Cardiology
Heart & circulation clinical trials
Heart disease, blood pressure, and disorders of the blood vessels and circulation. We’re tracking 9,989 recruiting studies in this area right now.
By phase
- Not applicable7,969
- Phase 2481
- Phase 4481
- Phase 3447
- Phase 1361
- Phase 1/Phase 2163
- Phase 2/Phase 387
Top conditions
- Stroke845
- Heart Failure564
- Hypertension400
- Cardiovascular Diseases389
- Coronary Artery Disease370
- Multiple Myeloma332
- Atrial Fibrillation267
- Ischemic Stroke200
- Atrial Fibrillation (AF)141
- Acute Ischemic Stroke139
- Pulmonary Hypertension100
- Myocardial Infarction99
- Congenital Heart Disease86
- Stroke, Ischemic85
- Peripheral Arterial Disease83
- Acute Coronary Syndrome82
- Obesity80
- Aortic Valve Stenosis79
Leading sponsors
- Mayo Clinic94
- Assistance Publique - Hôpitaux de Paris91
- National Taiwan University Hospital74
- China National Center for Cardiovascular Diseases59
- Beijing Tiantan Hospital52
- Riphah International University51
- Second Affiliated Hospital, School of Medicine, Zhejiang University51
- Massachusetts General Hospital50
- Insel Gruppe AG, University Hospital Bern49
- Johns Hopkins University47
Where studies are running
- California466
- Alabama197
- Massachusetts182
- Arizona173
- New York162
- Florida144
- Maryland120
- Minnesota120
- Illinois119
- Texas118
Recruiting studies9,986 total
- NCT05487612Recruiting
MiECC heart-lung machine vs standard bypass during heart surgery
This trial compares a newer heart-lung machine setup (MiECC) with the usual bypass technique during certain heart operations. It may help see whether MiECC changes outcomes like the need for blood transfusions or recovery after surgery.
TorontoAges 18–85 - NCT05488431RecruitingPhase 2
Bempedoic acid to lower cholesterol and inflammation in HIV
This Phase 2 trial studies whether bempedoic acid can lower cholesterol and inflammation in people with HIV who are already on effective HIV medications. It may help reduce signs of artery inflammation that can contribute to heart and stroke risk.
Los Angeles, CaliforniaAges 40 years+ - NCT05488665Recruiting
Two-stent approach comparison for new bifurcation heart blockages
This study compares two different ways of placing two drug-eluting stents for new (de novo) coronary artery blockages that split into two branches. It may help doctors choose the safest, most effective technique for patients with specific coronary anatomy.
SeoulAges 19 years+ - NCT05489575Recruiting
CPAP machine for high blood pressure when lying down at night
This study tests whether using a CPAP breathing machine at night can lower high blood pressure that happens while you sleep. It targets people with nervous-system problems that affect blood pressure changes when standing.
Nashville, TennesseeAges 40–80 - NCT05491577Recruiting
Diabetes foot nerve disease patients without ulcers
This study looks at what affects changes in quality of life in people with diabetes who have a long-term, wound-free Charcot foot. It may help doctors understand what matters most for day-to-day wellbeing in this condition.
Boulogne-sur-Mer, Pas-de-CalaisAges 18 years+ - NCT05491655Recruiting
Testing a new pacing approach in some heart failure patients
This study looks at whether a high-intensity “His bundle” heart pacing method can help people with heart failure who have a specific heart rhythm pattern on ECG. It likely aims to improve heart pumping and symptoms in people who are otherwise a good match for an ICD and meet other criteria.
Acquaviva delle Fonti, BariAges 18–90 - NCT05491668Recruiting
Testing heart artery narrowing before planned stent procedure
This study checks how severely blocked a coronary artery is using measurements taken during a planned heart catheterization, to help guide whether and how to do a stent (PCI). It may help doctors choose the best treatment plan for people with about 70% or more narrowing.
Boston, MassachusettsAges 18 years+ - NCT05492513Recruiting
Constraint therapy for adults with mild arm weakness after stroke
This study tests a therapy that focuses on using your weaker arm more after a stroke by “constraining” the better arm during training. It may help improve how you move and use your hand and wrist in daily life if you still have mild movement and can participate in clinic sessions.
Birmingham, AlabamaAges 18 years+ - NCT05493514Recruiting
Robotic training program for walking and balance
This trial studies whether a robotic training system (called G-EO) can help people with neurological conditions improve walking and balance. It may help by testing which factors predict who benefits most, and it requires regular training sessions.
MilanAges 18 years+ - NCT05493657Recruiting
Aspirin vs clopidogrel after TAVR valve procedure
This trial compares aspirin and clopidogrel (two blood-thinning medicines) after TAVR to see which is safer or more effective for preventing clots. You may be able to join if you recently had a TAVR for severe aortic valve narrowing and can follow the study plan.
SeoulAges 19 years+ - NCT05494034Recruiting
Monitoring heart rhythms after stroke to guide care
This study uses a small implantable heart monitor to track heart rhythm in people after an acute ischemic stroke or TIA. It aims to learn how often hidden heart rhythm problems show up, which could help doctors choose better stroke prevention treatments.
AthensAges 40–100 - NCT05496998Recruiting
Heart valve replacement using a catheter for leaking mitral valve
This trial studies a catheter-based procedure to replace the mitral valve in people with severe (or specific moderate) mitral valve leakage that causes symptoms. It may help by reducing leaking and related symptoms when standard surgery or less invasive fixes aren’t suitable for you.
AarhusAges 18 years+ - NCT05498584Recruiting
Testing a treatment approach for scar tissue after heart failure
This study tests an approach aimed at reducing heart scarring (fibrosis) after heart failure. It enrolls people with moderate to severe heart failure who have signs of active heart strain and can complete study tests.
Kaohsiung CityAges 20–100 - NCT05498675Recruiting
Sacubitril/valsartan study for high blood pressure by body size
This study tests how sacubitril/valsartan may affect heart function in people with high blood pressure, and whether results differ by body size (BMI). You may benefit by getting closer heart monitoring, though it depends on whether you fit the safety and medical criteria.
Beijing, Beijing MunicipalityAges 18–70 - NCT05500859Recruiting
Registry for people in outpatient heart rehab programs
This study is a health registry that collects information about people taking part in outpatient (ambulatory) cardiac rehabilitation. It may help improve and organize future support, since your details can be used to understand outcomes and care needs.
BaselAges Any age - NCT05504356Recruiting
Study to improve atrial fibrillation ablation and new therapies
This study looks at what results from atrial fibrillation ablation (a heart rhythm procedure) and newer related therapies. If you recently had the procedure—or are scheduled for it soon—you may use an app and website to share information that helps researchers compare outcomes and improve care.
San Francisco, CaliforniaAges 18 years+ - NCT05504928Recruiting
School program to prevent hidden heart valve disease
This study tests whether a prevention program done at a specific school can reduce how common “latent” (hidden) rheumatic heart disease is in children. If you attend the study’s school in Tulsipur, this program may be offered to help protect students’ heart health over time.
Tulsi̇̄purAges 5–16 - NCT05504941Recruiting
Testing a treatment target map in sudden brain bleeding
This study looks at a special scan (DSA, done with contrast dye) to find a likely “target” that doctors can use when treating sudden brain bleeding. It’s meant to help doctors better understand where treatment may be needed soon after symptoms start.
BaselAges 18 years+ - NCT05506293Recruiting
Registry study for sealing leaking heart valve devices
This is a study that collects information from people who are having a minimally invasive procedure to close a leak around a heart valve replacement device. It may help doctors better understand how well this procedure works and what outcomes to expect.
CharleroiAges 16–110 - NCT05508256RecruitingPhase 4
Ablation for atrial fibrillation in heart failure with preserved function
This trial tests whether a catheter procedure that treats atrial fibrillation works better than standard care for people with heart failure with preserved ejection fraction. It aims to improve heart rhythm symptoms and overall outcomes compared with conventional treatment.
BerlinAges 18 years+ - NCT05509010Recruiting
AI registry using CT scan to assess coronary artery disease
This trial builds and tests an AI system using information from a heart CT scan to help evaluate coronary artery disease (clogged heart arteries). If you need a CT coronary angiography for medical reasons, this may help improve how such scans are analyzed and used in care.
SingaporeAges 21–80 - NCT05508932Recruiting
Heart rhythm study for people with transfusion-dependent beta-thalassemia
This trial studies atrial fibrillation (an irregular heartbeat) in people with beta-thalassemia who need regular blood transfusions. It may help doctors better understand how this heart rhythm problem affects you and guide future care.
FerraraAges 18 years+ - NCT05514340RecruitingPhase 2
Test drug for brain injury after low oxygen at birth
This Phase 2 study tests whether sovateltide can improve safety and outcomes for babies whose brains may have been injured by low oxygen around birth. It focuses on babies who show signs of moderate to severe injury soon after delivery, and who receive standard supportive care.
Mangalore, KarnatakaAges Any age - NCT05515237Recruiting
Therapy to improve arm use after stroke
This study tests a therapy plan that focuses on using your more-affected arm more often after stroke, plus added sensory activities. It may help improve how well you can move and use that arm in daily life.
Birmingham, AlabamaAges 18–89
Common questions
- How many heart & circulation clinical trials are recruiting?
- Clin2 is tracking 9,989 recruiting cardiology studies from the U.S. registry right now, out of 15,300 we cover in this area in total.
- What does “Heart & circulation” cover here?
- Heart disease, blood pressure, and disorders of the blood vessels and circulation. We group each study into heart & circulation based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a heart & circulation trial near me?
- Use the search to filter heart & circulation studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Immune system & allergy
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.