Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,371 recruiting studies in this area right now.
By phase
- Not applicable978
- Phase 2168
- Phase 399
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia73
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Nasopharyngeal Carcinoma (NPC)24
- Allergic Rhinitis23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke20
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)17
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University59
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida30
- Massachusetts21
- Illinois20
- Texas18
- Arizona17
- Colorado16
- Alabama15
Recruiting studies1,371 total
- NCT06657690RecruitingPhase 2
New drug combo for advanced nasopharyngeal cancer after immunotherapy
This trial tests a combination of two drugs, irinotecan liposome and S-1, for people with a type of nose and throat cancer that has spread or come back after treatment with immunotherapy (PD-1/L1 inhibitors). The goal is to see if this new combination can help when standard treatments have stopped working.
Zhuhai, GuangzhouAges 18–70 - NCT06660082Recruiting
Early rehab after inner ear tumor surgery
This trial tests if early rehabilitation using a head movement test can help people recover balance after surgery for an inner ear tumor called a vestibular schwannoma.
BronAges 18–65 - NCT06662929Recruiting
Arabic quality of life measure for head and neck cancer patients
This study will test a new Arabic questionnaire to measure how radiotherapy affects the quality of life of head and neck cancer patients. If you are receiving, have received, or will receive radiation treatment for head or neck cancer, you may be able to help by filling out surveys.
RiyadhAges 18 years+ - NCT06663917Recruiting
Testing sound frequency settings for cochlear implant users with a hearing aid
This study tests different ways to set sound frequencies for people who have a cochlear implant and also use a hearing aid in the other ear. The goal is to find which setting helps you hear speech better.
New York, New YorkAges 18 years+ - NCT06664697Recruiting
Study of the IotaSOFT Insertion System for cochlear implants
This trial tests a new robotic system that helps doctors insert cochlear implant electrodes more gently. It may lead to safer surgery and better hearing outcomes for people with severe hearing loss.
Indianapolis, IndianaAges 12 years+ - NCT06664710Recruiting
Robot-assisted cochlear implant surgery with hearing monitoring
This study tests a new robotic system that helps place a cochlear implant while measuring your inner ear's natural electrical signals during surgery. The goal is to make the procedure more precise and possibly improve hearing outcomes.
Iowa City, IowaAges 12 years+ - NCT06665971RecruitingPhase 4
Dupilumab for esophagus muscle function in EoE
This trial tests if dupilumab, a weekly injection, can improve the muscle function of the esophagus in people with eosinophilic esophagitis (EoE) who haven't gotten better with acid-reducing medications. Researchers want to see if it helps with swallowing and reduces inflammation.
La Jolla, CaliforniaAges 22 years+ - NCT06670261Recruiting
Testing a new way to diagnose breathing problems
This study uses computer modeling to understand nasal breathing. It compares people without nasal symptoms and those with chronic nasal blockage from a deviated septum, to see if modeling can help diagnose the cause.
BordeauxAges 18–69 - NCT06670521RecruitingPhase 2
Steroids for swallowing problems after breathing tube removal
This trial tests a steroid medication (corticosteroids) to reduce swelling in the voice box after a breathing tube is taken out. It may help improve swallowing and reduce the risk of food or drink going into the lungs.
Aurora, ColoradoAges 18 years+ - NCT06674356Recruiting
Chin tuck exercise for swallowing after stroke
This trial tests a simple neck exercise (chin tuck against resistance) to help people who have trouble swallowing after a recent stroke. The goal is to see if this exercise improves swallowing safety and strength.
TaipeiAges 18–100 - NCT06675214RecruitingPhase 3
Immunotherapy with modified radiation for advanced NPC
This trial tests a new way to give radiation therapy after immunotherapy and chemotherapy for people with advanced nasopharyngeal cancer (NPC) that has partially shrunk. It aims to see if a different radiation schedule works better and has fewer side effects.
Zhuhai, GuangdongAges 18–65 - NCT06678100Recruiting
Swallowing study for adults with Alzheimer's
This study looks at swallowing problems in people with Alzheimer's disease compared to healthy older adults. If you have Alzheimer's, you'll have a swallowing test and your caregiver will answer questions about your daily life.
Nashville, TennesseeAges 60 years+ - NCT06680934Recruiting
CABP2 patient registry and natural history study
This study tracks people with hearing loss caused by changes in the CABP2 gene. It aims to understand how the condition develops over time.
GöttingenAges Any age - NCT06682442Recruiting
Chemotherapy-guided radiation for EBV-related nasopharyngeal cancer
This trial tests whether the response to initial chemotherapy can guide the dose of radiation given to patients with Epstein-Barr virus (EBV)-associated nasopharyngeal cancer. The goal is to tailor treatment to reduce side effects while still being effective.
San Francisco, CaliforniaAges 18 years+ - NCT06682494Recruiting
Oral Cancer Awareness for African Americans
This study aims to raise awareness about oral cancer in the African American community. It will help researchers understand how to better communicate about prevention and early detection.
Richmond, VirginiaAges 18 years+ - NCT06688578Recruiting
Can a device that makes small noises improve balance and walking?
This study tests whether a device that plays small, random sounds (called stochastic noise) can help people feel steadier and walk better. It is for healthy adults of two age groups — those 60 and older, and those 21–59.
Baltimore, MarylandAges 21 years+ - NCT06688760Recruiting
Surgery vs surgery plus lower-dose radiation for early nasopharyngeal cancer
This trial compares two treatments for newly diagnosed Stage I nasopharyngeal cancer: surgery alone versus surgery followed by a lower dose of radiation. The goal is to see if adding a gentler radiation dose can prevent the cancer from coming back without too many side effects.
Guangzhou, GuangdongAges 18–70 - NCT06689865Recruiting
Hearing aid study for adults with mild to moderate hearing loss
This study tests four different ways to provide over-the-counter hearing aids to adults with mild-to-moderate hearing loss. It aims to find the best approach to help people hear better and improve their quality of life.
Aurora, ColoradoAges 40 years+ - NCT06695455Recruiting
Can music help people with Parkinson's swallow better?
This trial tests if a rhythmic sound cue can reduce rolling (a swallowing problem) in people with Parkinson's. If you have trouble with solid foods but not severe liquid aspiration, you may qualify.
Saint-Sébastien-de-Morsent, NormandyAges 18 years+ - NCT06702033RecruitingPhase 2
Surgery for HPV-related oropharyngeal cancer
This trial is testing a surgical approach for people with HPV-related oropharyngeal cancer that is stage I or II (but not the very smallest). The goal is to see if removing the tumor through the mouth and taking out neck lymph nodes is effective and safe. It may be an option if you are healthy enough for surgery.
St Louis, MissouriAges 18 years+ - NCT06702085Recruiting
Lifestyle changes for older adults with tinnitus and metabolic syndrome
This study tests whether lifestyle changes (like diet and exercise) can help older adults who have both metabolic syndrome and chronic tinnitus (ringing in the ears). It is for people 65 and older with class 1 obesity and long-term ear ringing in both ears.
Dokki, Giza GovernorateAges 65–75 - NCT06706401RecruitingPhase 3
Lymphocyte-sparing radio-immunotherapy for head and neck cancer
This trial tests a new approach that combines radiation and immunotherapy, while trying to protect your immune cells. It is for people with head and neck cancer that has not spread across the midline of the body and has not been treated yet.
Lyon, FranceAges 18 years+ - NCT04695600RecruitingPhase 2/Phase 3
Botox for swallowing problems after brain injury
This trial tests if Botox injections in the throat can help people who have trouble swallowing due to a brain condition like stroke. It aims to improve safety and ease of eating and drinking.
New Delhi, National Capital Territory of DelhiAges 14 years+ - NCT06819228RecruitingPhase 1
Lighted antibody imaging in head and neck cancer surgery
This trial tests a special fluorescent dye attached to panitumumab, a cancer-targeting antibody, to help surgeons see tumor tissue more clearly during head and neck cancer surgery. The goal is to improve removal of all cancer cells while sparing healthy tissue.
Nashville, TennesseeAges 18 years+
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,371 recruiting otolaryngology studies from the U.S. registry right now, out of 2,216 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.