Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,057 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 381
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University52
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California39
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,057 total
- NCT06736964Enrolling by invitation
Testing new fillings for gum-line cavities in high-risk adults
This study tests how well two newer, tooth-friendly filling materials work for cavities at the gum line in people who are prone to tooth decay. If you need a couple of these fillings, this trial could help restore your teeth and protect them from future cavities.
CairoAges 25–45 - NCT07289932Enrolling by invitation
Peptide vs fluoride varnish for white spots on teeth
This study compares a new peptide treatment to a standard fluoride varnish for reversing small white spots on teeth (early cavities) in teens and young adults. You’ll receive one treatment on one side of your mouth and the other treatment on the other side, and we’ll see which works better.
CairoAges 15–25 - NCT06912451Recruiting
Sport mouthguards: Preventing dental injuries
This is a study looking at different types of sport mouthguards to see which ones best protect teeth during sports. You can join if you are 7 to 30 years old, play sports at least twice a week, and have healthy teeth and gums.
Rio de Janeiro, Rio de JaneiroAges 7–30 - NCT07740265Recruiting
Scanning methods for accurate jaw implants
This study compares different dental scanning techniques to see which one helps make more accurate replacement teeth for people without any natural teeth. It aims to improve how well permanent implants and their attachments fit.
Tanta, Gharbia GovernorateAges 40–60 - NCT06910579RecruitingPhase 2/Phase 3
Oxygen gel for mouth sores
This study tests a special oxygen gel to treat canker sores (small, painful mouth ulcers). If you have a single small sore and are generally healthy, this trial might help it heal faster.
Al Sherouk City, Cairo GovernorateAges Any age - NCT06890988Recruiting
Dental team study to help end HIV epidemic
This trial tests if training dental teams (dentists, hygienists, assistants, navigators) can help end the HIV epidemic by offering HIV testing and prevention in dental visits. You may be able to join if you work in a dental practice that is part of this study.
New York, New YorkAges 18 years+ - NCT06891313Recruiting
One stage ridge splitting in the lower jaw
This trial tests two techniques for widening a narrow jawbone so dental implants can be placed, all in one surgery. It is for people who have lost at least one tooth and have a bone width between 3 and 5 mm.
CairoAges 20–48 - NCT07740278Recruiting
3D-printed dentures for people without teeth
This study tests whether the way 3D-printed dentures are made affects how they fit. It aims to improve comfort and function for people who have no teeth and need a complete upper denture.
Tanta, Gharbia GovernorateAges 50–70 - NCT06892041Recruiting
MRI study for jaw muscle pain
This trial uses a special MRI scan to measure jaw muscle pain. It aims to better understand this condition and may help improve future treatments.
New York, New YorkAges 18–65 - NCT06755034Recruiting
Single implant to hold lower denture on preferred chewing side
This study tests whether a single dental implant placed in the canine area of your preferred chewing side can better stabilize your lower denture. It may be an option if you are at least 60 years old, have full upper and lower dentures that fit well or can be adjusted, and have healthy jawbone in the front area.
Geneva, Canton of GenevaAges 60 years+ - NCT06892184Recruiting
How the dentist talks during numbing injections
This study tests whether the way your dentist communicates with you during a numbing shot (para-apical anesthesia) affects your pain and comfort. It may help find the best way to talk to patients during dental procedures.
Clermont-FerrandAges 18 years+ - NCT06746935Recruiting
Rebuilding thin jawbone for dental implants after failed graft or implant
This trial tests a method to rebuild thin jawbones so they can support dental implants. It is for people who have lost a tooth and have had a previous implant or bone graft that didn't work.
CairoAges 20–48 - NCT06880094Recruiting
Genetic study of complex or inherited cleft lip and palate
This study uses a new genetic test called Optical Genome Mapping to look for hidden genetic causes of cleft lip or palate that are syndromic, complex, or run in families. It may help find answers for people who haven't gotten a genetic diagnosis yet.
AmiensAges Any age - NCT07410780Recruiting
Pain after root canal with two different sealers
This trial compares two types of root canal filling materials—bioceramic and calcium hydroxide—to see which one causes less pain after the procedure. If you have a tooth with a live but inflamed nerve, you may be able to join.
Rawalpindi, Punjab ProvinceAges 18–40 - NCT06863051Recruiting
Comparing two types of fibrin for dental implant success
This trial tests whether a special blood-based bandage (albumin platelet-rich fibrin) or a different type (leukocyte-platelet-rich fibrin) helps a dental implant heal better in the lower jaw. It may be an option if you need an implant for a back tooth that can't be saved.
Kafr ash Shaykh, KafrelsheikhAges 18–45 - NCT07411092Recruiting
3D-printed expander vs. traditional expander for widening the upper jaw in teens
This trial compares a new 3D-printed expander with a standard one to widen the upper jaw in teenagers. It aims to see if the newer device works better or is easier to tolerate.
Cairo, Cairo GovernorateAges 12–17 - NCT06853639Recruiting
Oral health study for USP students
This trial looks at the oral health of current and former students at the University of São Paulo. It may help understand how to better support dental care in this group.
São PauloAges 18–60 - NCT06845449Enrolling by invitation
Screws vs bone grafts for horizontal jaw ridge repair
This trial compares using small screws or a ring-shaped bone graft to rebuild a narrow upper jaw ridge so dental implants can be placed. It is for people who need a simple horizontal bone build-up in the front of the upper jaw.
Beni-seufAges 18 years+ - NCT06831214Recruiting
Bone growth with collagen membrane graft for jaw atrophy
This trial studies a new technique to help build up bone in the upper jaw (maxilla) that has become thin. It uses a special membrane and graft material to encourage bone growth, which may help people who need dental implants.
CairoAges 18–60 - NCT06827665RecruitingPhase 1/Phase 2
Dentin Bone Graft for Jawbone Preservation After Tooth Extraction
This trial tests a new type of bone graft made from donated teeth to help preserve the jawbone after multiple teeth are pulled. It aims to see if this natural material helps the bone heal better than standard treatments.
AmmanAges 18–60 - NCT06822127Recruiting
Simulating face soft tissue changes after jaw surgery
This trial uses computer simulations to predict how your facial soft tissues will change after corrective jaw surgery. It aims to make the surgical planning more accurate and help you see possible outcomes beforehand.
AnnecyAges 18 years+ - NCT02874599Recruiting
Dental resin material study with body monitoring
This study checks how safe and “compatible” resin-based dental materials are, by monitoring you before and after dental work. It may help scientists better understand any effects these materials could have on the body.
LeuvenAges 18 years+ - NCT06808724Recruiting
Effect of implant surface treatment on stability
This trial compares how different surface treatments on dental implants affect their stability. It is for people who need implants in both upper premolar/molar areas and have healed enough bone without grafts.
Trieste, TSAges 18 years+ - NCT06806202RecruitingPhase 2
Warm vs. standard numbing medicine for tooth injections
This trial tests if warming the numbing medicine before injecting it into the jaw makes the numbing work better for people with a painful tooth infection. If you have a bad toothache in a lower molar and need a dental procedure, this study might help make the numbing more effective.
Rawalpindi, Punjab ProvinceAges 18–50
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,057 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,953 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.