Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,058 recruiting studies in this area right now.
By phase
- Not applicable1,634
- Phase 2148
- Phase 183
- Phase 382
- Phase 459
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma80
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Oral Cancer35
- Head and Neck Cancer34
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Nasopharyngeal Carcinoma (NPC)24
- Alveolar Bone Loss23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,058 total
- NCT05819697Recruiting
Helping burning mouth symptoms with improved memory recall
This trial looks at ways to reduce how much people with burning mouth syndrome struggle to recall information during the study. If you qualify, you may be asked to complete study tasks and share saliva to support the research.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05821075RecruitingPhase 1/Phase 2
Prednisolone vs Cerebrolysin for sudden facial weakness
This early-stage study compares two medicines—prednisolone and cerebrolysin—to see which works better for Bell’s palsy (sudden one-sided facial weakness with no clear cause). You may be asked to take one of the study treatments and be followed to measure how well facial movement improves.
GizaAges 18–60 - NCT05821972RecruitingPhase 4
Breathing-mist medicines for cleft palate surgery pain control
This trial tests whether a breathing mist of two medicines (dexmedetomidine plus ketamine) works better than dexmedetomidine alone during cleft palate repair surgery. It may help improve comfort and safety around anesthesia for eligible patients.
AsyutAges 1–4 - NCT05825170Recruiting
Hyaluronic acid lip filler for lip deformity after cleft surgery
This trial tests a hyaluronic acid filler (placed in the lips) to improve lip shape in people who had cleft lip and palate surgery. It looks at how well the filler works and how safe it is for your lips and surrounding skin.
Lille, NordAges 18 years+ - NCT05832541Recruiting
Study tissue changes around dental implants in adults
This trial studies signs of inflammation and tissue change around dental implants (especially in people with peri-implantitis) compared with people getting implants in healthier gum/bone areas. It may help doctors understand what markers to look for to better monitor or treat implant problems.
KarbalaAges 18 years+ - NCT05837221Recruiting
Study of the mouth microbiome in oral cancer
This study looks at the types of bacteria in the mouth (the microbiome) in people with oral squamous cell cancer and compares them to people without this cancer. It may help researchers understand what’s different in oral cancer and what could be useful for diagnosis or treatment planning.
Aurora, ColoradoAges 18–100 - NCT05838365RecruitingPhase 4
Earlier vs later placement of single tooth implants
This study compares two timing approaches for placing a single implant tooth: putting the implant load (chewing force) on it sooner versus later. It may help show which timing works best for healing and long-term comfort in people with suitable bone and gum tissue.
MilanAges 18–80 - NCT05845723RecruitingPhase 2
Study drugs for blood-vessel Behçet’s to reduce inflammation
This Phase 2 trial tests tocilizumab and tofacitinib to see if they can better control vascular (blood-vessel) Behçet’s syndrome. It may help by lowering inflammation and reducing complications from aneurysms in the aorta or peripheral arteries.
Beijing, Beijing MunicipalityAges 18–65 - NCT05851248Recruiting
Gum graft treatment for a single lower front tooth
This trial studies a “free mucogingival graft,” a surgical gum tissue transplant, to cover exposed root (recession) in a specific area of the lower front teeth. If you have a deep recession in a healthy mouth with low gum bleeding, you may be able to try this approach and help researchers learn how well it works.
Murcia, MurciaAges 18 years+ - NCT05852145RecruitingPhase 1/Phase 2
Testing sweet drinks effect on children’s mouth health
This early-stage study looks at how drinking soft drinks with and without sweeteners affects children’s mouths and teeth. It may help researchers understand which types of sweet drinks contribute to more tooth damage.
Mexico City, CuahutemocAges 12–18 - NCT05853692Recruiting
Preventing mouth sores during head and neck radiation
This trial tests a gel called “Gel X” to help prevent painful mouth sores (oral mucositis) in people receiving radiation for head and neck cancer. It may help you stay more comfortable and maintain eating and speaking during treatment.
Roma, ItalyAges 18 years+ - NCT05853783Recruiting
Testing a mouth test on biopsy samples from abnormal lesions
This trial looks at archived (saved) mouth biopsy samples to see how well the STRATICYTE™ test can identify potentially dangerous “pre-cancer-like” changes. It may help doctors screen or better understand which abnormal areas in the mouth later turn into oral cancer.
Birmingham, AlabamaAges 18 years+ - NCT05854849RecruitingPhase 3
Testing three-drug therapy versus cisplatin for recurrent NPC
This trial studies whether gemcitabine plus camrelizumab plus apatinib works better than cisplatin alone for people with recurrent or metastatic non-keratinizing nasopharyngeal cancer. It’s meant for people who haven’t had prior whole-body (systemic) treatment for the returning/spreading cancer.
Guangzhou, GuangdongAges 18–75 - NCT05858411Recruiting
Biologic gum treatments added to non-surgical cleaning
This trial studies whether adding a biologic medicine to standard non-surgical gum (periodontal) treatment can improve deep gum pockets in certain bone defects. It may help people whose gum disease has specific “intrabony” defects, but you must meet several health and medication rules.
TiranaAges 18 years+ - NCT05860712Recruiting
Cinnamon vs chlorine rinse after baby tooth nerve treatment
This trial tests whether a cinnamon extract rinse works as well as a chlorine-based rinse to reduce pain and fight infection after pulpectomy (removing the nerve tissue) in baby teeth. It may help you understand which rinse causes less post-treatment discomfort.
CairoAges 4–8 - NCT05862792Recruiting
Liposomal bupivacaine during robotic throat surgery
This study gives a pain-relief medicine (bupivacaine in a slow-release form) during transoral robotic throat surgery. It aims to see if it improves comfort and pain control around the time of surgery.
Danville, PennsylvaniaAges 18 years+ - NCT05877872RecruitingPhase 3
Smaller surgery after chemotherapy for recurring nasopharyngeal cancer
This trial tests whether doing a smaller surgery (after chemotherapy works well) can control recurring nasopharyngeal cancer while reducing treatment burden. It is for people whose cancer can be removed by surgery and who respond to an initial course of chemotherapy plus immunotherapy (or another targeted regimen).
Guangzhou, GuangdongAges 18–75 - NCT05880797Recruiting
Study of throat cancer profiles using multiple tests
This trial studies oropharyngeal (throat) cancer, including certain HPV-related cancers of unknown starting point, using several ways to measure tumor features. The goal is to better understand these cancers and possibly guide future care.
Palo Alto, CaliforniaAges 18 years+ - NCT05884320RecruitingPhase 2
Sacituzumab govitecan for advanced salivary gland cancers
This Phase 2 trial tests sacituzumab govitecan, an anti-cancer medicine, in people with recurrent or metastatic (coming back or spread) secretory gland cancers or related salivary gland cancers. It aims to see how well the treatment can shrink tumors and control disease when surgery or radiation is not a cure.
Houston, TexasAges 18 years+ - NCT05884983Recruiting
Check if special CT and nose scope help screen nasopharyngeal cancer
This study tests whether combining a special CT scan with a nose/throat camera exam (nasopharyngeal endoscopy) can better find nasopharyngeal cancer early. You might benefit if the study shows this approach is accurate and safer for screening.
Zhongshan, GuangdongAges 30–69 - NCT05888935Recruiting
AI checks for tooth root infections on dental X-rays
This study tests an artificial intelligence tool to detect small infections around tooth roots using routine panoramic dental X-rays. You might benefit if your scans are used to more accurately spot these problems compared with standard reading.
MetzAges 18 years+ - NCT05892354Recruiting
Immunonutrition to reduce mouth sores after cancer treatment
This trial studies whether special nutritional supplements (immunonutrients) can reduce painful mouth sores (oral mucositis) in people with nasopharyngeal cancer after chemoradiotherapy. If you qualify, you’ll be followed with visits and lab tests to see if the supplements improve comfort and recovery.
Fuzhou, FujianAges 18–70 - NCT05894070Recruiting
Using your voice recordings to spot cancer coming back
This study looks at whether changes in your voice can help detect early return of laryngeal or hypopharyngeal cancer. If you’ve finished curative treatment and are disease-free for a certain period, your voice will be monitored to see if it can signal recurrence sooner.
BernAges 18 years+ - NCT05894083RecruitingPhase 2
PET-Scan Tailored De-escalation for p16+ throat cancer
This trial tests a treatment plan that may lower (de-escalate) therapy intensity for certain p16+ or HPV-positive throat cancers. It uses PET scan results and tumor features to try to keep cancer control while reducing side effects.
Ann Arbor, MichiganAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,058 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,961 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.