Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT07456163Recruiting
How zirconia abutments affect gum and bone around dental implants
This study compares how well the gum and bone around dental implants heal when using zirconia (a white ceramic) versus standard metal abutments. It aims to see if zirconia leads to healthier tissues around single-tooth replacements.
Piracicaba, São PauloAges 18–70 - NCT07137533Recruiting
Comparing two tooth replacement methods for lower jaw with PEEK framework
This study compares two ways to replace all missing teeth in the lower jaw using a special plastic framework called PEEK. One method uses four implants that support a removable overdenture, the other uses a fixed all-on-4 bridge. The goal is to see which lasts better over 4 years.
Shibīn al Kawm, MenoufiaAges 40–70 - NCT06454955RecruitingEarly Phase 1
PET scan imaging study for solid tumors using a new probe
This trial tests a new imaging agent that targets a protein called B7-H3 found on many solid tumors. It uses PET/CT to help doctors see and stage tumors more clearly.
Beijing, Beijing MunicipalityAges 18–75 - NCT07400471RecruitingEarly Phase 1
Pain relief before root canal: a medicine combination
This trial tests whether a combination of pain medicines given before a root canal can lower pain afterward. It is for people who have moderate to severe tooth pain and are healthy enough for standard treatment.
Chittagong, ChattogramAges 18 years+ - NCT06642753Recruiting
Bone graft with immediate implant for front teeth
This trial tests a special bone graft material placed at the same time as a dental implant to improve bone support around front teeth. It may help people who need a tooth replaced and have healthy gum tissue.
CairoAges 18 years+ - NCT07446790Recruiting
Comparing two digital methods for full-arch implant bridges
This trial tests a faster digital scanning method using a special camera (photogrammetry) versus a standard intraoral scanner for making a full set of implant-supported teeth. It aims to see which method leads to fewer problems with the final restoration.
CairoAges Any age - NCT06590753Recruiting
Comparing two implant methods for lower denture support
This study compares two different ways of placing dental implants to hold a lower denture (overdenture). One method is a newer 'osseodensification' technique that helps make the bone denser around the implant, while the other is the standard drilling approach. The goal is to see which method gives better results for people who need a stable, implant-supported denture.
CairoAges 55–65 - NCT06450093Recruiting
Comparing three crown types for baby teeth
This study compares three types of crowns (BioFlx, zirconia, and stainless steel) placed on lower baby molars that have cavities. It aims to find which crown works best for children, focusing on how easy they are to place and how well they hold up over time.
Al Mansurah, Dakahlia GovernorateAges 4–7 - NCT07432165Recruiting
AI vs. Digital Design for Fixed Dental Prostheses
This study compares artificial intelligence (AI) versus conventional digital methods to design fixed dental prostheses like crowns and bridges. It may help improve how these replacements are created.
GizaAges 18–65 - NCT07439289Recruiting
Turtle help during dental visit to reduce child's anxiety
This study uses a calm, supervised turtle interaction to help children feel less anxious during a routine dental visit. It may be a good fit if your child is ages 6-10, generally healthy, and not afraid of turtles.
Iğdır, IğdırAges 6–10 - NCT06449391Recruiting
Tooth-like implant for immediate replacement
This trial tests a new type of dental implant that is shaped like a natural tooth root, placed immediately after removing a damaged tooth. It may be a good option if you need a single tooth replaced and have healthy bone and gums.
Hangzhou, ZhejiangAges 20–60 - NCT07409896Recruiting
Comparing two numbing shots for painful lower first molars
This study compares two numbing methods for severe tooth pain (pulpitis) in a lower first molar. If you have a tooth that needs a root canal and the pain lingers after cold, this trial may help determine which anesthetic works better for you.
Rawalpindi, Punjab ProvinceAges 18–55 - NCT07433920Recruiting
Comparing two methods for tooth implant with root shield
This trial tests whether using a special blood and bone mixture (sticky bone) around a saved tooth fragment helps heal better than using a blood clot alone, during same-day implant placement guided by a computer.
Kafr ash Shaykh, KafrelsheikhAges 18–45 - NCT06973057Enrolling by invitation
Comparing two treatments for deep cavities in baby molars
This trial tests two different ways to treat deep cavities in back baby teeth (molars) that are close to the nerve, to see which works better. It may help children who have cavities in both matching teeth on each side.
IrbidAges 4–10 - NCT07146464Recruiting
Peptide vs calcium paste for early cavity spots
This trial tests whether a new peptide treatment or a calcium-phosphate paste works better at reversing early white-spot cavities on front teeth. If you're a young adult with early decay on your front teeth, you may be able to join.
Cairo, Cairo GovernorateAges 15–25 - NCT07429812Enrolling by invitation
Chitosan-Chlorhexidine Gel for Healing After Tooth Extraction
This trial tests a gel made from chitosan and chlorhexidine to see if it helps heal wounds faster after tooth removal in people with diabetes.
Al KharjAges 20–50 - NCT06589570Recruiting
Titanium partial dentures and speech clarity study
This study tests how well a new type of metal partial denture made from titanium works for people missing multiple teeth. It looks at how the denture affects your speech and how easy it is to understand you.
CairoAges Any age - NCT06585852Recruiting
Bone graft with or without RGD protein for jawbone widening
This trial tests a new way to widen a narrow jawbone so a dental implant can be placed. It compares using a bone graft material alone versus mixing it with a special protein (RGD) to help the bone grow better.
Cairo, Nasr CityAges 18–30 - NCT06585566Recruiting
Bone graft trial for children with cleft palate
This trial tests a new way to repair a gap in the upper jawbone (called an alveolar cleft) using thin layers of bone, called cortical shells, taken from the patient's own body. It is for children who have not had this surgery before and who are generally healthy.
CairoAges 8–15 - NCT07410156Recruiting
Comparing treatments for dark gums
This trial tests a new technique using tiny needles and a plant extract (silymarin) to lighten dark gums, and compares it to laser and scalpel methods.
Al FayyumAges 18 years+ - NCT07408778Recruiting
One vs. two implants for lower dentures
This trial compares using one implant versus two implants to help keep your lower denture in place. If your upper denture fits well but your lower denture is loose, you may be able to get a more stable solution.
Jenin, PalestineAges 40 years+ - NCT06885983Enrolling by invitation
Healing after gum bone repair with a collagen membrane
This trial tests how well a collagen membrane helps heal the gum and jawbone after an implant is placed. If you need a dental implant and have a small bone gap or thin bone, this study may be a good option.
BelgradeAges 18–65 - NCT07402720Recruiting
Brush vs bur for gum color treatment
This trial compares two methods to lighten dark gums caused by melanin: a polishing brush and a ceramic bur. It will help find which works better and is safer for people with gum pigmentation.
CairoAges 18–40 - NCT06577285Recruiting
Botox for gummy smile with zinc and phytase supplements
This trial tests if taking zinc and phytase supplements can make Botox work better for treating a gummy smile. It may help people who show too much gum when they smile.
CairoAges 18–60
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.