Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT06163807Recruiting
Asthma and nasal polyps long-term observation study
This study follows people with asthma (with or without nasal polyps) to learn more about how the disease changes over time. If you already take part in the MEGA cohort or use a biologic drug for severe asthma, this may be a way to contribute to research while continuing your normal care.
Santiago de Compostela, AcoruñaAges 18–80 - NCT06164483Recruiting
Hearing tests in people with MS or Parkinson's
This study checks how well people with multiple sclerosis (MS) or Parkinson's disease hear. It uses simple hearing tests to see if these conditions affect hearing.
Catania, SicilyAges 20–40 - NCT06165536Recruiting
Using voice strategies to reduce vocal fold pressure
This study tests different ways of using your voice to reduce pressure on vocal fold lesions caused by overuse. If you are between 18 and 40, have been diagnosed with such lesions, and are going to voice therapy, you may be able to join.
Los Angeles, CaliforniaAges 18–40 - NCT04057209Recruiting
Voice outcomes after laser surgery vs radiation for early vocal cord cancer
This trial compares two treatments—CO2 laser surgery through the mouth versus one-vocal-cord irradiation—for early-stage larynx (voice box) cancer. It aims to see which option better preserves voice quality after treatment.
ParisAges 18 years+ - NCT06129864RecruitingPhase 3
Study of Volrustomig for advanced head and neck cancer after chemoradiation
This trial tests a new drug called volrustomig (MEDI5752) for people with advanced head and neck cancer that was not removed by surgery and has been treated with chemoradiation. The goal is to see if the drug can help prevent the cancer from coming back.
Birmingham, AlabamaAges 18–130 - NCT06152627Recruiting
Voice Therapy for Muscle Tension Dysphonia
This study tests a new way of doing voice therapy for people with muscle tension dysphonia — a condition where the muscles around the voice box are too tight, making it hard to speak clearly. The goal is to see if this structured approach helps improve voice function.
Atlanta, GeorgiaAges 14 years+ - NCT06130176Recruiting
Single-step sinus and dental surgery for tooth-related sinusitis
This trial tests a combined procedure to fix sinus infections caused by tooth problems. If you have chronic sinusitis from a dental issue that hasn't improved with other treatments, this surgery might help by addressing both the tooth and sinus in one operation.
Buraidah, Qassim ProvinceAges 18 years+ - NCT06114706Recruiting
Better assessment of sore throat and antibiotic use
This study tests a new way to assess sore throats in primary care and pharmacies to help decide when antibiotics are needed. It aims to improve treatment and reduce unnecessary antibiotic use.
StenungsundAges 6 years+ - NCT06117254Recruiting
Hearing aids for Veterans with trouble hearing in noise
This trial tests whether hearing aids help Veterans who have trouble hearing in noisy places but whose hearing loss is not severe. You'll visit the VA Portland Medical Center several times to see if the aids improve your daily life.
Portland, OregonAges 18–79 - NCT06112860Recruiting
Over-the-counter hearing aids for memory loss study
This trial tests whether over-the-counter hearing aids can help people with mild memory loss (mild cognitive impairment or mild dementia) who also have hearing loss. You and a communication partner will participate together to see if improving hearing can also help with thinking and communication.
Evanston, IllinoisAges 60–90 - NCT06118554Recruiting
Testing a 3D-printed tool for better sinus rinses
This study tests whether a 3D-printed tool can help people with chronic sinusitis get better results from nasal rinses. It might help if your sinus rinses don't reach deep enough into your nasal passages.
Columbus, OhioAges 18–75 - NCT06115772Recruiting
HPV and genital health in women with HPV-positive throat cancer
This study looks at HPV-related health in the genital and anal areas of women who have HPV-positive oropharyngeal cancer, or are the female partners of someone who does. The goal is to better understand how HPV affects these areas over time.
Rochester, MinnesotaAges 18 years+ - NCT05923203Recruiting
Testing combined hearing with cochlear implant and hearing aid
This trial studies a “combined” hearing approach that uses a cochlear implant plus low-frequency sound from a hearing aid. It may help people with different hearing profiles (including cochlear-implant users) hear more naturally by testing how well this combined setup works.
Edmond, OklahomaAges 5 years+ - NCT06100393Recruiting
New sound processing for better hearing in cochlear implant users
This trial tests new sound-processing software in cochlear implants to help users hear speech better in noisy places. It may help adult implant users who struggle with conversations in background noise.
Melbourne, VictoriaAges 18 years+ - NCT05916235Recruiting
Laser light treatment for jaw pain from TMJ disorder
This trial tests whether a specific type of light therapy (called photobiomodulation/laser) can reduce pain from temporomandibular disorder (TMJ) affecting the jaw muscles. If you have jaw muscle pain for at least 3 months, the study will compare your symptoms while you follow the treatment and diary requirements.
Gainesville, FloridaAges 18–99 - NCT06093061RecruitingPhase 2
Maintenance therapy for high-risk nasopharyngeal cancer
This trial tests a combination of two drugs—tislelizumab (an immunotherapy that helps your immune system fight cancer) and capecitabine (a chemo pill taken daily)—as maintenance therapy after initial chemotherapy for high-risk nasopharyngeal cancer. The goal is to see if this approach can lower the chance of cancer coming back.
SingaporeAges 21–99 - NCT06088381RecruitingPhase 2
HPV-related throat cancer treatment based on tumor DNA levels
This trial tests if monitoring cancer DNA left in your blood after surgery can help decide if you need additional treatment. It is for people with HPV-positive oropharynx (throat) cancer who have a certain amount of cancer DNA detected before surgery.
Baltimore, MarylandAges 18 years+ - NCT03452774Recruiting
AI matches your cancer tests to possible treatment trials
This trial uses an AI system to help match people with certain cancer types and specific tumor test results (like gene or protein markers) to relevant clinical trials. It may help you and your doctor find studies that fit your cancer biology faster.
Birmingham, AlabamaAges Any age - NCT05107466Recruiting
Tests brain responses in adults with hearing loss
This study measures how your brain reacts to sounds and visual information. It may help researchers better understand brain function changes that can happen with hearing loss and how to assess them.
Lebanon, New HampshireAges 18 years+ - NCT06064097RecruitingPhase 2
Nivolumab plus chemo for young people with nasopharyngeal cancer
This trial tests combining the immunotherapy drug nivolumab with standard chemotherapy to treat newly diagnosed nasopharyngeal cancer in children and young adults. The goal is to see if adding this immune-boosting medicine can help shrink tumors and prevent the cancer from coming back.
Birmingham, AlabamaAges Up to 21 years - NCT06076304RecruitingPhase 4
Comparing treatments for acute sinusitis
This trial tests whether nasal steroids, nasal irrigation, or oral antibiotics work best for acute sinusitis. It may help if you have ongoing sinus symptoms or a 'double-sickening' pattern after a cold.
Los Angeles, CaliforniaAges 18–75 - NCT06070376Recruiting
Comparing two stents for esophageal cancer swallowing problems
This study compares two types of stents (metal tubes) placed in the esophagus to help people with advanced esophageal cancer swallow more easily. Both stents are designed to keep the esophagus open and improve quality of life.
São Paulo, São PauloAges 18 years+ - NCT06058767Recruiting
Hearing screening for preschoolers
This study offers a free hearing screening for children aged 2 to 6 who attend a community preschool. The goal is to find any hearing issues early so children can get the help they need.
San Francisco, CaliforniaAges 2–6 - NCT06080503Recruiting
Comparing shorter vs. standard radiation for early vocal cord cancer
This study tests if a shorter course of radiation (hypofractionated) works as well as the standard longer course for people with early-stage cancer of the vocal cords. The goal is to find a treatment that is more convenient and has similar results.
Dallas, TexasAges 18 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.