Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,771
- Phase 2283
- Phase 1235
- Phase 3216
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 352
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis128
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona78
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT06893614Recruiting
Facial mesh study for jaw surgery patients
This trial uses computer scans to create facial shape meshes for patients who had jaw surgery to correct an underbite. It aims to improve planning for future surgeries.
Cairo, AbbassiaAges 18–50 - NCT06893926Recruiting
Cord blood S100B protein in growth-restricted newborns
This study measures a protein called S100B in umbilical cord blood to learn more about brain development in newborns with fetal growth restriction (FGR), a condition where a baby is smaller than expected. Understanding this protein could help doctors identify babies who may need extra support after birth.
WarsawAges 18 years+ - NCT06894290Recruiting
International heart disease registry for amyloidosis
This study collects information from people with a specific type of heart disease called cardiac amyloidosis (AL or ATTR type). By joining a registry, you help doctors learn more about these conditions and how to better treat them.
BrugesAges 18 years+ - NCT06895395Recruiting
Speech therapy for kids with cleft palate
This study compares different types of speech therapy for children born with a cleft palate who have developed certain speech errors. The goal is to learn which therapy works best from the perspective of the child, their family, and the speech therapist.
GhentAges 4–12 - NCT06896188RecruitingPhase 1
Study of 9-ING-41 and retifanlimab plus chemo for advanced pancreatic cancer
This trial tests a new combination of two experimental drugs (9-ING-41 and retifanlimab) plus a standard chemotherapy regimen (modified FOLFIRINOX) for people with advanced or metastatic pancreatic cancer who have not yet received treatment for their advanced disease. The goal is to see if this combination is safe and effective.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06897839RecruitingPhase 2/Phase 3
Testing zelpultide alfa for preterm babies at risk of lung disease
This trial tests a medicine called zelpultide alfa in very premature babies who are at high risk of developing bronchopulmonary dysplasia (BPD), a chronic lung disease. The goal is to see if it can help prevent or lessen lung problems compared to standard care alone.
Buenos AiresAges birth–4 days - NCT06898307Recruiting
Genetic test study for inherited heart rhythm conditions
This study uses genetic testing to better diagnose, predict, and manage inherited heart rhythm diseases. It is designed for patients at the University of Ferrara's Cardiogenetic Center who have a confirmed genetic heart condition.
FerraraAges Any age - NCT06898450RecruitingPhase 1/Phase 2
Study of new drug NDI-219216 for advanced solid tumors
This study tests a new drug called NDI-219216 for people with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if it is safe and can help shrink or control the cancer.
Los Angeles, CaliforniaAges 18–99 - NCT06898996Recruiting
Stool test study for Lynch syndrome colon screening
This trial tests a new stool-based test (FIT) to see if it can help find colon cancer early in people with Lynch syndrome. You will collect stool samples at home and complete surveys before your regular colonoscopy.
Chicago, IllinoisAges 20–80 - NCT06900049RecruitingEarly Phase 1
Testing LE051 for boys with Duchenne muscular dystrophy (exon 51)
This study tests a new medicine called LE051 for boys with Duchenne muscular dystrophy (DMD) who have a specific genetic change that allows 'exon 51 skipping.' The goal is to see if it is safe and can help improve muscle function. Boys who join will be closely monitored for heart and lung health.
Shanghai, Shanghai MunicipalityAges 4–8 - NCT06901245RecruitingPhase 4
Tirzepatide for young adults with obesity
This study tests the diabetes/weight-loss drug tirzepatide (Mounjaro) in young adults aged 18–26 who have obesity and either Prader-Willi syndrome, hypothalamic obesity, or general obesity. It looks at whether a weekly injection can help with weight management.
Saint Paul, MinnesotaAges 18–26 - NCT06904027Recruiting
Glycerol phenylbutyrate for children with urea cycle disorders
This trial tests a medicine called glycerol phenylbutyrate in children with urea cycle disorders, which are genetic conditions that make it hard for the body to get rid of extra ammonia. The goal is to see if the medicine can help lower ammonia levels and manage the condition safely.
Beijing, Beijing MunicipalityAges birth–18 years - NCT06905600Recruiting
A study on salt-wasting in children with urinary tract issues
This study looks back at medical records of young children who had a condition called pseudohypoaldosteronism (a temporary salt-wasting problem) along with a urinary tract malformation or infection. Researchers want to learn more about this condition to help doctors recognize and treat it better.
StrasbourgAges 1–6 - NCT06905678Recruiting
Cleft palate cost and emotion study
This study looks at how having a cleft palate affects your family's finances and emotions. You may be able to join if you are 5, 12, or 18 years old and have a cleft lip or palate.
GhentAges 4–22 - NCT06906367Recruiting
Long-term study of Fabry disease treatments in the US
This study looks at how well available Fabry disease treatments (like migalastat or ERT) work over time in real life. It may help doctors understand who benefits most from these medicines.
Birmingham, AlabamaAges 18 years+ - NCT06906406Recruiting
Quality of life in children with clubfoot
This study looks at how clubfoot affects the daily life and well-being of children aged 2 to 15. It uses questionnaires to understand their physical and emotional health, which can help improve care and support for kids with this condition.
Drammen, BuskerudAges 2–15 - NCT06906497RecruitingPhase 4
Lebrikizumab for moderate-to-severe eczema
This trial tests an injectable drug called lebrikizumab for people with moderate-to-severe eczema (atopic dermatitis) that has not been well controlled with topical treatments. It may help reduce skin symptoms and itching.
Folsom, CaliforniaAges 18 years+ - NCT06907745Recruiting
Accuracy of 3D virtual surgery planning for jaw correction
This trial tests a new digital method for planning jaw surgery that uses virtual guides instead of traditional splints. It may help make surgery more precise and reduce discomfort.
Milan, MilanAges Any age - NCT06907836Recruiting
Transthyretin cardiac amyloidosis in internal medicine
This study looks back at medical records of patients who were diagnosed with transthyretin cardiac amyloidosis (a type of protein buildup in the heart) while hospitalized in internal medicine at Strasbourg University Hospitals between 2013 and 2023. It aims to describe their health journey and outcomes.
StrasbourgAges 18 years+ - NCT06907914Recruiting
Special exercises for hyperkyphosis in children
This study tests whether special exercises (Schroth and scapular muscle activation) can improve posture and reduce the curve in children with a rounded upper back (hyperkyphosis). It may help if you are a young person with a moderate curve and no other spinal issues.
Istanbul, IstanbulAges 7–18 - NCT06909656Recruiting
Brain Activity Study in Tourette Syndrome with Deep Brain Stimulation
This study looks at brain activity in people with Tourette syndrome who are already receiving deep brain stimulation (a treatment that uses electrical pulses to help control tics). The goal is to learn more about the brain signals linked to tics, which could help improve future treatments.
BordeauxAges 16 years+ - NCT06911190Recruiting
10-year follow-up study for FSHD patients
This study follows FSHD patients for 10 years to see how the disease progresses. It includes people who were in earlier FSHD studies and some new patients with genetic confirmation of FSHD.
NijmegenAges 6 years+ - NCT06911749Recruiting
Using MSOT and MRI to measure bowel transit in children
This trial tests whether two imaging techniques, MSOT and MRI, can safely and non-invasively measure how long it takes for food to move through the bowels in children with chronic constipation or other bowel emptying problems. It may help doctors better understand and treat these conditions.
Erlangen, BavariaAges 1 year+ - NCT06912061Recruiting
New needle technique for Achilles tendon lengthening in kids
This study tests a new needle-based method to lengthen a tight Achilles tendon in children, which can help with toe walking or foot pain. The goal is to see if it works well and is safe.
DrammenAges 5–16
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,779 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.