Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06747390RecruitingPhase 1
Lidocaine injection before throat cancer surgery
This early-phase trial tests whether injecting lidocaine (a numbing medicine) into the tumor before surgery can help with pain or other outcomes in people with oropharyngeal cancer. It's for patients who are already scheduled for a scope procedure and surgery at the University of Pennsylvania.
Philadelphia, PennsylvaniaAges 18 years+ - NCT04711200RecruitingPhase 1/Phase 2
Study of special stem cells for severe skin peeling (SJS-TEN)
This early-phase trial tests stem-cell treatment to help people with severe skin reactions called SJS-TEN. It may reduce ongoing skin damage and help recovery when treatment is started soon after symptoms begin.
CréteilAges 18–75 - NCT06736379RecruitingPhase 1
Injected immune therapy for head and neck cancer
This trial tests an experimental treatment that is injected directly into the tumor to stimulate your immune system to fight the cancer. It is for people with head and neck cancer who have not been helped by prior treatments or who are scheduled for surgery.
Stanford, CaliforniaAges 18 years+ - NCT06732167Recruiting
Lyoplant for bone regrowth in dental implant surgery
This trial tests a special membrane called Lyoplant® that helps your jawbone grow back around a new dental implant. If you need a dental implant and your jawbone has a small gap or defect, this study might be a good fit for you.
Barcelona, CataloniaAges 18 years+ - NCT06736964Enrolling by invitation
Testing new fillings for gum-line cavities in high-risk adults
This study tests how well two newer, tooth-friendly filling materials work for cavities at the gum line in people who are prone to tooth decay. If you need a couple of these fillings, this trial could help restore your teeth and protect them from future cavities.
CairoAges 25–45 - NCT06731465Enrolling by invitation
Clear aligners vs braces for crowded lower front teeth
This study compares clear aligners (removable trays) to traditional braces for treating crowded lower front teeth. It aims to see which method works better and is more comfortable for patients.
Sharjah city, Emirate of SharjahAges 16–45 - NCT03580785Recruiting
Study of delayed tooth eruption in children and teens
This study looks at how doctors diagnose delayed tooth eruption and how that affects treatment. It focuses on people with a condition called Primary Failure of Eruption (PFE) and tries to refine the best diagnostic checks.
StrasbourgAges 6 years+ - NCT06265636Recruiting
Nerve stimulation for jaw pain and function in TMD
This trial tests whether gentle electrical stimulation of a nerve in your jaw can reduce pain and improve chewing, talking, and mouth opening for people with temporomandibular joint disorder (TMD).
Alcorcón, MadridAges 18–65 - NCT06723106Enrolling by invitationPhase 1
Long-term safety study of RAY121 for immune conditions
This study is for people who already took RAY121 in a previous trial and did well. It tests whether continuing the treatment is safe and effective over a longer period. The goal is to manage chronic immune conditions.
Camperdown, New South WalesAges 18–85 - NCT06722482Recruiting
Comparing bone grafts for front tooth implants
This trial compares two types of bone graft materials used when a front tooth is removed and replaced with a dental implant. It aims to see which works better for healing and long-term success.
Rochester, New YorkAges 18 years+ - NCT06726876RecruitingPhase 3
Manuka honey rinse for gum disease in dialysis patients
This study tests whether a manuka honey mouth rinse can help treat gum disease in people who are on dialysis for kidney failure. If you have both kidney failure and gum disease, this study may offer a natural way to improve your oral health.
BanhāAges 18 years+ - NCT06724497Enrolling by invitationPhase 1/Phase 2
Comparing 3D face scan methods for jaw surgery patients
This trial tests whether using a handheld 3D scanner is as accurate as a standard optical scanner for predicting soft tissue changes after corrective jaw surgery. It aims to find a more convenient and accessible way to plan surgery for patients with an underbite.
Cairo, Giza GovernorateAges 18–50 - NCT06724029Recruiting
Neurosurgery outcomes research for multiple conditions
This study collects data from people having brain or spine surgery for many different conditions. It aims to understand how well different treatments work and how people recover. If you are scheduled for certain brain, spine, or nerve surgeries, you may be able to join.
Bergamo, BGAges 18 years+ - NCT06725095Enrolling by invitation
Enamel gel for gum inflammation around dental implants
This study tests whether a special enamel gel can reduce inflammation around dental implants. It might help if your implant has bleeding gums but no deeper infection.
Catania, CtAges 18–75 - NCT06726902Enrolling by invitation
Comparing air polishing powders for gum disease treatment
This trial tests whether different air polishing powders improve nonsurgical gum disease treatment in people with moderate to severe periodontitis. It aims to find a better way to clean below the gum line without surgery.
AlexandriaAges 30–65 - NCT06727110Recruiting
New liquid treatment for tooth cavities
This study tests a new method to treat cavities that reach the middle layer of a tooth. It may help repair the tooth with a liquid that hardens into a filling. If you have a back tooth with a cavity that hasn't been filled yet, you might be eligible to join.
San Francisco, CaliforniaAges 18–64 - NCT06725134Recruiting
Do therapy dogs help kids feel calmer during dental shots?
This study tests if having a trained therapy dog in the room reduces a child's anxiety and improves their behavior when getting numbing medicine for dental work. It could help children who are nervous about dental procedures feel more at ease.
Ann Arbor, MichiganAges 4–12 - NCT06152081Recruiting
Detecting cavities with two new devices
This study tests two different devices for finding cavities in adults at high risk for tooth decay, comparing how well they work against each other and standard methods.
Boston, MassachusettsAges 21 years+ - NCT06486012Recruiting
Light therapy for gum disease in diabetic patients
This trial tests if regular use of antibacterial light therapy can help manage and prevent gum disease symptoms in people with diabetes. It may offer a simple, non-invasive way to improve oral health.
Tampere, PirkanmaaAges 18 years+ - NCT06714253RecruitingPhase 1/Phase 2
Circular RNA treatment for dry mouth after radiation
This trial tests a new type of treatment called circular RNA to see if it can help people with long-term dry mouth after radiation for head and neck cancer. It's for patients whose dry mouth hasn't gone away with other treatments.
Palo Alto, CaliforniaAges 18 years+ - NCT06714929Recruiting
School water study for students in grades K-5
This study looks at how a new water program in schools might affect student health and hydration. It includes watching what kids drink at lunch, checking teeth and body weight for older students, and asking 4th and 5th graders and staff about their drinks.
Henrico, VirginiaAges 4 years+ - NCT06706401RecruitingPhase 3
Lymphocyte-sparing radio-immunotherapy for head and neck cancer
This trial tests a new approach that combines radiation and immunotherapy, while trying to protect your immune cells. It is for people with head and neck cancer that has not spread across the midline of the body and has not been treated yet.
Lyon, FranceAges 18 years+ - NCT06713330Recruiting
Stainless steel vs. resin crowns for baby molars
This study compares two types of dental crowns (stainless steel vs. resin) for baby molars to see which works better. If your child needs full mouth dental work under general anesthesia, they may be able to join.
Cincinnati, OhioAges 2–5 - NCT06622759RecruitingPhase 2
Using a collagen membrane to preserve gum bone after dental implant
This trial tests whether a special collagen material placed around a new dental implant can help prevent bone loss in the upper front gum area. It is for people needing a single implant in a specific tooth zone and may help keep the bone strong for a better cosmetic result.
Thessaloniki, ThessalonikiAges 18–75
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.