Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07450612Recruiting
Blood test and AI for early colorectal cancer detection
This study uses a simple blood test (liquid biopsy) and computer analysis to find early signs of colorectal cancer, precancerous growths, and Lynch syndrome. It aims to improve early detection and monitor for any remaining cancer after treatment.
Milan, LombardyAges 18 years+ - NCT07451613RecruitingPhase 1/Phase 2
Stem cell therapy trial for Huntington's disease
This trial tests whether human neural stem cells are safe and tolerable for people with Huntington's disease. It involves a neurosurgical procedure to inject the cells into the brain, along with MRI scans and other monitoring.
Irvine, CaliforniaAges 18–65 - NCT07453251Recruiting
Tracking aortic strength for aneurysm surgery patients
This study tracks how the thickness of the aortic wall relates to strength in people having surgery for an aortic aneurysm. It aims to better understand the condition and possibly improve future care.
San Donato Milanese, MIAges 18 years+ - NCT07454174Recruiting
Study of a dietary program for polycystic kidney disease
This study tests a special medical food (Ren-Nu) to see if it helps with metabolism and kidney health in people with ADPKD. You would follow a dietary program and attend online classes.
Cleveland, OhioAges 18 years+ - NCT07455578RecruitingPhase 1
Study of S-4321 for people with autoimmune or immune diseases
This trial tests a new medicine, S-4321, for people with various autoimmune conditions like rheumatoid arthritis, psoriasis, eczema, or lupus. It aims to see if the drug is safe and can help control the overactive immune system.
Charlestown, New South WalesAges 18–75 - NCT07459582Recruiting
Home lactate meter and glucose meter accuracy in GSD
This study tests how well a home lactate meter and a standard blood sugar meter work for people with certain types of Glycogen Storage Disease (GSD Ia, Ib, or XI). If you or your child has one of these types, joining could help improve home monitoring.
Hartford, ConnecticutAges Up to 60 years - NCT07461519Recruiting
Study on female puberty in classic galactosemia
This study looks at how classic galactosemia affects puberty and ovary function in girls and women born between 1980 and 2024. It may help us understand and improve care.
Bologna, ItalyAges Up to 45 years - NCT07461896Recruiting
Nerve function study in Charcot-Marie-Tooth and related neuropathies
This study looks at how nerves work and their structure in people with Charcot-Marie-Tooth disease, CIDP, or anti-MAG neuropathy. It may help doctors better understand these conditions.
MilanAges 18 years+ - NCT07463599RecruitingPhase 1/Phase 2
Tegavivint for advanced colorectal cancer after other treatments
This early-phase trial tests an experimental drug called tegavivint for people with advanced colorectal cancer who have already tried several standard treatments. It aims to see if the drug can shrink or slow the growth of tumors.
Scottsdale, ArizonaAges 18 years+ - NCT07464821Recruiting
Lipid profile study in Noonan syndrome and related disorders
This study looks at cholesterol and fat levels in people with Noonan syndrome or related conditions. It aims to understand how these levels change with age, gender, and genetic cause.
AlessandriaAges 2–35 - NCT07467187Recruiting
Home Ventilation with Tracheostomy in Denmark (2016–2025)
This study looks at people in Denmark who need a home ventilator through a tracheostomy. It aims to understand their care and outcomes over several years.
CopenhagenAges Any age - NCT07468019Recruiting
New denture for upper jaw with some teeth
This trial tests a new denture design for people who still have some teeth in their upper jaw. It aims to help you eat and speak better.
CairoAges 10–35 - NCT07468513RecruitingPhase 4
Primaquine for vivax malaria in G6PD-intermediate or deficient adults
This trial tests how well the drug primaquine works for people with vivax malaria who have intermediate or low levels of an enzyme called G6PD. It aims to find safe and effective treatment options for this group.
ManausAges 18 years+ - NCT07470320Recruiting
Placenta study in healthy and complicated pregnancies
This study looks at how the placenta works in healthy pregnancies and in pregnancies with conditions like pre-eclampsia, gestational diabetes, or fetal growth restriction. It may help find new ways to detect or treat these problems.
OxfordAges 18 years+ - NCT07470723Recruiting
Familial Hypercholesterolemia in pregnancy and newborns study
This study looks at how familial hypercholesterolemia (a genetic condition that causes high cholesterol) affects mothers and their newborns. It aims to learn more about cholesterol levels during pregnancy and the baby's first week of life.
Madison, WisconsinAges 18 years+ - NCT07471516RecruitingPhase 1/Phase 2
Zoledronic acid for congenital dyserythropoietic anemia
This trial tests if a bone-strengthening drug called zoledronic acid can help people with congenital dyserythropoietic anemia (CDA), a rare type of anemia. It's for adults with moderate to severe anemia who may also need blood transfusions.
TianjinAges 18 years+ - NCT07472686Recruiting
Capsule endoscopy for small bowel in Lynch syndrome
This study looks at how well a tiny camera in a pill (capsule endoscopy) can find early growths or cancer in the small intestine of people with Lynch syndrome. Lynch syndrome increases your risk for certain cancers, and this test might help catch them earlier.
ParisAges 18 years+ - NCT07473739Recruiting
AI ultrasound for predicting pregnancy outcomes in early FGR
This study uses artificial intelligence (AI) to analyze ultrasound images and predict pregnancy outcomes for babies with early-onset fetal growth restriction (FGR) caused by placenta problems. If you are carrying a single baby with this condition and your doctor is continuing to monitor the pregnancy without immediate delivery, this trial may apply to you.
ShanghaiAges 20–43 - NCT07473804Recruiting
Salt loss in newborns: beyond common adrenal issues
This study looks at babies who lose too much salt (hyponatremia) due to hormone problems in the first two months of life. It aims to learn more about conditions other than the common one (21-hydroxylase deficiency).
BolognaAges 1–35 - NCT07474935Recruiting
Real-world stroke treatment device registry
This trial collects information about the use of a specific stroke treatment device in real-world medical practice. It helps researchers see how well this device works for a wide range of patients, not just those in strict study conditions.
BrestAges Any age - NCT07476365Recruiting
Finding new markers for early CMT1A disease
This study looks for new markers of early Charcot-Marie-Tooth 1A (CMT1A) disease using blood tests and special MRI scans. It aims to help understand how the disease progresses and may lead to better treatments.
GöttingenAges 10–30 - NCT07477197Recruiting
Heart Institute Biobank for Adult Congenital Heart Disease
This study collects blood and tissue samples and health information from adults with or at risk for congenital heart disease or related heart conditions. It aims to help researchers better understand these conditions and improve future treatments.
Cincinnati, OhioAges 16 years+ - NCT07477691RecruitingPhase 4
Immune therapy during Palynziq treatment for PKU
This study tests whether combining a drug called methotrexate with Palynziq (a treatment for PKU) can help control immune responses and improve treatment outcomes. It may be an option for adults with PKU who have never used Palynziq or who have not reached target blood levels after at least 24 weeks.
Los Angeles, CaliforniaAges 18–65 - NCT07478172Recruiting
Electrical muscle stimulation exercise for neuromuscular disease
This study tests whether whole-body electrical muscle stimulation (using small electrodes on the skin) can help adults with certain neuromuscular diseases exercise and improve muscle strength. It may be an option if you can stand for about 15 minutes at a time and have some muscle strength left.
Columbia, MissouriAges 18 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.