Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06110143Recruiting
Gum health and pregnancy complications study
This study looks at how gum disease (periodontitis) during pregnancy might affect pregnancy outcomes. It may help you if you have gum disease and want to learn more about its impact on your pregnancy.
Holbæk, HolbaekAges 16–48 - NCT06583720RecruitingPhase 1
Light therapy and probiotics for bad breath
This trial tests a new approach for treating bad breath (halitosis) using a special light therapy combined with probiotics (good bacteria). It aims to see if this combination works better than standard treatments.
São Paulo, São PauloAges 18–60 - NCT07258303Recruiting
Probiotic Spray for Gum Disease in Older Adults
This trial tests an oral spray that contains good bacteria (probiotics) to help prevent and treat gum disease in older adults. It may be a simple addition to your daily routine to support gum health.
Hanoi, HanoiAges 35 years+ - NCT07257887Recruiting
Testing OROXID oral solution for gum disease
This trial tests a mouth rinse (OROXID) to see if it helps treat advanced gum disease (periodontitis). You may qualify if you have at least three deep gum pockets and have not had dental cleanings or used antibiotics recently.
LjubljanaAges 18 years+ - NCT07258979RecruitingPhase 1/Phase 2
YL201 and Toripalimab with or without Cisplatin for Nasopharyngeal Cancer
This trial tests a new drug combination for people with advanced or recurrent nasopharyngeal cancer. It aims to see if YL201 plus Toripalimab (and sometimes cisplatin) can help when standard treatments are not an option.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07255261Recruiting
Study of facial fillers for wrinkles and volume loss
This study tests several hyaluronic acid fillers to improve the look of hollows under the eyes, lips, lines around the mouth, smile lines, and cheeks. It is designed to see how well these fillers work in everyday use.
ArrasAges 18 years+ - NCT07256106Recruiting
Mini vs. regular implants for lower dentures
This trial compares two types of dental implants for holding a lower denture in place. It aims to see if smaller, mini implants work as well as regular-sized ones in terms of how the teeth come together and apart when you chew or speak.
CairoAges 55–70 - NCT07253402Recruiting
Microbiota-guided radiation therapy for head and neck cancer
This trial is testing a new way to use radiation therapy for head and neck cancer by also looking at the bacteria in your mouth and gut. The goal is to see if adjusting the treatment based on your bacteria can improve outcomes and reduce side effects.
Milan, MilanAges 18 years+ - NCT07255976RecruitingPhase 4
Comparing two methods to move gums for a dental crown
This trial tests two ways to gently move gum tissue so a dentist can take an impression for a bridge or crown. It compares a traditional retraction cord with an aluminum chloride gel to see which works better.
Karachi, SindhAges 18–50 - NCT07251543Enrolling by invitation
Salivary gland massage for dry mouth in older adults
This study tests whether a simple salivary gland massage program can help older adults with dry mouth improve chewing, swallowing, and overall oral health. It's designed for people aged 65 and older who can follow instructions and participate in activities.
Chiayi City, TaiwanAges 65 years+ - NCT07250906Recruiting
Oral health and life quality in children with enamel defects
This study measures how a child's daily life and happiness are affected by a condition called Amelogenesis Imperfecta, which affects tooth enamel. It focuses on children who need veneers for their front teeth, and the results will help dentists improve care.
IstanbulAges 11–14 - NCT07254494Recruiting
Bone Regrowth Guide for Lower Jaw Implants
This study tests two types of membranes used to grow bone in the lower jaw before placing dental implants. Participation lasts about one year and involves a bone-regrowth procedure to prepare for implants.
BeirutAges 18–80 - NCT07256691Recruiting
Bioceramic vs. resin sealer for root canal pain
This study tests two types of sealing materials used in root canals (a newer bioceramic one vs. a standard resin one) to see which causes less pain after treatment. If you have an infected, pain-free tooth that needs a root canal, this trial may help guide better care.
Lahore, Punjab ProvinceAges 18–55 - NCT07250022Recruiting
Checking for hidden decay after tooth fillings in children
This study tests a gentle way to fill cavities in baby teeth (called Atraumatic Restorative Treatment, or ART) to see if some decay is left behind. It may be a good option for children with cavities who are nervous about traditional dental drills.
Çanakkale, KepezAges 4–9 - NCT07254117Recruiting
Study on gum tissue healing for severe gum disease
This trial tests whether special granulation tissue can help regenerate bone and gum support in people with severe gum disease who still have deep bone pockets after initial treatment. It may offer a better way to heal these defects.
RigaAges Any age - NCT06472323Recruiting
Pulsed radiofrequency with platelet-rich plasma for trigeminal neuralgia
This trial tests a treatment that combines pulsed radiofrequency and platelet-rich plasma to see if it works better for trigeminal neuralgia pain that hasn't been helped by standard medicines like carbamazepine.
Beijing, Beijing MunicipalityAges 18–75 - NCT07241052Recruiting
Probiotic spray for cavities in kids
This study tests a probiotic spray that you use in your mouth to help stop cavities from getting worse and to prevent new ones. It is for children ages 7–10 who already have at least one cavity.
Hà Nội, Sơn TâyAges 7–10 - NCT06905678Recruiting
Cleft palate cost and emotion study
This study looks at how having a cleft palate affects your family's finances and emotions. You may be able to join if you are 5, 12, or 18 years old and have a cleft lip or palate.
GhentAges 4–22 - NCT04960904Recruiting
Long-term study of Global D dental implant systems
This study looks at how safe and well certain Global D dental implant systems work over many years. You may be able to join if you received one of these implants during specific dates and can do long-term follow-up visits.
Andrézieux-BouthéonAges 18 years+ - NCT07244614Recruiting
Study of ustekinumab or apremilast for Behçet's disease symptoms
This study tests if ustekinumab or apremilast can help control Behçet's disease symptoms like mouth and genital ulcers, skin sores, and joint pain. It may be an option if standard treatments haven't worked well.
BordeauxAges 18 years+ - NCT07248956RecruitingPhase 2
Chemo plus immunotherapy before surgery for throat cancer
This trial tests giving chemotherapy combined with an immunotherapy drug (finotonlimab) before surgery for locally advanced hypopharyngeal cancer. It aims to shrink the tumor enough to improve surgery outcomes.
Harbin, HeilongjiangAges 18–75 - NCT07249242Recruiting
Gum healing around different healing caps on implants
This study compares how well gum tissue heals around different types of healing caps placed on dental implants. It may help you if you have a recently placed implant that meets certain space and strength requirements.
Boston, MassachusettsAges 18 years+ - NCT07244991Recruiting
Effect of a special toothpaste on plaque bacteria and cavities during braces treatment
This trial tests whether a special paste (MI Paste Plus) can reduce cavity-causing bacteria and prevent early white spots on teeth while you are wearing braces.
Tirana, AlbaniaAges 5–45 - NCT07249060Recruiting
Interferon levels in cancer and autoimmune disease patients
This study looks at a protein called interferon in the blood of people with cancer who are starting immunotherapy, and people with certain autoimmune diseases (such as lupus, Sjögren's syndrome, scleroderma, or inflammatory myopathy). The goal is to compare interferon patterns and better understand immune responses.
Pamplona, NavarreAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.