Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06181032RecruitingPhase 1
Immunotherapy and chemo combo before surgery for bile duct cancer
This trial tests a combination of an immunotherapy (adebrelimab), a targeted therapy (apatinib), and two chemotherapy drugs (gemcitabine and cisplatin) given before surgery for biliary tract cancers that are removable but at high risk of coming back. The goal is to see if this approach helps shrink the tumor and improve outcomes after surgery.
Fuzhou, FujianAges 18–75 - NCT06183892Recruiting
Extended-release tacrolimus in stable child liver transplant recipients
This study tests an extended-release version of the anti-rejection drug tacrolimus in children who have already had a stable liver transplant. The goal is to see if the longer-acting capsule works as well as the immediate-release form, potentially simplifying daily medication routines.
ShanghaiAges 6 months–18 years - NCT07727837Recruiting
Pelvic floor health in children with poop problems
This trial looks at how defecation disorders (trouble pooping or soiling) in children affect their quality of life, walking, balance, and physical function. It aims to understand the links between these problems and the pelvic floor muscles.
Izmir, BornovaAges 6–18 - NCT06182319RecruitingPhase 3
Optimizing treatment for adhesive small bowel obstruction
This study tests the best way to treat a small bowel blockage caused by scar tissue (adhesions). It compares different care approaches to help you recover faster and avoid repeat blockages.
Los Angeles, CaliforniaAges 18 years+ - NCT06174233Recruiting
French Gut Study: stool samples before colonoscopy
This study looks at how gut bacteria might affect colon health. If you are between 50 and 75 and scheduled for a colonoscopy, you may be asked to provide a stool sample before the procedure to help researchers understand the link between gut bacteria and colon findings.
BobignyAges 50–75 - NCT06168214RecruitingPhase 4
Comparing treatments for H. pylori infection
This study compares several different 2-week treatment plans to see which works best for wiping out H. pylori, a bacteria that can cause stomach ulcers and other digestive problems. If you have H. pylori, you may be able to join and receive one of the treatments.
Xi'an, ShaanxiAges 18–70 - NCT06155318Recruiting
PET scan for neuroendocrine tumors
This trial tests a special PET scan to better evaluate gastroenteropancreatic neuroendocrine tumors (GEP-NETs). It may help your doctor see where the tumors are in your body.
MilanAges 18 years+ - NCT06154538RecruitingPhase 2
Immunotherapy plus chemo vs. chemo alone for advanced colorectal cancer before surgery
This trial tests whether adding immunotherapy (a treatment that helps your immune system fight cancer) to standard chemotherapy before surgery works better than chemotherapy alone for people with locally advanced colorectal cancer.
Beijing, Beijing MunicipalityAges 18–75 - NCT06088537Recruiting
Blood in newborn stool: allergy or temporary colitis?
This study looks at very young babies (less than a month old) who have blood in their stool but are otherwise well. The goal is to find out whether the bleeding is due to a food allergy or a short-term gut irritation, so doctors can give the right care.
Nice, Alpes-MritimesAges 1 day–4 weeks - NCT07006142Recruiting
Fasting time and stomach volume for GLP-1 patients
This trial studies how a longer fasting period affects stomach contents in people taking GLP-1 receptor agonists (a type of diabetes or weight-loss drug). It helps doctors understand if extra fasting time is needed before an upper endoscopy (a camera test for the stomach).
Rochester, MinnesotaAges 18 years+ - NCT07284134RecruitingPhase 3
JS107 vs standard therapy for advanced stomach cancer
This trial tests a new drug, JS107, against standard treatments for people with advanced stomach or gastroesophageal junction cancer that has continued to grow after at least one prior treatment. The cancer must have a specific protein called CLDN18.2 on its cells.
Hefei, AnhuiAges 18 years+ - NCT07298200RecruitingPhase 1
XH001 injection plus T-cells for advanced gastric cancer
This trial tests a new treatment combining an injection (XH001) with specially made immune cells (T-cells) that target your tumor's unique markers. It's for people with advanced stomach cancer who have not responded to standard therapies.
Nanjing, JiangsuAges 18–70 - NCT07007598Recruiting
Preventing bleeding after polyp removal with clips
This trial tests whether placing small clips at the site of polyp removal in the colon can reduce bleeding in patients who take blood thinners afterwards.
Schwerin, Mecklenburg-VorpommernAges 18 years+ - NCT07297004RecruitingPhase 2
Targeted radiation for recurrent rectal cancer
This trial tests targeted radiation (SBRT) for people whose rectal cancer has come back in the pelvis and cannot be surgically removed. The goal is to see if this focused radiation can control the tumor with fewer side effects.
Guangzhou, GuangdongAges 18–75 - NCT06130046Recruiting
Study of MR-proADM as a biomarker for kidney and liver transplant
This trial is testing a simple blood biomarker called MR-proADM to see if it can help doctors detect early signs of transplant rejection or poor kidney function after a kidney or liver transplant.
RomeAges 18–70 - NCT07064681Recruiting
AK104 plus TACE for resectable liver cancer
This trial tests whether adding an immunotherapy drug (AK104) to a standard liver cancer treatment (TACE) helps prevent the cancer from coming back after surgery. It is for people with early-stage liver cancer that can be surgically removed and who have a high risk of recurrence.
Guangzhou, GuangdongAges 18–75 - NCT07726433RecruitingPhase 2
Preventing nausea from Trastuzumab Rezetecan with two anti-nausea drugs
This trial tests whether a combination of two anti-nausea drugs (fosrolapitant and palonosetron) can better prevent nausea and vomiting caused by Trastuzumab Rezetecan. If you are starting this cancer treatment, you may be able to join.
TianjinAges 18 years+ - NCT07307248Recruiting
Removing a metal stent early vs. standard timing after cyst drainage
This study compares removing a special metal stent early (after 2 weeks) versus waiting the usual 4 weeks in people who had a cyst in their pancreas drained. It is for those whose cyst has shrunk at least 70% after 2 weeks, to see if earlier removal is safe and effective.
Hyderabad, TelanganaAges 18 years+ - NCT05345847Recruiting
Steroid-sparing treatment for immune hepatitis during cancer immunotherapy
This trial studies a way to treat inflammation of the liver (hepatitis) caused by immune cancer medicines (anti-PD-1/PD-L1, sometimes with anti-CTLA-4) without relying on high-dose steroids. It may help reduce steroid side effects while keeping liver inflammation under control.
Calgary, AlbertaAges 18 years+ - NCT07575529Recruiting
Senior Milk Powder and Gut Health in Healthy Aging
This study tests whether a special milk powder containing beneficial bacteria and fiber (called synbiotics) can improve gut health in adults aged 40–65. You'll use a smartphone app and Apple Watch to track your health and provide samples over several weeks.
SingaporeAges 40–65 - NCT06890234Enrolling by invitation
Monitoring liver grafts with a tiny probe during transplant
This study uses a tiny probe placed in the new liver during transplant surgery to monitor its health in real time. It may help doctors detect problems early and improve recovery after transplant.
Ljubljana, SloveniaAges 18–65 - NCT04359069Recruiting
Shorter urinary catheter time after pelvic surgery
This study looks at whether the urinary (Foley) catheter can stay in place for a shorter time after certain pelvic operations. It aims to see if timing of catheter removal is safer and more comfortable, especially for bladder function.
Los Angeles, CaliforniaAges 18 years+ - NCT07620665Recruiting
Pain Relief Medicine for Gallbladder Removal Surgery
This trial tests a new pain medication called opiranserin for patients having minimally invasive gallbladder surgery (a small-cut procedure). The goal is to see if it safely reduces pain after surgery.
SeoulAges 19 years+ - NCT07563530Recruiting
Early Drinking After Urological Surgery to Ease Thirst
This study tests whether patients can drink water soon after urological endoscopic surgery (a minimally invasive procedure on the urinary system) to feel better and reduce post-surgery thirst. The goal is to see if safe, early drinking improves how patients feel during recovery.
Karachi, SindhAges 18–65
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.