Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT07097714Recruiting
Collagen scaffold with gum surgery to improve orthodontic results
This trial tests if a special collagen scaffold placed during gum surgery can improve orthodontic treatment for people with thin gums. It may help protect the gums and bone during teeth straightening.
Novosibirsk, Novosibirsk OblastAges 18–50 - NCT07100574Recruiting
Bacteria in dental plaque and artery plaque study
This study looks at bacteria found in dental plaque and in the fatty buildup inside your arteries. It might help researchers understand links between mouth health and blood vessel health after your endarterectomy surgery.
IstanbulAges 18–85 - NCT07100613RecruitingPhase 2
Mouth film for treating oral lichen planus
This trial tests a new sticky mouth film that slowly releases medicine to treat painful sores from oral lichen planus. It may help people who have not been treated before for this condition.
Palermo, ItalyAges 18 years+ - NCT07101068Recruiting
Comparing two ways to give dental numbing for kids
This study tests a new dental injector against a traditional syringe to see which one causes less pain and anxiety for children getting numbed for their first cavity treatment.
Cairo, Cairo GovernorateAges 6–8 - NCT07101744RecruitingPhase 2
Drug combination study for advanced nasopharyngeal cancer
This trial tests a combination of three drugs for people with nasopharyngeal cancer that has come back or spread and stopped responding to first-line chemotherapy. It aims to see if this new combination can help when standard treatment no longer works.
GuangdongAges 18–70 - NCT07102758Recruiting
Comparing gum grafts for immediate dental implants
This trial tests two ways to support the gum around a new dental implant placed right after a tooth is pulled. It compares a special blood-clot material (L-PRF) to a connective tissue graft to see which heals better.
Kafr ash Shaykh, KafrelsheikhAges 21–45 - NCT07103941Recruiting
Study of whether MAD therapy prevents bite changes
This study tests how well a dental device called a Mandibular Advancement Device (MAD) prevents changes in your bite and jaw alignment. It is for adults with sleep-disordered breathing who already have healthy, well-restored teeth.
Lexington, KentuckyAges 18 years+ - NCT07104019Recruiting
Biofiller for Thinning Gums: A Gum-Thickening Study
This study tests a biofiller to make thin gums thicker in the lower front teeth area. It may help people with thin gums who want to improve their gum health and appearance.
MalatyaAges 18–65 - NCT07105969Recruiting
Studying coated mini-screws for tooth movement
This trial tests whether special coated mini-screws placed in the jaw can help move teeth and resist infection. It's for teens and young adults getting premolars removed as part of braces treatment.
Al Mansurah, Dakahlia GovernorateAges 16–20 - NCT07109882RecruitingPhase 4
Comparing two muscle relaxants for bruxism pain
This study compares two muscle relaxant medications—chlorzoxazone and orphenadrine citrate—to see which works better for relieving pain caused by teeth grinding or jaw clenching (bruxism). If you have jaw or face pain and no other major health issues, you may be able to join.
BaghdadAges 15 years+ - NCT07110142Recruiting
Tongue strength exercises after tongue cancer surgery
This study tests a tongue strengthening exercise program for people who have had partial tongue removal and reconstruction. The goal is to see if these exercises can help you regain better tongue function and speech after surgery.
Cleveland, OhioAges 18 years+ - NCT07115212Recruiting
Bromelain for facial swelling after jaw surgery
This trial tests whether a natural enzyme called bromelain (found in pineapple) can reduce swelling after jaw surgery. You may be eligible if you're having orthognathic surgery and don't have certain health conditions or allergies.
Lexington, KentuckyAges 18–65 - NCT07118241RecruitingPhase 2
Testing a new eye drop for Sjögren's dry eye
This trial tests a new eye drop made from a natural protein (rhPRG4) to see if it safely and effectively relieves dry eye symptoms in people with Sjögren's syndrome. You'll be randomly assigned to receive the study drop or a placebo (inactive) drop for several weeks.
Sydney, New South WalesAges 18–80 - NCT07121595RecruitingPhase 2
Personalized neck radiation for mouth cancer with sentinel node biopsy
This study tests whether a personalized approach to radiation therapy after surgery, guided by a special lymph node biopsy (sentinel node biopsy), can effectively treat mouth cancer while reducing side effects. It is for people whose cancer is on one side of the mouth and has not spread to the other side of the neck or beyond.
Ann Arbor, MichiganAges 18 years+ - NCT07123025Recruiting
Partial pulp treatment for painful tooth decay
This study tests if removing only the top part of the damaged tooth nerve can save a deeply decayed molar. It is for people with moderate to severe toothache that doesn't stop, especially when lying down.
Rohtak, HaryanaAges 15–40 - NCT07125963Recruiting
Custom vs. standard jaw positioning for jaw surgery
This study compares two ways of positioning your jaw during surgery to correct jaw alignment. The goal is to see if using a custom-made guide based on your own CT scans leads to better results than the standard method.
Istanbul, BağcılarAges 18 years+ - NCT07130760Recruiting
Testing two numbing methods for tooth pain in a back molar
This trial compares two ways to numb a painful lower back molar. If you have a tooth infection that needs a root canal, you may receive one of two injection techniques to see which works better.
Ferrol, A coruñaAges 18 years+ - NCT07131813RecruitingPhase 4
Tofacitinib for oral lichen planus
This trial tests whether adding the drug tofacitinib to standard treatment helps reduce symptoms of oral lichen planus, a chronic inflammatory mouth condition. It is for people with moderate to severe disease who have not taken certain immune-suppressing medicines recently.
Bhubaneswar, OdishaAges 18 years+ - NCT07133464Recruiting
CDH1 gene and BCDS syndrome registry
This registry studies people with changes in the CDH1 gene who may have blepharocheilodontic syndrome (BCDS). It collects information to better understand the condition and improve care.
Columbus, OhioAges Any age - NCT07133919Recruiting
AI communication to reduce dental anxiety in children
This trial tests whether a child-friendly, AI-assisted conversation method can help reduce anxiety in children who need a dental filling, pulpotomy, or similar treatment. It is for children ages 6-12 who are coming to the dentist for the first time and will receive local anesthesia.
Çanakkale, KepezAges 7–12 - NCT07134114Recruiting
How Hall Crowns Affect Your Child's Bite
This study tests the Hall Technique, a way to place stainless steel crowns on baby molars without numbing or drilling. It looks at how the crown affects your child's bite, and may help kids with cavities in back baby teeth who can cooperate for treatment.
Ankara, KeçiörenAges 7–10 - NCT07141680Recruiting
Replantation vs splinting for loose lower front teeth
This study compares putting a loose lower front tooth back in place and splinting it (replantation) versus splinting alone. It's for people with severe gum disease that has caused bone loss and tooth looseness.
IstanbulAges 18–65 - NCT07141758Recruiting
Saliva tests for recurrent mouth ulcers
This study looks at certain proteins in saliva to better understand recurrent aphthous stomatitis (common mouth ulcers). If you have frequent mouth ulcers, you might help researchers learn more about the condition.
Aydin, EfelerAges 18 years+ - NCT07146776Recruiting
Injectable PRF and bone graft for gum disease bone defects
This trial tests a treatment for deep gum disease pockets using a combination of your own blood components (injectable platelet-rich fibrin) and a bone graft material. It aims to help regenerate bone lost to periodontitis.
Istanbul, ÜsküdarAges 18–65
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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- Genetic & congenital
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- Pain
- Injuries & trauma
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.