Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07445555Recruiting
Gum Recession Study: Braces vs. No Braces
This study looks at gum recession (when gums pull away from teeth) in adults, comparing those who had braces in the past to those who did not. It aims to understand if orthodontic treatment affects gum health.
LeuvenAges 18 years+ - NCT07453147Recruiting
Gum graft surgery for multiple teeth with recession
This study compares two ways of doing a gum graft surgery to cover exposed tooth roots. It may help patients who have gum recession on multiple teeth and want a less invasive treatment.
Liège, LiègeAges 18 years+ - NCT07445516Recruiting
Bite adjustment for TMD: long-term follow-up
This trial follows up with people who previously had a dental bite adjustment (occlusal equilibration) for TMD (jaw or face muscle/joint pain). It compares their long-term results with a group that received a 'sham' (fake) procedure.
Santiago de Compostela, A CoruñaAges 18–85 - NCT07449806Recruiting
Comparing two bone graft materials for front tooth implants
This trial looks at two different types of bone graft material used when placing a dental implant right after removing a front tooth. It aims to see which one better maintains the thickness of the bone on the lip side of the implant.
AlexandriaAges Any age - NCT07448571Recruiting
Testing i-PRF for better root canal retreatment healing
This study tests whether using a special platelet-rich concentrate (i-PRF) during a root canal retreatment can help heal infection at the tip of the root better than standard retreatment alone. It is for adults with a previously treated upper front tooth that now shows signs of infection on X-ray.
IstanbulAges 18–50 - NCT06031298RecruitingPhase 4
Healing times for preserving jawbone after tooth extraction
This study tests if using a special type of bone graft made from a patient's own tooth can help preserve the jawbone after a tooth is removed. It compares different healing times to see which works best for keeping the bone strong for a future dental implant.
CairoAges 20–50 - NCT06806202RecruitingPhase 2
Warm vs. standard numbing medicine for tooth injections
This trial tests if warming the numbing medicine before injecting it into the jaw makes the numbing work better for people with a painful tooth infection. If you have a bad toothache in a lower molar and need a dental procedure, this study might help make the numbing more effective.
Rawalpindi, Punjab ProvinceAges 18–50 - NCT06805448RecruitingPhase 1/Phase 2
Stem cell treatment for dry mouth in Sjögren's disease
This trial tests if injecting fat-derived stem cells into the salivary glands can help relieve dry mouth in people with Sjögren's disease. It aims to improve saliva flow and reduce discomfort.
CopenhagenAges 18 years+ - NCT06806605Recruiting
3D computer planning for jaw surgery
This trial tests whether a full 3D computer-assisted approach helps better diagnose and correct jaw and facial deformities during orthognathic surgery. It may benefit patients who need surgery to realign their jaws.
Bologna, Emilia-RomagnaAges 18–60 - NCT07439614Recruiting
Comparing two ways to clean a dead nerve during a root canal
This trial compares two different ways to clean a molar tooth during a root canal when the nerve is dead. The goal is to find which method is better at removing infection without causing discomfort.
Buffalo, New YorkAges 18–70 - NCT07441681RecruitingPhase 3
Comparing radiation plus targeted therapy vs standard chemo for head and neck cancer
This trial compares two treatments for advanced head and neck cancer in patients who cannot take the drug cisplatin. One group gets radiation plus a targeted drug called cetuximab, the other gets radiation plus standard chemotherapy. The goal is to see which approach works better and is safer for people who are not candidates for cisplatin.
Beverly Hills, CaliforniaAges 18 years+ - NCT07440303Recruiting
Comparing two gum graft techniques for lower jaw
This trial tests whether a new type of gum graft (Star Matrix) works as well as the standard gum graft (autogenous graft) for increasing gum width on both sides of the lower jaw. It may help patients who need gum augmentation and want a potentially less invasive option.
Boston, MassachusettsAges 20–80 - NCT07443410Recruiting
Probiotics for gum disease treatment
This trial tests whether taking pre- and probiotics alongside non-surgical gum treatment improves healing and reduces harmful bacteria. It may help people with advanced gum disease (stage III or IV periodontitis).
Heidelberg, Baden-WurttembergAges 18 years+ - NCT07436650Recruiting
Laser therapy for mouth sores in children having a bone marrow transplant
This study tests whether a special kind of laser therapy (called high-level laser therapy) can help heal severe mouth sores in children who are having a bone marrow transplant. If your child has painful mouth sores from the transplant, this treatment might reduce pain and speed healing.
Cairo, Cairo GovernorateAges Up to 18 years - NCT07439289Recruiting
Turtle help during dental visit to reduce child's anxiety
This study uses a calm, supervised turtle interaction to help children feel less anxious during a routine dental visit. It may be a good fit if your child is ages 6-10, generally healthy, and not afraid of turtles.
Iğdır, IğdırAges 6–10 - NCT07441148Recruiting
Digital vs. parent-led toothbrushing for kids
This study compares two ways of teaching children how to brush: with a digital tool or by having a parent show them. It looks at how well they brush and how their teeth look after brushing.
Los Angeles, CaliforniaAges 3–6 - NCT07439679Recruiting
Anxiety Before Double Jaw Surgery and Your Recovery
This trial studies how anxiety before double jaw surgery affects your body during surgery and your recovery (pain, swelling, and ability to open your mouth). Researchers will use a simple anxiety questionnaire to see if feeling anxious changes your surgical experience.
IstanbulAges 18 years+ - NCT07437417Recruiting
Recession coverage with a new gum graft material
This study tests a new volume-stable gum graft material to cover exposed tooth roots caused by receding gums. It is for healthy patients seeking treatment for gum recession on front teeth.
BernAges 18 years+ - NCT07436039Recruiting
Toothpaste for sensitivity and color improvement in MIH
This study tests a new toothpaste containing nano-hydroxyapatite, a substance that mimics natural enamel, to see if it can help reduce sensitivity and improve the color of teeth affected by Molar-Incisor Hypomineralization (MIH)—a condition where first molars and sometimes front teeth have white, yellow, or brown spots. It is for children aged 6 to 12 who have these spots on at least one permanent molar or baby molar.
JeddahAges 6–12 - NCT07436091Enrolling by invitation
Using pig skin to improve gum thickness around dental implants
This study tests a material made from pig skin (porcine dermis) to see if it can help make the gum tissue thicker and healthier around dental implants. It may be a good option for people who already have an implant in a back tooth area and need more gum tissue.
PortoAges 18 years+ - NCT07437924Enrolling by invitation
Bruxism and pelvic floor health in young women
This study looks at whether teeth grinding (bruxism) is linked to pelvic floor muscle function in young women. If you are 18–30 and either grind your teeth or do not, you may help researchers understand this connection.
KonyaAges 18–30 - NCT07443917Recruiting
Study of Treponema Parvum in gum disease patients
This study looks for a specific bacteria called Treponema Parvum in the gums of people with periodontitis (severe gum disease). It aims to understand if this bacteria is linked to gum disease and could help improve future treatments.
BaghdadAges 30 years+ - NCT06707909RecruitingPhase 4
Vitamin K2 gel for bone healing after tooth extraction
This study tests if applying a vitamin K2 gel directly into the tooth socket after extraction can help rebuild healthy bone faster. It is for people who need to have a single-rooted lower tooth removed.
Cairo, Cairo GovernorateAges 18–80 - NCT06808373Recruiting
Hypnosis for gum disease treatment
This study tests whether hypnosis can help with gum disease treatment. It is for adults who have chronic gum disease but are otherwise healthy.
AfyonkarahisarAges 20–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.