Ophthalmology
Eyes & vision clinical trials
Eye disease and conditions that affect sight. We’re tracking 1,764 recruiting studies in this area right now.
By phase
- Not applicable1,204
- Phase 3133
- Phase 2119
- Phase 1117
- Phase 492
- Phase 1/Phase 285
- Phase 2/Phase 314
Top conditions
- Glaucoma107
- Myopia88
- Cataract76
- Diabetic Retinopathy51
- Dry Eye38
- Keratoconus34
- Retinitis Pigmentosa33
- Age-Related Macular Degeneration31
- Amblyopia26
- Eye Diseases24
- Graves Disease24
- Sjogren's Syndrome24
- Dry Eye Disease (DED)23
- Multiple Sclerosis22
- Astigmatism21
- Ocular Hypertension21
- Diabetic Macular Edema20
- Macular Degeneration20
Leading sponsors
- Zhongshan Ophthalmic Center, Sun Yat-sen University25
- Medical University of Vienna20
- Second Affiliated Hospital, Zhejiang University, School of Medicine19
- Fondation Ophtalmologique Adolphe de Rothschild18
- Assistance Publique - Hôpitaux de Paris16
- National Taiwan University Hospital16
- The Hong Kong Polytechnic University16
- Eye & ENT Hospital of Fudan University15
- National Eye Institute (NEI)15
- Shanghai Eye Disease Prevention and Treatment Center15
Where studies are running
- California133
- Arizona68
- Florida43
- Maryland39
- Texas37
- New York36
- Massachusetts35
- Alabama26
- North Carolina20
- Pennsylvania20
Recruiting studies1,764 total
- NCT05401357RecruitingPhase 3
Test eye drops for glaucoma or high eye pressure in both eyes
This Phase 3 study compares two versions of the same glaucoma eye-drop medicine (bimatoprost 0.01%) to see how similarly they work and their effect on eye pressure. It may help people with chronic open-angle glaucoma or ocular hypertension who need treatment in both eyes.
Newport Beach, CaliforniaAges 18 years+ - NCT05472844Recruiting
Study of cataracts in children under 18
This is a research study that follows children with cataracts to learn more about the condition. If your child is under 18 and has a cataract in one or both eyes, this study may be able to include them.
Guangzhou, GuangdongAges Up to 18 years - NCT05563623Recruiting
Study of people at risk for angle-closure progression
This study follows people who have eye anatomy that suggests a higher risk of angle closure, but who do not currently have high eye pressure or glaucoma damage. It aims to understand how often and how fast this risk can progress, which may help guide earlier monitoring or prevention.
Beijing, BeeijingAges 40–75 - NCT03321201Recruiting
Glue or cautery for a first pterygium surgery
This study compares two methods used during surgery for a first-time pterygium (a non-cancer growth on the eye surface): using a special glue versus cauterization. It may help determine which method works better to keep the growth from coming back and to heal more smoothly.
SplitAges 18 years+ - NCT05605314Recruiting
Study different types of dry eye in Sjögren’s
This study looks at patients with Sjögren’s-related dry eye to understand how different subtypes affect tear function and eye symptoms. It may help doctors better sort out dry eye types, which can guide more tailored care.
BeijingAges 18–80 - NCT04912843RecruitingPhase 2/Phase 3
Gene therapy for inherited optic nerve vision loss
This trial tests a gene therapy injection into the eye to improve vision in people with a specific type of inherited optic nerve disease called Leber’s hereditary optic neuropathy (LHON). It is aimed at people who have a particular genetic change and a history of vision loss lasting long enough to measure change, while checking for safety first.
BeijingAges 12–75 - NCT05340647Recruiting
Study of micro-invasive glaucoma surgery options
This trial studies outcomes after certain minimally invasive glaucoma surgeries, including the Preserflo microshunt. It may help improve how safely and effectively glaucoma surgery is done, and how patients are followed afterward.
OsloAges 18 years+ - NCT05072262RecruitingPhase 4
Topical anti-inflammatory eye drops after corneal transplant
This study tests whether anti-inflammatory eye drops (nepafenac, an NSAID) can help reduce swelling in the macula (the sharp-vision part of the eye) after certain cornea transplant surgeries. It compares outcomes in adults having DSAEK or DMEK who can safely use the study drops.
OsloAges 18 years+ - NCT03635645Recruiting
Testing stimulation in people with an implanted retinal prosthesis
This study looks at how retinal stimulation works for people who already have an Argus II retinal prosthesis implanted. It may help researchers understand how well the stimulation creates a visual perception and how reliably people can do the required testing.
Ann Arbor, MichiganAges 25–89 - NCT05663684RecruitingPhase 4
Topical numbing drops to reduce pain during tear duct testing
This Phase 4 trial studies whether numbing eye drops (proparacaine 0.5%) can reduce pain during a procedure called probing and irrigation of the tear drainage system. If you need this test for ongoing watery eyes, the trial may help make the procedure more comfortable.
New Orleans, LouisianaAges 18 years+ - NCT05705778Recruiting
Blood biomarker study in children with amblyopia
This trial looks at a blood test (a “biomarker”) in children with amblyopia, a common vision development problem. It may help researchers understand what changes go along with treatment and vision improvement.
Guangzhou, GuangdongAges 3–12 - NCT03542734Recruiting
Imaging study for thinking and brain changes in older adults
This study looks at brain scans and eye/eye-nerve findings to understand why thinking can change with aging. It may help researchers connect eye and brain changes, which could guide future ways to prevent or detect dementia early.
HangzhouAges 40 years+ - NCT04251143Recruiting
Study for corneal disease and corneal thinning
This study looks at people with corneal disease, especially corneal thinning that can change how the eye focuses light. It may help researchers understand treatments and care plans for these conditions.
Dresden, SaxonyAges 18–65 - NCT05752214Recruiting
Quality-of-life study for adults with vision problems
This study looks at how life quality changes or is measured in adults who have vision problems and are in specialized vision rehabilitation. You may be asked to answer questionnaires to help the research team understand your experience.
RomaAges 18 years+ - NCT05756959Recruiting
Tested light-based treatment plus special lenses for childhood myopia
This study tests whether combining PBM (a light/laser treatment used in eye studies) with a special myopia-defocus lens can slow nearsightedness in children. It may help reduce how fast eyesight gets worse over time.
Xuzhou, JiangsuAges 6–13 - NCT05474729RecruitingPhase 1/Phase 2
Minocycline for chronic autoimmune eye inflammation
This trial tests whether minocycline, an antibiotic that can also reduce inflammation, helps improve chronic autoimmune uveitis and protect vision. It may help by lowering ongoing immune irritation that damages the eye.
Guangzhou, GuangdongAges 18–70 - NCT05814952Recruiting
LX103 eye treatment for X-linked retinoschisis
This trial studies whether LX103 can improve vision and is safe for people with X-linked retinoschisis (XLRS) caused by RS1 gene changes. It focuses on a specific level of vision in the study eye and checks for medical conditions that could affect eye testing or safety.
ShanghaiAges 6 years+ - NCT05844384Recruiting
Testing a new eye drop bottle for glaucoma
This study checks whether a device called the Nanodropper helps deliver glaucoma medicine as well as standard use. It is for adults with stable primary open-angle glaucoma (or ocular hypertension) who are on a limited number of eye-pressure medicines.
Lackland Air Force Base, TexasAges 18 years+ - NCT05486546Recruiting
Compare two LASIK mapping methods for myopia and astigmatism
This trial compares two ways of mapping your eye to guide LASIK surgery for people with nearsightedness and mild astigmatism. It looks at how well vision (especially best-corrected vision) does after surgery one month later.
Bozeman, MontanaAges 21–38 - NCT05733728Recruiting
Uveal melanoma medical record study
This study looks back at past medical records of people diagnosed with uveal melanoma. It helps researchers learn about the typical course of the disease by analyzing what already happened in care.
ViennaAges 18–99 - NCT05858983RecruitingPhase 1/Phase 2
Gene therapy for certain RPE65 inherited eye conditions
This early-stage trial tests a gene therapy aimed at treating inherited retinal dystrophy caused by changes in the RPE65 gene on both copies. It may help slow vision loss or improve eye function, but the study is mainly about safety and learning how the treatment works.
Beijing, Beijing MunicipalityAges 8–45 - NCT05865093Recruiting
Check early vision changes in infants at risk for brain vision problems
This pilot study looks at early vision (what babies can see and how their eyes respond) in children who have risk factors for future “cerebral visual impairment,” meaning vision problems caused by the brain. It may help doctors spot issues earlier and better understand which early visual signs matter.
RomeAges 2 days–3 years - NCT05874310RecruitingEarly Phase 1
Gene therapy trial for RPGR-related vision loss
This early study tests a gene therapy designed for people whose vision problems are caused by an RPGR genetic change. It may help slow or improve the eye disease by treating the underlying cause.
Beijing, Beijing MunicipalityAges 8–45 - NCT05883072Recruiting
Using AI to support care for people with diabetes in Pakistan
This study tests whether AI-generated support can be helpful for adults living with diabetes. You may be asked to participate if you live in Pakistan and can legally consent.
Karachi, SindhAges 18–100
Common questions
- How many eyes & vision clinical trials are recruiting?
- Clin2 is tracking 1,764 recruiting ophthalmology studies from the U.S. registry right now, out of 2,747 we cover in this area in total.
- What does “Eyes & vision” cover here?
- Eye disease and conditions that affect sight. We group each study into eyes & vision based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a eyes & vision trial near me?
- Use the search to filter eyes & vision studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.