Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,879 recruiting studies in this area right now.
By phase
- Not applicable4,909
- Phase 21,183
- Phase 1583
- Phase 3465
- Phase 1/Phase 2392
- Phase 4235
- Phase 2/Phase 3112
Top conditions
- Colorectal Cancer494
- Gastric Cancer298
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer146
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer99
- Pancreas Cancer94
- Ovarian Cancer90
- Esophageal Squamous Cell Carcinoma88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic75
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center59
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California463
- Arizona177
- Texas147
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio78
- Pennsylvania72
Recruiting studies7,879 total
- NCT06380309RecruitingEarly Phase 1
Study of experimental drug IDOV-SAFE for advanced digestive cancers
This trial tests an investigational drug for people with advanced digestive system cancers (like colorectal, stomach, or liver cancer) that have stopped responding to standard treatments. The goal is to see if the drug is safe and helps control the cancer.
BeijingAges 18–75 - NCT07334678Recruiting
Two surgeries for high anal fistula: which works better?
This study compares two surgical techniques—TROPIS and coring-out fistulectomy—for treating high anal fistulas (a tunnel connecting the anal canal to the skin that goes through a lot of muscle). It aims to find which method helps heal better and is safer for you.
Cairo, Al-Manial CairoAges 18 years+ - NCT07247396RecruitingPhase 1
CEA CAR-T therapy after surgery for colorectal cancer spread
This trial tests a special immune cell therapy (CAR-T) that targets a protein called CEA on cancer cells. It is for people with colorectal cancer that has spread to the lining of the belly (peritoneum) and who have already had surgery to remove as much of the spread as possible.
Hangzhou, ZhejiangAges 18–75 - NCT06521866RecruitingPhase 2
Study of serplulimab plus standard therapy for advanced colorectal cancer
This trial tests an immunotherapy drug (serplulimab) combined with targeted therapy, chemo, and radiation as a first treatment for people with advanced colorectal cancer that has spread and cannot be surgically removed. It aims to see if this combination can help control the cancer.
Fuzhou, FujianAges 18 years+ - NCT06916052Recruiting
Digital platform for preparing for outpatient colonoscopy
This trial tests a digital platform to help patients prepare for and follow up after a colonoscopy. It may make the process easier and more accessible for people who regularly use a smartphone.
Barcelona, BarcelonaAges 18–80 - NCT07034742RecruitingEarly Phase 1
MRD testing after stomach cancer surgery
This study looks at whether a blood test for leftover cancer cells (called MRD) after stomach cancer surgery can help guide treatment. It is for people with a certain type of stomach cancer that has spread to nearby tissues but not to distant organs, and who are having surgery as their first treatment.
BeijingAges 18–75 - NCT06641778Recruiting
Fecal transplant for drug-resistant Klebsiella pneumonia
This trial tests whether transplanting healthy donor stool into the lungs can help treat a severe pneumonia caused by a bacteria that is resistant to many antibiotics. It may offer a new option for people whose infection is not responding to standard treatments.
Wuhan, HubeiAges 18–75 - NCT07226440RecruitingPhase 1/Phase 2
Trial to help firefighters reduce PFAS with a gastrointestinal product
This trial tests if taking a special tablet twice daily can help male firefighters lower PFAS chemicals in their bodies. It involves three visits in the San Francisco Bay Area, at-home blood tests, and weekly text surveys over about 6.5 months.
San Francisco, CaliforniaAges 18 years+ - NCT06642844RecruitingPhase 3
Bevacizumab dose adjustment for colorectal cancer
This trial tests whether adjusting the dose of bevacizumab based on your blood levels can improve first-line treatment for metastatic colorectal cancer that can't be removed with surgery.
BesançonAges 18–99 - NCT07721181Recruiting
STEP-UP: Higher radiation for recurrent rectal cancer
This trial tests giving a higher dose of radiation to people whose rectal cancer has come back in the pelvis after surgery and cannot be removed. It aims to see if more radiation can help control the tumor when surgery is not an option.
ArnhemAges 18 years+ - NCT06138223Recruiting
Exercise and diet for incurable esophagus or stomach cancer
This study tests whether an exercise and nutrition program can improve quality of life for people with incurable esophageal or stomach cancer. It is designed to help you feel better and stay active during treatment.
Amsterdam, North HollandAges 18 years+ - NCT06108011Recruiting
Lollipop to help children's stomach recovery after surgery
This trial gives children a lollipop after major abdominal surgery to see if it helps their stomach and intestines work better sooner. Children who can suck and swallow, are not on a breathing machine, and have no food allergies may be able to join.
Hong KongAges Up to 18 years - NCT06106685RecruitingPhase 1/Phase 2
Washed microbiota transplant for chronic constipation
This trial tests a treatment called washed microbiota transplantation (a procedure that delivers healthy gut bacteria to your colon) for adults with chronic constipation. The goal is to see if it can improve bowel movements without the need for laxatives.
Nanjing, JiangsuAges 18–70 - NCT06896240Recruiting
Fiber smoothie trial for knee replacement patients
This trial tests if drinking a special fiber smoothie for 2 weeks before knee revision surgery can reduce inflammation and improve recovery. It is for people who are scheduled for knee replacement and have certain chronic health conditions.
New York, New YorkAges 40–80 - NCT07035964Recruiting
Lactoferrin supplement for gut health in adults
This trial tests whether a daily supplement called Effera Human Lactoferrin can improve gut health in adults with belly fat and mild stomach issues. It compares the supplement to a placebo (a dummy pill) over several weeks.
Addison, IllinoisAges 18–40 - NCT07251803Recruiting
GLP-1 medication stomach emptying study
This study uses an ultrasound to look at how full your stomach is after taking GLP-1 medications for diabetes or weight loss. It will help doctors understand if current fasting guidelines are safe before surgery or a colonoscopy.
Charleston, South CarolinaAges 18 years+ - NCT05177133RecruitingPhase 2
First-line treatment for MSI-high stomach or esophagus cancer
This Phase 2 trial tests whether adding an anti–PD-1 immunotherapy (retifanlimab) and chemotherapy (capecitabine plus oxaliplatin, with leucovorin) works better for people with metastatic or inoperable stomach or gastroesophageal junction cancer that has defective mismatch repair (dMMR). If you’re eligible, it may help shrink tumors and slow the disease without needing prior chemotherapy for metastatic cancer.
AmsterdamAges 18 years+ - NCT07230665Enrolling by invitation
Comparing two procedures for stomach blockage from cancer
This trial compares two ways to treat blockage at the end of the stomach caused by cancer: a stent (a small metal tube) or a newer endoscopic bypass. The goal is to see which works better for patients who cannot have surgery.
TaipeiAges 18 years+ - NCT07039448Recruiting
Acupressure for constipation in adults with mental illness
This trial tests if learning and practicing acupressure on yourself can help relieve constipation in adults who are staying in a psychiatric hospital. You would receive training and practice at home for four weeks.
Tuenmen, New TerritoriesAges 18 years+ - NCT06078176Recruiting
Spinal cord injury trial for easier bowel emptying
This trial tests if stimulating certain nerves can help people with spinal cord injury empty their bowels faster and with less effort. It may help reduce the time needed for bowel routines and make them easier.
Syracuse, New YorkAges 18 years+ - NCT07584135RecruitingPhase 3
JS107, Toripalimab, and Chemotherapy for Advanced Stomach Cancer
This study tests a combination of three treatments—JS107, toripalimab (an immunotherapy), and chemotherapy—for advanced stomach cancer that has a specific protein marker called CLDN18.2. The goal is to see if this combination can shrink tumors and help patients live longer.
Guangzhou, GuangdongAges 18 years+ - NCT07392541RecruitingPhase 1/Phase 2
Study of adebrelimab plus chemo and simvastatin for bile duct cancer
This trial tests a combination of immunotherapy (adebrelimab), chemotherapy (gemcitabine and cisplatin), and a cholesterol-lowering drug (simvastatin) for advanced bile duct or gallbladder cancer that cannot be removed by surgery. It aims to see if the addition of simvastatin improves treatment outcomes.
Wuhan, HubeiAges 18 years+ - NCT07731542Recruiting
Vonoprazan Alone or With Itopride for Stomach Discomfort
This trial tests if a new stomach acid blocker (vonoprazan) works better alone or with a medicine that helps stomach movement (itopride) for people with ongoing stomach discomfort. It aims to find a better treatment for functional dyspepsia.
Hyderabad, TelanganaAges 20–50 - NCT07139951Enrolling by invitationPhase 2
Heated Chemotherapy for Stomach Cancer at High Risk of Recurrence
This trial tests a special type of chemotherapy that is heated and delivered directly into the belly during surgery (called HIPEC). It uses two drugs, cisplatin and paclitaxel, and is for people with stomach cancer who are at high risk of the cancer returning in the lining of the belly.
Rochester, MinnesotaAges 18–80
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,879 recruiting gastroenterology studies from the U.S. registry right now, out of 12,351 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.