Medical genetics
Genetic & congenital clinical trials
Inherited and congenital conditions present from birth or written into the genes. We’re tracking 3,858 recruiting studies in this area right now.
By phase
- Not applicable2,772
- Phase 2282
- Phase 1235
- Phase 3215
- Phase 1/Phase 2204
- Phase 497
- Phase 2/Phase 353
Top conditions
- Sickle Cell Disease140
- Atopic Dermatitis129
- Congenital Heart Disease86
- Cystic Fibrosis78
- Down Syndrome54
- Genetic Disease42
- Duchenne Muscular Dystrophy39
- Fabry Disease38
- Hemophilia A38
- Cystic Fibrosis (CF)37
- Cardiac Amyloidosis35
- Huntington Disease32
- Lynch Syndrome32
- Heart Failure31
- Retinitis Pigmentosa31
- Bronchopulmonary Dysplasia30
- Congenital Diaphragmatic Hernia29
- Duchenne Muscular Dystrophy (DMD)27
Leading sponsors
- Assistance Publique - Hôpitaux de Paris62
- Boston Children's Hospital42
- National Institute of Allergy and Infectious Diseases (NIAID)38
- Mayo Clinic37
- Children's Hospital Medical Center, Cincinnati33
- Hospices Civils de Lyon32
- IRCCS Azienda Ospedaliero-Universitaria di Bologna32
- Riphah International University26
- Massachusetts General Hospital23
- National Cancer Institute (NCI)23
Where studies are running
- California340
- Maryland161
- Alabama132
- Massachusetts116
- New York84
- Arizona79
- Texas73
- Minnesota67
- Pennsylvania65
- Ohio57
Recruiting studies3,858 total
- NCT07590882Enrolling by invitation
Sports Recovery After Hip Realignment Surgery
This study follows patients who had hip socket realignment surgery (PAO) to understand how well they return to sports and physical activities. Researchers will review medical records from the past 7+ years to learn what helps patients get back to the sports they love.
BolognaAges 12–40 - NCT07565272Enrolling by invitation
Virtual Reality Game for Duchenne Muscular Dystrophy Arm Strength
This study tests a video game played in virtual reality to see if it helps people with Duchenne muscular dystrophy (a muscle-weakening condition) use their arms and hands better. Researchers want to understand if the game is easy to use and enjoyable.
IstanbulAges 7 years+ - NCT07561359Enrolling by invitation
12-Week Home Exercise Program for Hereditary Spastic Paraplegia
This trial tests whether a guided 12-week strength and movement exercise program, done at home using your phone or computer, can improve walking ability and muscle strength in people with hereditary spastic paraplegia (a genetic condition that causes leg stiffness and weakness). The program is tailored to your current fitness level.
Porto Alegre, Rio Grande do SulAges 16–70 - NCT07549295Enrolling by invitationPhase 1
Melatonin to help babies grow better in the womb
This study tests whether melatonin (a natural sleep hormone) can help babies who are not growing well in the womb due to placental blood-flow problems. Researchers will measure if melatonin improves the baby's growth and health before delivery.
Shanghai, Shanghai MunicipalityAges 20–43 - NCT07543302Enrolling by invitation
Can Ear Nerve Stimulation Reduce Inflammation in Duchenne Muscular Dystrophy?
This trial tests whether gently stimulating a nerve in the ear can lower inflammation levels in boys with Duchenne muscular dystrophy (DMD). The goal is to see if this non-invasive approach might help slow disease progression or ease symptoms.
StockholmAges 5–17 - NCT07527975Enrolling by invitation
Long-term safety and benefit check-up for RP-L102 gene therapy
This is a follow-up study for patients who previously received RP-L102, an experimental gene therapy designed to treat Fanconi anemia by fixing a faulty gene. The study tracks how well the treatment continues to work and watches for any long-term side effects.
Palo Alto, CaliforniaAges Any age - NCT07511660Enrolling by invitation
Ovarian cell injection for perimenopause symptom relief
This trial tests injecting special cells called Muse cells into the ovaries to help relieve perimenopause symptoms and possibly restore ovarian function. It may help women experiencing irregular periods, hot flashes, sleep problems, mood changes, or trouble thinking clearly.
Monterrey, Nuevo LeónAges 28–70 - NCT07503197Enrolling by invitation
Cholesterol cream for child eczema
This trial tests a 2% cholesterol cream to see if it helps children with mild to moderate eczema on their inner elbows. It's designed for Thai children aged 7 to 17 who are not using strong immune-suppressing drugs.
BangkokAges 7–17 - NCT07495410Enrolling by invitation
Exercise training for Anderson-Fabry disease
This study tests whether a supervised exercise and physiotherapy program can improve fitness, stamina, and daily life for people with Anderson-Fabry disease. It is designed for people who are medically stable and able to join a gentle, progressive training program.
PragueAges 18 years+ - NCT07483424Enrolling by invitation
Growth restriction in full-term babies: body composition study
This study looks at how body composition differs in full-term babies who had intrauterine growth restriction. It may help doctors better understand and care for these infants.
LisbonAges 9 months–9 months - NCT07477873Enrolling by invitation
Emotions and jaw surgery recovery study
This study looks at how patients feel emotionally and physically before and after jaw surgery. It uses special software and questionnaires to track emotions, and checks the jaw joint and muscles after surgery. The goal is to see how these relate to recovery in patients having planned jaw surgery.
Kaunas, KaunoAges 18 years+ - NCT07445347Enrolling by invitation
Bevacizumab for severe HHT liver issues with high heart output
This study looks at how well the drug Bevacizumab works and how safe it is for people with HHT who have severe liver problems that cause their heart to pump too much blood. It aims to help doctors understand if this treatment can help manage these serious symptoms.
PoitiersAges 18 years+ - NCT07442682Enrolling by invitation
Studying cystic fibrosis in adults at a Belgian center
This trial gathers information about adults with cystic fibrosis at the Erasme Hospital in Belgium. Your participation helps doctors better understand the condition and how it affects quality of life.
BrusselsAges 18 years+ - NCT07435116Enrolling by invitation
Duchenne Muscular Dystrophy and Upper Limb Muscle Stiffness Study
This study looks at how Duchenne Muscular Dystrophy (DMD) affects the stiffness of muscles in the upper limbs (arms and shoulders). The goal is to better understand muscle changes and help improve care.
Gaziantep, GaziantepAges 5–18 - NCT07431437Enrolling by invitation
GENOSS paclitaxel balloon for leg artery disease
This trial tests a special balloon coated with paclitaxel (a drug that helps keep arteries open) in people with narrowed or blocked leg arteries. It aims to see how well the balloon works over one year.
SeoulAges 19–85 - NCT07424976Enrolling by invitation
Early brain injury detection after infant heart surgery
This study looks for early signs of brain injury in infants after heart surgery that uses a heart-lung machine. It aims to improve monitoring and care for babies with congenital heart disease.
LjubljanaAges 1 week–1 year - NCT07417267Enrolling by invitation
Clean Air Study for Lung Health in CF or PCD
This study tests whether using air cleaners in your home can improve lung health for people with cystic fibrosis (CF) or primary ciliary dyskinesia (PCD). It takes place in Cyprus and requires you to stay at home most days.
Nicosia, AglantziaAges 6 years+ - NCT07413224Enrolling by invitation
Effects of AEF0217 in People with Down Syndrome
This study looks at the effects of a medication called AEF0217 in people with Down syndrome. It is for participants who have already completed an earlier study of AEF0217 and their caregivers.
BarcelonaAges Any age - NCT07401823Enrolling by invitationPhase 2
Long-term follow-up study for sickle cell disease treatment
This study is a follow-up for people with sickle cell disease who already saw a benefit in fetal hemoglobin from the earlier Pioneer study. It tests the long-term safety and effects of the study drug pociredir (also called FTX-6058) while allowing most standard sickle cell treatments except hydroxyurea.
Little Rock, ArkansasAges 18 years+ - NCT07399080Enrolling by invitation
Study of a drug-coated balloon for leg artery disease
This trial is testing a special balloon coated with a drug (paclitaxel) to treat narrowed or blocked arteries in the leg. It aims to see how well this balloon works to keep the artery open.
SeoulAges 19–85 - NCT07398872Enrolling by invitationPhase 1
Gene therapy trial for children with ML4
This trial tests a gene therapy given by a one-time injection into the spinal fluid for children with Mucolipidosis type IV. It aims to see if the therapy is safe and can help slow or stop the disease.
Hangzhou, ZhejiangAges 1.5 years–8 years - NCT07393373Enrolling by invitationPhase 2
Long-term study of infigratinib in children with hypochondroplasia
This study is for children with hypochondroplasia who already completed the ACCEL 2/3 trial. It tests the long-term safety and effects of the study drug infigratinib, and gives continued access to the treatment.
Oakland, CaliforniaAges 3–18 - NCT07381985Enrolling by invitation
Managing hereditary cancer risk in rural areas
This study tests a way to help people with inherited cancer gene mutations manage their health, especially if they live in rural areas. You join if you found out about the mutation more than a year ago.
Burlington, VermontAges 18 years+ - NCT07376785Enrolling by invitation
Can smartphones check heart sounds for birth defects?
This study tests whether a smartphone app can accurately detect inborn heart diseases by listening to heart sounds. Participation involves having your heart sounds recorded with a smartphone, which may help find problems earlier.
Hong KongAges 6 years+
Common questions
- How many genetic & congenital clinical trials are recruiting?
- Clin2 is tracking 3,858 recruiting medical genetics studies from the U.S. registry right now, out of 5,795 we cover in this area in total.
- What does “Genetic & congenital” cover here?
- Inherited and congenital conditions present from birth or written into the genes. We group each study into genetic & congenital based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a genetic & congenital trial near me?
- Use the search to filter genetic & congenital studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.