Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07671950Recruiting
Deep brain stimulation for neuropathic dental pain
This trial studies whether deep brain stimulation (DBS) can help people with a type of nerve-related tooth pain called atypical odontalgia. It is for those who have not found relief from standard treatments like medications or injections.
Vancouver, British ColumbiaAges 19–80 - NCT07673185Recruiting
Omega-3 and low-dose aspirin for gum disease in smokers
This trial tests whether taking omega-3 supplements with low-dose aspirin can improve gum health in smokers with advanced gum disease (stage III periodontitis). It aims to see if this combination safely reduces gum pocket depth and tissue damage.
CairoAges 30–50 - NCT05113004RecruitingPhase 2
Testing new outcomes in primary Sjögren’s syndrome
This Phase 2 study tests how to measure changes in primary Sjögren’s syndrome symptoms and body activity. It may help researchers confirm which outcomes best reflect improvement and how different patient types respond to treatment.
BrestAges 18 years+ - NCT06562816RecruitingPhase 4
Comparing two pain relievers after root canal treatment
This study tests two different pain medicines (trypsin-chymotrypsin and naproxen sodium) to see which one works better for pain after a root canal. It may help you if you need a root canal and are generally healthy.
Karachi, SindhAges 18–45 - NCT06671743RecruitingPhase 3
Medication before root canal to reduce pain
This study tests whether taking a medication before a root canal can reduce pain afterward. It is for people who need a root canal on a lower back tooth that has a painful, inflamed nerve but no infection at the root tip.
AjmanAges 20–50 - NCT06428188RecruitingPhase 1/Phase 2
CAR-T cells targeting BCMA/CD19 for autoimmune diseases
This trial tests a new treatment called CAR-T cells that target two proteins (BCMA and CD19) on immune cells. It is for people with certain autoimmune diseases that have not improved with standard treatments.
Beijing, Beijing MunicipalityAges 21–90 - NCT06673576Recruiting
Comparing 3D scanning methods to measure gum changes after crown lengthening
This study tests a new 3D scanning technique to measure gum changes after crown lengthening surgery. It aims to see if the new method is as accurate as the current standard approach.
CairoAges 18 years+ - NCT07664592RecruitingPhase 3
Comparing toothpastes for sensitive teeth
This trial tests whether a new toothpaste technology can block the tiny tubules in dentin that cause tooth sensitivity. It lasts 2 weeks and will help find better ways to treat sensitive teeth.
Porto Alegre, Rio Grande do SulAges 18–70 - NCT06675214RecruitingPhase 3
Immunotherapy with modified radiation for advanced NPC
This trial tests a new way to give radiation therapy after immunotherapy and chemotherapy for people with advanced nasopharyngeal cancer (NPC) that has partially shrunk. It aims to see if a different radiation schedule works better and has fewer side effects.
Zhuhai, GuangdongAges 18–65 - NCT07666126Recruiting
Uric acid and gum bone health study
This study looks at whether high uric acid levels affect the bone around your teeth. If you are between 18 and 65, have at least 20 natural teeth, and are either healthy or have high uric acid and gum disease, this trial may be for you.
RizeAges 18–65 - NCT07664605Recruiting
Comparing two bone grafting methods for dental implants
This trial compares two surgical techniques for building up narrow jawbone before placing a dental implant. It may be an option if you have mild to moderate bone loss in your jaw.
CairoAges 20–75 - NCT07669792Recruiting
Bone shell vs fabric for narrow lower jawbone
This study compares two ways to rebuild a narrow lower jawbone so you can get dental implants. One method uses a special bone shell technique, and the other uses a strong fabric material. Your doctor will check if your jawbone is wide enough and healthy for this surgery.
CairoAges 18–65 - NCT07671651Recruiting
Ozone therapy for early tooth decay in children
This trial tests whether ozone therapy can help reverse the earliest stages of tooth decay (white spots on teeth) in children. Children aged 6–12 with small, non-cavity spots may benefit from this treatment instead of traditional fillings.
Istanbul, MaltepeAges 6–14 - NCT07667088Recruiting
Whitening mouthwash using oil pulling
This study tests a whitening mouthwash that uses an oil-pulling method. It lasts a few months and compares the mouthwash to not using any whitening product. If you have naturally darker front teeth and haven't whitened them recently, this might be an option for you.
San Antonio, TexasAges 18–60 - NCT07666360Recruiting
Jaw pain study: factors that predict TMD severity
This trial looks at how your head, neck, and jaw work together to understand why some people have more severe jaw joint (TMD) pain. If you have jaw pain, the findings may help researchers identify better treatments.
AnkaraAges 18–55 - NCT07671274RecruitingEarly Phase 1
Comparing two ways to treat gum disease without surgery
This study compares a standard deep cleaning method with a newer, less invasive approach for treating advanced gum disease (periodontitis). It aims to see if one works better for patients with good oral hygiene and no other health issues.
Al Mansurah, DakhliaAges 20–40 - NCT07664488Recruiting
AI vs. Manual Analysis of Skull X-rays
This trial tests whether a computer program using artificial intelligence can measure skull and jaw landmarks from X-rays as accurately as a human expert. It may help improve future orthodontic care.
Pavia, ItalyAges Any age - NCT07664046Recruiting
Peptide for remineralizing white spot lesions in teens
This trial tests a self-assembling peptide (P11-4) to help reverse early white spots on teeth caused by cavities in teenagers. If effective, it could rebuild enamel without drilling or fillings.
Warsaw, Masovian VoivodeshipAges 10–18 - NCT07666100Recruiting
Study of medication side effects in a periodontology clinic
This study looks at side effects from medications prescribed in a gum disease clinic. It aims to understand what types of side effects patients experience, which can help doctors choose safer medicines.
SivasAges 16 years+ - NCT07671326Recruiting
Bioceramic vs calcium hydroxide for infected molars
This study compares two types of medication placed inside a root canal to fight infection. It may be an option if you have an infected lower molar and are in generally good health.
Istanbul, IstanbulAges 18–65 - NCT05853783Recruiting
Testing a mouth test on biopsy samples from abnormal lesions
This trial looks at archived (saved) mouth biopsy samples to see how well the STRATICYTE™ test can identify potentially dangerous “pre-cancer-like” changes. It may help doctors screen or better understand which abnormal areas in the mouth later turn into oral cancer.
Birmingham, AlabamaAges 18 years+ - NCT04622462Recruiting
Testing a lab marker to predict oral cancer risk
This study looks at biopsy samples from mouth lesions that seem concerning, to see if a specific lab marker pattern can help predict whether oral cancer may be present or developing. It may help doctors sort which suspicious lesions need closer attention sooner.
Edmonton, AlbertaAges 15–90 - NCT06677983Recruiting
How well do Bioflx crowns work for children's back baby teeth?
This study tests how well children and parents like a new type of crown for baby molars. The crowns are placed on back baby teeth that need full coverage, and the study looks at how they perform and how comfortable and satisfied you and your child are.
AlexandriaAges 4–8 - NCT07661277Enrolling by invitation
Success rate of cheekbone mini-screws for braces
This study tests how well tiny screws placed in your upper cheek area work to support braces and move teeth into the right position. It is for adults aged 19 to 35 who need fixed braces on their upper teeth and have not had braces before.
DhakaAges 19–35
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.