Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06715722Recruiting
Comparing implant connector designs for 3-tooth bridges
This study compares two types of connector designs for dental implants that support a 3-tooth bridge in the lower jaw. It may help you understand which design gives better stability and comfort.
AmmanAges 18 years+ - NCT07601347Recruiting
Immediate dental implants: two loading methods compared
This study compares two ways of placing and loading dental implants for damaged upper back teeth. Researchers will test whether a newer compression technique works as well as or better than the standard method for tooth replacement and bone healing.
Banī SuwayfAges 20–40 - NCT07599254RecruitingPhase 4
Pain Relief After Root Canal Retreatment
This study tests two different ways of cleaning and treating a tooth that had a root canal treatment before. Researchers want to see which method causes less pain after the procedure.
KayseriAges 18–60 - NCT07599657Recruiting
Protein Levels in Gum Disease Before and After Minimally Invasive Surgery
This study measures a natural protein in your gums before and after a minimally invasive surgical treatment for moderate to advanced gum disease. Researchers want to understand how this protein changes with treatment, which may help improve gum disease care in the future.
CairoAges 18 years+ - NCT07597213Recruiting
Hyaluronic acid to help gum disease treatment in smokers
This study tests whether adding hyaluronic acid (a natural substance) to standard gum disease treatment helps smokers recover better. Gum disease is serious in smokers, and this treatment might improve healing.
IstanbulAges 18–65 - NCT04001842Recruiting
Tested new jaw bone repair to support future dental work
This trial is studying a method to rebuild part of the lower jaw using a blood-supply bone replacement, so you can later get dental rehabilitation. It’s for adults who need a sizable, tumor-free jaw bone reconstruction and who can safely undergo surgery.
AlexandriaAges 18–65 - NCT07593131Recruiting
Studying dental implant crowns in the front upper teeth
This study looks at why some dental implant crowns (artificial teeth anchored by implants) in the front upper jaw sit lower than they should. Researchers want to understand what factors affect how well these implants are positioned to help improve future placements.
StockholmAges 18 years+ - NCT07586774Recruiting
Complete Denture Outcomes: 3D Printed vs. Traditional Design
This study compares two ways of making complete dentures (upper and lower teeth replacements): using newer 3D printing technology versus traditional milling methods. Participants will wear these dentures for 5 years and report how well they work and feel.
Chapel Hill, North CarolinaAges 18 years+ - NCT06339957Recruiting
Rheumatology diet study for arthritis and related conditions
This study looks at how diet affects people with different types of arthritis and related autoimmune conditions. If you are a UCF Health patient between 18 and 65, you may be able to help researchers learn more about which foods help or worsen symptoms.
Orlando, FloridaAges 18–65 - NCT07593495Recruiting
Electric Nerve Stimulation to Treat Dry Mouth
This study tests whether a gentle electrical nerve stimulation treatment (called TENS) can help increase saliva production in people with dry mouth. Participants will receive this treatment along with standard care and answer questions about how the treatment affects their quality of life.
Toluca, State of MexicoAges 12–90 - NCT07590960Enrolling by invitation
Gum Grafting Surgery for Lower Front Tooth Root Coverage
This study tests a surgical technique to cover exposed tooth roots on the inside of your lower front teeth using gum tissue from the roof of your mouth. It may help reduce sensitivity and improve the appearance of receded gums.
Pittsburgh, PennsylvaniaAges 18–65 - NCT07590024RecruitingPhase 3
Personalized Cancer Treatment Guidance for Nasopharyngeal Cancer
This trial tests whether a special analysis of blood markers and imaging scans can help doctors choose the best combination of chemotherapy and radiation for nasopharyngeal cancer. The goal is to improve outcomes by tailoring treatment to each patient's specific cancer characteristics.
Beijing, Beijing MunicipalityAges 18–65 - NCT07587606Enrolling by invitation
Studying Healing Tissue in Deep Gum Pockets
This study examines how gum tissue heals in deep pockets that remain after standard gum disease treatment. Researchers will collect small samples of healing tissue to better understand gum disease and improve future treatments.
Roma, RomaAges 18–75 - NCT07589751Enrolling by invitation
Comparing dental materials after tooth extraction
This study compares different biomaterials (artificial materials that work with your body) placed in the socket after a tooth extraction to see which one works best for healing. You would need to have a non-molar tooth removed and be willing to let researchers track how well different materials help your mouth heal.
Porto Alegre, Rio Grande do SulAges 18–65 - NCT07594184Recruiting
Can hyaluronic acid injections help dry mouth?
This study tests whether injections of hyaluronic acid—a naturally occurring substance—can relieve chronic dry mouth (xerostomia). If it works, it could offer a new treatment option for people who have had dry mouth for at least a year.
Barcelona, BarcelonaAges 18 years+ - NCT07586631Recruiting
Silver Diamine Fluoride Effects on Baby Teeth Over Time
This study looks at how a special silver-based liquid (silver diamine fluoride) affects the inner health of baby teeth over the long term. Researchers will monitor teeth that were previously treated with this liquid to understand if it helps protect teeth and keep them healthy.
CairoAges 7–10 - NCT06698276Recruiting
Testing Next-X for preserving bone after tooth removal
This trial tests a new method (Next-X) to help preserve the bone where a tooth is removed. It may be for you if you need a single-rooted tooth pulled and your mouth and health are in good condition.
São Paulo, São PauloAges 18–80 - NCT06721104Recruiting
Balance and jaw health in autism
This study looks at balance, jaw joint function, and social skills in people with autism. It aims to understand how these areas are connected and could help improve care.
KirikkaleAges 4–21 - NCT06721377Recruiting
Comparing denture attachments for implant-supported lower dentures
This trial tests different ways to attach a lower denture to dental implants. It aims to find which attachment type works best for people who need a stable, comfortable denture.
Cairo, Nasr City - CairoAges 65–69 - NCT06514885Recruiting
Silver diamine fluoride for root cavities in older adults
This trial studies a special liquid called silver diamine fluoride that is painted onto cavities on tooth roots. It may help stop the decay and keep the tooth healthy without drilling.
Hong KongAges 60 years+ - NCT07578662Recruiting
Direct Pulp Capping for Deep Cavities in Back Teeth
This study tests a treatment where dentists cap (seal) an exposed tooth nerve in deep cavities of back teeth to see if it heals properly. This might help save your tooth instead of needing a root canal.
Rohtak, HaryanaAges 15–40 - NCT07584499RecruitingPhase 1
New drug test for children with EGFR-positive solid tumors
This study tests a new cancer drug called Becotatug Vedotin in children ages 2–18 with certain types of solid tumors (cancers that form in organs or tissues) that have an EGFR protein. The drug is designed to find tumors with this protein and attack cancer cells while sparing healthy ones.
Guangzhou, GuangdongAges 2–18 - NCT07579338Enrolling by invitation
Bacteria and Gum Health: A Detection Study
This study examines specific bacteria in your mouth to understand their role in healthy gums versus gum disease. Researchers will collect samples to measure bacterial levels and help improve how gum disease is diagnosed and treated.
Hillah, BabelAges 30 years+ - NCT07580495Recruiting
Collagen Membrane to Preserve Jaw Bone After Tooth Extraction
This study tests whether a collagen membrane (a thin, natural material) placed after a tooth extraction helps preserve the jaw bone. Keeping bone healthy can make future tooth replacement easier and more successful.
Pittsburgh, PennsylvaniaAges 18–80
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.