Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT05763420Enrolling by invitation
Testing a bioceramic root-canal sealer in adult molar teeth
This trial tests how well a bioceramic sealer works for primary (first-time) root canal treatment in permanent back teeth. It may help by improving the chances that the treated tooth heals and stays functional.
Janūb as Surrah, Hawalli GovernateAges 18–65 - NCT04920136Recruiting
Tissue graft to strengthen gum around teeth or implants
This study tests a gum-repair approach that may help create more durable, firm gum tissue around teeth or dental implants. If your area lacks “keratinized” (firmer, protective) gum tissue, this could improve comfort and stability after dental work.
Birmingham, AlabamaAges 18–99 - NCT07709195RecruitingPhase 2
Chlorophyllin to reduce mouth sores from radiation before transplant
This trial tests whether taking chlorophyllin can reduce mouth sores caused by total body radiation given before a stem cell transplant. The goal is to make the treatment easier to tolerate.
Navi Mumbai, MaharashtraAges 12–65 - NCT07716254Recruiting
Dental cavity risk quiz study for Egyptian adults
This study tests a new questionnaire to see how well it can predict your risk of cavities. You will answer questions about your teeth and habits, and your answers will be compared with a dentist's exam.
Giza, Sixth of OctoberAges 18–65 - NCT07166575Recruiting
Trapezius muscle changes after physiotherapy in oral cancer
This trial tests whether physical therapy can help improve shoulder muscle movement in people recently treated for oral cancer. It focuses on patients with scapular dyskinesis, a condition where the shoulder blade doesn't move properly.
TaipeiAges 20–65 - NCT07180537Recruiting
Health course for joint and mood conditions
This study tests an online health course that helps improve diet and self-care to support cell health and wellbeing. It is for people with certain rheumatological conditions like rheumatoid arthritis, lupus, or psoriatic arthritis, who also have mood concerns.
Iowa City, IowaAges 18–100 - NCT07603934RecruitingEarly Phase 1
Testing Medications Inside Root Canals to Reduce Pain
This study tests different medications placed inside a tooth's root canal during treatment to see which one best reduces pain afterward. If you have a tooth with a dead nerve (necrotic pulp), this trial might help determine the best way to manage your pain during the healing process.
Cairo, Cairo GovernorateAges 18–40 - NCT01306084Recruiting
Study of viral infections in healthy and immune-compromised people
This trial studies how viruses affect the body, and how the immune system responds, in both healthy people and people with weakened immunity. It may include people who currently have a suspected or recent viral infection, close contacts, people around the time of a viral vaccine, and healthy adults used for comparison.
Bethesda, MarylandAges 6 months–120 years - NCT05492266Recruiting
Breathing muscle training for nasal speech in children
This trial tests whether strengthening the muscles you use to breathe out can help children ages 5–17 who have too much nasal sound in their speech. If it works, it could reduce the need for surgery.
Pittsburgh, PennsylvaniaAges 5–17 - NCT07714265Recruiting
Gum thickening around dental implants: comparing three methods
This trial compares three techniques to thicken gum tissue around a single dental implant in the back of the lower jaw. It may help if you have thin gums and need a dental implant.
CairoAges 20 years+ - NCT07710391Recruiting
3D printed brace for children with underbite
This trial tests a special 3D-printed brace to fix underbite in children aged 8-13 who still have growing upper jaws. The brace encourages the upper jaw to grow forward and corrects the bite.
BaghdadAges 8–13 - NCT05172245RecruitingPhase 1
Testing a new drug added to chemoradiation for head and neck cancer
This study tests whether adding a new targeted drug called ipatasertib to standard chemoradiation can improve treatment for people with locally advanced head and neck cancer. Ipatasertib may help block a protein that helps cancer grow, possibly making the standard therapy more effective.
Tampa, FloridaAges 18 years+ - NCT07711431Recruiting
Connection between gum disease and ongoing neck pain
This study looks at whether there is a link between gum (periodontal) disease and long-term neck pain without a clear cause. If you are between 30 and 55, have most of your own teeth, and don't take regular pain medicine, you may be able to help doctors understand this connection.
Niğde, Niğde ProvinceAges 30–55 - NCT07688421Enrolling by invitation
Short 3D-printed implants for back jaw teeth: 3-year study
This trial tests shorter implants made with 3D-printing for replacing missing teeth in the back of the mouth. Researchers will check how well they work over 3 years using X-rays.
Guarulhos, São PauloAges 18 years+ - NCT06723106Enrolling by invitationPhase 1
Long-term safety study of RAY121 for immune conditions
This study is for people who already took RAY121 in a previous trial and did well. It tests whether continuing the treatment is safe and effective over a longer period. The goal is to manage chronic immune conditions.
Camperdown, New South WalesAges 18–85 - NCT07506018Recruiting
MucoLock for mouth pain caused by stomatitis
This study tests a new mouth rinse, MucoLock, to see if it can help people with severe mouth pain (stomatitis). If you have burning or painful mouth sores that rate very high on a pain scale, this trial may offer a new treatment option.
Miami, FloridaAges 18 years+ - NCT07709286RecruitingPhase 1
New tooth stain treatment compared to standard acid microabrasion
This study tests a new product called Antivet to see if it removes tooth stains better than regular acid treatments. It may help people with mild to moderate tooth discoloration.
Badr, Cairo GovernorateAges 16–50 - NCT07707063RecruitingPhase 4
Gum disease treatment with I-PRF, iodine, or laser in smokers and non-smokers
This trial tests whether adding I-PRF (a concentrate from your own blood), povidone-iodine, or laser treatment to standard deep-cleaning helps smokers and non-smokers with gum disease. You may qualify if you have moderate to severe gum disease with at least one bleeding pocket in each area of your mouth.
Tunis, Mont FleuryAges 18 years+ - NCT07706985RecruitingPhase 3
Immunotherapy for advanced nasopharyngeal cancer
This trial tests a new combination of chemotherapy and immunotherapy drugs for advanced nasopharyngeal cancer that has not spread to distant parts of the body. The goal is to see if this approach works better than standard treatment.
Guangzhou, GuangdongAges 18–70 - NCT06662058Recruiting
Remote hearing test for head and neck cancer patients on cisplatin or radiation
This study tests a remote hearing test to monitor hearing changes in patients with head and neck cancer getting cisplatin chemotherapy and/or radiation. The goal is to catch hearing loss early so treatment can be adjusted.
Atlanta, GeorgiaAges 18 years+ - NCT07669792Recruiting
Bone shell vs fabric for narrow lower jawbone
This study compares two ways to rebuild a narrow lower jawbone so you can get dental implants. One method uses a special bone shell technique, and the other uses a strong fabric material. Your doctor will check if your jawbone is wide enough and healthy for this surgery.
CairoAges 18–65 - NCT07568249Recruiting
How full arch dental implants affect your quality of life
This study looks at how getting a full set of dental implants (for a whole upper or lower jaw) affects your oral health and quality of life. Researchers want to see how your experience changes from before treatment through recovery.
Lisbon, Lisbon DistrictAges 18 years+ - NCT07703176Recruiting
Testing a new tooth filling in children's first molars
This study compares how well a newer filling material (Cention-N) works in children's permanent back teeth that have cavities. It's for healthy children ages 8 to 10 who have cavities in both lower or both upper first molars.
Minya, Asyut GovernorateAges 8–10 - NCT05799144RecruitingPhase 2
Pembrolizumab plus investigational HPV drugs for throat cancer
This Phase 2 trial studies pembrolizumab (an immune therapy) combined with investigational treatment(s) pBI-11 and TA-HPV for advanced or recurrent oropharyngeal cancer that is HPV-positive and has certain immune marker levels (PD-L1 CPS ≥ 1). It may help your immune system better attack cancer.
Birmingham, AlabamaAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.