Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,366 recruiting studies in this area right now.
By phase
- Not applicable975
- Phase 2167
- Phase 398
- Phase 146
- Phase 434
- Phase 1/Phase 232
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma80
- Dysphagia72
- Hearing Loss61
- Tinnitus31
- Hearing Loss, Sensorineural25
- Allergic Rhinitis23
- Nasopharyngeal Carcinoma (NPC)23
- Head and Neck Cancer22
- Oropharynx Cancer21
- Stroke19
- Sensorineural Hearing Loss18
- Nasopharyngeal Cancinoma (NPC)16
- Chronic Rhinosinusitis With Nasal Polyps15
- Oropharyngeal Cancer15
- Nasopharyngeal Cancer14
- Vestibular Schwannoma14
- Head and Neck Squamous Cell Carcinoma13
- Chronic Rhinosinusitis (CRS)12
Leading sponsors
- Sun Yat-sen University58
- Eye & ENT Hospital of Fudan University17
- Cairo University15
- Assistance Publique - Hôpitaux de Paris14
- NYU Langone Health14
- Mayo Clinic12
- National Cancer Institute (NCI)12
- Johns Hopkins University11
- Ming-Yuan Chen10
- Cochlear9
Where studies are running
- California62
- Maryland37
- New York35
- Florida29
- Massachusetts21
- Illinois20
- Arizona17
- Texas17
- Colorado16
- Alabama15
Recruiting studies1,366 total
- NCT05821140Recruiting
Assessing jaw and bite function in children with oral health issues
This study looks at how a child’s mouth, jaw, and biting function work in different dental and oral health situations. It may help clinicians better understand what support or treatments children need.
Clermont-FerrandAges 3–17 - NCT05625191Recruiting
Study of voice strain with and without vocal fold injury
This study compares people with “phonotrauma” (injury from voice overuse/strain) to people without voice injury. It may help researchers better understand voice changes and how they develop, which could guide future treatment.
Dallas, TexasAges 18–65 - NCT04320251Enrolling by invitation
Testing tissue changes during cochlear implant revision surgery
This study looks at how tissue heals or changes in people who are getting a revision cochlear implant surgery. It may help doctors better understand healing and improve future care for cochlear implant users.
Nashville, TennesseeAges 18 years+ - NCT05874102Enrolling by invitation
Testing how body position affects swallowing in infants
This study checks whether changing an infant’s body position (for example, side-lying or more upright) changes how safely they swallow. It focuses on infants who have swallowing difficulty seen during a special swallow test with imaging.
Hartford, ConnecticutAges 9 months–1.1 years - NCT04869436RecruitingPhase 4
Dupilumab to improve smell in nasal polyps
This trial studies whether dupilumab can improve smell in adults whose nasal polyps are causing long-lasting smell loss. It may help learn how well the treatment restores smell, so future patients can benefit sooner.
London, OntarioAges 18 years+ - NCT05193240Recruiting
Swallowing test to predict vocal cord paralysis after lung surgery
This study checks whether a simple swallowing test can forecast vocal cord paralysis after lung surgery, compared with a camera exam of the throat. If predictions are accurate, it may help doctors prevent or plan treatment for swallowing and voice problems.
RouenAges 18 years+ - NCT01558804Recruiting
Study for children with strep throat using beta-lactam antibiotics
This study looks at children ages 5–15 who test positive for Group A strep (often called strep throat). It may help by testing an antibiotic approach with beta-lactam medicines for children who are expected to need treatment.
Madison, WisconsinAges 5–15 - NCT04988074RecruitingPhase 2
Test cemiplimab for HPV-positive throat cancer using tumor biomarkers
This Phase 2 trial studies whether cemiplimab (with or without chemotherapy first) can improve treatment for HPV-positive oropharynx throat cancer. It also uses lab “biomarkers” to help guide which treatment you get next.
Baltimore, MarylandAges 18 years+ - NCT03980275Recruiting
Nerve-sparing surgery for both vocal cords that won’t move
This trial studies a surgical technique to improve breathing and voice in people whose both vocal cords do not move. It’s meant for cases that have not improved on their own for at least 6 months, and it may help restore better movement and function.
New York, New YorkAges 18–70 - NCT04647968Recruiting
Testing one-step versus two-step closure of a trachea skin leak
This study compares two surgical ways to close an abnormal connection between your trachea (windpipe) and your skin (a tracheo-cutaneous fistula). It may help find the safer, more effective closure approach when you’re ready to remove your breathing tube.
Sherbrooke, QuebecAges 18 years+ - NCT04318717RecruitingPhase 2
Pembrolizumab plus radiation for resected mucosal melanoma
This trial studies whether giving pembrolizumab (an immunotherapy) together with a targeted form of radiation can help after surgery for mucosal melanoma. It aims to lower the chance of the cancer coming back and improve outcomes in people whose tumor was removed.
St Louis, MissouriAges 16 years+ - NCT03882229Recruiting
MED-EL hearing implant registry study
This study collects real-world information from people who have, or will have, a MED-EL cochlear implant. The goal is to build a registry so researchers and the company can better understand outcomes over time.
CairoAges Any age - NCT04016675Recruiting
Radiation before surgery for cancer of the tear sac
This trial studies giving radiation before surgery for malignant (cancerous) tumors of the tear sac. It may help shrink the tumor and improve how well treatment works when surgery is planned.
ShanghaiAges 18–80 - NCT04569500Recruiting
Therapy education program for laryngectomy patients and caregivers
This study tests a structured education and support program for people after a total laryngectomy (surgery to remove the voice box) and for their close family caregivers. It aims to improve quality of life for both the patient and the caregiver.
CaenAges 18 years+ - NCT03502590Recruiting
Test of a throat breathing device for people with neck radiation
This study tests how well a specific airway device works during general anesthesia for people who had radiation therapy to the neck. It may help improve safety and comfort during planned surgeries.
LivingstonAges 18 years+ - NCT05319678Recruiting
Music and voice testing in cochlear implant users
This study looks at how well cochlear implant users do musical and voice skills, including children and adults who use one or two implants. You might benefit by helping researchers understand how these skills develop and how devices work over time.
Madrid, MadridAges 6 years+ - NCT02137824Recruiting
Sinus bone lift procedure for people with limited jaw bone
This pilot study tests a modified technique to add bone in the upper jaw area (the sinus floor) so dental implants may be possible. You may be considered if you have a small amount of remaining bone height and enough bone width, and you do not have certain infections or risk factors.
ViennaAges 18–100 - NCT05427695RecruitingPhase 2
Probiotic rinse to treat chronic sinus inflammation
This Phase 2 study tests whether washing your sinuses with a probiotic solution can improve chronic sinusitis symptoms and inflammation. It’s for adults with chronic sinus symptoms that have flared, especially if you’ve had sinus surgery in the past.
Chicago, IllinoisAges 18 years+ - NCT03426579Recruiting
Testing sedation monitoring during anesthesia for children’s throat surgery
This trial looks at whether a monitoring method for how deeply a child is sedated matches how the child’s reflexes react during intravenous anesthesia. It may help anesthesiologists keep children safer and more comfortable during direct laryngoscopy procedures using medications like dexmedetomidine and remifentanil.
Edegem, AntwerpAges 1 month–8 years - NCT05740683Recruiting
Studies alpha-synuclein and brain symptoms in smell loss
This study looks at whether a specific brain protein (alpha-synuclein) is linked to other neurologic symptoms in people who have long-lasting smell loss. It may help researchers understand what causes smell loss and how it relates to later brain or nerve changes.
CopenhagenAges 55–75 - NCT01612949Recruiting
Photos to help predict difficult breathing tube placement
This trial looks at pictures of the face and neck to help classify which people are harder to place a breathing tube. It may help anesthesiology teams prepare and choose safer steps if a tube is difficult to insert.
Winston-Salem, North CarolinaAges 18–99 - NCT03306082Enrolling by invitation
Test whether guided programming improves cochlear implant settings
This study checks whether an imaging-guided method can help tune your cochlear implant to improve hearing performance compared with the usual programming approach. It mainly looks at adults who already have a cochlear implant and have shown expected improvements with standard setup.
Nashville, TennesseeAges 18–90 - NCT06505187RecruitingPhase 2
Celecoxib for Pain After Parotid Gland Surgery
This trial is testing whether the pain reliever celecoxib (Celebrex) can help control pain after a specific type of salivary gland surgery called superficial parotidectomy. If you're having this surgery, you may be able to join and take celecoxib for pain rather than other common pain medicines.
Madison, WisconsinAges 18 years+ - NCT06467292Recruiting
Speech Learning and Memory Study
This study looks at how people learn and remember speech movements. It may help explain how we improve speaking skills over time.
New Haven, ConnecticutAges 18–40
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,366 recruiting otolaryngology studies from the U.S. registry right now, out of 2,207 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.