Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT06096714RecruitingEarly Phase 1
Testing nicotine's addictive threshold in smokers
This study tests how nicotine affects the brain's reward system in people who smoke. It aims to find the level of nicotine that becomes addictive, helping guide future treatments.
West Haven, ConnecticutAges 21–59 - NCT03492060Recruiting
Study of genetic variants in neurogenetic disorders over time
This study looks at how people’s genetic test results relate to health changes over time in conditions caused by gene differences. If you already have genetic confirmation of a disease-causing variant, you may be able to join.
New York, New YorkAges Any age - NCT05418894Recruiting
Study brain signals and improve treatment-resistant depression
This trial studies how brain activity relates to feelings and depression, using brain electrodes to measure signals. It’s meant for people with long-lasting, treatment-resistant major depression who may need stimulation while continuing psychiatric care.
Houston, TexasAges 22–70 - NCT03665831Recruiting
Deep TMS for depression and memory problems in older adults
This study tests a type of brain stimulation called Deep TMS to help reduce depression and improve or stabilize memory-related symptoms in older adults with Alzheimer’s disease. It’s mainly for people whose depression did not improve or could not be tolerated with antidepressant medicine.
Toronto, OntarioAges 60 years+ - NCT04558541Recruiting
Speech and grammar training study for kids with language disorder
This study looks at how children with developmental language disorder understand and produce parts of speech, especially verb endings and grammar patterns. It may help researchers develop better ways to support communication in kids who struggle with language.
Tucson, ArizonaAges 4–8 - NCT02773082Recruiting
Deep brain stimulation for severe OCD
This trial studies whether placing a deep brain stimulation device can reduce symptoms in people with severe obsessive-compulsive disorder (OCD) who did not improve with several standard treatments. It may help when medications and therapy have not worked well enough.
Queens, New YorkAges 18 years+ - NCT05560113Recruiting
Study uses brain stimulation to disrupt fear memory in PTSD
This study tests a brain stimulation approach to affect how fear memories “stick” after they are formed. If you have PTSD, it may help reduce fear-related learning, but you must meet several safety and health criteria.
Atlanta, GeorgiaAges 18–65 - NCT05336695RecruitingPhase 1/Phase 2
Brain scan study to measure fibrin in Alzheimer’s
This early study (Phase 1/2) uses brain imaging to look for “fibrin” (a blood-clot–related protein) in people with Alzheimer’s disease and related conditions. The goal is to understand whether fibrin changes can be seen on scans and what it might mean for Alzheimer’s.
Boston, MassachusettsAges 55–90 - NCT05734313Recruiting
Teletherapy CBT for anxiety and depression in people with diabetes
This trial tests a unified, talk-therapy program delivered by video (telemedicine) to help with anxiety and depressive symptoms. If you have type 1 diabetes and symptoms of anxiety or depression, it may help you learn coping skills and improve mood.
Boston, MassachusettsAges 18–64 - NCT06037681Recruiting
Study on cannabis use and pain outcomes in Black and white patients with cancer
This study looks at how cannabis affects pain and daily life in Black and white patients with solid tumors. It compares people who use cannabis at least once a week to those who don't use it at all.
Buffalo, New YorkAges 21–99 - NCT05178069RecruitingPhase 2
Probiotic supplement study for alcohol use disorder and liver injury
This Phase 2 trial studies whether a probiotic (LGG) can improve health in people with alcohol use disorder and alcohol-related liver injury. It’s not an alcohol treatment study, so participants are mainly joining to see how the supplement affects the body and liver-related outcomes.
Louisville, KentuckyAges 21–65 - NCT06004115RecruitingPhase 4
Brain scanning study for depression and anxiety
This study uses brain scans (fMRI) to understand how people with both depression and anxiety respond to threat. If you have either or both conditions, participating could help researchers find better treatments.
Tulsa, OklahomaAges 18–65 - NCT05588934Recruiting
Testing the best daily caffeine dose for sleep and alertness
This study compares an adjusted caffeine plan versus a typical caffeine dose to see how it affects your sleep timing and daytime alertness. It may help find a caffeine amount that supports wakefulness without disrupting sleep.
Tucson, ArizonaAges 18–39 - NCT05616819Recruiting
Morning light program to improve mood in some service members
This study tests whether getting morning light exposure can improve mood for service members who currently have mild or more depression symptoms. You’d follow a plan for morning light over about 6 weeks, and the researchers check changes in mood.
Tucson, ArizonaAges 18–60 - NCT05805397Recruiting
Motivation skills training for schizophrenia or schizoaffective disorder
This study tests whether “Motivation Skills Training” can help people with schizophrenia or schizoaffective disorder. It’s for people who are stable on treatment and can participate in English-speaking sessions.
New York, New YorkAges 18–65 - NCT05377177Recruiting
Brain stimulation type test for suicidal thoughts in depression
This study tests whether stimulating the brain on both sides at once versus one side can reduce suicidal thoughts in people with treatment-resistant depression. It also looks at brain “inhibition” signals to help predict who benefits.
San Diego, CaliforniaAges 18–70 - NCT05885542RecruitingPhase 1/Phase 2
Testing CBD pills for cannabis use and stress in young adults
This early-phase study tests whether a CBD pill (compared with a placebo sugar pill) can affect cannabis use and stress in people ages 18–25 who use cannabis very frequently. It may help your stress levels and cannabis-related symptoms while researchers carefully monitor safety and abstinence periods during visits.
Charleston, South CarolinaAges 18–25 - NCT05869552Recruiting
Screening and support to reduce suicide risk in young adults
This trial tests a support program in primary care for sexual and gender diverse young adults who screen positive for suicide risk. The goal is to help prevent suicidal thoughts and actions by offering structured support—especially through trusted people in your life.
Pittsburgh, PennsylvaniaAges 18–24 - NCT03755401Recruiting
Therapy trial for PTSD after prior treatment didn’t fully help
This trial studies a specific talk-therapy approach (psychodynamic psychotherapy) for people with post-traumatic stress disorder (PTSD) who still have significant symptoms despite prior treatment. You may be able to join if your PTSD symptoms are in a moderate range and you can safely participate without urgent safety risks or certain other conditions.
New York, New YorkAges 18–70 - NCT05245903Recruiting
Test a supplement and track brain changes with wearable sensors
This study tests whether taking nicotinamide riboside (a form of niacin) affects early memory changes in people with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). It also uses passive wearable or sensor data (“digital biomarkers”) to measure changes over time.
Belmont, MassachusettsAges 18–89 - NCT04585685Recruiting
Healthy recovery program for PTSD after sexual trauma
This study looks at how to help people recover from PTSD symptoms after sexual trauma, including feeling mentally “contaminated.” You may be eligible if you currently meet criteria for PTSD and report these contamination feelings, and you can avoid starting other trauma treatments during the study.
Lexington, KentuckyAges 18 years+ - NCT03583684Recruiting
Brain scan study to predict response to Pivotal Response Treatment
This study uses brain scans to learn which young children with autism are most likely to improve with Pivotal Response Treatment (PRT). It may help families and clinicians choose the best early treatment based on early brain signals.
Stanford, CaliforniaAges 2–4 - NCT06079216Recruiting
Music and connection for older adults
This trial uses music to help older adults in residential care feel more connected. Volunteers will attend music sessions to see if they improve mood and social bonds.
Winchester, MassachusettsAges 18–103 - NCT06064890RecruitingPhase 1/Phase 2
Gene therapy trial for genetic frontotemporal dementia
This trial tests a new gene therapy called AVB-101 for people with a specific genetic cause of frontotemporal dementia (FTD). The therapy is given as a one-time injection into the brain to potentially slow or stop the disease.
Columbus, OhioAges 30–75
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.