Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07688421Enrolling by invitation
Short 3D-printed implants for back jaw teeth: 3-year study
This trial tests shorter implants made with 3D-printing for replacing missing teeth in the back of the mouth. Researchers will check how well they work over 3 years using X-rays.
Guarulhos, São PauloAges 18 years+ - NCT07683351Recruiting
Gel for healing after gum graft surgery
This study compares two gels, active oxygen gel and hyaluronic acid gel, to see which one helps the roof of the mouth heal better after a gum graft. It may help reduce discomfort and speed up recovery.
Ismailia, Ismailia GovernorateAges 18–60 - NCT07687654Recruiting
Gum recession repair with tooth-colored fillings
This study tests whether placing a tooth-colored filling in a cavity near the gum line can help cover exposed roots when combined with a common gum graft procedure. It may be an option for people who need both a filling and gum recession surgery.
Adıyaman, MerkezAges 18–65 - NCT07683962Recruiting
Early healing and gum surgery outcomes
This trial tests whether early wound healing affects the results of regenerative gum surgery, which aims to rebuild bone around teeth affected by advanced gum disease.
Rome, RomeAges 18 years+ - NCT07682883Enrolling by invitation
Mouth screening to prevent oral cancer
This study checks how well routine mouth exams can find early signs of oral cancer. It is for adults who do not already have a condition called OPMD (a mouth problem that can lead to cancer) and are not being treated for it.
Warsaw, Masovian VoivodeshipAges 18 years+ - NCT07683650Recruiting
Hyaluronic acid and platelet gel for jaw joint disc pain
This study tests a mixture of hyaluronic acid (a natural lubricant) and platelet-rich fibrin (from your own blood) injected into the jaw joint to see if it helps people with a misaligned jaw disc and pain. It may improve jaw movement and reduce discomfort.
Al MansurahAges 18–45 - NCT07688278Recruiting
Diabetes screening for people with advanced gum disease
This trial tests whether checking blood sugar (HbA1c) at the dentist can find undiagnosed diabetes. It is for adults with advanced periodontitis (severe gum disease) who have not already been told they have diabetes.
SkåneAges 18 years+ - NCT07680491Recruiting
Non-surgical treatment for gum pockets around implants
This study tests a new, non-surgical gel called H42 for treating deep gum pockets around dental implants. It's for adults with moderate pocket depths who are not on blood thinners.
SevilleAges 25–65 - NCT06186908Recruiting
Saliva test for gum disease diagnosis
This trial studies certain proteins in your saliva to see if they can help identify different types of gum disease. It may help improve how we diagnose and treat periodontal problems.
Izmir, ÇiğliAges 20–60 - NCT06660797Recruiting
Irrigation methods for root canal treatment
This trial tests different ways to flush and clean inside a tooth during root canal treatment. It aims to see which method best reaches deep into the tooth and reduces bacteria.
TantaAges 18–40 - NCT06580821Recruiting
Modified gum graft for lower front teeth
This trial tests a modified gum grafting technique to treat gum recession on lower front teeth. It may help if you have a small amount of recession and keep your teeth very clean.
Samborondón, GuayasAges 18–64 - NCT06662929Recruiting
Arabic quality of life measure for head and neck cancer patients
This study will test a new Arabic questionnaire to measure how radiotherapy affects the quality of life of head and neck cancer patients. If you are receiving, have received, or will receive radiation treatment for head or neck cancer, you may be able to help by filling out surveys.
RiyadhAges 18 years+ - NCT06070181Recruiting
Adding Emdogain to deep cleaning for gum disease
This trial tests whether adding a treatment called Emdogain to a standard deep cleaning helps heal gum pockets better than deep cleaning alone. Emdogain is a gel that helps gums and bone regrow, and it is applied during the cleaning.
Linköping, Region ÖstergötlandAges 18 years+ - NCT07672236RecruitingPhase 3
Comparing two mouth pain treatments for head and neck cancer patients
This trial tests a new mouthwash (BupiZenge) against a standard numbing medicine (lidocaine) for pain caused by mouth sores from radiation therapy. It may help you if you are about to start radiation for certain head and neck cancers.
CopenhagenAges 18–80 - NCT07672873Recruiting
Steroid injection for tooth nerve pain during root canal
This trial tests whether a single injection of dexamethasone (a steroid) near the nerve of a painful lower molar can improve pain relief during a root canal. It's for people with severe tooth nerve pain who haven't taken pain meds recently.
IstanbulAges 18–65 - NCT07672847Enrolling by invitation
Denture cleaners and their effect on milled denture materials
This study tests how different denture cleaning solutions affect the surface of two special types of denture materials (PMMA and PEEK) that are made by computer-controlled milling. It aims to see if these cleaners cause wear or damage over time.
Shibīn al KawmAges Any age - NCT07671794Enrolling by invitation
Jaw repositioning surgery for facial deformities
This trial tests a surgical procedure to reposition the upper jaw in adults with certain jaw or facial irregularities, such as an overbite, underbite, or asymmetry. It aims to improve facial balance as an alternative to braces or other non-surgical treatments.
CairoAges 18 years+ - NCT07678515Enrolling by invitation
Massage and scents to help people with dementia eat better
This study tests whether a gentle massage of the salivary glands (under the jaw) and pleasant smells (like essential oils) can help people with dementia who have trouble eating. It may encourage them to eat by mouth and reduce feeding difficulties.
TainanAges Any age - NCT07671963Recruiting
Bone Graft Options for Gum Disease Surgery
This trial tests two bone-replacement materials (a synthetic bone substitute and a natural bone graft) placed during gum surgery to see which one better helps rebuild bone and gum support around teeth with deep pockets.
Cagliari, ItalyAges 18–80 - NCT07676695Recruiting
Jaw Device and Sound Waves for Class II Malocclusion
This trial tests a special jaw repositioning device (Twin-Block) combined with low-intensity sound waves (LIPUS) to help treat a class II malocclusion (when the lower jaw is set back) in children and teens. It aims to improve jaw alignment and joint outcomes.
CairoAges 10 months–1.2 years - NCT07679451Recruiting
Comparing two membranes for jawbone grafting before dental implants
This trial compares two types of membranes (PEEK vs PTFE) used in a bone-grafting procedure to rebuild the upper jawbone where teeth are missing. It may be an option for you if you need extra bone before getting dental implants.
Al Mansurah, DakhaliyaAges 20–45 - NCT07673185Recruiting
Omega-3 and low-dose aspirin for gum disease in smokers
This trial tests whether taking omega-3 supplements with low-dose aspirin can improve gum health in smokers with advanced gum disease (stage III periodontitis). It aims to see if this combination safely reduces gum pocket depth and tissue damage.
CairoAges 30–50 - NCT07678749Enrolling by invitation
Closed sinus lift with bone graft and a natural supplement scaffold
This trial tests whether adding a natural supplement (apigenin) to a bone graft scaffold helps improve bone healing during a closed sinus lift procedure. It may be an option for people who need extra bone in their upper jaw before getting dental implants.
CairoAges 18–50 - NCT07671950Recruiting
Deep brain stimulation for neuropathic dental pain
This trial studies whether deep brain stimulation (DBS) can help people with a type of nerve-related tooth pain called atypical odontalgia. It is for those who have not found relief from standard treatments like medications or injections.
Vancouver, British ColumbiaAges 19–80
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.