Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT07329296Enrolling by invitation
Liver regeneration after living donor transplant study
This study looks at how the donor's liver grows back after donating a part of it for a living donor liver transplant. If you have donated a part of your liver between 2004 and 2026, joining could help doctors learn more about liver healing.
Rotterdam, South HollandAges 18–60 - NCT07375329Enrolling by invitation
Breath test for fiber intake
This trial checks if breath hydrogen and methane levels can show how much fiber you eat. It is only for people already taking part in the parent study (NCT07219706).
Oklahoma City, OklahomaAges 18–80 - NCT07327905Recruiting
Lidocaine or dexmedetomidine for pain during weight-loss surgery
This trial compares two medicines given through an IV during sleeve gastrectomy (weight-loss surgery) to see which provides better pain control. It may help patients have a smoother recovery with less discomfort.
AlexandriaAges 20–50 - NCT07415616Enrolling by invitation
Cold vs warm tube feeding and stomach emptying in ICU
This study compares giving liquid food at room temperature (cold) versus body temperature (warm) through a feeding tube to see which helps the stomach empty better in ICU patients. It may help find a way to improve comfort and nutrition for people who need tube feeding.
BursaAges 18 years+ - NCT07310316Recruiting
A trial for variceal bleeding in cavernous transformation of portal vein
This study tests a combined procedure to stop bleeding from enlarged veins in the food pipe (varices) in people with a rare condition called cavernous transformation of the portal vein. The treatment involves blocking the bleeding veins and reducing blood flow to the spleen to prevent future bleeding.
Xi'an, ShaanxiAges 18–75 - NCT06107504Recruiting
Preventing bleeding after bile duct stone removal
This trial tests a medicine called sucralfate to see if it helps prevent bleeding after a procedure that removes bile duct stones. If you are having this procedure, you might be able to join.
Tainan, Other (Non U.s.)Ages 18–95 - NCT06107634Recruiting
Comparing hernia repair with and without stomach tuck
This study tests whether adding a procedure called gastropexy (tacking the stomach in place) to standard hernia repair helps prevent the hernia from coming back. It may be a good option for people having their first surgery for a paraesophageal hernia.
GothenburgAges 18 years+ - NCT07672691Recruiting
How diet affects gut health and inflammation
This study looks at how different types of food (fats, carbs, protein) affect your gut bacteria, inflammation, and metabolism. It may help understand how diet can improve health.
KrakowAges 18–60 - NCT07723937Recruiting
GelPOINT-assisted removal of colon and rectal polyps
This study tests a new way to remove large or complex colon and rectal polyps using a special port system called GelPOINT Path. If you have polyps that are hard to remove with standard colonoscopy, this approach may help your doctor remove them safely.
Houston, TexasAges 18 years+ - NCT06113068Recruiting
Fistura procedure for complex anal fistulas
This trial tests a new procedure called Fistura to treat complex anal fistulas (abnormal tunnels between the anal canal and skin). It uses radiofrequency energy to close the fistula while preserving muscle. The study is for people whose fistula has already been drained with a temporary seton stitch.
Braine-l'AlleudAges 18 years+ - NCT07723261Recruiting
Testing NalIriFOx as first treatment for metastatic pancreatic cancer
This trial is testing a drug combination called NalIriFOx as the first treatment for people with pancreatic cancer that has spread. The goal is to see if it is safe and works well over the long term.
AthensAges 18 years+ - NCT07321431Recruiting
Finding the best time to check gallbladder function
This study is looking for people with healthy gallbladders and bile ducts to find the best time to measure how well the gallbladder works. It uses a simple ultrasound test and does not involve any drugs or procedures.
Lanzhou, GansuAges 18–70 - NCT06401174Enrolling by invitation
Patient navigation for colorectal cancer screening
This study tests a patient navigation program to help people who are due for colorectal cancer screening get the test they need. It connects you with a guide to make scheduling and completing screening easier.
Washington D.C., District of ColumbiaAges 45–75 - NCT07213271Recruiting
Exercise study for obese breast cancer survivors
This study tests whether a physical exercise program can improve metabolism, gut health, fitness, and quality of life in obese women who have completed breast cancer treatment at least one year ago.
BratislavaAges 25–70 - NCT06398340Recruiting
Can a wearable device track what you eat?
This study uses a wearable device (like a smartwatch) to see if it can track what you eat. You would wear the device for a few days and report your meals. It is for generally healthy adults.
LondonAges 18–65 - NCT07290985RecruitingPhase 2
Can biomarkers guide organ-sparing treatment for stomach and esophagus cancer?
This trial tests if using specific biomarkers (like HER2 and PD-L1) can help choose the best treatment to potentially avoid surgery. It aims to preserve the stomach or esophagus while effectively treating the cancer.
Los Angeles, CaliforniaAges 18 years+ - NCT06118437Recruiting
Gastrointestinal cancer screening prediction study
This study aims to build a model to predict your risk of gastrointestinal cancer based on personal risk factors. It involves having both an upper endoscopy (gastroscopy) and a colonoscopy at the same time.
Xi'an, ShaanxiAges 18–80 - NCT07021534RecruitingPhase 1
CAR-NK and CAR-T cells for cancer with liver spread
This trial tests a new treatment that uses special immune cells (CAR-NK and CAR-T cells) given directly into the liver artery, then through a vein, to fight advanced solid tumors that have spread to the liver. It is for people who have already tried standard treatments and need new options.
Hangzhou, ZhejiangAges 18–75 - NCT07327229RecruitingPhase 1/Phase 2
Study of ATG-022 plus pembrolizumab for stomach or GEJ cancer
This trial tests a new drug combo (ATG-022 plus pembrolizumab, with or without chemo) for people with advanced stomach or gastroesophageal junction cancer that has a specific protein (CLDN 18.2) and is HER2-negative and PD-L1-positive. It may be an option if you have not had certain prior treatments.
Hefei, AnhuiAges 18 years+ - NCT07408505Recruiting
New appetite drug for weight loss in advanced pancreatic cancer
This trial tests a new form of a drug (nano-megestrol acetate) to help people with advanced pancreatic cancer who are losing weight and have poor appetite. It aims to see if it can improve cachexia, a condition of severe weight loss and muscle wasting.
JinanAges 18–75 - NCT05329636RecruitingPhase 1/Phase 2
Fecal microbiome transplant after H. pylori antibiotic treatment
This trial tests whether transplanting healthy gut bacteria (from fecal material) can help your recovery and gut health after you take antibiotics to clear H. pylori (a stomach germ). If you qualify, you would start with confirmed H. pylori and then follow the study steps for the transplant.
Tel AvivAges 18–70 - NCT05894694RecruitingPhase 4
Testing Compound Kushen injection for advanced colon cancer survival
This trial studies whether Compound Kushen injection can improve survival in people with advanced colorectal cancer. It’s aimed at people starting first-line treatment, and only includes certain cancer and health situations to keep results clear.
BeijingAges 18 years+ - NCT07272122RecruitingPhase 3
Reducing flies to lower illness in camps
This trial tests a method to reduce fly populations in camp settings to see if it can lower the spread of germs that cause diarrhea. The goal is to find a low-tech way to keep families healthier.
Bunj, Maban CountyAges 1 year+ - NCT07040098RecruitingPhase 2
Optimizing immunotherapy with chemo-radiation for rectal cancer
This trial tests combining immunotherapy with standard chemotherapy and radiation before surgery for locally advanced rectal cancer. It aims to see if this approach can improve outcomes for patients whose tumors have certain genetic features (pMMR or MSS).
BeijingAges 18–75
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.