see if the probiotic improves both gut and mood symptoms.
Hanoi, HanoiAges 18 years+ - NCT07658755Recruiting
LiverSeek: Finding advanced liver scarring in MASLD
This study uses routine blood tests to find people with advanced liver scarring caused by a condition called MASLD. If you are between 50 and 75, have certain metabolic risks, and get blood work from your primary care doctor at select centers, you may be eligible.
Madrid, MadridAges 50–75 - NCT07655375Recruiting
Study of UCB8600 on gut mast cells in IBS and colorectal cancer
This study looks at how a medicine called UCB8600 affects certain immune cells (mast cells) in the gut. It is for people having colorectal cancer surgery and for patients with irritable bowel syndrome (IBS). The goal is to understand how the medicine works in the body and if it can help with IBS symptoms.
Leuven, Vlaams-BrabantAges 18–65 - NCT07656571Recruiting
Green dye vs standard surgery for pancreas tail tumors
This trial compares standard laparoscopic surgery to surgery using a green dye that helps the surgeon see the pancreas more clearly. It may help patients needing removal of tumors in the body or tail of the pancreas.
AlexandriaAges 18 years+ - NCT07655024RecruitingPhase 2
TAIC plus FOLFOX for advanced stomach cancer
This trial tests a traditional Chinese medicine (TAIC) combined with chemotherapy (FOLFOX) for people with advanced stomach or gastroesophageal junction cancer that can't be removed with surgery. It aims to see if the combination can help shrink the tumor and improve survival.
BeijingAges 18 years+ - NCT07662902Enrolling by invitation
Gut Barrier Study in Ulcerative Colitis Remission
This study looks at gut barrier function in people with ulcerative colitis who are in remission. It uses a non-invasive liver test to check for subtle changes in the body.
ZagrebAges 18–70
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,606 recruiting gastroenterology studies from the U.S. registry right now, out of 11,952 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.