Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07661784Recruiting
Saliva tests to track gum disease
This study looks at whether substances in your saliva can show if gum disease is getting worse. It might help find a simple way to monitor gum health without needles or X-rays.
IspartaAges 18–65 - NCT07660146Recruiting
Predicting extraction needs for orthodontic treatment
This trial tests a method to help dentists decide if you need tooth extractions before braces. Researchers will look at dental models to see if this analysis tool is accurate.
Cairo, Giza GovernorateAges 12 years+ - NCT07662603Recruiting
Breathing exercise program for teens with Behcet's after lung surgery
This trial is for teenagers with Behcet's disease who have had a specific lung surgery to remove a clot. It tests a breathing exercise program to help improve lung function after surgery.
Giza, DokkiAges 13–17 - NCT07661277Enrolling by invitation
Success rate of cheekbone mini-screws for braces
This study tests how well tiny screws placed in your upper cheek area work to support braces and move teeth into the right position. It is for adults aged 19 to 35 who need fixed braces on their upper teeth and have not had braces before.
DhakaAges 19–35 - NCT07657364Recruiting
Comparing zirconia vs titanium for full-arch dental implants
This study compares two types of material (zirconia or titanium) used as a frame in full-arch screw-retained implant bridges. It aims to find which material has fewer complications, helps patients who have lost all teeth in one or both jaws.
CairoAges 18–70 - NCT07658144Enrolling by invitation
Immediate dental implant for upper back teeth
This trial tests a new way to place a dental implant right away after removing a damaged upper molar. It aims to see if placing the implant using the tooth's natural root as a guide is accurate and effective.
TantaAges 18–60 - NCT06681844Recruiting
Predicting tooth wear from knocked-out teeth
This study will look at teeth that have been knocked out to find out if the amount of wear on the tooth can help predict how much more wear might happen. If you have a tooth like this, it might help researchers understand tooth wear better.
Indianapolis, IndianaAges 18–80 - NCT06685523Recruiting
Peri-implantitis study for patients with gum disease around implants
This trial studies a substance called fractalkine and its receptor in the gum fluid around dental implants affected by peri-implantitis. It aims to understand the role of these markers in inflammation, which may help improve diagnosis or treatment.
KirikkaleAges 40–60 - NCT07649265RecruitingPhase 1
Testing a new drug for autoimmune diseases
This study tests a new drug called HBM7020 to see if it is safe and how well it is absorbed by the body. It is for healthy people and people with certain autoimmune diseases like lupus, scleroderma, rheumatoid arthritis, or Sjögren's disease.
Brisbane, QueenslandAges 18–75 - NCT07649239Recruiting
Gum Grafting Methods for Dental Implants in Front Teeth
This trial compares two techniques to improve the appearance and health of gum tissue around dental implants in your front teeth. One uses a special blood product (PRF), and the other uses a traditional gum graft. The goal is to see which gives better-looking results.
Ajman, Ajman EmirateAges 20–70 - NCT07648654Recruiting
Hall Technique vs. Traditional Crowns for Decayed Baby Molars
This study compares two ways to treat decayed baby molars in children ages 5–8: the Hall Technique (a newer method) and traditional stainless-steel crowns. Researchers will measure which method works better, reduces anxiety, takes less time, and costs less.
CairoAges 5–8 - NCT07649226Enrolling by invitation
Laser gum contouring for a more balanced smile
This study compares two minimally invasive laser techniques to reshape your gums and reduce a gummy smile (excessive gum show). The goal is to see which approach—without cutting or with a small tunnel cut—gives better results with less discomfort and faster healing.
Alexandria, Alexandria GovernorateAges 21 years+ - NCT07648212Recruiting
AI Tool for Detecting Tooth Decay in Dental Training
This study tests whether artificial intelligence can help dental students and residents better detect early tooth decay (cavities) between teeth. Participants will learn to use an AI tool and compare it to traditional detection methods to see if it improves accuracy.
Ann Arbor, MichiganAges 18–99 - NCT07653802Recruiting
Laser vs. surgery for crown lengthening
This study compares a new laser method for crown lengthening to the traditional surgical approach. Crown lengthening reshapes gum and bone to expose more tooth, often needed before placing a crown or for cosmetic reasons. The laser may be less invasive and allow faster healing.
Ajman, Ajman EmirateAges 20–70 - NCT07654166Recruiting
Glue vs stitches for mouth growth removal
This trial compares using a skin glue (tissue adhesive) versus stitches (sutures) to close the small wound after removing a harmless growth inside your mouth. It may help reduce discomfort and healing time.
Damascus, MazzhAges 18–80 - NCT06688760Recruiting
Surgery vs surgery plus lower-dose radiation for early nasopharyngeal cancer
This trial compares two treatments for newly diagnosed Stage I nasopharyngeal cancer: surgery alone versus surgery followed by a lower dose of radiation. The goal is to see if adding a gentler radiation dose can prevent the cancer from coming back without too many side effects.
Guangzhou, GuangdongAges 18–70 - NCT07640074Enrolling by invitation
Coconut-based filling material for children's cavities
This study tests a new filling material made from coconut to repair cavities in children's primary (baby) teeth. Researchers want to see how well this material works compared to traditional fillings.
IslamabadAges 5–9 - NCT07639944Recruiting
REN Device Study for Jaw Pain and Headaches
This study tests whether a treatment called REN can help reduce headaches and jaw pain caused by temporomandibular disorders (TMD). You would use the REN device at home on your smartphone or tablet over several months.
Newark, DelawareAges 12 years+ - NCT07642284Recruiting
Root Canal Sealer Performance Study
This study tests how well a new root canal sealant (AH Plus Jet) works when used with a simplified filling technique. Root canal treatment removes infected nerve tissue from inside a tooth, and this trial evaluates whether this newer sealant keeps the tooth healthy long-term.
New York, New YorkAges 18–75 - NCT06685016Recruiting
Study of dental health after IPR with clear aligners
This study looks at how the teeth and gums are doing after a common orthodontic step called IPR (a slight smoothing between teeth) in people wearing clear aligners. It will help understand if this procedure keeps your mouth healthy.
NaplesAges 17–100 - NCT07638358RecruitingEarly Phase 1
Bone filler to preserve jaw structure after tooth removal
This early-stage trial tests a bone-filling material called Neobone® placed in the socket after tooth extraction to help maintain jawbone volume. This is important because losing bone after tooth removal can make future implants or dentures difficult to fit.
Caparica, Monte Da CaparicaAges 18 years+ - NCT07638254Recruiting
Buffered vs. Standard Numbing for Dental Pain in Children
This study tests whether a specially prepared numbing medicine works better than standard numbing to reduce pain and anxiety during a dental procedure for children with a painful infected tooth. The goal is to find the gentlest way to numb the area before treatment.
San Luis Potosí City, San Luis PotosíAges 6–12 - NCT07643311Recruiting
Comparing two types of tooth caps for root-canal-treated molars
This study compares two ways to restore (cap) back teeth that have had root-canal treatment and lost a cusp or more. Researchers want to see which method—computer-milled or 3D-printed crowns—works better and lasts longer.
Santiago, Santiago MetropolitanAges 18–70 - NCT07644676Enrolling by invitation
Comparing Bonding Methods for Dental Crowns
This study tests different ways to attach a crown to your back tooth to see which method works best and lasts longest. If you need a single crown and have healthy teeth and gums, you may be able to participate.
Hörby, Skåne CountyAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.