Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT07707323Recruiting
Testing photo software for tooth color matching
This study tests a new photo-analysis software that helps dentists match the color of a tooth-colored filling (resin composite) to your natural teeth. It only involves taking pictures of your upper front teeth, and may lead to more natural-looking results.
Sixth of October, Giza GovernorateAges 18–45 - NCT06347263Recruiting
Gum surgery technique for deep pockets between teeth
This trial tests a surgical technique to treat deep gum pockets between teeth. It compares using a special gum-saving method alone, with a bone graft, or with a platelet-rich fibrin injection to see which helps heal the bone best.
CairoAges 18–50 - NCT07388901Recruiting
Comparing two root canal sealers for infection treatment
This trial compares two materials (iRoot SP and nRoot SP) used to fill root canals after infection. It aims to see which works better for healing apical periodontitis, an infection around the tooth root.
Hangzhou, ZhejiangAges 18 years+ - NCT06623110RecruitingPhase 2
RP2 vaccine to prevent mouth cancer in high-risk pre-cancer
This trial tests an injected virus therapy (RP2) to stop pre-cancerous mouth lesions from turning into cancer. It is for people with high-risk oral pre-cancer or a history of early-stage head and neck cancer with certain worrisome features.
Boston, MassachusettsAges 18 years+ - NCT07379632Recruiting
Comparing two appliances for fixing open bite in children
This trial tests two different dental appliances to fix an open bite in children. It compares a vertical holding appliance to a special arch bar to see which works better.
CairoAges 6–12 - NCT07227792Recruiting
Tongue-out radiation therapy for head and neck cancer
This trial tests if sticking your tongue out during radiation therapy can reduce side effects. It is for people with certain types of head and neck cancer who are getting radiation to the main tumor.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05650359Recruiting
Light therapy study for braces alignment in adults
This trial studies whether Orthopulse light therapy (a form of light treatment) can help during orthodontic treatment with fixed braces. It’s for adults who need braces for crowded front lower teeth, and it will compare outcomes during the alignment phase.
Chandler, ArizonaAges 18 years+ - NCT05663385Recruiting
Testing a gum graft seal during follow-up care
This follow-up study checks whether using Mucograft Seal during aftercare can improve healing for people who took part in an earlier trial. It may help by supporting healthier gum and mouth recovery over time.
RotterdamAges 18 years+ - NCT07368621Recruiting
Gum graft with or without platelet-rich fibrin for dental implant thickness
This trial tests if adding a special blood concentrate (platelet-rich fibrin) to a standard gum graft helps thicken the gum tissue around a dental implant. It is for people with thin gums who are missing a single tooth.
Cairo, Cairo GovernorateAges 18–60 - NCT07367464Recruiting
Bone Grafting Methods for Upper Jaw Implants
This trial tests two ways to rebuild the jawbone so there's enough space for a tooth implant. One method uses a mix of man-made bone and donated bone, the other uses man-made bone and your own bone chips. It might help you if you need more bone for an implant in your upper jaw.
CairoAges 20–50 - NCT06561087RecruitingPhase 2
Nivolumab injection for high-risk mouth lesions
This trial tests whether injecting nivolumab directly into high-risk pre-cancerous mouth spots can prevent them from becoming cancer. You randomly receive either the drug or a placebo, and the study monitors how the spots change over time.
Houston, TexasAges 18 years+ - NCT05837780Enrolling by invitation
Different braces techniques for babies with a cleft lip and palate
This trial compares two different techniques for making a molding device (a baby “nasal/cheek shape” support) for newborns with a cleft lip and palate on one side. It may help your baby get a better starting nose and lip shape during early treatment.
MinyaAges 1 week–1 month - NCT07337538Recruiting
Mini-implant study for orthodontic treatment
This study compares two sizes of mini-implants (small bone screws) placed in the upper jaw to help move teeth back. It tests which size works better for people already in braces who need extra support for tooth movement.
Baghdad, Baghdad GovernorateAges 15–38 - NCT07206108Recruiting
Crown vs post-core for large tooth repairs after root canal
This trial compares two ways to fix large holes in premolars after root canal treatment: a modified crown attached to the remaining tooth, or a personalized post-and-crown. It looks for people with good oral health whose tooth has enough strong structure left for a successful repair.
ChinaAges 18–65 - NCT06543004Recruiting
Comparing pain after root canal with two filling materials
This study is comparing two different materials used to fill the tooth after a root canal to see which one causes less pain afterward. If you need a root canal on a front tooth or a premolar and you don't have pain or swelling, this trial may help find the gentler option for you.
DohaAges 18–60 - NCT07333534Recruiting
Bone graft with or without gum graft for front tooth implants
This study compares two ways to rebuild bone and gum around a dental implant placed immediately after removing a failing front tooth. It may help patients who need a tooth replaced in the smile zone and have enough healthy bone to support the implant.
Baghdad, RusafaAges 18–65 - NCT06789458Recruiting
Pro-resolution mediators in severe gum disease before and after treatment
This study looks at natural substances in your blood that help reduce gum inflammation. Researchers want to see how these substances change after standard gum disease treatment, which may lead to better ways to manage severe periodontitis.
Manial, Cairo GovernorateAges 18–80 - NCT06541912Recruiting
UV light vs standard dental implants for jaw healing
This trial tests whether treating dental implants with ultraviolet (UV) light before placing them helps them heal better and stay stable compared to standard implants. It may be a good fit if you are missing teeth in the back of your lower jaw and are in generally good health.
Bengaluru, KarnatakaAges 18 years+ - NCT07330154Recruiting
Gel for Faster Healing After Gum Graft Surgery
This trial tests a new gel (Nano Bio Fusion Gingival Gel) to see if it helps the roof of your mouth heal faster after a gum graft. It compares the gel to a placebo (inactive gel). The study is for people who need gum graft surgery for receding gums.
Irbid, Irbid GovernorateAges 18 years+ - NCT04766255RecruitingPhase 4
Comparing materials to thicken gum tissue around dental implants
This study compares three types of graft (tissue/covering materials) to help build up thicker gum and soft tissue around a dental implant. It may help improve appearance and protect the implant area when you have thin or missing gum tissue.
Sant Cugat del Vallès, BarcelonaAges 18 years+ - NCT07325643Recruiting
Toothpaste and mouthwash to prevent white spots during braces
This study tests if a special toothpaste and mouthwash can stop white spots from forming on teeth while you have braces. It is for people starting orthodontic treatment who have healthy teeth and gums.
BaghdadAges Any age - NCT07320924Recruiting
Custom Plate for Lower Jaw Bone Defects
This trial tests a custom-made metal plate designed to replace a missing piece of your lower jaw bone. It may be a good option if you have a gap in your jaw from a tumor, infection, or injury, as long as the joint near your ear is not involved.
Alexandria, Alexandria GovernorateAges Any age - NCT05727670Enrolling by invitation
Treatment for teeth that stay in place
This study looks at a treatment plan for people who have “retentive teeth,” meaning certain teeth are not coming through or are staying in a problem way. The goal is to see whether this approach works better for fixing that issue.
Samara, Samara OblastAges 15–25 - NCT07319299Enrolling by invitation
Liver cancer screening study for people with chronic liver disease
This study tests a new way to screen for liver cancer in people with chronic liver disease, especially those with cirrhosis or significant liver scarring. It uses blood tests and imaging to catch cancer early.
Bangkoknoi, BangkokAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.