Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06340711RecruitingPhase 2
Gene therapy plus Keytruda for advanced stomach or esophageal cancer
This study tests a new type of gene therapy (OBP-301) injected directly into the tumor, combined with the immunotherapy drug Keytruda (pembrolizumab), for people with advanced stomach, junction, or esophageal cancer. Researchers want to see if this combination can help when standard treatments have stopped working.
New York, New YorkAges 18 years+ - NCT06338332Recruiting
Stent before surgery for right-sided colon blockage from cancer
This trial tests whether placing a stent first to relieve a blockage in the right side of the colon improves outcomes before surgery for colon cancer. It aims to help patients who come to the hospital with a blocked colon due to cancer.
Breda, North BrabantAges 18 years+ - NCT06337565Recruiting
Safety of IBD drugs during pregnancy and breastfeeding
This study looks at how safe certain IBD medications are when taken during pregnancy and while breastfeeding. It follows mothers and their babies to check for any health effects.
Madrid, MadridAges 18–70 - NCT06335797Recruiting
Improving bowel habits after pelvic surgery
This study looks at ways to improve bowel habits after vaginal surgery for pelvic organ prolapse. It aims to find better routines to help you recover comfortably.
Winston-Salem, North CarolinaAges 18 years+ - NCT06760364RecruitingPhase 1
CHT102 for Advanced Pancreatic Cancer with Mesothelin
This trial tests a new treatment called CHT102 for people with advanced pancreatic cancer that has a specific protein (mesothelin) on their tumor cells. It's for those who have already tried standard treatments without success or couldn't tolerate them.
TianjinAges 18–70 - NCT06292598Recruiting
Gut bacteria and sleep disorder study
This study compares gut bacteria and substances from the gut in people with type 1 narcolepsy versus those without. It aims to understand how gut health might be linked to this sleep disorder.
Nîmes, GardAges 10 years+ - NCT07197619Recruiting
Hernia sac removal in paraesophageal hernia repair
This study compares two surgical techniques for fixing a paraesophageal hernia (a type of hiatal hernia). It looks at whether removing the hernia sac affects tension during repair.
Grand Rapids, MichiganAges 18–80 - NCT06279299Recruiting
Lymph node removal for rectal neuroendocrine tumors during laparoscopic surgery
This trial tests whether removing lymph nodes in the pelvis during laparoscopic surgery for rectal neuroendocrine tumors (a type of slow-growing or aggressive tumor) improves outcomes. It is for people with larger or recurrent tumors, or those at higher risk due to tumor grade or depth.
Beijing, Beijing MunicipalityAges 18–75 - NCT07220369Recruiting
Gut mini-pill study: testing a new capsule
This trial tests a special mini-pill that may help your gut health. You'll take the pill and provide stool samples while eating provided meals.
Boston, MassachusettsAges 50–75 - NCT06280469Recruiting
One vs. two people for small-bowel scope test
This trial is comparing a one-person vs. two-person method for doing a small-bowel scope test (enteroscopy) using a single-balloon tube. It aims to find out which technique is better for patients who need a deep look into the small intestine.
Lanzhou, GansuAges 18 years+ - NCT06259396Recruiting
8x5 Diet for Bile Acid Diarrhea
This trial tests a special 8-hour eating window (8x5 Diet) for people with bile acid diarrhea. It aims to see if this diet can help manage symptoms when medication alone is not enough.
Manchester, Greater ManchesterAges 18 years+ - NCT06482671RecruitingPhase 3
Rikkunshito for newly diagnosed functional dyspepsia
This trial tests a herbal medicine called rikkunshito for people newly diagnosed with functional dyspepsia (stomach pain or discomfort). It aims to see if the treatment can improve symptoms in adults who fit certain health requirements.
Leuven, Vlaams-BrabantAges 18 years+ - NCT07235202RecruitingPhase 1/Phase 2
MR001 plus chemo for advanced pancreatic cancer after first treatment
This trial tests a new drug, MR001, combined with chemotherapy for people whose pancreatic cancer has spread and no longer responds to their first treatment. It aims to see if this combination can help shrink tumors or slow the disease.
Beijing, Beijing MunicipalityAges 18–75 - NCT06260878RecruitingPhase 4
Fluids before ERCP to prevent pancreatitis
This trial tests if giving fluids before an ERCP procedure can lower the risk of developing pancreatitis (inflammation of the pancreas). It may help people who have not had this procedure before.
Calgary, AlbertaAges 18–75 - NCT06230731Recruiting
Oxygen levels in colon blood vessels during colonoscopy
This study measures oxygen levels in the colon during a routine colonoscopy to understand how blood flow differs between people with vascular lesions (abnormal blood vessels) and those with a healthy colon. It may help doctors better diagnose and treat these conditions.
Chicago, IllinoisAges 18–89 - NCT06992362RecruitingPhase 2
Pre- and post-surgery treatment for HER2+ hepatoid stomach cancer
This trial tests a treatment plan given before and after surgery for a rare type of stomach cancer called hepatoid adenocarcinoma. It's for people whose tumors have a specific HER2 protein marker and are at an early enough stage that surgery is still possible.
BeijingAges 18–75 - NCT06660680Enrolling by invitationPhase 3
Methylene blue for pain after hemorrhoid surgery
This trial tests whether injecting methylene blue (a dye) into the area around the anus during hemorrhoid surgery can reduce pain after the operation. If you are having Milligan-Morgan surgery for mixed hemorrhoids, this study may help find a way to make your recovery more comfortable.
Hefei, AnhuiAges 18–75 - NCT06620328Recruiting
Comparing two tools for bile duct drainage when ERCP fails
This study tests two ways of opening a blocked bile duct when standard methods fail: one using a special balloon and the other using heat. It looks at which is safer and works better for people who cannot get the usual ERCP or PTCD drainage.
TaipeiAges 18 years+ - NCT06232434RecruitingPhase 2/Phase 3
New gel treatment for advanced stomach cancer that has spread
This trial tests a new gel called Prospidelong given once into the abdomen during surgery for stomach cancer that has spread to the lining of the belly. The goal is to see if it is safe and works well.
Minsk, Minsk CityAges 18–75 - NCT06477991Recruiting
No surgery after immunotherapy for MSI-H colorectal cancer
This trial is studying whether some people with a specific type of advanced colorectal cancer (MSI-H/dMMR) might be able to skip surgery after immunotherapy. Doctors will use a blood test (MRD monitoring) to track the cancer, and then decide whether to keep an eye on it or operate.
Kunming, YunnanAges 18–75 - NCT07476560Recruiting
Suture Mesh vs. Planar Mesh for Small Ventral Hernias
This trial compares two types of mesh used to repair small ventral hernias (belly hernias up to 3 cm). It tests whether a suture mesh works better than a standard planar mesh, helping surgeons choose the best approach.
HjørringAges 18 years+ - NCT06205992Recruiting
Comparing 2D and 3D MRI scans for liver scarring and pressure
This study compares two types of MRI scans (2D and 3D) to see which is better at measuring liver scarring and high blood pressure in the liver's main vein. It is for people with cirrhosis who are already scheduled to have their liver vein pressure measured.
Shenyang, LiaoningAges 18–75 - NCT06212635Recruiting
Bleeding risk in liver cirrhosis and liver cancer
This trial studies bleeding problems in people with advanced liver cirrhosis or liver cancer. It aims to improve understanding of when blood transfusions or treatments are needed.
Stockholm, HuddingeAges 18 years+ - NCT06197425RecruitingPhase 3
Extra chemotherapy after surgery for colorectal cancer with positive ctDNA
This trial tests whether giving more chemotherapy can help people who still have cancer DNA in their blood after surgery and standard chemotherapy for colorectal cancer. The goal is to prevent the cancer from coming back.
DijonAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.