Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07640893RecruitingPhase 2
Testing a new injection for von Willebrand disease
This study tests whether SR604, a new injection given under the skin, can reduce bleeding episodes in people with von Willebrand disease (a condition where blood doesn't clot properly). The trial will measure how well it works, how safe it is, and how your body processes it.
ChangshaAges 18–65 - NCT07642466Recruiting
Bladder Health and Life Quality in Spina Bifida
This study asks adults and teens with spina bifida about how their bladder care affects their daily life and well-being. Your answers will help doctors better understand what matters most to patients.
London, OntarioAges 13 years+ - NCT07643896Recruiting
Blood test for pregnancy risk assessment using fetal cells
This study tests a new blood test that looks for fetal cells in your bloodstream to check your baby's health during pregnancy. The test is non-invasive—just a regular blood draw—and aims to help identify pregnancy risks earlier than traditional methods.
Phoenix, ArizonaAges Any age - NCT07644078Recruiting
Understanding Cavovarus Foot Deformity in Nerve Disorders
This study examines how nerve disorders like Charcot-Marie-Tooth disease cause a specific type of foot deformity (cavovarus feet, where the foot has a high arch and turned-in appearance). Researchers will either examine you directly or review your existing medical records to better understand this condition and how it affects people.
StanmoreAges 18 years+ - NCT07644715Recruiting
AI Analysis of Heart Rhythms and Immune-Related Heart Damage
This study uses artificial intelligence to analyze heart electrical recordings (ECGs) from existing patient databases to better detect dangerous heart rhythm problems and heart inflammation caused by cancer immunotherapy. Researchers are not giving any new treatments—they're studying existing data to improve diagnosis.
ParisAges Any age - NCT07644832RecruitingPhase 1/Phase 2
New Blood-Clotting Injection for Hemophilia and Factor VII Deficiency
This early-stage trial tests a new injectable medicine called SR604 designed to help people with hemophilia A, hemophilia B, or congenital Factor VII deficiency—conditions where the blood doesn't clot properly. The study will look at how safe the medicine is and whether it reduces bleeding episodes.
ChangshaAges 18–65 - NCT07645820Recruiting
Testing a device to detect eczema flares early
This study tests a non-invasive home device called Nevisense Go that may help detect atopic dermatitis (eczema) flares before they become severe. You'll use the device at home, track your symptoms, and visit the clinic a few times to see if it helps predict when flares are coming.
Phoenix, ArizonaAges 12–89 - NCT07645898Recruiting
Glucose monitoring study of cornstarch in glycogen storage disease
This study uses a glucose monitor (a small sensor you wear) to measure how your blood sugar responds after eating raw cornstarch, a common treatment for glycogen storage disease type I. The goal is to understand how well cornstarch helps keep your blood sugar steady.
Naples, NapoliAges 18 years+ - NCT07646704Recruiting
Study of HeartR PDA Heart Device Safety and Function
This study follows patients who had a small heart device (HeartR PDA Occluder) placed to close an opening in their heart called a PDA. Researchers will check how well the device is working and track the patient's health over time.
Pekanbaru, RiauAges 6 months+ - NCT07652684RecruitingPhase 4
Fat supplement to help premature babies' lungs
This study tests whether adding a special fat supplement to the feeding of very premature babies can help prevent or reduce lung damage, which is common in babies born early. The supplement is given through a feeding tube.
ThessalonikiAges 6 months–7 months - NCT07652879RecruitingPhase 2
KCD drug combination for newly diagnosed POEMS syndrome
This trial tests a combination of three drugs (carfilzomib, cyclophosphamide, and dexamethasone) for people newly diagnosed with POEMS syndrome. It aims to see how well this treatment helps control the disease and its symptoms.
ShanghaiAges 18–75 - NCT07654114RecruitingPhase 2
Testing CTH120 for men with Fragile X syndrome
This trial tests a new medicine called CTH120 to see if it is safe and helpful for adult men with Fragile X syndrome. You may be able to join if you meet certain health and age requirements.
Barcelona, BarcelonaAges 18–45 - NCT07654647Recruiting
Custom 3D-printed implants for facial bone repair
This trial tests personalized 3D-printed titanium implants to fix facial bone problems, like from cysts, tumors, or birth defects. It's for people who need a custom-shaped implant to improve their face's look and function.
LatakiaAges 18–60 - NCT07657598Recruiting
Fluid monitor for children having skull surgery
This study checks if a special monitor (called Pleth Variability Index) helps doctors manage fluids better during surgery for children with craniosynostosis. It may lead to safer recovery for your child.
Istanbul, BasaksehirAges Up to 6 years - NCT07659756Recruiting
Global study on atopic dermatitis (eczema)
This study gathers information from people around the world who have atopic dermatitis (eczema). It aims to better understand the condition and how it affects people's lives.
ZurichAges 14 years+ - NCT07661784Recruiting
Saliva tests to track gum disease
This study looks at whether substances in your saliva can show if gum disease is getting worse. It might help find a simple way to monitor gum health without needles or X-rays.
IspartaAges 18–65 - NCT07662603Recruiting
Breathing exercise program for teens with Behcet's after lung surgery
This trial is for teenagers with Behcet's disease who have had a specific lung surgery to remove a clot. It tests a breathing exercise program to help improve lung function after surgery.
Giza, DokkiAges 13–17 - NCT07663903RecruitingPhase 3
New longer-lasting factor VIII for severe hemophilia A (on-demand use)
This trial tests a new longer-lasting factor VIII medicine (FRSW107) for on-demand treatment of bleeding episodes. It is for males with severe hemophilia A who have been previously treated at least 150 times.
Tianjin, Tianjin MunicipalityAges 12–65 - NCT07664930Recruiting
Pompe Disease: Nerve and Diaphragm Testing
This study looks at the nerve that controls your diaphragm (the main muscle you use to breathe) in people with Pompe disease. It aims to better understand breathing problems in Pompe and may help guide future care.
PaviaAges 18 years+ - NCT07672275Recruiting
How blood transfusions affect stress markers in newborns
This study looks at how blood transfusions change stress-related substances in the blood of newborns. It might help doctors understand how transfusions affect babies in the NICU.
Graz, StyriaAges 5 minutes–5 months - NCT07640503Enrolling by invitationPhase 2
Lamivudine Treatment Study for Rett Syndrome
This study tests whether lamivudine, a medication originally used for HIV, might help improve symptoms in people with Rett syndrome. Researchers will monitor how safe and effective the treatment is over time.
Fortaleza, CearáAges 2 years+ - NCT07635030Enrolling by invitation
Brain Chemistry Study in Young People with Friedreich's Ataxia
This study looks at two brain chemicals (GABA and glutathione) in children and teens aged 8–15 with Friedreich's ataxia, a rare genetic condition affecting movement and coordination. The research aims to understand how these chemicals change in the brain and may help guide future treatments.
Philadelphia, PennsylvaniaAges 8–16 - NCT07603466Enrolling by invitationPhase 4
Two drugs combined to treat Cushing's disease
This trial tests whether taking two medications together—osilodrostat and cabergoline—can help control Cushing's disease by lowering excess cortisol levels. Cushing's disease is caused by a pituitary tumor that makes too much of a hormone called ACTH, which drives cortisol overproduction.
BasraAges 18–70 - NCT07603232Enrolling by invitation
Long-Term Health Outcomes in Children With Hirschsprung's Disease or Anorectal Malformations
This study follows children who were born with Hirschsprung's disease (a condition affecting the nerves in the colon) or anorectal malformations (differences in how the rectum or anus formed) to understand how they do over time. Researchers will track health outcomes and quality of life to help improve care for future children with these conditions.
Montreal, QuebecAges Up to 18 years
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.