Otolaryngology
Ear, nose & throat clinical trials
Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We’re tracking 1,269 recruiting studies in this area right now.
By phase
- Not applicable890
- Phase 2154
- Phase 3103
- Phase 147
- Phase 431
- Phase 1/Phase 230
- Phase 2/Phase 314
Top conditions
- Nasopharyngeal Carcinoma73
- Dysphagia66
- Hearing Loss61
- Tinnitus29
- Hearing Loss, Sensorineural24
- Nasopharyngeal Carcinoma (NPC)24
- Head and Neck Cancer23
- Allergic Rhinitis22
- Oropharynx Cancer21
- Nasopharyngeal Cancinoma (NPC)18
- Sensorineural Hearing Loss18
- Stroke17
- Oropharyngeal Cancer14
- Vestibular Schwannoma14
- Chronic Rhinosinusitis With Nasal Polyps13
- Deafness13
- Head and Neck Squamous Cell Carcinoma13
- Nasopharyngeal Cancer13
Leading sponsors
- Sun Yat-sen University57
- Assistance Publique - Hôpitaux de Paris14
- Eye & ENT Hospital of Fudan University14
- National Cancer Institute (NCI)14
- Cairo University13
- NYU Langone Health13
- Mayo Clinic12
- Johns Hopkins University11
- Ming-Yuan Chen11
- Massachusetts Eye and Ear Infirmary10
Where studies are running
- California61
- Maryland38
- Florida32
- New York32
- Massachusetts24
- Illinois20
- Texas20
- Alabama15
- Arizona15
- Colorado15
Recruiting studies1,269 total
- NCT04498221Recruiting
Mapping lymph flow in oropharyngeal cancer with scans
This study uses a special dye or tracer to map how lymph fluid travels from an oropharyngeal (throat) cancer to nearby lymph nodes. It may help doctors understand the most likely spread pattern and plan future treatment more accurately.
LondonAges 18 years+ - NCT07750379Recruiting
Acid-reducing medicine for aspiration in children with laryngomalacia
This study tests whether giving a common acid-reducing medicine (a proton pump inhibitor) to children with laryngomalacia can reduce choking and aspiration. It may help if your child has frequent choking episodes.
Minya, Minya GovernorateAges 6 months–5 years - NCT07751354Enrolling by invitation
Balance measurement study for older adults with dizziness
This study tests a wearable sensor to measure how your body controls balance during walking and simple movements. It may help doctors better understand balance problems in older adults with dizziness or vestibular conditions, potentially improving future treatments.
Sheffield, South YorkshireAges 65 years+ - NCT07754266Recruiting
Headache, ear, and dizziness registry
This study collects information from people who have headaches, ear problems, dizziness, or sinus issues to better understand these symptoms and how they relate to migraine. Your participation may help improve future treatments and diagnosis.
North Kingstown, Rhode IslandAges 18 years+ - NCT07755397RecruitingPhase 1
Study of JBI-778 for lung, brain, and salivary gland tumors
This trial tests a new oral medication, JBI-778, in patients with certain types of lung cancer, brain tumors, or salivary gland cancer. The drug is designed to target specific genetic changes in these tumors, and the study aims to assess its safety and effectiveness.
Surat, GujaratAges 18 years+ - NCT06137378RecruitingPhase 2
Pembrolizumab for advanced throat cancer to avoid laryngectomy
This trial tests whether a drug called pembrolizumab (Keytruda) can help people with advanced throat cancer avoid removal of the voice box. You may be eligible if you have a specific type of larynx or hypopharynx cancer that hasn't been treated with radiation or immunotherapy before.
Mannheim, Baden-WürtembergAges 18–70 - NCT07749586RecruitingPhase 1/Phase 2
Study of ARV-6723 alone or with pembrolizumab for advanced solid tumors
This trial tests an experimental drug called ARV-6723, alone or with another drug called pembrolizumab, for people with advanced solid tumors that have not responded to other treatments. The goal is to see if these combinations can help shrink tumors or slow their growth.
New York, New YorkAges 18 years+ - NCT07745127Recruiting
Nasal stitch versus packing after nose surgery
This study compares two ways to stop bleeding after nasal surgery (septoplasty): using a special stitch inside the nose versus using nasal packing. It aims to see which method is more comfortable and effective for patients like you.
Islamabad, FedralAges 18–50 - NCT06611150RecruitingPhase 1
Chemo and radiation for advanced nasopharyngeal cancer
This trial tests whether a specific chemotherapy drug (nab-paclitaxel) given along with targeted radiation therapy can help people with stage III or IVa nasopharyngeal cancer. The goal is to improve treatment outcomes while managing side effects.
Guangzhou, GuangdongAges 18–70 - NCT06611137RecruitingPhase 2
SBRT plus chemoimmunotherapy to save the voice box
This trial tests a new approach to treat advanced larynx or hypopharynx cancer without removing the voice box. First, you get targeted radiation (SBRT), then a combination of chemotherapy and an immunotherapy drug called Toripalimab, which helps your immune system fight the cancer.
Guangzhou, GuangdongAges 18–70 - NCT06614686RecruitingPhase 1
CAR-T therapy for advanced head and neck cancer
This study tests a new type of CAR-T cell therapy that targets a protein called Trop2 found on some head and neck cancer cells. It's for people who have tried standard treatments and need a new option.
ShanghaiAges 18–70 - NCT06463392Recruiting
Deep learning tool to diagnose post-radiation nasopharyngeal changes
This trial tests a new computer-based tool (deep learning) to help diagnose a condition called sbORN (suspected benign or recurrent nasopharyngeal carcinoma) after radiation therapy. It aims to see if the tool can accurately tell if a suspicious spot is a recurrence or something harmless.
Guangzhou, GuangdongAges 18 years+ - NCT06623123RecruitingPhase 3
Phone app vs. talking therapy for tinnitus relief
This trial compares a smartphone app called Oto to standard talking therapies for treating tinnitus. If you have had tinnitus for at least 3 months and can use an app, this study may help you find relief.
Stevenage, HertfordshireAges 18 years+ - NCT05740683Recruiting
Studies alpha-synuclein and brain symptoms in smell loss
This study looks at whether a specific brain protein (alpha-synuclein) is linked to other neurologic symptoms in people who have long-lasting smell loss. It may help researchers understand what causes smell loss and how it relates to later brain or nerve changes.
CopenhagenAges 55–75 - NCT07735078Recruiting
Smart balance and thinking exercise for older adults
This study tests a smart digital tool that combines balance and thinking exercises to help older adults stay steady and prevent falls. If you are 55+ and can walk a short distance, you may be able to join.
Taipei, TaipeiAges 55 years+ - NCT07734298Recruiting
Ultrasound vs. scope for swallowing problems after ICU breathing tube
This study compares two ways to check swallowing after a breathing tube is removed in the ICU: one uses an ultrasound machine, the other uses a small camera through the nose. If you qualify, you may help doctors find the best method to spot swallowing issues early.
Querétaro City, QuerétaroAges 18 years+ - NCT05738421Recruiting
Tests a breathing tube cap and safe swallowing after throat surgery
This study looks at whether using a capped breathing tube for about 48 hours is safe and whether it fits with swallowing training after head and neck surgery. It may help people transition more safely from a breathing tube back toward normal swallowing and breathing.
RomaAges 18–70 - NCT07726147RecruitingPhase 1
Testing a new allergy shot for Japanese cedar pollen
This trial tests a new allergy shot (ITI-9001) for people with Japanese cedar pollen allergy. It aims to see if the shot is safe and can reduce allergy symptoms. The study is for people who have not tried immunotherapy before.
Tokyo, Shinjuku-kuAges 18–65 - NCT07731321Enrolling by invitation
Are Earplug Instructions Better One Way Or Another?
This study compares different ways of teaching people how to use earplugs. It will look at which method works best to protect hearing in a noisy workplace.
Chiang MaiAges 20–60 - NCT07726121Recruiting
Mapping the upper jaw artery using 3D X-ray scans
This study uses existing CBCT scans to map a small artery (the alveolar antral artery) in the upper jaw. It helps dentists and surgeons plan procedures to avoid bleeding.
KielceAges Any age - NCT07726251Recruiting
Heart changes during jaw surgery
This study looks at how your heart and blood pressure change during a type of jaw surgery called bimaxillary orthognathic surgery. It will help doctors understand a reflex that can affect your heart rate during the procedure.
Kirikkale, KırıkkaleAges 18–40 - NCT05108896Recruiting
Testing breathing and swallowing recovery after ICU breathing support
This study looks at aspiration (food or liquid going “the wrong way” into the airway) in people who survived a serious ICU breathing problem. It may help doctors better support safe swallowing and breathing recovery after being on a breathing machine.
Stanford, CaliforniaAges 18 years+ - NCT06633068RecruitingPhase 2
Pain relief study: nalbuphine added to numbing medicine for thyroid surgery
This study tests if adding nalbuphine to the numbing medicine (bupivacaine) given as a nerve block before thyroid surgery provides better pain relief. It is for adults having planned thyroid surgery.
Giza, الجيزةAges 18–60 - NCT07722091Recruiting
Steroid spray to prevent hoarseness after abdominal surgery
This study tests a new way to prevent hoarseness after upper abdominal surgery by spraying a steroid (dexamethasone) near certain nerves during the operation. The goal is to reduce voice changes that can happen from the breathing tube or surgical stress.
Fuzhou, FujianAges 18–75
Common questions
- How many ear, nose & throat clinical trials are recruiting?
- Clin2 is tracking 1,269 recruiting otolaryngology studies from the U.S. registry right now, out of 2,074 we cover in this area in total.
- What does “Ear, nose & throat” cover here?
- Hearing, balance, and conditions of the ears, nose, sinuses, and throat. We group each study into ear, nose & throat based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a ear, nose & throat trial near me?
- Use the search to filter ear, nose & throat studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.