Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT07287826RecruitingPhase 4
Steroid mouthwash to prevent mouth sores during chemo
This trial tests if using a steroid mouthwash can prevent painful mouth sores caused by certain chemotherapy drugs. It aims to help patients who are starting or already receiving chemotherapy known to cause mouth sores.
Baton Rouge, LouisianaAges 18 years+ - NCT07282483RecruitingPhase 2
Chinese medicine mouthwash for radiation mouth sores
This trial tests whether a traditional Chinese medicine mouthwash and oral liquid can help prevent or reduce mouth sores caused by radiation therapy for head and neck cancer. If you are getting radiation and are at risk for these painful sores, this study might offer you extra relief.
Chengdu, SichuanAges 18–65 - NCT07282977Enrolling by invitation
Comparing methods to move gums for a front crown
This trial compares three ways to temporarily push the gums away from a tooth so a dentist can take an accurate mold for a single front crown. It is for people with healthy gums and a crown margin that sits slightly below the gumline.
Zhengzhou, HenanAges 18 years+ - NCT07287540Recruiting
Anti-inflammatory diet for gum disease treatment
This trial tests whether an anti-inflammatory diet can improve the results of standard gum disease treatment. It is for people diagnosed with periodontitis who are otherwise healthy and do not smoke.
RizeAges 20–65 - NCT07280260RecruitingPhase 4
Testing a new dental implant system for replacing a missing back tooth
This trial tests the Nobel N1 dental implant system in people missing a single back tooth. It aims to see how well the implant works when a replacement tooth is placed right away.
New Orleans, LouisianaAges 18 years+ - NCT07286344Recruiting
Fluoride varnish for tooth sensitivity
This trial tests whether a special fluoride varnish can reduce dentin hypersensitivity (tooth sensitivity). If you have sensitive teeth, this study may help find a better treatment.
Concepción, BiobioAges 18–40 - NCT07287709Recruiting
Laser vs. standard treatment for painful adult molars
This study tests if using a laser is better than the usual method for treating painful, inflamed teeth that still have a live nerve. The goal is to save the tooth and reduce pain without removing the nerve entirely.
AlexandriaAges 16–50 - NCT07280455Recruiting
Comparing gold vs. steel retainers after braces
This study compares two types of fixed retainers (gold vs. stainless steel) to see which works better after braces are removed. It's for people aged 15–30 who have completed orthodontic treatment and have a well-aligned lower front teeth.
Baghdad, Baghdad GovernorateAges 15–30 - NCT07278999Recruiting
Light therapy and clobetasol for oral lichen planus
This trial tests two light-based treatments (photobiomodulation and photodynamic therapy) and a steroid cream (clobetasol) for painful oral lichen planus. The goal is to see which treatment works best to reduce mouth sores and discomfort.
Zabrze, Silesian VoivodeshipAges 20–70 - NCT07287293Recruiting
Suctioning vs no suctioning when waking from anesthesia
This trial compares two ways of managing your breathing tube when you wake up from general anesthesia: suctioning the tube or not. It aims to see which method is more comfortable and safer for you after surgery.
Samut SakhonAges 18 years+ - NCT07282756Recruiting
Lovastatin gel for gum disease treatment
This study tests whether a lovastatin gel applied to the gums (after a deep cleaning) helps treat gum disease better than cleaning alone. Participants must not have had previous gum treatment or antibiotics recently, and can be a smoker or non-smoker.
Bielsko-Biala, Silesian VoivodeshipAges 18–59 - NCT07279883Recruiting
Nerve block for pain after cleft palate surgery in children
This study looks back at the medical records of children who had cleft palate surgery in 2017 or 2018. It compares how long they stayed in the hospital and their pain needs after surgery, between those who got standard pain medicine alone and those who also got a nerve block to help with pain.
StockholmAges 3 months–15 years - NCT05077618Recruiting
Teeth bacteria study in seniors with and without Alzheimer’s
This study looks at the bacteria in the mouth (periodontal microbiota) to see whether they differ between seniors with Alzheimer’s disease and seniors without it. You may be asked for a sample from your gums/teeth and background health information.
Nice, CHU de NICEAges 18–90 - NCT06886347RecruitingPhase 1
New treatment for metastatic nasopharyngeal cancer before chemotherapy
This trial tests a new treatment for people with advanced nasopharyngeal cancer that has spread (stage IVb) and who have not yet had chemotherapy. It aims to see if the experimental treatment is safe and effective as a first option.
Hangzhou, ZhejiangAges 18–75 - NCT07270705Recruiting
OROXID® mouth rinse for gum disease
This trial tests an oral rinse called OROXID® for people with gingivitis (gum disease). It looks at whether the rinse helps reduce gum bleeding and swelling. You may join if you are generally healthy, have at least 20 natural teeth, and have mild gum inflammation but not severe gum disease.
LjubljanaAges 18 years+ - NCT04342234Recruiting
Neural network tool to measure cleft palate from scans
This trial studies a computer “neural network” that uses existing dental impressions, scans, and photos to measure cleft palate features. The goal is to reduce the amount of repeated cleft lip and palate clinic work for patients and families.
BaselAges Any age - NCT07273968Recruiting
Virtual reality for anxiety during wisdom tooth extraction
This study tests whether wearing a virtual reality headset during wisdom tooth removal can help reduce anxiety. It is for generally healthy adults who are having multiple wisdom teeth extracted.
StrasbourgAges 18–65 - NCT07273123Recruiting
Chewing gum and fatigue in jaw joint health
This study tests if chewing sugar-free gum for a while can affect how tired you feel and how your jaw muscles work. It compares people with and without jaw joint problems (TMJ disorders).
Milan, MilanAges 19–35 - NCT07277764RecruitingPhase 2
Radiation and immunotherapy for returning nasopharyngeal cancer
This trial tests a combination of high and low dose radiation plus an immunotherapy drug (PD-1 inhibitor) for people whose nasopharyngeal cancer has come back after previous treatment. The goal is to see if this approach can be more effective while reducing side effects.
Nanchang, JiangxiAges 18–75 - NCT07274189Recruiting
Gum health and sodium bicarbonate toothpaste study
This trial tests whether a sodium bicarbonate (baking soda) toothpaste can improve gum health compared to a standard toothpaste. If you have some gum problems (but not too severe), it might help.
PlymouthAges 18 years+ - NCT07273552Recruiting
Root control in 3D-printed clear aligners
This study tests a new type of 3D-printed clear aligner and how well it can control the way teeth roots move. It may be a good option if you have gaps in your teeth (not crowding) and do not need any tooth extractions.
Banī SuwayfAges 18–45 - NCT07276087Recruiting
Physical and Mental Health in Takayasu Arteritis and Behçet's Disease
This study compares physical and mental health in people with Takayasu arteritis or Behçet's disease to healthy volunteers. It aims to better understand how these conditions affect day-to-day life and well-being.
Denizli, DenizliAges 18 years+ - NCT07276191Recruiting
Mobile app for teen oral health
This study tests a mobile app designed to help Portuguese teenagers improve their oral health. You would use the app at least twice in the first month to see if it makes a difference.
Lisbon, Lisbon DistrictAges 15–19 - NCT06884813Recruiting
Color-changing fillings after teeth whitening
This study tests a new type of tooth-colored filling that can adjust its color after professional whitening. It may help people who already have certain white fillings on their front teeth and want to see if the new filling blends better after whitening.
IrbidAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.