Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT06676098Recruiting
Best spot for a guided numbing shot for root canals
This study compares different injection spots for a new device that helps numb lower back teeth before root canal treatment. If you need a root canal on a lower molar or premolar, you may be able to help find the best spot for the numbing shot.
Boston, MassachusettsAges 18 years+ - NCT05884983Recruiting
Check if special CT and nose scope help screen nasopharyngeal cancer
This study tests whether combining a special CT scan with a nose/throat camera exam (nasopharyngeal endoscopy) can better find nasopharyngeal cancer early. You might benefit if the study shows this approach is accurate and safer for screening.
Zhongshan, GuangdongAges 30–69 - NCT06665451Recruiting
Erythropoietin gel for better dental implant stability
This trial tests whether applying a special gel containing erythropoietin (a protein that helps healing) around a dental implant can improve how well the implant holds in the bone. It may help people who need a front tooth replaced after extraction.
Asyut, Asyut GovernorateAges 20–50 - NCT06659991RecruitingEarly Phase 1
Pain and daily tasks in jaw joint disorder
This study tests how pain from a jaw joint disorder (TMD) affects your ability to do daily tasks. You'll track your pain and activities on your smartphone to help researchers understand the link.
Minneapolis, MinnesotaAges 21–65 - NCT06657651Enrolling by invitation
Immediate Implant with Different Membranes for Lower Back Teeth
This study tests placing a dental implant and a special membrane right after removing a damaged lower back tooth. It looks at how well different types of membranes help the bone heal around the implant.
Al MansurahAges 18–60 - NCT06662058Recruiting
Remote hearing test for head and neck cancer patients on cisplatin or radiation
This study tests a remote hearing test to monitor hearing changes in patients with head and neck cancer getting cisplatin chemotherapy and/or radiation. The goal is to catch hearing loss early so treatment can be adjusted.
Atlanta, GeorgiaAges 18 years+ - NCT05500755Recruiting
Study testing PrimeTaper dental implants with x-ray follow-up
This study looks at outcomes of Dentsply Sirona PrimeTaper dental implants after placement. It includes people who already received at least one of these implants and evaluates results using dental x-rays.
Alicante, AlicanteAges 18–99 - NCT06656325Recruiting
Laser treatment for gum disease study
This study tests a special low-level laser (Erchonia FX-405) as an extra treatment for gum disease (periodontitis). It aims to see if adding this laser to standard care helps improve gum health and reduce infection.
Thousand Oaks, CaliforniaAges 22–75 - NCT06648564Enrolling by invitation
20-25 Year Follow-Up on Bone Grafts for Gum Disease Around Implants
This study follows up on patients who had a bone graft procedure to treat gum disease around dental implants 20 to 25 years ago. It aims to see how well the treatment worked over the long term.
KristianstadAges Any age - NCT06647381Enrolling by invitation
Long-term outcomes of implants with sinus lifts
This study looks at how well dental implants hold up many years after a sinus lift procedure. If you had a sinus lift and implant around 1997–2001 at the University of Bern, you may be asked to come in for an exam to check your implant health.
BernAges 18–100 - NCT06636734RecruitingPhase 2
Lovastatin plus pembrolizumab for advanced head and neck cancer
This trial tests whether adding lovastatin (a cholesterol-lowering drug) to pembrolizumab (an immunotherapy) works better than pembrolizumab alone for head and neck cancer that has come back or spread. It's for people who haven't had immunotherapy before and aren't already on a statin.
Atlanta, GeorgiaAges 18 years+ - NCT06636097Enrolling by invitation
Dental implant bridge inner surface study
This study looks at the inside surface of full-arch dental bridges that are screwed into implants. It aims to understand how this surface affects the health of the surrounding gums and bone.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06633640Enrolling by invitationEarly Phase 1
Algae bone graft for gum disease bone defects
This study tests a new bone graft material made from algae, used with a collagen membrane, to help repair bone damage caused by gum disease. It might be an option if you have a deep pocket in the bone around a tooth and are healthy enough for the procedure.
CairoAges 20–65 - NCT06643507RecruitingPhase 2/Phase 3
Testing a new gum repair technique for receding gums
This trial compares two ways to fix receding gums (a condition where your gums pull away from your teeth). It tests a newer technique using your own blood products versus a traditional graft to see which works better for moderate gum recession.
CairoAges 18–60 - NCT06643468Enrolling by invitation
ALB-PRF with bone grafts for immediate dental implants
This trial tests whether using a special protein-rich blood product (ALB-PRF) with two different types of putty-like bone grafts helps improve the success of dental implants placed right after a tooth is removed in the front upper jaw. It may help people who need a tooth replaced in the 'smile zone' and have good oral health.
Al MansurahAges 20–60 - NCT06037694Recruiting
Healthy tissue graft around dental implants
This trial tests whether a gum tissue graft can help people with dental implants who have too little attached gum tissue around them, causing discomfort or difficulty cleaning. The goal is to see if the graft improves comfort and gum health.
Dubai, DubaiAges 18–70 - NCT06270303Recruiting
Bone substitute for gum disease between tooth roots
This trial tests a bone substitute material to help repair gum defects between the roots of back teeth (molars) that have not healed with standard deep cleaning. If you have a single area of gum bone loss between the roots, this surgery might help regenerate the bone.
GothenburgAges 18 years+ - NCT06619574Recruiting
Testing the dental compass for jaw joint positioning
This study tests a new tool called a Dental Compass that helps dentists place your jaw joint back in the right position more accurately and quickly. It may help relieve TMJ pain and improve jaw function.
Gainesville, TexasAges 18–90 - NCT06629038Recruiting
AI estimates jaw, neck, and shoulder movement
This study uses an artificial intelligence (AI) model to estimate how much you can move your jaw, neck, and shoulders. It aims to help doctors better measure movement problems in people with or without oral cancer.
TaipeiAges 20–65 - NCT06627270RecruitingPhase 2
Antibiotics before surgery for oral cancer
This trial tests if taking antibiotics and using a mouth rinse before surgery can help treat oral cancer by targeting bacteria inside the tumor. It is for people with a new diagnosis of oral cancer who are scheduled for surgery.
Cleveland, OhioAges 18 years+ - NCT06623266Recruiting
Observation vs. neck surgery for early mouth cancer
This study compares two approaches for early-stage mouth cancer: careful observation of the neck versus a preventive surgery to remove neck lymph nodes. The goal is to see which strategy works better to prevent cancer from spreading.
ShanghaiAges 18–75 - NCT06623110RecruitingPhase 2
RP2 vaccine to prevent mouth cancer in high-risk pre-cancer
This trial tests an injected virus therapy (RP2) to stop pre-cancerous mouth lesions from turning into cancer. It is for people with high-risk oral pre-cancer or a history of early-stage head and neck cancer with certain worrisome features.
Boston, MassachusettsAges 18 years+ - NCT06624982Recruiting
Bone Changes After Tooth Extraction and Grafting
This study looks at how your jawbone changes after a tooth is pulled and a bone graft is put in. If you need a single tooth removed and have good general health, you may be able to join.
Milwaukee, WisconsinAges 18–75 - NCT06627855Recruiting
Fascial stretch method for jaw pain relief
This study tests a hands-on technique called the fascial distortion model to see if it works better than a sham treatment for reducing jaw, face, or neck pain. It may help if you have had a jaw disorder for at least 3 months.
Merkez, Karabük ProvinceAges 18–64
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.