Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07638969Recruiting
Study of complications around dental implants
This study looks at problems that can happen around dental implants after they've been in place for over a year. Researchers want to understand what factors lead to these complications so they can help prevent them in the future.
BadajozAges Up to 90 years - NCT07638358RecruitingEarly Phase 1
Bone filler to preserve jaw structure after tooth removal
This early-stage trial tests a bone-filling material called Neobone® placed in the socket after tooth extraction to help maintain jawbone volume. This is important because losing bone after tooth removal can make future implants or dentures difficult to fit.
Caparica, Monte Da CaparicaAges 18 years+ - NCT07638254Recruiting
Buffered vs. Standard Numbing for Dental Pain in Children
This study tests whether a specially prepared numbing medicine works better than standard numbing to reduce pain and anxiety during a dental procedure for children with a painful infected tooth. The goal is to find the gentlest way to numb the area before treatment.
San Luis Potosí City, San Luis PotosíAges 6–12 - NCT07642596Recruiting
Root Canal Treatment Methods and Post-Procedure Pain
This study compares two different techniques for cleaning and shaping root canals (the nerve chambers inside teeth) to see which one causes less pain after treatment. If you have a dead nerve in a back lower tooth, this trial may help us understand the best way to treat it with minimal discomfort.
Eskişehir, OdunpazarıAges 18–65 - NCT07638319RecruitingEarly Phase 1
Bone filler to preserve jawbone after tooth extraction
This early-stage trial tests a bone filler material (Neocement Inject P) placed in the socket after tooth removal to help preserve jawbone volume. This may help if you need a dental implant later.
Caparica, Monte Da CaparicaAges 18 years+ - NCT07641933RecruitingPhase 1
Root Canal Retreatment Dressing Comparison Study
This study compares different medicines placed inside root canals between appointments to help heal infections. You'll have a tooth retreated (cleaned and filled again) and help researchers find which dressing works best.
CairoAges 21–45 - NCT06381414Recruiting
Childhood early oral aging: causes and effects on teeth
This study looks at why some young children have early signs of oral aging and how it affects their bite. It aims to find the causes and possible consequences for kids ages 3 to 6.
São Paulo, São PauloAges 3–6 - NCT06693297Recruiting
Early vs. standard tooth implant loading study
This trial compares putting a permanent crown on a dental implant soon after surgery versus waiting the usual time. It's for people who need to replace a single missing tooth and have healthy bone and gums.
AmmanAges 18 years+ - NCT07633665Recruiting
Safety and effectiveness study of dental implants
This study tests two types of dental implants (BIODENTOSS® and DWC®) to see how well they work and how safe they are in patients who need tooth replacement. If you have a missing tooth and want an implant, this study will track how your implant performs over time.
KonyaAges 18 years+ - NCT07632443Recruiting
Testing temporary dental crowns and bridges made of PMMA
This study tests the safety and performance of ON DENT® temporary dental crowns and bridges made from a tooth-colored plastic material called PMMA. If you need a temporary crown or bridge while waiting for a permanent restoration, this trial may help determine how well these temporary options work.
IzmirAges 18 years+ - NCT07636733Recruiting
Vitamin D for Gum and Bone Health in Periodontal Disease
This study tests whether vitamin D supplements can reduce inflammation and improve healing in people with gum disease, ranging from mild gingivitis to advanced periodontitis. Researchers will compare how vitamin D affects different stages of gum disease.
RizeAges 18–70 - NCT07637227Recruiting
Comparing two types of clear aligners for teeth straightening
This study tests two different ways of making clear aligners (custom plastic trays that move your teeth). Researchers want to see if 3D-printed aligners work as well as traditional heat-formed ones for mild crowding or spacing.
Baghdad, Bab Al-MuadhamAges 15–30 - NCT07634276Recruiting
Custom surgical guides for jaw realignment surgery
This trial tests personalized surgical guides and implants to help surgeons precisely reposition the upper and lower jaw in patients with facial asymmetry or misalignment. The goal is to improve surgical accuracy and final bite alignment.
BeijingAges 18–40 - NCT07634900Recruiting
Pain relief methods for children's emergency tooth root treatment
This study compares two different numbing techniques used during emergency root canal treatment in children's back lower teeth. Researchers want to see which method works better at relieving pain during the procedure.
Malatya, MalatyaAges 6–14 - NCT07633405Enrolling by invitation
Light therapy to improve gum disease treatment
This study tests whether shining a special light on your gums after standard cleaning can help treat gum disease better. Researchers will compare light therapy combined with standard treatment versus standard treatment alone to see if it reduces gum pocket depth and improves healing.
Guayaquil, GuayasAges 18–65 - NCT06222736Recruiting
Cervical core exercises for jaw joint pain relief
This study tests whether exercises for the neck and upper back can reduce pain and improve function in women with jaw joint problems caused by muscle pain. It could help if you have jaw pain related to tense or sore muscles.
Istanbul, AvcılarAges 18 years+ - NCT06517927Recruiting
Long-term dental effects of childhood cancer chemo
This study looks at how chemotherapy given before age 10 affects teeth later in life. Researchers want to know if childhood cancer survivors have more dental problems than others.
BrusselsAges 12–36 - NCT06576284Recruiting
Tracking custom dental implant performance over 3 years
This study follows people who already received a personalized dental implant designed by computer. Researchers want to see how the implant performs over 3 years, measuring things like how well it works and if any problems come up.
São PauloAges Any age - NCT06695208RecruitingPhase 4
Bone graft options to save socket after tooth extraction
This trial tests two materials, Biodentin and a xenograft, to see which one better preserves the bone socket after a single-rooted tooth is pulled. It may help you if you need a tooth extracted and plan to get a dental implant later.
GizaAges 25–50 - NCT06694532RecruitingPhase 1/Phase 2
Arthrocentesis with hyaluronic acid for TMJ disorders
This trial tests two types of hyaluronic acid (high vs low molecular weight) given during a jaw joint procedure (arthrocentesis) to see which better relieves pain and improves jaw function in people with TMJ disorders.
AsyutAges 18–100 - NCT03480971RecruitingPhase 2
Tempol to reduce mouth and other side effects from radiation and cisplatin
This Phase 2 trial tests tempol to lessen harmful side effects caused by head-and-neck radiation and the chemotherapy drug cisplatin. If you qualify, you may receive tempol during treatment to help protect normal tissues and reduce toxicity.
La Jolla, CaliforniaAges 18 years+ - NCT07621809RecruitingPhase 3
Ianalumab versus placebo for Sjögren's disease with high symptom burden
This study tests whether a new drug called ianalumab can reduce dry mouth and other symptoms in people with Sjögren's disease—a condition where the immune system attacks moisture-producing glands. Participants will receive either ianalumab or a placebo (inactive injection) over 52 weeks to see if the drug helps.
Peoria, ArizonaAges 18 years+ - NCT07622043Recruiting
Testing two varnishes to reduce tooth sensitivity
This study compares two special varnish coatings applied to teeth to see which works better at reducing tooth sensitivity and pain. If you have teeth that hurt when exposed to cold or touch, this trial might help you find relief.
SchaanAges 18–65 - NCT07624331Recruiting
PEEK vs. Standard Healing Caps for Tooth Implants
This study compares two types of temporary healing caps (PEEK and standard materials) used during dental implant surgery for a single back tooth. Researchers will measure how well the gum tissue heals around each type to see which works better.
Sungai Buloh, SelangorAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.