Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT05717985Recruiting
Gum tissue grafts using two modified surgical methods
This trial compares two ways of taking donor tissue from the roof of the mouth to rebuild gum/soft tissue. It may help people who need a gum tissue graft to improve the health and appearance of the oral area.
Kuala LumpurAges 18 years+ - NCT05822271Recruiting
Surgery first plus aligners to improve jaw alignment
This trial studies how well a treatment plan works when you start with jaw surgery and then use clear aligners for orthodontic (teeth/jaw) finishing. It may help people whose jaw growth/position problems are mainly due to the lower jaw being too far forward or the upper jaw being too far back.
Rio de JaneiroAges 17–35 - NCT06141239Recruiting
3D imaging to study bone healing after tooth extraction
This trial uses advanced 3D imaging to measure how well your jawbone heals after a tooth is removed, specifically for people who plan to get a dental implant later. It aims to understand natural bone regrowth without additional procedures.
TaoyuanAges 20–70 - NCT07609797Recruiting
Fluoride and Mouthwash Effects on Cavity Markers in Children
This study tests whether sodium fluoride and chlorhexidine (a prescription mouthwash) change certain markers in saliva that may relate to tooth decay in children with cavities. The goal is to understand if these common dental treatments affect the body's natural cavity-fighting substances.
Alanya, AntalyaAges 6–8 - NCT07611942Recruiting
Plaque Removal in Children With Learning Disabilities
This study compares how well children with learning disabilities can remove plaque from their teeth compared to children without learning disabilities. It aims to understand if dental plaque removal is harder for children with specific learning challenges.
Alanya, AntalyaAges 7–12 - NCT07611981Recruiting
Tooth Decay and Oral Health in Children With Learning Disabilities
This study compares tooth decay and brushing habits between children with specific learning disabilities and healthy children. Researchers want to understand if children with learning disabilities need special dental care strategies.
Alanya, AntalyaAges 7–12 - NCT07611461Enrolling by invitation
How Dental Crowns Affect Gum Health Long-Term
This study follows patients who receive tooth-colored metal crowns to see how these dental restorations affect the health of gums and supporting tissues over time. Understanding this helps dentists place crowns in ways that keep your mouth healthiest.
Riga, Dzirciema Iela 20Ages 20–75 - NCT07607639Recruiting
Gum Health Markers in Children and Young Adults
This study looks at special proteins in the fluid around your gums to understand how gum disease develops in young people. By studying these markers, researchers hope to better understand and treat gum inflammation.
NiğdeAges 8–24 - NCT07611643Recruiting
Treating Jaw Clenching and Facial Pain With a Custom Bite Guard
This study tests whether a custom-made bite guard (called an occlusal splint) can help relieve jaw and facial pain caused by temporomandibular disorders—conditions affecting the jaw joint and muscles. Researchers will monitor how well the treatment works and how it affects your symptoms.
Roma, RomaAges 18 years+ - NCT07603934RecruitingEarly Phase 1
Testing Medications Inside Root Canals to Reduce Pain
This study tests different medications placed inside a tooth's root canal during treatment to see which one best reduces pain afterward. If you have a tooth with a dead nerve (necrotic pulp), this trial might help determine the best way to manage your pain during the healing process.
Cairo, Cairo GovernorateAges 18–40 - NCT07604142Enrolling by invitation
Donor bone to close sinus opening after tooth extraction
This trial tests using sterilized donor bone to repair a hole that opens into your sinus when a severely damaged upper back tooth is removed. The goal is to rebuild the bone so a dental implant can be placed safely later.
TantaAges 20 years+ - NCT07606638Enrolling by invitation
Pain Relief Options for Oral Cancer Patients
This study compares two different pain management approaches for people with oral cancer: opioid medication versus a combination of pregabalin (a nerve pain reliever) and naproxen sodium (an anti-inflammatory painkiller). The goal is to see which approach works better and is safer for controlling cancer-related pain.
Lahore, Punjab ProvinceAges 18 years+ - NCT07604493Recruiting
Italian Doctors' Survey on Oral Health and General Wellness
This study asks Italian general practitioners (family doctors) about their views on how oral health—like teeth and gum health—affects overall body health. Your answers help researchers understand what doctors know and think about the connection between mouth and systemic diseases.
Roma, RMAges 18 years+ - NCT07604155Enrolling by invitation
Bone grafting for sinus lift in dental implants
This trial tests two ways to add bone in your upper jaw so dental implants can be placed. Researchers compare custom-made bone blocks to bone particles to see which works better for your bone growth.
TantaAges 20 years+ - NCT07608289Recruiting
Preserving Bone After Tooth Extraction Using Your Own Tooth
This study tests whether using natural material from your own tooth can help preserve jawbone after a tooth is removed. Keeping bone healthy after extraction may make future tooth replacement easier and more successful.
OstravaAges 18–70 - NCT07610876Recruiting
Dentin Graft With Melatonin for Tooth Implant Success
This study tests whether a special graft made from your own tooth material, with or without melatonin (an antioxidant), helps new dental implants integrate better into bone after tooth extraction. The goal is to improve how well implants take hold and function.
IsmailiaAges 20 years+ - NCT06711081Recruiting
Laser and cold therapy for painful back tooth
This study tests whether using a low-level laser and cold therapy together helps heal a back tooth that has deep decay and is causing severe pain. The goal is to save the tooth and avoid a root canal.
TantaAges 15–60 - NCT06713733Recruiting
Steroid injection vs. pill for wisdom tooth recovery
This trial compares two treatments—a steroid placed under the gum and a pill—to reduce pain, swelling, and other problems after removing a lower wisdom tooth. It is for generally healthy patients who need that surgery and haven't taken anti-inflammatory drugs recently.
Dharān, KoshiAges 18 years+ - NCT03916809Recruiting
Voice and swallowing therapy device during head and neck cancer treatment
This trial tests whether using a mouth-based training device (called EMST150) during planned radiation (with or without chemotherapy) can help people with head and neck cancer with swallowing and related muscle function. It may be useful if you’re starting radiation for a cancer in the mouth, throat, or voice box area.
Milwaukee, WisconsinAges 18 years+ - NCT04083417RecruitingPhase 4
Sore throat study comparing antibiotics versus no antibiotics
This trial looks at whether phenoxymethylpenicillin (an antibiotic) helps people with a certain type of sore throat more than not using antibiotics. You may qualify if your symptoms match a likely bacterial cause and a rapid test for strep is negative.
JönköpingAges 15 years+ - NCT06662279Recruiting
Hyrax vs. Invisalign palatal expander study
This study compares a traditional metal palatal expander (Hyrax) to a new clear aligner-based expander (Invisalign) for widening the upper jaw in children aged 6-11. It aims to see which device works better and is more comfortable.
Laguna Hills, CaliforniaAges 6–11 - NCT06714760Recruiting
Flap surgery for mouth reconstruction
This trial tests a new surgical flap (using tissue from the scalp) to repair defects in the mouth after cancer surgery. It may be an option for patients with certain jawbone defects that haven't been operated on before in a specific area.
Bologna, Emilia-RomagnaAges 18 years+ - NCT06714695Recruiting
Testing a mouthwash for black stains on kids' teeth
This trial tests if a special mouthwash made from chitosan (a natural substance from shellfish) can prevent black stains from coming back on children's teeth. Kids will use the mouthwash and be checked over 18 weeks to see if it works.
Cairo, Cairo GovernorateAges 6–12 - NCT07596485RecruitingPhase 1/Phase 2
RP-008 Plus Varenicline for Trigeminal Neuralgia Pain
This trial tests a new drug called RP-008 combined with varenicline (a quit-smoking medication) to relieve severe facial pain from trigeminal neuralgia. If you've already tried standard pain medications without enough relief, this combination might help reduce your pain attacks.
SherbrookeAges 18–80
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.