Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,371 recruiting studies in this area right now.
By phase
- Not applicable978
- Phase 2168
- Phase 399
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia73
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Nasopharyngeal Carcinoma (NPC)24
- Allergic Rhinitis23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke20
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)17
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University59
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida30
- Massachusetts21
- Illinois20
- Texas18
- Arizona17
- Colorado16
- Alabama15
Recruiting studies1,371 total
- NCT05688488RecruitingPhase 1/Phase 2
Curcumin to help prevent vocal cord scar adhesions after surgery
This trial tests whether curcumin (a natural compound) can reduce scar-like “adhesions” that can form between both vocal cords after endoscopy surgery. If you’re having a procedure on both vocal cords, this could help lower the chance of postoperative sticking and related voice problems.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05694039Recruiting
Track thinking changes in older adults with hearing loss
This study follows older adults who have age-related hearing loss to see whether wearing hearing aids helps protect thinking and memory over time. You may be included if your hearing loss is the type that hearing aids can usually improve and if your thinking test scores suggest mild cognitive difficulties.
Guangzhou, GuangdongAges 60–85 - NCT05695131Recruiting
Testing virtual reality speech therapy for adults
This study checks whether a virtual reality (VR) version of a speech-language therapy program is practical and works the way it should. You might benefit by getting speech therapy in a new, technology-based format, and helping researchers confirm it is safe and feasible.
Edmonton, AlbertaAges 18 years+ - NCT05700825RecruitingPhase 2
Rehab training to improve swallow safety in Parkinson’s
This trial tests a rehabilitation approach aimed at improving airway protection during swallowing in people with Parkinson’s disease. It may help reduce the risk of food or liquid going down the wrong way by improving swallow safety.
West Lafayette, IndianaAges 50–90 - NCT05702749Recruiting
Vestibular physical therapy before treatment for acoustic tumors
This trial tests whether physical therapy focused on balance and dizziness before surgery or targeted radiation (SRS) can improve how people with vestibular schwannoma (an acoustic tumor) feel and function. It aims to help prepare your balance system before treatment begins.
Milwaukee, WisconsinAges 18 years+ - NCT05707819Recruiting
Sintilimab plus chemoradiotherapy for high-risk nasopharyngeal cancer
This trial tests whether adding sintilimab (an immune treatment) to standard chemoradiotherapy can improve outcomes for people with high-risk, locally advanced nasopharyngeal (throat) cancer. It may help your immune system work better against the cancer alongside radiation and chemotherapy.
Nanning, GuangxiAges 18–70 - NCT05708300Recruiting
Testing how mepolizumab works for people with nasal polyps
This study looks at blood and other measures (biomarkers) to understand how well mepolizumab helps people with nasal polyps, with or without asthma. It aims to find response clues that could help personalize treatment in the future.
Thessaloniki, ExochiAges 18 years+ - NCT05708898Recruiting
Testing a throat exerciser to improve swallowing
This trial studies whether using an external throat exerciser helps people with swallowing problems (dysphagia) move food more safely and reduce the risk of choking. You would do swallowing rehab exercises, with the goal of preventing aspiration (food or liquid going into the airway).
Milwaukee, WisconsinAges 18 years+ - NCT05708885Recruiting
Testing a tool to change esophagus muscle movement
This study looks at how a device affects how the esophagus muscles squeeze and relax. It may help people better understand swallowing problems, even if their usual esophagus test looks normal.
Milwaukee, WisconsinAges 18–90 - NCT05708911Recruiting
Testing a throat exercise and swallowing measurements
This study tests a device and exercises designed to improve or assess the swallowing process. It uses measurements taken through the nose to understand how the throat and swallowing muscles work.
Milwaukee, WisconsinAges 18–85 - NCT05710809Recruiting
Exercise and health check study for older colorectal cancer patients
This trial looks at sarcopenia (loss of muscle strength/size) and vertigo (feeling dizzy or off-balance) in older adults with colorectal cancer. It tests whether a structured, exercise-based approach can help these issues alongside cancer care.
CopenhagenAges 65 years+ - NCT05717790Recruiting
Nimotuzumab with chemo and radiation for advanced nose cancer
This trial tests whether adding nimotuzumab (an anti-EGFR antibody) to standard chemotherapy and radiation can improve outcomes for people with advanced nasopharyngeal carcinoma. It may help the cancer respond better and control it more effectively after treatment.
Baise City, GuangxiAges 18–70 - NCT05719779Recruiting
Oral device trial for snoring and sleep apnea in throat cancer
This trial tests whether a custom mouth (mandibular advanced) device can reduce snoring and breathing pauses during sleep in people with oropharyngeal (throat) cancer. It also looks at how well you tolerate the device and whether it helps with sleep symptoms.
Montreal, QuebecAges 18–65 - NCT05732883RecruitingPhase 2
Dexamethasone after thyroid surgery to help voice and calcium
This Phase 2 study tests whether giving dexamethasone (a steroid medicine) around the time of total thyroid surgery can improve voice outcomes and reduce low-calcium problems. It may help people avoid hoarseness and symptoms of hypocalcemia after surgery, especially those at risk.
Hong KongAges 18 years+ - NCT05738421Recruiting
Tests a breathing tube cap and safe swallowing after throat surgery
This study looks at whether using a capped breathing tube for about 48 hours is safe and whether it fits with swallowing training after head and neck surgery. It may help people transition more safely from a breathing tube back toward normal swallowing and breathing.
RomaAges 18–70 - NCT05757817Recruiting
New flap surgery for mouth or throat cancer reconstruction
This trial studies whether a new surgical reconstruction method can improve outcomes for people with oral cavity or oropharyngeal squamous cell carcinoma (a type of head and neck cancer). The goal is to rebuild the area using a tissue flap while reducing problems where the tissue is taken from.
MontpellierAges 18 years+ - NCT05765162Recruiting
Research study on safer, more tailored anesthesia
This study looks at safer anesthesia—meaning medicines used during procedures—using a more personalized approach. It may help make anesthesia safer for adults having medical procedures.
Nykøbing FalsterAges 18–100 - NCT05768178RecruitingPhase 2/Phase 3
Vemurafenib plus cobimetinib for BRAF-mutant cancers
This trial tests whether combining two targeted cancer medicines—vemurafenib and cobimetinib—can treat adults whose tumors have a specific “BRAF V600” mutation. You may be screened with blood tests and a tissue biopsy before starting treatment.
BelfastAges 18 years+ - NCT05772208RecruitingPhase 3
New treatment plan for nasopharyngeal cancer after EBV DNA stays detectable
This Phase 3 trial tests a stronger treatment approach for people with locally advanced nasopharyngeal cancer whose EBV “DNA” (a cancer-related virus signal in blood) does not go away after one cycle of chemotherapy. It may help improve outcomes by changing treatment based on how the cancer responds early.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05774561Recruiting
Using blood tests to monitor HPV-related cancer treatment
This study checks whether “liquid biopsies” (blood tests that look for cancer-related signals) can help monitor how HPV-related cancers respond to treatment. It may help doctors spot changes earlier during care.
OlomoucAges 18–99 - NCT05775367Recruiting
Cochlear implants for young children with one-sided deafness
This study checks whether cochlear implants help young children (ages about 7 months to under 3 years) who have very severe hearing loss in one ear. It also compares them with similar children who do not get implants, to understand what outcomes to expect.
Durham, North CarolinaAges 7 months–5.9 years - NCT05793151Recruiting
Guided care to start cancer treatment on time after surgery
This trial tests a navigation program (help from a care coordinator) versus usual care to help people start the recommended “next-step” treatments (like radiation, sometimes with chemo) on time after surgery. It’s for certain stages of squamous cell cancer in the head and neck area where late treatment could matter.
St Louis, MissouriAges 18 years+ - NCT05800574RecruitingPhase 2
Targeted neck radiation for p16-positive favorable throat cancer
This Phase 2 study tests whether a more precisely targeted radiation plan to the neck can work for people with p16-positive oropharynx cancer that is considered “favorable risk.” Doctors use special imaging to map where lymph nodes are likely involved, aiming to treat the right areas while avoiding unnecessary treatment.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05802459Recruiting
Check how two bowel-reconstruction options affect daily life
This study looks at how surgeons rebuild the esophagus using either a jejunum (small intestine) or a colon (large intestine) piece, and how that affects your day-to-day function and quality of life. It may help doctors choose the approach that best supports recovery and independence for patients needing esophageal reconstruction.
BarcelonaAges 18 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,371 recruiting otolaryngology studies from the U.S. registry right now, out of 2,216 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.