Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,366 recruiting studies in this area right now.
By phase
- Not applicable975
- Phase 2167
- Phase 398
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia72
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Allergic Rhinitis23
- Nasopharyngeal Carcinoma (NPC)23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke19
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)16
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University58
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen10
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida29
- Massachusetts21
- Illinois20
- Arizona17
- Texas17
- Colorado16
- Alabama15
Recruiting studies1,366 total
- NCT07496112Enrolling by invitation
Bioactive glass for ear surgery cavity filling
This trial tests using a special glass material to fill in the cavity left after ear surgery, which can cause problems like drainage, dizziness, and trouble with hearing aids. The goal is to see if this material helps create a more stable ear.
Legnano, ItalyAges 18 years+ - NCT07457346RecruitingPhase 2
Testing emactinib with chemo and immunotherapy before head and neck cancer surgery
This trial tests whether combining the drug emactinib with chemotherapy and immunotherapy before surgery helps treat advanced head and neck cancer. It aims to shrink tumors and make surgery more effective.
Hangzhou, ZhejiangAges 18–75 - NCT06959108RecruitingPhase 2
Comparing two treatments for head and neck cancer before chemoradiation
This trial tests two different drug combos—one using an EGFR-targeted therapy alone, the other adding an immunotherapy—before standard chemoradiation for locally advanced head and neck cancer. The goal is to see which approach works better without prior treatment.
VillejuifAges 18–75 - NCT07692243Recruiting
Study of nose and sinus tissue differences
This study looks at tissue samples taken during nose or sinus surgery to better understand how these tissues vary. It may help researchers learn more about conditions affecting the nose and sinuses.
Guangzhou, GuangdongAges Any age - NCT06997796RecruitingPhase 1/Phase 2
Treating Nosebleeds in the ER with Powder Tranexamic Acid
This trial tests whether a powder form of tranexamic acid can stop nosebleeds faster in people who come to the emergency room with active bleeding. It may offer a new option if standard treatments don't work well.
Peterborough, OntarioAges 18 years+ - NCT06454955RecruitingEarly Phase 1
PET scan imaging study for solid tumors using a new probe
This trial tests a new imaging agent that targets a protein called B7-H3 found on many solid tumors. It uses PET/CT to help doctors see and stage tumors more clearly.
Beijing, Beijing MunicipalityAges 18–75 - NCT07024524Recruiting
Hearing evaluation and rehab system for congenital hearing loss
This study is developing a system to evaluate and improve hearing for people with congenital hearing loss. It compares participants who have hearing loss (and have used hearing aids, cochlear implants, or gene therapy) with healthy controls, to better understand and treat hearing challenges.
ShanghaiAges 1–35 - NCT06607146Recruiting
Computer training to improve hearing after cochlear implant
This study tests whether practicing listening exercises on a computer can help adults who just got a cochlear implant understand speech better and feel more satisfied with their hearing. If you are getting a cochlear implant at Mayo Clinic in Rochester, MN, you might be able to join.
Rochester, MinnesotaAges 18 years+ - NCT07389213Recruiting
Can brain stimulation and hearing aids slow memory loss in older adults with hearing loss?
This trial tests whether a non-invasive brain stimulation technique (rTMS) combined with hearing aids can help slow down thinking and memory decline in older adults who have age-related hearing loss.
Guangzhou, GuangdongAges 50–85 - NCT05874908Enrolling by invitation
Strep throat and head/neck infection study with hospital samples
This study looks at germs (microbiology) in people with a new, short-term head and neck infection caused by streptococcus bacteria. Your sample would help researchers learn more about these infections and how they behave.
NorthamptonAges 18 years+ - NCT07446738Recruiting
Study of recovery and quality of life after nasal polyp surgery
This study looks at how well patients recover and their quality of life after surgery for nasal polyps caused by chronic sinusitis. It is for people in China who have just had surgery to remove nasal polyps.
ChangchunAges Any age - NCT06640725RecruitingPhase 2
TPEx chemo with maintenance immunotherapy for advanced head and neck cancer
This trial tests a combination of chemotherapy drugs (TPEx) followed by two immunotherapy drugs (avelumab and cetuximab) as a first treatment for head and neck cancer that has spread or come back. It is for people whose tumors show a protein called PD-L1 and who have not had chemotherapy for advanced disease before.
Vandœuvre-lès-NancyAges 18–74 - NCT06776042Recruiting
Nasal polyps and smell loss study
This study looks at why people with nasal polyps lose their sense of smell and how it might come back. You may be able to join if you have had nasal blockage, runny nose, smell loss, or facial pain for at least 12 weeks, have polyps seen inside your nose, and are using a steroid spray regularly.
BrusselsAges 18–70 - NCT04185974Recruiting
Carbon ion re-irradiation for returning head and neck cancer
This trial tests a type of radiation called carbon-ion re-irradiation for people whose head and neck cancer has come back or grown again after earlier radiation. It may help control the cancer after certain surgeries, but it also requires specific safety conditions about timing, prior treatment areas, and overall health.
HeidelbergAges 18 years+ - NCT07073664Enrolling by invitation
Endoscopic sinus expansion plus Stapokibart for chronic sinusitis
This trial tests if a new drug (Stapokibart) combined with a sinus surgery improves symptoms like nasal congestion, discharge, and loss of smell in people with type 2 chronic sinusitis.
Changchun, JilinAges 18–75 - NCT05882903RecruitingPhase 2
Nasal steroid cream after sinus surgery for chronic sinus trouble
This trial studies whether placing a steroid nasal cream inside your sinus area can reduce symptoms in people with chronic rhinosinusitis (CRS) even after sinus surgery. It may help lower ongoing inflammation and symptoms for those who still feel unwell despite usual medical treatments.
Sydney, New South WalesAges 18–80 - NCT07420803Recruiting
Nerve stimulation study for chronic dizziness
This study tests if a gentle, non-invasive nerve stimulation in the ear can help reduce chronic dizziness. It is for people with a specific type of dizziness called PPPD that has lasted at least 3 months.
Jacksonville, FloridaAges 18 years+ - NCT06580509RecruitingEarly Phase 1
Spray medicine for bleeding after tonsil removal in children
This study tests if a sprayed form of the medicine tranexamic acid (which helps blood clot) can stop bleeding after tonsillectomy in children. It is for children ages 2 to 17 who come to the emergency room with bleeding that starts more than a day after surgery.
San Antonio, TexasAges 2–17 - NCT06896695Recruiting
Financial Help for Head and Neck Cancer Patients
This study tests a program called Financial Compass that helps people with head and neck cancer who are struggling with money problems because of their treatment. The goal is to see if this program can reduce financial stress and connect you with helpful resources.
Buffalo, New YorkAges 18 years+ - NCT07397234Recruiting
Awake breathing tube placement study
This study tests two ways to numb the neck for placing a breathing tube while you're awake. It might help if you have a difficult airway that makes regular intubation harder.
Nanjing, JiangsuAges 18–85 - NCT06575946Recruiting
Vestibular test results and dizziness severity
This study looks at how the degree of dizziness relates to specific balance tests in people with a weak or underactive inner ear balance system (vestibular hypofunction). The goal is to better understand your condition and improve future treatments.
Bağcılar, GüneşliAges 12–85 - NCT07449949Enrolling by invitation
Sequential chemoradiation and surgery for nasal rhabdomyosarcoma
This trial tests a treatment plan of chemotherapy, radiation, and then surgery for adults with rhabdomyosarcoma in the nose or sinus cavities. It aims to see if this sequence helps control the cancer.
Shanghai, ChinaAges 18–70 - NCT06572423Recruiting
Personalized focused radiation for head and neck cancer
This trial tests a personalized, very precise radiation treatment (called PULS-Pal) for head and neck cancer that cannot be cured with standard therapies. It aims to shrink tumors and help with symptoms while limiting side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT07227792Recruiting
Tongue-out radiation therapy for head and neck cancer
This trial tests if sticking your tongue out during radiation therapy can reduce side effects. It is for people with certain types of head and neck cancer who are getting radiation to the main tumor.
Pittsburgh, PennsylvaniaAges 18 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,366 recruiting otolaryngology studies from the U.S. registry right now, out of 2,207 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.