Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT07212660Recruiting
Comparing two curing methods for fillings in baby teeth
This trial tests two different ways of hardening (curing) the material used for fillings in baby molars. It aims to see which method works better and is safer for children needing fillings for cavities or other damage.
Herzogenbuchsee, Canton of BernAges 4–9 - NCT07213661Recruiting
Long-term results of two cavity treatments
This study looks at how well two cavity treatments work over time. It's for people who already took part in an earlier study at one of 33 housing sites.
Cleveland, OhioAges 62 years+ - NCT07236762RecruitingPhase 1
YTS109 cell therapy for severe autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with severe autoimmune diseases like lupus, Sjögren's syndrome, systemic sclerosis, inflammatory myopathy, vasculitis, and antiphospholipid syndrome. It's for those whose disease hasn't improved with standard treatments.
BengbuAges 18–65 - NCT07236801RecruitingPhase 1
Cell therapy for hard-to-treat autoimmune diseases
This trial tests a new cell therapy called YTS109 for people with several autoimmune diseases that have not improved with standard medications. It aims to see if this treatment can help control the disease when other treatments have failed.
Xuzhou, JiangsuAges 18–65 - NCT07237620Recruiting
Comparing medicines for failed root canal treatment
This trial compares different medicines placed inside the tooth after a failed root canal to help heal the infection at the root tip. If you have a back tooth that still has an infection even though it had a root canal years ago, this study may test which medicine works best for you.
Hatay, AntakyaAges 18–60 - NCT07237672Recruiting
AI physiotherapy follow-up for oral cancer
This trial checks if an AI-based physiotherapy program helps oral cancer patients recover better. If you finished the original therapy, you can join and attend check-ups at 3 and 9 months.
TaipeiAges 20–70 - NCT07239505Recruiting
Pre-operative medication for tooth pain relief study
This trial tests a medication called Trinase, given before a root canal, to see if it reduces pain after the procedure compared to a placebo. It may help if you have a painful tooth that needs treatment.
Al Fayyum, Faiyum GovernorateAges 18–50 - NCT07241052Recruiting
Probiotic spray for cavities in kids
This study tests a probiotic spray that you use in your mouth to help stop cavities from getting worse and to prevent new ones. It is for children ages 7–10 who already have at least one cavity.
Hà Nội, Sơn TâyAges 7–10 - NCT07241728Recruiting
Bruxism and electrical current for jaw pain relief
This study tests whether a type of mild electrical current (called diadinamic current) can help relieve jaw pain caused by bruxism (teeth grinding or clenching). It is for adults who have not tried other treatments for this pain.
MalatyaAges 18 years+ - NCT07242742Recruiting
Pulpotomy vs. root canal for deep cavities
This trial compares two treatments for very deep cavities that reach the tooth's nerve. It tests whether a less invasive partial nerve removal (pulpotomy) works as well as a full root canal. It may help you keep your tooth without needing a full root canal.
SingaporeAges 12 years+ - NCT07242859Recruiting
Rice bran for mouth sores from radiation in head and neck cancer
This trial tests whether a rice bran supplement can help prevent or reduce mouth sores caused by radiation therapy for head and neck cancer. If you're getting radiation with or without chemo, this simple addition might ease side effects.
CairoAges 18 years+ - NCT07244614Recruiting
Study of ustekinumab or apremilast for Behçet's disease symptoms
This study tests if ustekinumab or apremilast can help control Behçet's disease symptoms like mouth and genital ulcers, skin sores, and joint pain. It may be an option if standard treatments haven't worked well.
BordeauxAges 18 years+ - NCT07244991Recruiting
Effect of a special toothpaste on plaque bacteria and cavities during braces treatment
This trial tests whether a special paste (MI Paste Plus) can reduce cavity-causing bacteria and prevent early white spots on teeth while you are wearing braces.
Tirana, AlbaniaAges 5–45 - NCT07248956RecruitingPhase 2
Chemo plus immunotherapy before surgery for throat cancer
This trial tests giving chemotherapy combined with an immunotherapy drug (finotonlimab) before surgery for locally advanced hypopharyngeal cancer. It aims to shrink the tumor enough to improve surgery outcomes.
Harbin, HeilongjiangAges 18–75 - NCT07249060Recruiting
Interferon levels in cancer and autoimmune disease patients
This study looks at a protein called interferon in the blood of people with cancer who are starting immunotherapy, and people with certain autoimmune diseases (such as lupus, Sjögren's syndrome, scleroderma, or inflammatory myopathy). The goal is to compare interferon patterns and better understand immune responses.
Pamplona, NavarreAges 18 years+ - NCT07250906Recruiting
Oral health and life quality in children with enamel defects
This study measures how a child's daily life and happiness are affected by a condition called Amelogenesis Imperfecta, which affects tooth enamel. It focuses on children who need veneers for their front teeth, and the results will help dentists improve care.
IstanbulAges 11–14 - NCT07680491Recruiting
Non-surgical treatment for gum pockets around implants
This study tests a new, non-surgical gel called H42 for treating deep gum pockets around dental implants. It's for adults with moderate pocket depths who are not on blood thinners.
SevilleAges 25–65 - NCT07576582Recruiting
Mud therapy for jaw joint pain
This trial tests whether a special mud treatment (peloid therapy) can reduce jaw joint pain and improve function in people with temporomandibular joint disorder. It is a non-drug approach that may help those who have had jaw pain for at least 4 weeks.
Uşak, MerkezAges 18–65 - NCT07013682Recruiting
Platelet-rich fibrin combined with deep cleaning for gum disease
This trial tests if adding platelet-rich fibrin (a natural healing concentrate from your blood) to standard deep cleaning improves treatment for advanced gum disease. It may help patients with widespread gum disease who have not had treatment in the last year.
BernAges 18 years+ - NCT06153212Enrolling by invitation
Regenerative treatment for gum infection around dental implants
This study tests a new regenerative treatment for gum infections around dental implants (peri-implantitis). It may help people whose implants are otherwise healthy and positioned correctly, and who have good overall health.
Ann Arbor, MichiganAges 18 years+ - NCT07253402Recruiting
Microbiota-guided radiation therapy for head and neck cancer
This trial is testing a new way to use radiation therapy for head and neck cancer by also looking at the bacteria in your mouth and gut. The goal is to see if adjusting the treatment based on your bacteria can improve outcomes and reduce side effects.
Milan, MilanAges 18 years+ - NCT07254117Recruiting
Study on gum tissue healing for severe gum disease
This trial tests whether special granulation tissue can help regenerate bone and gum support in people with severe gum disease who still have deep bone pockets after initial treatment. It may offer a better way to heal these defects.
RigaAges Any age - NCT07255976RecruitingPhase 4
Comparing two methods to move gums for a dental crown
This trial tests two ways to gently move gum tissue so a dentist can take an impression for a bridge or crown. It compares a traditional retraction cord with an aluminum chloride gel to see which works better.
Karachi, SindhAges 18–50 - NCT07256106Recruiting
Mini vs. regular implants for lower dentures
This trial compares two types of dental implants for holding a lower denture in place. It aims to see if smaller, mini implants work as well as regular-sized ones in terms of how the teeth come together and apart when you chew or speak.
CairoAges 55–70
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.