Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,599 recruiting studies in this area right now.
By phase
- Not applicable4,683
- Phase 21,187
- Phase 1568
- Phase 3457
- Phase 1/Phase 2366
- Phase 4228
- Phase 2/Phase 3110
Top conditions
- Colorectal Cancer478
- Pancreatic Cancer287
- Gastric Cancer283
- Hepatocellular Carcinoma256
- Esophageal Cancer189
- Rectal Cancer168
- Breast Cancer146
- Crohn Disease134
- Ulcerative Colitis129
- Colon Cancer114
- Hepatocellular Carcinoma (HCC)112
- Liver Cancer99
- Lung Cancer95
- Inflammatory Bowel Diseases94
- Pancreas Cancer91
- Ovarian Cancer89
- Esophageal Squamous Cell Carcinoma86
- Cystic Fibrosis77
Leading sponsors
- Fudan University101
- Sun Yat-sen University85
- Mayo Clinic75
- Second Affiliated Hospital, Zhejiang University, School of Medicine56
- Chinese University of Hong Kong55
- M.D. Anderson Cancer Center55
- Assistance Publique - Hôpitaux de Paris53
- Sixth Affiliated Hospital, Sun Yat-sen University51
- National Cancer Institute (NCI)49
- National Taiwan University Hospital45
Where studies are running
- California438
- Arizona189
- Texas140
- Alabama129
- Florida128
- New York120
- Massachusetts119
- Maryland88
- Ohio79
- Illinois69
Recruiting studies7,599 total
- NCT07577505Recruiting
Histidine supplement to boost immunity in colorectal cancer
This study tests whether taking a histidine supplement (an amino acid building block) alongside standard colorectal cancer treatment helps your immune system fight the cancer better. Researchers want to see if this simple addition can improve outcomes for people with stage II or higher colorectal cancer.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07581912RecruitingPhase 2
Fulzerasib Plus Cetuximab for Advanced Colorectal Cancer With KRAS G12C
This trial tests a combination of two drugs (fulzerasib and cetuximab) given before surgery to shrink locally advanced colorectal cancer that has a specific genetic mutation called KRAS G12C. The goal is to help make the cancer easier to remove surgically and improve outcomes.
Hangzhou, ZhejiangAges 18–85 - NCT07584278Recruiting
Probiotics and Biomarkers for Irritable Bowel Syndrome
This study tests whether probiotics (beneficial bacteria) can help reduce irritable bowel syndrome (IBS) symptoms and change certain markers in your gut. You'll take a probiotic supplement for 12 weeks while researchers track how your symptoms and gut health change.
GothenburgAges 18 years+ - NCT07583342Enrolling by invitationPhase 4
RELiZORB for feeding problems in severe pancreatitis
This study tests whether a medication called RELiZORB can help adults with moderate to severe acute pancreatitis (sudden, severe pancreas inflammation) tolerate nutrition delivered through a feeding tube. If your body is struggling to accept enough nutrition during acute pancreatitis, this trial may help you receive adequate nutrition while you recover.
Bay Shore, New YorkAges 18 years+ - NCT07586046RecruitingPhase 2
Radiation treatment for liver tumors
This study tests a higher dose of radiation delivered directly to liver tumors through small beads. It aims to improve tumor control while keeping side effects manageable for people whose liver cancer is not removable by surgery.
Chicago, IllinoisAges 18 years+ - NCT07579780Recruiting
Nerve Block During Laparoscopic Colorectal Cancer Surgery
This trial tests a pain-relief technique called a nerve block during minimally invasive surgery to remove colorectal cancer. The block numbs nerves in the lower abdomen to potentially reduce pain and improve recovery after surgery.
Guangzhou, GuangdongAges 18 years+ - NCT07584473Recruiting
Testing for Non-Celiac Wheat Sensitivity in Celiac Disease Relatives
This study investigates whether relatives of celiac disease patients who have digestive symptoms and other health concerns might have non-celiac wheat sensitivity or irritable bowel syndrome. Researchers will perform a small intestinal biopsy and dietary testing to understand the connection between wheat sensitivity and symptoms in this family group.
Palermo, PAAges 18 years+ - NCT07585669Recruiting
Omega-3 Supplements for New Celiac Disease Patients
This study tests whether omega-3 fatty acids (a type of fish oil supplement) can reduce inflammation and improve gut health in people newly diagnosed with celiac disease. Participants will follow a gluten-free diet while taking the supplement to see if it helps their body heal.
Santiago, Metropolitan RegionAges 18–65 - NCT07584577Recruiting
Nutrition Support During Cancer Treatment Before Surgery
This study tests whether a special feeding tube placed in the small intestine helps patients recover better after surgery for esophageal or stomach cancer. The tube delivers nutrition directly during chemotherapy or radiation before surgery.
PessacAges 18 years+ - NCT07585032Recruiting
Ultrasound-guided heat treatment for pancreatic insulinoma tumors
This trial tests a minimally invasive procedure that uses heat (delivered through an ultrasound scope) to treat insulinoma—a hormone-producing pancreatic tumor that causes low blood sugar. The procedure may offer a less invasive alternative to surgery.
GothenburgAges 15–80 - NCT07578103Recruiting
Dairy vs Plant-based Yogurt for Weight and Bone Health
This study compares how dairy yogurt and plant-based yogurt affect weight, body composition, bone strength, and gut bacteria in postmenopausal women. It may help identify which type of yogurt is better for overall health during this life stage.
Québec, QuebecAges 40 years+ - NCT06724133Recruiting
Mouth bacteria and colon polyps study
This study looks at the bacteria in your mouth and how they might be linked to colon polyps. Researchers want to see if certain mouth bacteria affect the body's immune system and increase the risk of polyps.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06500468Recruiting
A capsule test for suspected upper GI bleeding
This trial tests a new ingestible capsule called PillSense that can detect bleeding in the upper part of your digestive system. If you come to the emergency room with signs of upper GI bleeding (like vomiting coffee-ground material or having black stools) but without obvious black stool on a physical exam, this study will see if the capsule works as well as the usual endoscopy procedure.
SingaporeAges 21–99 - NCT06059989RecruitingPhase 3
Testing a new form of infliximab for Crohn's disease
This trial is testing a new way to give infliximab, a treatment for moderate to severe Crohn's disease, as a shot under the skin. It's for people who haven't gotten better with other treatments or need strong medication right away.
Amsterdam, North HollandAges 18–80 - NCT06019455Recruiting
How patients participate in lung and esophageal cancer care
This study looks at how much patients with lung or esophageal cancer get involved in decisions about their care when they receive chemotherapy and radiation together. It aims to learn what helps or challenges patients in taking an active role.
GuangzhouAges 18–75 - NCT04855838Recruiting
Study of swallowing problems after neck spine surgery
This study looks at how swallowing recovers after surgery on the front of the neck spine after a trauma. Some people may also be followed more closely if a swallowing test shows a problem a few weeks after surgery.
UmeåAges 18 years+ - NCT05349227Recruiting
After-cancer digital coaching and wearable tracking outcomes study
This study tests a digital health coaching program (using phone/tablet check-ins and wearable data) to understand health and quality-of-life outcomes after cancer treatment. It may help you learn healthy habits and track progress over time.
Gainesville, FloridaAges 18 years+ - NCT06108011Recruiting
Lollipop to help children's stomach recovery after surgery
This trial gives children a lollipop after major abdominal surgery to see if it helps their stomach and intestines work better sooner. Children who can suck and swallow, are not on a breathing machine, and have no food allergies may be able to join.
Hong KongAges Up to 18 years - NCT07569068RecruitingPhase 2
Combination Cancer Drugs Before Surgery for Stomach Cancer
This trial tests whether giving immunotherapy and chemotherapy drugs before surgery can help treat stomach cancer that has a specific protein marker (claudin 18.2). The goal is to shrink the tumor and improve outcomes for patients whose cancer can be surgically removed.
Shanghai, Huangpu DistrictAges 18 years+ - NCT07574398Recruiting
Growth and Development Study After Infant Liver Transplant
This study tracks how babies grow and develop after receiving a liver transplant. Researchers want to understand how transplantation affects children's physical growth and overall development in early infancy.
Shanghai, Shanghai MunicipalityAges Up to 1 year - NCT07575061Recruiting
Long-term study of survival factors in intestinal tuberculosis
This 15-year study follows patients with intestinal tuberculosis (a bacterial infection of the digestive tract) to understand what factors affect how long patients survive and live with this condition. The research may help doctors better predict outcomes and improve care for future patients.
Beijing, Beijing MunicipalityAges 18–100 - NCT07574437Recruiting
At-Home Bowel Stimulation After Colon Surgery
This study tests whether a at-home bowel stimulation device can help patients who have had part of their colon removed and currently have a temporary ileostomy (an opening in the belly that drains stool). The goal is to see if this approach might improve bowel function before or after closing the ileostomy.
Weston, FloridaAges 18 years+ - NCT07574515Recruiting
Nasogastric Tube for Small Bowel Blockages
This trial tests whether placing a thin feeding tube through the nose into the stomach helps reduce complications in patients with small bowel obstruction (a blockage in the small intestines). Researchers want to see if this tube improves outcomes and reduces symptoms like nausea and vomiting.
LinköpingAges 18 years+ - NCT07576959RecruitingPhase 3
Bismuth with dual therapy for H. pylori infection treatment
This trial tests whether adding bismuth (a mineral compound) to standard two-drug therapy helps cure H. pylori, a common stomach bacteria that can cause ulcers and inflammation. The goal is to see if this combination works better than dual therapy alone.
TaipeiAges 20 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,599 recruiting gastroenterology studies from the U.S. registry right now, out of 11,991 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.