Psychiatry
Mental health clinical trials
Depression, anxiety, and other mental-health and behavioral conditions. We’re tracking 7,779 recruiting studies in this area right now.
By phase
- Not applicable6,422
- Phase 2492
- Phase 1250
- Phase 3240
- Phase 4212
- Phase 1/Phase 294
- Phase 2/Phase 369
Top conditions
- Anxiety387
- Depression382
- Alzheimer Disease338
- Autism Spectrum Disorder239
- Dementia228
- Mild Cognitive Impairment198
- Schizophrenia184
- Major Depressive Disorder173
- Insomnia159
- Cognitive Impairment150
- Alcohol Use Disorder145
- Opioid Use Disorder143
- Stress117
- PTSD105
- Mental Health99
- Autism94
- Mild Cognitive Impairment (MCI)89
- Suicidal Ideation89
Leading sponsors
- VA Office of Research and Development104
- Yale University87
- Massachusetts General Hospital77
- Stanford University68
- Assistance Publique - Hôpitaux de Paris64
- Johns Hopkins University62
- University of California, Los Angeles58
- University of Pennsylvania53
- Karolinska Institutet51
- The University of Hong Kong51
Where studies are running
- California520
- Massachusetts267
- New York255
- Texas209
- Maryland176
- Pennsylvania170
- Florida149
- Alabama118
- Arizona109
- Illinois104
Recruiting studies7,779 total
- NCT05331937RecruitingPhase 3
TMS plus exposure therapy for severe OCD that won’t improve
This trial studies whether TMS (a brain stimulation treatment) can help people with severe OCD who have not responded well to exposure therapy. It combines brain stimulation with intensive exposure therapy to reduce obsessions and compulsions.
Amsterdam, North HollandAges 18 years+ - NCT05316883RecruitingPhase 4
Testing blood markers in people on clozapine for schizophrenia
This study looks at “biomarkers,” or blood measures, in people with schizophrenia who respond to clozapine. It may help researchers understand who benefits from clozapine and why, by linking test results to symptom changes.
Glostrup Municipality, DenmarkAges 18–64 - NCT05333250RecruitingPhase 1/Phase 2
Modafinil to reduce cancer-related fatigue
This trial tests whether modafinil can improve cancer-related fatigue in people with advanced cancer. It may help you feel more able to function day to day by reducing how “worn out” you feel.
Ottawa, OntarioAges 18 years+ - NCT05318222Recruiting
Virtual genetic evaluation for undiagnosed rare disease
This study helps children who have a rare genetic illness but have not yet received a diagnosis. It uses virtual evaluation to try to find answers and possible next steps for care.
Edinburg, TexasAges 1 day–18 years - NCT05340348Recruiting
Study of a patient guide for young people at risk of psychosis
This study tests how a “patient guide” (Patientheque) may help young people who are either having a first psychosis episode or showing early warning signs. It aims to support care decisions and reduce stress by improving understanding and follow-up.
BrestAges 15–30 - NCT05361122Recruiting
Study to prevent developmental delays using xylitol
This study looks at whether giving xylitol can help prevent developmental delays in children. Families will do several developmental checkups, including tests done at a specific travel site, to see how children are doing.
LilongweAges 4–8 - NCT05343598Recruiting
Using TMS to study hallucinations in schizophrenia
This study uses a non-invasive brain stimulation method (TMS) along with brain scans (MRI) to better understand why hallucinations happen in schizophrenia. It may help researchers learn more about brain processes involved, which could guide future treatments.
Belmont, MassachusettsAges 18–55 - NCT05332275Recruiting
Online parenting program to help with middle school kids
This trial tests an online program and phone “reminder” messages to help parents with middle school-aged children. If you have internet access and can read basic English, you may be invited to join the parent intervention groups.
Gainesville, FloridaAges 10–14 - NCT05358067Recruiting
Testing a symptom rating tool after recent trauma
This study looks at how well a clinician’s rating scale (a questionnaire-based score) matches patients’ symptoms after a traumatic event. It may help improve how quickly and accurately symptoms are tracked in the days after trauma.
ArrasAges 18 years+ - NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65 - NCT05334992Recruiting
Support for family caregivers of people with dementia
This study aims to improve mental health for people who care for someone with dementia or memory problems. If you’re an unpaid caregiver and you have anxiety or depression symptoms, this program may offer structured support to help you cope better.
Lubbock, TexasAges 18–120 - NCT05359562Recruiting
Hormones and OCD treatment approach on the brain
This study looks at how hormone changes and a specific OCD therapy method affect brain activity. It may help researchers understand why OCD symptoms and brain patterns differ between people and across time.
New York, New YorkAges 18–45 - NCT05336188Enrolling by invitation
Smartphone help to prevent relapse in opioid use disorder
This study looks at whether a smartphone-based program can help people avoid relapse from opioid use disorder. Some participants may also do brain scans to better understand the brain changes behind relapse prevention.
Little Rock, ArkansasAges 18 years+ - NCT05336201RecruitingPhase 2
Brain training program for teens with sickle cell disease
This Phase 2 study tests a cognitive (thinking) training program to help teens with sickle cell disease prepare for the changes in their care as they grow older. It may help with skills like learning, attention, and planning for transition to adult care.
Birmingham, AlabamaAges 10–18 - NCT05354622Recruiting
Genetic testing study for inherited leg stiffness
This study looks at genes (DNA) to understand an inherited condition that causes gradually worsening leg stiffness. It may help researchers learn what causes the condition and potentially guide future care.
Boston, MassachusettsAges 1 month–30 years - NCT05336084Recruiting
Study how sleep timing affects mood and thinking in teens
This study looks at how your body clock and sleep “pressure” affect reward feelings and thinking control. It may help researchers understand teen sleep patterns and how they connect to brain and behavior.
Pittsburgh, PennsylvaniaAges 13–18 - NCT05318755Recruiting
Gender-affirming hormone therapy study for adults starting care
This study looks at starting gender-affirming hormone therapy (GAHT) for transgender people who have never had these treatments before. It may help you learn whether this approach is safe and effective for your goals as you begin care.
Beijing, Beijing MunicipalityAges 18–40 - NCT05329441Recruiting
Testing an anti-depression medicine for threat-related brain changes in teens
This trial studies how fluoxetine or escitalopram (anti-depression medicines) may affect brain systems involved in feeling threatened and staying anxious when you have depression. It also uses brain scanning and blood tests to measure these changes.
Los Angeles, CaliforniaAges 14–21 - NCT05326451Recruiting
At-home brain stimulation for Huntington’s behavior and thinking symptoms
This trial tests an at-home, noninvasive brain stimulation treatment to help with behavioral and cognitive (thinking) symptoms in people with Huntington’s disease. You and a caregiver work together during sessions and questionnaires to see if symptoms improve and stay stable.
Houston, TexasAges 18–80 - NCT05320835Recruiting
Talk-based overdose prevention for people using opioids
This trial tests an overdose prevention approach for people who have used opioids recently. It aims to help reduce the risk of overdose by offering a structured prevention intervention.
Baltimore, MarylandAges 18 years+ - NCT05326750Recruiting
Brain stimulation to help diagnose and manage memory conditions
This trial studies a non-invasive brain-stimulation approach to help doctors assess and manage certain brain-related conditions. You might benefit by contributing to better diagnostic tools and treatment planning for memory and thinking problems.
KuopioAges 18 years+ - NCT05267665Recruiting
Family-involved PTSD therapy coaching for Veterans
This study tests a brief way to include a Veteran’s family member to improve PTSD treatment results and help people stay engaged in care. It’s for Veterans who are just starting evidence-based PTSD therapy and have a closely involved family member who can participate too.
Boston, MassachusettsAges 18 years+ - NCT05268588Recruiting
Post-birth health texting study during late pregnancy
This study tests whether phone-based (mHealth) messages and support can improve health after you give birth. It may help you stay informed and get support during the weeks right after delivery.
Chandīgarh, HaryanaAges 18–49 - NCT05292612Recruiting
Coach vs clinician self-help for social anxiety
This trial tests whether two different self-help programs (one guided by a coach and one by a clinician) can improve generalized social anxiety. You may be able to use an evidence-based approach at home, with the goal of reducing fear and avoidance in social situations.
ShatinAges 18–100
Common questions
- How many mental health clinical trials are recruiting?
- Clin2 is tracking 7,779 recruiting psychiatry studies from the U.S. registry right now, out of 12,461 we cover in this area in total.
- What does “Mental health” cover here?
- Depression, anxiety, and other mental-health and behavioral conditions. We group each study into mental health based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mental health trial near me?
- Use the search to filter mental health studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.