Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT07736495RecruitingPhase 2/Phase 3
Alpha-lipoic acid for chemo mouth sores in colorectal cancer
This trial tests if a supplement called alpha-lipoic acid (ALA) can protect against painful mouth sores caused by chemotherapy (FOLFOX-6) in people with colorectal cancer. If you are starting FOLFOX-6 for the first time for colorectal cancer, this study may help reduce treatment side effects.
CairoAges 18 years+ - NCT07734987Recruiting
Root tip surgery accuracy with a 3D-printed guide
This trial tests whether using a custom 3D-printed guide helps make root-end surgery more accurate and improves healing. It may be right for you if you have an infected or damaged root tip that needs surgery.
Ho Chi Minh CityAges 16 years+ - NCT04198766RecruitingPhase 1/Phase 2
New OX40 immunotherapy for advanced solid tumors
This trial tests a new immunotherapy drug (INBRX-106) alone or with Keytruda (pembrolizumab) for adults with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can help the immune system fight cancer.
Duarte, CaliforniaAges 18 years+ - NCT07590960Enrolling by invitation
Gum Grafting Surgery for Lower Front Tooth Root Coverage
This study tests a surgical technique to cover exposed tooth roots on the inside of your lower front teeth using gum tissue from the roof of your mouth. It may help reduce sensitivity and improve the appearance of receded gums.
Pittsburgh, PennsylvaniaAges 18–65 - NCT05727761RecruitingPhase 2
Pioglitazone plus metformin for high-risk mouth lesions
This trial studies whether a two-medicine diabetes drug combination can reduce or control risky early changes in certain mouth and throat lesions. You may be asked for small tissue samples (biopsies) before and after 12 weeks to see how the lesions respond.
Minneapolis, MinnesotaAges 18 years+ - NCT07732647Enrolling by invitation
Immediate tooth replacement with a temporary implant crown
This trial tests placing a temporary crown on a dental implant right after removing a front tooth. It may be an option if you need a front tooth replaced and have good overall health and oral hygiene.
Ann Arbor, MichiganAges 18 years+ - NCT07718061Recruiting
Bacteria in dental plaque with orthodontic retainers
This trial studies the types of bacteria found in dental plaque from people who have orthodontic retainers after braces. It aims to understand how retainers affect oral bacteria.
MurciaAges 18–40 - NCT07727200Recruiting
Tooth color and enamel loss in children with MIH
This study looks at how the color of white, yellow, or brown spots on children's first permanent molars (the back teeth that come in around age 6) relates to the breakdown of the enamel (the outer layer). It aims to help dentists better identify and treat this condition early.
Basel, Canton of Basel-CityAges 5–8 - NCT06543823Recruiting
New bandage for throat surgery pain relief
This trial tests a special wound dressing (SUPRATHEL 250) placed inside the throat after tonsil removal. It aims to see if it helps throat wounds heal faster with less pain.
Stuttgart, Baden-WurttembergAges 18 years+ - NCT07727044Recruiting
Color and sensitivity of MIH teeth in children
This study looks at whether the color of spotted first permanent molars (caused by MIH) is linked to tooth sensitivity. It compares children with MIH to children with healthy teeth to understand the connection between color and pain.
Basel, Canton of Basel-CityAges 5–8 - NCT07726199Recruiting
Neck treatment approaches for oral cancer without neck spread
This study compares different ways to treat the neck in patients with early-stage oral cancer that hasn't spread to the neck. The goal is to find which approach works best while keeping side effects low.
Kolhāpur, MaharashtraAges 21–75 - NCT07725913Recruiting
Gel for gum treatment after deep cleaning
This trial tests if a special gel placed in the gums after deep cleaning helps treat periodontitis (advanced gum disease). You may qualify if you have gum pockets of 5mm or deeper that bleed when probed.
Bologna, BOAges 18 years+ - NCT07725393Recruiting
Pomegranate gel for moderate to advanced gum disease
This study tests a gel made from pomegranate peel extract placed under the gums, along with standard deep-cleaning treatment, for people with moderate to advanced gum disease. It may help reduce gum inflammation and pocket depth naturally.
Cairo, Cairo GovernorateAges 30–60 - NCT07711626Recruiting
Foot massage and ear stimulation for head and neck cancer symptoms
This study tests whether foot massage (reflexology) and a mild nerve-stimulation device on the ear can help reduce side effects during chemotherapy and radiation for head and neck cancer.
Hualien CityAges 30–75 - NCT07722715Recruiting
AmbiJet treatment for gum disease around dental implants
This study tests a device called AmbiJet to treat gum infections around dental implants. It may help people with early to moderate bone loss caused by implant-related gum disease.
RomnyAges 18–65 - NCT07723612Recruiting
Spirulina for mouth ulcers from radiation or other causes
This trial tests if spirulina supplements can prevent or heal mouth ulcers caused by radiation therapy or other conditions like canker sores. Participants take spirulina and are monitored to see if their ulcers improve.
Yiwu, ZhejiangAges 18–100 - NCT06475300RecruitingPhase 2
BL-B01D1 plus immunotherapy for advanced lung and throat cancers
This trial tests a new combination treatment (BL-B01D1 plus a PD-1 inhibitor) for people with advanced lung cancer or nasopharyngeal cancer. It aims to see if the combination is safe and effective for patients whose cancer has not responded to earlier treatments.
Guangzhou, GuangdongAges 18 years+ - NCT06371417RecruitingPhase 1
Testing RAY121 for several immune diseases (RAINBOW trial)
This trial tests a new medicine called RAY121 (an antibody) for people with certain autoimmune diseases. It aims to see if RAY121 is safe and how the body handles it. If you have one of these conditions and meet the basic health requirements, you might be able to join.
Orange, CaliforniaAges 18–85 - NCT07718620Recruiting
HPV-related throat cancer radiation trial
This trial tests whether radiation or chemoradiation works well for HPV-positive throat cancer. It may be an option if you have this type of cancer and are getting or have already had surgery.
Brno, Czech RepublicAges 18 years+ - NCT07718932Recruiting
Healing gel for wisdom tooth extraction recovery
This trial tests a regenerative gel placed in the socket after wisdom tooth removal to improve healing. It may reduce pain, swelling, and speed up recovery.
ThessalonikiAges 18–35 - NCT07712939RecruitingPhase 1
Study of CND319 for rheumatic diseases
This study tests a new drug called CND319 in healthy volunteers and people with rheumatoid arthritis or Sjögren's disease. The goal is to see if it is safe and how the body responds to it.
Melbourne, VictoriaAges 18–65 - NCT05973656Recruiting
Study how alcohol affects the risk of mouth cancer
This study looks at how a breakdown product from alcohol (acetaldehyde) may play a role in oral (mouth) cancer. It may help researchers understand who is more affected by alcohol and why.
Minneapolis, MinnesotaAges 18–45 - NCT06798922RecruitingPhase 3
Flap-sparing radiation for mouth cancer after reconstructive surgery
This trial tests a special radiation technique for people who have had reconstructive surgery for oral cavity cancer. The goal is to see if we can spare the flap (the rebuilt tissue) from high radiation doses to improve healing and quality of life.
AmiensAges 18 years+ - NCT07124000Recruiting
T-DXd for advanced HER2-positive solid tumors
This trial is for people with advanced HER2-positive solid tumors (cancers that cannot be removed by surgery or have spread). It tests the drug T-DXd (also called Enhertu) when your doctor has already decided it's the right treatment for you and you have no other good options.
Birmingham, AlabamaAges 18–130
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.