Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,544
- Phase 2144
- Phase 384
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Head and Neck Cancer35
- Gingivitis34
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Maryland21
- Massachusetts21
- Florida20
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06808724Recruiting
Effect of implant surface treatment on stability
This trial compares how different surface treatments on dental implants affect their stability. It is for people who need implants in both upper premolar/molar areas and have healed enough bone without grafts.
Trieste, TSAges 18 years+ - NCT06809829Recruiting
Doxycycline gel sponge for front tooth implants
This trial tests whether a special sponge containing doxycycline (a type of antibiotic) placed around a new implant in the front of the mouth helps it heal better. It's for people who need a single tooth replaced in the upper front area.
Kafrelsheikh, KafrelsheikhAges 18–50 - NCT04567030Recruiting
AI tool to help improve gum treatment outcomes
This trial tests whether an artificial intelligence (AI) system can help plan and improve results of gum (periodontal) treatment. You may be a good match if you have diagnosed periodontal disease and enough healthy teeth.
Kaohsiung CityAges 35–65 - NCT06083649Recruiting
Dental education: AI vs. human counseling for gum disease
This trial compares two ways of teaching about dental care—AI-assisted education versus speaking with a counselor—to see which one helps people with gum disease better control plaque and improve treatment outcomes.
Kaohsiung CityAges 35–65 - NCT07426224Enrolling by invitation
Blood sugar screening for advanced gum disease patients
This trial checks if treating advanced gum disease at a specialist clinic can help find hidden high blood sugar and support you in managing your overall health.
StockholmAges 18 years+ - NCT07433322Recruiting
Preserving gum and bone after back tooth removal
This study tests a procedure to preserve the bone and gum after removing upper back teeth, which may help prepare the area for future dental implants.
Richmond, VirginiaAges 18 years+ - NCT07430670Recruiting
Gum healing with oral and tissue care after recession surgery
This study tests a special oral product and skin care along with gum surgery for people with gum recession on a lower front tooth. It looks at whether the product helps the healing process after adding a small piece of gum tissue.
Madrid, MadridAges 18 years+ - NCT07433920Recruiting
Comparing two methods for tooth implant with root shield
This trial tests whether using a special blood and bone mixture (sticky bone) around a saved tooth fragment helps heal better than using a blood clot alone, during same-day implant placement guided by a computer.
Kafr ash Shaykh, KafrelsheikhAges 18–45 - NCT07432165Recruiting
AI vs. Digital Design for Fixed Dental Prostheses
This study compares artificial intelligence (AI) versus conventional digital methods to design fixed dental prostheses like crowns and bridges. It may help improve how these replacements are created.
GizaAges 18–65 - NCT07429812Enrolling by invitation
Chitosan-Chlorhexidine Gel for Healing After Tooth Extraction
This trial tests a gel made from chitosan and chlorhexidine to see if it helps heal wounds faster after tooth removal in people with diabetes.
Al KharjAges 20–50 - NCT07433725Recruiting
Comparing 3D-printed vs. standard splints for teeth grinding and jaw pain
This trial compares a new 3D-printed splint with a standard acrylic splint for treating teeth grinding (bruxism) and jaw joint problems. Participants wear the splint at night for 3 months to see which type works better.
AnkaraAges 18–25 - NCT06574802Recruiting
Laser and air polishing for gum disease treatment
This study tests if a special laser and air polishing can help treat gum disease. It may offer a gentler, more effective way to clean below the gum line compared to standard scaling.
Beijing, Beijing MunicipalityAges 35–65 - NCT07419269Recruiting
Comparing donor vs. patient bone grafts for jawbone repair
This trial tests whether donated (allogenic) bone blocks work as well as your own bone to rebuild the jaw so dental implants can be placed. It's for people missing 1-4 teeth where the bone ridge is too thin.
Graz, StyriaAges 18 years+ - NCT07424742Recruiting
Toothless upper jaw implant study without bone grafts
This trial tests a way to place dental implants in the upper jaw where bone is thin (4-6 mm height) without needing a bone graft. It uses special self-tapping implants to lift the sinus floor gently through the implant site.
Sanaa, Sanaa GovernorateAges 18–80 - NCT07424716Recruiting
Bone healing with platelet-rich fibrin after cyst removal
This trial tests whether a natural blood concentrate (PRF) helps jawbone heal better after removing a dental cyst. It may improve recovery and reduce the need for additional bone grafting.
Sanaa, Sanaa GovernorateAges 18–80 - NCT07420777Recruiting
3D-printed aligners for treating an open bite
This study tests whether new 3D-printed shape-memory aligners can effectively fix a mild-to-moderate open bite (when front teeth don't touch when you bite down). It may be a good option if you are between 18 and 35, generally healthy, and have a mild open bite with fairly straight teeth.
Erbil, Erbil GovernorateAges 18–35 - NCT07424846RecruitingPhase 2/Phase 3
Xylitol gum to prevent gum disease and early birth
This trial tests if chewing xylitol gum during pregnancy can reduce gum disease and preterm birth. You would chew gum after meals and attend dental visits and follow-ups.
LilongweAges Any age - NCT07418684Recruiting
Comparing two versus four 3D miniplates in jaw surgery
This trial compares using two custom titanium miniplates versus four to fix the upper jaw after surgery to correct jaw and teeth misalignment. The goal is to see which approach provides better stability and healing.
CairoAges 18–40 - NCT07421960Recruiting
Periodontitis and sleep quality study
This study looks at how gum disease (periodontitis) might be related to sleep quality. It compares people with healthy gums to those with gum disease.
Istanbul, IstanbulAges 18–65 - NCT07424820Enrolling by invitation
Magnetic mallet vs. drilling for dental implants in soft jawbone
This trial compares two techniques for placing dental implants in the upper jaw where the bone is very soft (type D4). It tests whether a magnetic mallet (a tool that uses gentle taps) is better than conventional drilling for placing implants in this challenging bone type.
Mosul, MosulAges 20–60 - NCT06470217RecruitingPhase 2
Study of tirilizumab plus chemo for advanced oral cancer
This trial tests a combination of immunotherapy (tirilizumab) and two chemotherapy drugs (albumin-bound paclitaxel and cisplatin) for people with advanced but removable oral cancer. The goal is to see if this treatment shrinks the tumor before surgery and improves outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07414173RecruitingPhase 4
Mouthrinse for plaque and gum health
This study tests whether a special antimicrobial mouthrinse can reduce plaque buildup and improve gum health over 6 months. If you have early gum disease (gingivitis) and are generally healthy, this trial may be a good fit.
SchenefeldAges 18–70 - NCT07408778Recruiting
One vs. two implants for lower dentures
This trial compares using one implant versus two implants to help keep your lower denture in place. If your upper denture fits well but your lower denture is loose, you may be able to get a more stable solution.
Jenin, PalestineAges 40 years+ - NCT07409896Recruiting
Comparing two numbing shots for painful lower first molars
This study compares two numbing methods for severe tooth pain (pulpitis) in a lower first molar. If you have a tooth that needs a root canal and the pain lingers after cold, this trial may help determine which anesthetic works better for you.
Rawalpindi, Punjab ProvinceAges 18–55
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,741 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.