Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06915649Recruiting
Understanding a specific brain surgery's results
This trial looks at the results of a specific type of brain surgery (amygdalo-hippocampectomy) done by Professor Coubes. It helps doctors better understand how the surgery works and how it affects patients.
Montpellier, HéraultAges Any age - NCT06915961Recruiting
HE4 Protein and Lung Function in Cystic Fibrosis
This study looks at a protein in the blood (HE4) and how it relates to lung function in children with cystic fibrosis. It also tests a quality improvement plan to help manage CF. The goal is to find better ways to track and treat the disease.
Cairo, AbbasiaAges 6 years+ - NCT06917690RecruitingPhase 3
Testing oleogel-S10 for epidermolysis bullosa in Japanese patients
This trial tests a gel called oleogel-S10 on wounds caused by a rare skin condition called epidermolysis bullosa (EB). It is only for people of Japanese descent who have a specific type of EB called junctional or dystrophic EB. The gel is put on the wound to help it heal.
FukuokaAges 3 weeks+ - NCT06918119Recruiting
Spinal cord stimulation for children with spina bifida
This study tests whether a special type of electrical stimulation applied to the skin over the lower spine can help improve function in children and teenagers with spina bifida. It aims to see if this treatment can make daily activities easier.
Rochester, MinnesotaAges 5–18 - NCT06918236Recruiting
Pregnancy after fertility treatment: study of outcomes
This study looks at pregnancy results for women who had fertility treatments (like IVF). You can join if your baby is alive on ultrasound and you are between 11 and 14 weeks pregnant.
PlevenAges 18 years+ - NCT06918392Recruiting
Testing a questionnaire for teens with pectus excavatum
This study tests a questionnaire about living with pectus excavatum (sunken chest). If you are a teen (12-18) scheduled for the Nuss procedure, you and your parent can help by filling out the questionnaire to see if it works well.
HeerlenAges 12–18 - NCT06918795Recruiting
Fontan Fitness Trial: Home exercise for better heart health
This study tests whether a home-based exercise training program can improve fitness in people with Fontan circulation. Participants will do regular aerobic exercise and be monitored for changes in heart and lung function over time.
Philadelphia, PennsylvaniaAges 10–17 - NCT06919003RecruitingPhase 2
Improving kidney transplant with a single injection of a protective protein
This trial tests whether a single injection of C1 esterase inhibitor into a donated kidney during preservation can improve transplant outcomes. It is for adults on dialysis waiting for a deceased-donor kidney who meet specific blood and tissue matching requirements.
Los Angeles, CaliforniaAges 18–75 - NCT06919224Recruiting
Text message support for adults with sickle cell disease
This study uses text messages to help adults with sickle cell disease learn about the latest medical guidelines and tools to manage their health. The goal is to see if this mobile approach improves how people follow their care plan.
Chicago, IllinoisAges 18 years+ - NCT06919757Recruiting
Early Lung Health in Very Premature Infants
This study compares the early lung development of very premature babies who had growth problems in the womb to those who did not. The goal is to understand how growth in the womb affects lung health after birth.
RomaAges Any age - NCT06919692Recruiting
Lying on left side for fetal growth restriction
This study tests if lying on your left side can help improve blood flow and oxygen for babies with fetal growth restriction (FGR), a condition where the baby is smaller than expected. If you are pregnant with one baby, between 24 and 34 weeks, and your baby is in the bottom 10% for weight, you may qualify.
Aurora, ColoradoAges 18–65 - NCT06920030Recruiting
Testing a new heart device for heart failure
This trial tests a new device that delivers a gentle electrical current to the heart to improve its pumping strength. It is for people with a certain type of heart failure caused by weak heart muscle, not a blocked artery.
Banja Luka, Republic of SrbskaAges 18–75 - NCT06922370Recruiting
Study of bone and joint problems in Gitelman syndrome
This study looks at bone and joint problems in people with Gitelman syndrome, a rare kidney disorder. It aims to understand how this condition affects the body's bones and joints.
Hangzhou, ZhejiangAges Any age - NCT06922851Recruiting
Protein filter therapy for dilated cardiomyopathy
This trial tests a protein filtering treatment (immunoadsorption) for people with dilated cardiomyopathy who have a specific antibody linked to heart damage. It aims to see if removing these antibodies can improve heart function.
Wuhan, HubeiAges 18–75 - NCT06923111Recruiting
Xromi safety study for children under 2 with sickle cell disease
This study is checking how safe and effective Xromi is for babies and toddlers (under 2 years old) with sickle cell disease. It compares kids who take Xromi to those who don't, to see if it helps prevent problems.
HamburgAges 9 months–1.9 years - NCT06924086Recruiting
Adaptive deep brain stimulation for children with epilepsy
This trial tests a new type of brain stimulation (adaptive deep brain stimulation) that adjusts in real time to stop seizures in children with Lennox-Gastaut syndrome. It's for children who haven't gotten enough help from medications and have frequent drop seizures.
LondonAges 5–14 - NCT06924125Recruiting
Natural history study for LAMA2 muscular dystrophy
This study follows people with LAMA2-related muscular dystrophy over time to better understand the condition. It may help with future treatments by learning more about how the disease progresses.
Barcelona, BarcelonaAges birth–100 years - NCT06924658RecruitingPhase 2
Metformin for gout patients study
This trial tests if metformin, a common diabetes drug, can help people with gout. It aims to see if the drug is safe and effective for reducing gout symptoms.
TantaAges 18–60 - NCT06925269Recruiting
DMD Voice: Interviews with patients and caregivers
This study invites people with Duchenne muscular dystrophy (DMD) and their caregivers to share their experiences through interviews. It focuses on those who have been taking the medication Givinostat for at least two years, or caregivers of patients with limited arm movement.
Yardley, PennsylvaniaAges 10 years+ - NCT06925360RecruitingPhase 2
IVIG for lung disease in premature babies
This trial tests if intravenous immunoglobulin (IVIG) can help prevent or treat bronchopulmonary dysplasia (BPD), a lung condition in premature babies. It is for very preterm infants born between 25 and 29 weeks who show early signs of BPD and are enrolled in the first day of life.
Shanghai, Shanghai MunicipalityAges Up to 2 months - NCT06926127Recruiting
Genomic study for rare and genetic diseases
This study aims to use advanced genetic testing to better understand rare and genetic diseases. It may help find a diagnosis or guide personalized care for you or your child.
Rome, LazioAges 1 minute–90 years - NCT06926491RecruitingPhase 3
Study of KK8398 for children with achondroplasia
This trial tests a new medicine (KK8398) for children with achondroplasia (a common cause of dwarfism). It aims to see if the medicine can help improve bone growth and safety. It may be a good option for children who haven't yet reached their final height and haven't been treated with other growth therapies.
Ōbu, Aichi-kenAges 3–18 - NCT06927375RecruitingPhase 4
Combination drug therapy for thyroid eye disease
This study tests a combination of two drugs, tocilizumab and flupentixol-melitracen, in people with active, moderate-to-severe thyroid-associated eye disease (TED). It aims to see if this combination can reduce eye bulging, double vision, and anxiety symptoms.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06927947Recruiting
Helping families learn about inherited cancer risk
This study tests different ways to help family members of people with inherited cancer syndromes get genetic testing. It aims to improve cancer prevention and early detection.
Ann Arbor, MichiganAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.