Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06617494Recruiting
Study of pain control in chronic jaw pain
This study looks at how well the body's natural pain control system works in people with long-term jaw pain (TMD). It compares people with and without jaw pain to better understand why some have trouble turning off pain signals.
Minneapolis, MinnesotaAges 18–74 - NCT06012019Recruiting
Gum Disease and Inflammation Study
This study looks at gum disease (periodontitis and gingivitis) and inflammation using blood and dental samples. It may help researchers understand how inflammation affects gum health.
Ivry-sur-SeineAges 18 years+ - NCT06182462Recruiting
Virtual reality for dental anxiety in children
This study tests whether wearing a virtual reality headset during dental treatment can help reduce fear and anxiety in children. If you feel nervous about dental visits, this may be a way to stay calm and comfortable.
Montreal, QuebecAges 6–17 - NCT06592599RecruitingPhase 2
Drug combo for EBV-related nasopharyngeal cancer
This trial tests a combination of three drugs (gemcitabine, docetaxel, and toripalimab) as a first treatment for a type of nasopharyngeal cancer linked to the Epstein-Barr virus. The goal is to see if this combination helps shrink tumors before other treatments like radiation.
Palo Alto, CaliforniaAges 18 years+ - NCT06587880RecruitingPhase 4
Mouthwash and wisdom tooth extraction recovery
This study compares different mouthwashes to see which one helps healing after wisdom tooth surgery. If you have a lower wisdom tooth that is impacted (stuck) and need it removed with some bone cutting, you may qualify.
AmmanAges 18 years+ - NCT06589570Recruiting
Titanium partial dentures and speech clarity study
This study tests how well a new type of metal partial denture made from titanium works for people missing multiple teeth. It looks at how the denture affects your speech and how easy it is to understand you.
CairoAges Any age - NCT06586892Recruiting
MRI study to predict jaw injury after radiation therapy
This study uses special MRI scans before and after radiation therapy to see if they can predict damage to your jawbone. If you are getting radiation to the head or neck area, this study may help monitor side effects.
Houston, TexasAges 18 years+ - NCT06588725Enrolling by invitation
Parent program to prevent cavities in young children
This study tests simple ways to help parents improve their child's dental health and prevent cavities. It focuses on changing behaviors to keep your child's teeth healthy.
Nashville, TennesseeAges 9 months–3 years - NCT06600295Recruiting
Taste changes and nutrition in new cancer patients
This study looks at how cancer and its treatments affect taste and nutrition. It aims to find ways to help patients maintain good nutrition during treatment.
DijonAges 18 years+ - NCT06545084Recruiting
Better healing after root-end surgery using a special blood clot
This study tests whether adding a concentrated blood clot (L-PRF) to standard root-end surgery helps tooth-related infections heal faster and better. You may be a good fit if you have a persistent infection at the tip of a tooth root and need this type of surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06536335Recruiting
Clear aligner treatment: Comparing two timing schedules
This study compares two different schedules for clear aligner treatment (invisible braces) to see which one feels better for patients. If you have a mild misalignment (Class I) and all your permanent teeth, you may be able to join.
RomaAges 18–40 - NCT06451913RecruitingPhase 4
Probiotic for gut health during Lyme disease antibiotics
This trial tests if a probiotic (Saccharomyces boulardii) can help maintain healthy gut bacteria while you take antibiotics for the early skin rash of Lyme disease (erythema migrans). You'll take amoxicillin for 14 days, plus either the probiotic or a placebo.
LjubljanaAges 18 years+ - NCT06580210Recruiting
Seawater spray with essential oils for stuffy nose
This trial tests a seawater and essential oil spray to clear a stuffy nose caused by a cold, sinus infection or allergies. The spray is meant to help you breathe easier without strong medicines.
BayeuxAges 12 years+ - NCT06571812Recruiting
Study of the TSX dental implant system (Xpresso)
This trial tests a new dental implant system (called TSX Xpresso) for replacing a single missing tooth, either right after pulling the tooth or after the gum has healed. It may be a good option if you need a dental implant and want to see how this system works.
Columbus, OhioAges 18 years+ - NCT06574152Recruiting
Light therapy for pain relief after dental root surgery
This trial tests whether a special light treatment, called photobiomodulation, can help reduce pain and speed up healing after a specific type of dental surgery on the root of a tooth. The surgery involves a small cut in the gum, and the light may help the gum recover faster.
Houston, TexasAges 18 years+ - NCT06581614Recruiting
Chewing ability after single implant for missing second molar
This trial checks how well you can chew after getting a single implant to replace a missing second molar tooth. It compares chewing function before and after treatment to see how the implant helps.
TaipeiAges 25–85 - NCT06576622Recruiting
Periodontal disease, bacteria, and miscarriage
This study looks at whether gum disease and oral bacteria are linked to repeated pregnancy loss. If you have had multiple miscarriages, your gum health may play a role.
ToulouseAges Up to 18 years - NCT06576830RecruitingPhase 4
Pain relief study for kids having tonsil surgery
This study tests different ways to manage pain after tonsillectomy in children. The goal is to find better pain relief options.
Durham, North CarolinaAges 3–17 - NCT06569264Recruiting
Comparing socket preservation methods after tooth extraction
This trial tests two different treatments to preserve the bone and gum after a tooth is removed. It compares using a dentin graft with I-PRF (a special blood concentrate) to the same treatment with added vitamin C. The goal is to see which helps the healing better before a dental implant.
CairoAges 18–65 - NCT06569329Recruiting
Extra cleaning for infected root canals
This study tests if extra cleaning steps after a standard root canal can remove more bacteria from an infected tooth. It is for adults with a dead nerve and an infection at the root tip in a single-rooted premolar that has never been treated before.
Iowa City, IowaAges 18–95 - NCT06007365Recruiting
Z5m dental implant registry study
This study looks at how well Z-Systems' Z5m dental implants work in patients. It may be a good fit if you have received or will receive up to 5 of these implants.
OltenAges 18 years+ - NCT06550050Recruiting
Study of Mouth Precancer and Cancer Features
This study looks at tissue and blood samples from people with mouth conditions that could become cancer or are already cancer. It aims to learn more about these conditions to improve diagnosis and treatment.
Houston, TexasAges 18 years+ - NCT06554158Recruiting
Lowering radiation for low-risk HPV throat cancer patients
This trial tests whether giving less radiation after surgery is safe and effective for people with early-stage HPV-related throat cancer. It aims to reduce side effects while still controlling the cancer.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06554366Recruiting
Comparing two cleaning systems for root canals on dead-nerve molars
This study compares two different cleaning methods (GentleWave and EdgePro) used during root canal treatment on lower back teeth where the nerve has died. The goal is to see which system removes more bacteria, which may lead to better healing.
Houston, TexasAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.