Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT05899933Recruiting
Compare two surgical treatments for peri-implantitis
This study compares two different surgical approaches to treat peri-implantitis, an infection/inflammation around dental implants. You may be enrolled because you have a qualifying implant and meet health and medication requirements.
AthensAges 18–80 - NCT05904301Recruiting
Registry for autoimmune and autoinflammatory disease patients
This study builds a nationwide list (registry) of people with certain autoimmune or inflammation-related illnesses. It helps researchers understand these diseases better over time, which can guide future care.
YerevanAges Any age - NCT05906810Recruiting
Treating gum inflammation around implants to improve blood vessel function
This study looks at whether non-surgical gum treatment around dental implants can improve early problems in blood vessel function. It includes people with implant gum disease, and also compares them with healthy people who do not have gum disease.
CataniaAges Any age - NCT05907161Recruiting
Low laser and hyaluronic acid for gum disease
This trial studies whether adding low-level laser treatment and hyaluronic acid can improve gum health when combined with regular non-surgical gum therapy. It may help reduce problems from more advanced gum disease without surgery.
LjubljanaAges 25–70 - NCT05907239Recruiting
Shock wave therapy for jaw muscle pain
This trial tests whether focused shock wave treatment can reduce chronic jaw pain caused by jaw muscle problems. You might qualify if you have moderate to severe temporomandibular (jaw) pain for at least 3 months.
São Paulo, São PauloAges 18 years+ - NCT05908682Recruiting
Study of ibrexafungerp safety during pregnancy
This study looks at what happens when ibrexafungerp is taken during pregnancy, including outcomes for the baby. You may join if you were exposed to this medicine during pregnancy (or very close to conception) and you agree to share information and complete study follow-up.
New Delhi, Vasant ViharAges birth+ - NCT05911750Recruiting
HPV study in men with Crohn’s or ulcerative colitis
This study looks at how common human papillomavirus (HPV) is in men with Crohn’s disease or ulcerative colitis and what it may mean for health. You would answer questions and provide biology samples so researchers can understand the link, if any, between HPV and bowel disease.
BarcelonaAges 18–79 - NCT05918510Recruiting
Blood and tumor study for virus markers in throat cancer
This study looks at virus-related markers and tiny gene regulators (microRNAs) in tumor tissue from people with certain throat cancers caused by human papilloma virus (HPV). It’s observational, meaning it does not change your treatment, but results may help doctors better understand these cancers and how they behave.
RomeAges 18 years+ - NCT05924373RecruitingPhase 2
Stem cell treatment for chronic gum disease defects
This Phase 2 trial studies whether injections of human dental pulp stem cells can improve chronic periodontitis (long-term gum disease) by helping repair damaged bone around teeth. If you have a specific type of bone defect and moderate gum pocket depth, you may be eligible and could benefit from a novel regenerative approach.
Beijing, BeijngAges 18–65 - NCT05924386Recruiting
Testing dental implants for jawbone change in full dentures
This study looks at how a specific implant connection (“OT bridge attachment system”) affects changes in the lower jawbone over time in people who have no teeth. You might benefit by getting a fixed All-on-Four style set of lower teeth, with close monitoring of your jawbone and fit.
CairoAges 40 years+ - NCT05927688Recruiting
Using patient reports to adjust treatment for autoimmune diseases
This study looks at whether doctors consider patient “electronic reports” (completed online/phone) when deciding how often to change treatment. It may help improve how well treatment plans match how patients feel over time.
StrasbourgAges 18 years+ - NCT05933889Recruiting
Study of robotic throat surgery for early oropharyngeal cancer
This study looks at how well different robotic surgery approaches work for people with early oropharyngeal squamous cell carcinoma (throat cancer). You may be asked for consent for extra tissue and imaging analysis to help researchers understand patterns related to outcomes.
LondonAges 18 years+ - NCT05938166Recruiting
Training foreign caregivers with an augmented reality system
This study tests whether an augmented reality (AR) training system can help foreign care workers learn how to provide care. It involves Indonesian caregivers training for caring for older adults in Kaohsiung, with tests based on the older adult’s ability to follow instructions.
Kaohsiung City, Sanmin DistAges 21–65 - NCT05941338RecruitingPhase 2
Tirelizumab plus chemotherapy before head and neck surgery
This Phase 2 trial tests tirelizumab combined with two chemotherapy medicines before surgery for certain head and neck squamous cell cancers. It aims to shrink the tumor and improve outcomes after the operation.
Guangzhou, GuangdongAges 18–65 - NCT05941741RecruitingPhase 3
Tested low-dose radiation plus cadonilimab for nasopharyngeal cancer
This Phase 3 trial studies whether adding low-dose radiation to cadonilimab (an immune therapy) can improve outcomes for people newly diagnosed with a specific type and stage of nasopharyngeal cancer. If you’re eligible, it may offer a new treatment approach and helps researchers confirm whether it works best.
Guangzhou, GuangdongAges 18–70 - NCT05941507RecruitingPhase 1/Phase 2
TROP2 antibody drug with anti–PD-1 for advanced solid tumors
This early-phase study tests an antibody-drug (an ADC) that targets TROP2, given by itself and together with an anti–PD-1 medicine. It’s for people with advanced solid cancers that have not responded to standard treatments, aiming to shrink tumors and improve control of the disease.
Los Angeles, CaliforniaAges 18 years+ - NCT05950581Recruiting
Twin-block braces with clear plates for jaw misalignment
This study tests a removable orthodontic device (twin-block with clear plates) to improve how the upper and lower jaws fit together in children. It may help if you have a specific “Class II” jaw pattern caused mainly by a lower jaw that sits back.
HamaAges 10–13 - NCT05955105RecruitingPhase 1/Phase 2
ILB-2109 plus toripalimab for advanced solid cancers
This Phase 1/2 study tests a combination medicine (ILB-2109) plus an immune therapy (toripalimab) in people with advanced solid tumors when standard treatments haven’t worked or aren’t available. It aims to find out if the treatment can shrink tumors and is safe enough to keep studying.
Jinan, ShandongAges 18–80 - NCT05956587RecruitingPhase 2
Testing two study drugs for advanced lung cancer and other tumors
This Phase 2 study tests a combination of two experimental medicines in people with advanced or metastatic solid cancers, including non-small cell lung cancer and nasopharyngeal cancer. It aims to see whether the drugs can shrink tumors and improve outcomes, while carefully checking safety and eligibility.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT05964387Recruiting
Silver fluoride treatment and local numbing for tooth cavities
This study tests whether applying silver diamine fluoride (a cavity-stopping liquid) changes how well local numbing works during dental treatment for certain tooth defects. It may help determine the safest and most comfortable way to treat weak, cavity-prone molars in children.
Ann Arbor, MichiganAges 6–11 - NCT05964699Recruiting
Gum surgery comparison with a minimally invasive flap
This trial compares a minimally invasive gum surgery method (using Emdogain MI) versus a more traditional approach for treating localized gum pockets. It may help people by promoting gum healing and improving gum “attachment” around the teeth.
Dallas, TexasAges 30–75 - NCT05965076Recruiting
Test glycine powder and a special brush for oral care
This trial studies whether using glycine powder and an angled implant brush helps keep dental implants healthy in people following the Columbus Bridge ProtocolTM. It may help by improving daily oral hygiene around implants and reducing implant problems.
TorinoAges Any age - NCT05968742Recruiting
Study of how gums respond to irritation
This study looks at how your gums react when exposed to a controlled irritant, comparing different gum response patterns. It may help researchers understand why gum inflammation happens and how to prevent it.
Seattle, WashingtonAges 18–35 - NCT05970965Recruiting
Teeth and gum study in children with Down syndrome
This study looks at how gums and inflammation work in children with Down syndrome by collecting and analyzing biological samples. It may help researchers understand gum health differences and improve future care.
Ivry-sur-SeineAges 3–12
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.