Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07581821RecruitingPhase 2
Immunotherapy plus targeted drugs for advanced nasopharyngeal cancer
This trial tests a combination of three drugs (sintilimab, anlotinib, and chemotherapy) for nasopharyngeal cancer that has returned or spread after initial treatment. The goal is to see if this combination helps slow or shrink the cancer.
Zhuhai, GuangdongAges 18–65 - NCT07584499RecruitingPhase 1
New drug test for children with EGFR-positive solid tumors
This study tests a new cancer drug called Becotatug Vedotin in children ages 2–18 with certain types of solid tumors (cancers that form in organs or tissues) that have an EGFR protein. The drug is designed to find tumors with this protein and attack cancer cells while sparing healthy ones.
Guangzhou, GuangdongAges 2–18 - NCT07578662Recruiting
Direct Pulp Capping for Deep Cavities in Back Teeth
This study tests a treatment where dentists cap (seal) an exposed tooth nerve in deep cavities of back teeth to see if it heals properly. This might help save your tooth instead of needing a root canal.
Rohtak, HaryanaAges 15–40 - NCT07579377Recruiting
Denture design and satisfaction in older adults
This study tests whether a specific denture design feature (palatal rugae patterns) affects how satisfied patients are with their new complete dentures and their quality of life. Complete dentures replace all missing teeth in the upper or lower jaw.
Karachi, SindhAges 40–80 - NCT06724783RecruitingPhase 4
Comparing two collagen membranes for bone growth around dental implants
This study compares two types of collagen membranes used to help rebuild bone around a dental implant. If you need a single implant in the front of your mouth and a bone graft at the same time, this trial may help determine which membrane works best.
Geneva, Canton of GenevaAges 18–90 - NCT06724133Recruiting
Mouth bacteria and colon polyps study
This study looks at the bacteria in your mouth and how they might be linked to colon polyps. Researchers want to see if certain mouth bacteria affect the body's immune system and increase the risk of polyps.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT04119180RecruitingPhase 4
Sedation vs protective positioning for kids' dental work
This study compares two ways of keeping children comfortable and safe during dental treatment: sedation or a protective positioning approach. It may help find which method works better for comfort and safety for children who need fillings or other cavity repair.
Goiânia, GoiásAges 1–7 - NCT06721234Recruiting
Vein thickness and inflammation in Behcet disease
This study looks at how the thickness of the femoral vein wall and certain markers of inflammation relate to Behcet disease. It may help doctors better understand and monitor the condition.
SohagAges 19–80 - NCT07575997Recruiting
Testing Different Interdental Brushes for Gum Disease
This study compares different types of small brushes designed to clean between your teeth in adults with periodontal disease (a serious gum condition). The goal is to see which brush works best at improving gum health.
BrusselsAges 18–80 - NCT04766255RecruitingPhase 4
Comparing materials to thicken gum tissue around dental implants
This study compares three types of graft (tissue/covering materials) to help build up thicker gum and soft tissue around a dental implant. It may help improve appearance and protect the implant area when you have thin or missing gum tissue.
Sant Cugat del Vallès, BarcelonaAges 18 years+ - NCT07569432Recruiting
Understanding Immune Cells Around Dental Implants
This study examines how immune cells behave around dental implants that are failing or healthy. Researchers will take small tissue samples during your implant surgery to better understand why some implants develop problems and how to prevent or treat them in the future.
IstanbulAges 18 years+ - NCT07574827Recruiting
Candida Fungus and Gum Disease in Syrian Patients
This study looks at whether a common fungus called Candida albicans is linked to chronic periodontitis (advanced gum disease). Researchers will examine gum samples from Syrian patients to understand this connection and may help improve gum disease treatment.
HomsAges 18 years+ - NCT07573761Enrolling by invitation
Tooth Grafts to Help Bone Grow for Dental Implants
This trial tests whether material made from extracted teeth can help bone regrow in the jaw after tooth removal, so you can get a dental implant. Researchers will compare this new approach to see if it works better for rebuilding bone in areas where teeth need to be replaced.
Istanbul, UskudarAges 18–65 - NCT07576439Recruiting
Gum grafting for receding gums
This study tests a gum grafting procedure to cover exposed tooth roots caused by receding gums. It aims to see if the width of the attached gum affects how well the graft works. If you have receding gums and are healthy, you might be a candidate.
Rohtak, HaryanaAges 18–60 - NCT07577232Recruiting
Ultrasound imaging for diagnosing throat abscesses
This trial tests whether using ultrasound (sound wave imaging) through the mouth helps doctors better diagnose a throat abscess—a pocket of infection near the tonsil. The goal is to see if this imaging method improves diagnosis accuracy and treatment decisions.
CopenhagenAges 18 years+ - NCT07576582Recruiting
Mud therapy for jaw joint pain
This trial tests whether a special mud treatment (peloid therapy) can reduce jaw joint pain and improve function in people with temporomandibular joint disorder. It is a non-drug approach that may help those who have had jaw pain for at least 4 weeks.
Uşak, MerkezAges 18–65 - NCT07575347Recruiting
Gum Disease and Rare Kidney Disorders Study
This study explores whether people with certain rare kidney diseases or chronic kidney problems have more gum disease than others. Researchers will examine your teeth and gums to understand the connection and help improve care for people with kidney conditions.
BucharestAges 18 years+ - NCT07574606Recruiting
Soft Tissue Coverage for Zygomatic Implants in Jaw Bone Loss
This study compares two surgical methods to cover zygomatic implants (special anchor posts for teeth) in patients with severe jawbone loss. Researchers will measure how much soft tissue (gum and fat) builds up over the implants to see which method produces better, longer-lasting results.
Cairo, New CairoAges 18 years+ - NCT05356806Recruiting
Tracking gum inflammation around implants after gum disease treatment
This study looks at how often gum inflammation (peri-implant mucositis) happens around dental implants in people who previously had gum disease and are now in maintenance care. The results may help clinicians spot risk earlier and improve oral care around implants.
MadridAges 18 years+ - NCT05451251RecruitingPhase 1
Deep brain stimulation for severe trigeminal nerve pain
This trial tests whether deep brain stimulation can reduce intense facial pain from trigeminal neuralgia when medicines and prior procedures have not helped. You may be eligible if you’re an adult with a specific MRI finding near the trigeminal nerve pathway.
Sherbrooke, QuebecAges 18 years+ - NCT06723678Recruiting
Bone changes around implants with All-on-Four technique
This trial tests a special technique called 'All-on-Four' for people who need full-arch dental implants. It looks at how the bone around the implants changes over time. If you are in good general health and have a healthy jawbone, this study might help you understand if this approach works well for you.
Cairo, Nasr CityAges 50–65 - NCT07562100Recruiting
AI-Powered Exercise Program for Oral Cancer Patients Returning to Work
This study tests a smartphone-based exercise and wellness program designed to help people recently diagnosed with oral cancer prepare their body and mind before treatment, with the goal of helping them return to work faster and more safely. Researchers will track whether the program improves recovery and reduces healthcare costs.
TaipeiAges 20–70 - NCT06733948RecruitingPhase 2
Dental stent to protect taste during NPC radiation
This trial tests whether a custom-fitted dental stent (like a mouthguard) can help protect your sense of taste during radiation and chemotherapy for nasopharyngeal cancer. If you qualify, you'll receive either standard care or the stent, and your taste changes will be tracked.
SingaporeAges 21–100 - NCT06732622Recruiting
Laser Acupuncture for Bell's Palsy
This trial tests laser acupuncture as a needle-free treatment for Bell's palsy (sudden facial weakness). It might help people with moderate to severe symptoms who start treatment within 8 weeks of onset.
Beijing, Beijing MunicipalityAges 18–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.