Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT07256743RecruitingPhase 2
Testing a probiotic drink for gum health in healthy adults
This trial tests if taking a daily probiotic drink can help keep gums healthy in people without gum disease. You would be asked to stop using certain dental products during the study.
Toronto, OntarioAges 18–70 - NCT07257887Recruiting
Testing OROXID oral solution for gum disease
This trial tests a mouth rinse (OROXID) to see if it helps treat advanced gum disease (periodontitis). You may qualify if you have at least three deep gum pockets and have not had dental cleanings or used antibiotics recently.
LjubljanaAges 18 years+ - NCT07258303Recruiting
Probiotic Spray for Gum Disease in Older Adults
This trial tests an oral spray that contains good bacteria (probiotics) to help prevent and treat gum disease in older adults. It may be a simple addition to your daily routine to support gum health.
Hanoi, HanoiAges 35 years+ - NCT07258979RecruitingPhase 1/Phase 2
YL201 and Toripalimab with or without Cisplatin for Nasopharyngeal Cancer
This trial tests a new drug combination for people with advanced or recurrent nasopharyngeal cancer. It aims to see if YL201 plus Toripalimab (and sometimes cisplatin) can help when standard treatments are not an option.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT07260344Recruiting
Testing two new ways to find early mouth precancer
This study compares two non-invasive methods to detect precancerous sores in the mouth. It aims to find a simpler way to catch early changes before they become cancer.
Taipei, TaipeiAges 30–80 - NCT07262606Recruiting
Saliva protein levels in gum disease severity and smoking
This study looks at a protein called Mitofusin-1 in your saliva to see if its levels are linked to how serious gum disease is, whether you smoke, and how you respond to treatment. Samples will be taken once before any treatment begins.
Erzincan, ErzincanAges 18–65 - NCT07264036Recruiting
Nasal Speech After Head and Neck Cancer Treatment Study
This study is for people who have had treatment for head or neck cancer and now have a nasal-sounding voice. It tests a procedure to help improve speech by adding a small amount of filler material to the back of the throat.
Charlottesville, VirginiaAges 18 years+ - NCT07264842RecruitingPhase 2
Comparing two pastes for infected baby molars in children
This trial tests whether a special antibiotic paste or a medicine called simvastatin works better to treat infected baby molars in children. It aims to save the tooth and heal the infection without pulling it.
Karachi, SindhAges 5–8 - NCT07270705Recruiting
OROXID® mouth rinse for gum disease
This trial tests an oral rinse called OROXID® for people with gingivitis (gum disease). It looks at whether the rinse helps reduce gum bleeding and swelling. You may join if you are generally healthy, have at least 20 natural teeth, and have mild gum inflammation but not severe gum disease.
LjubljanaAges 18 years+ - NCT07273123Recruiting
Chewing gum and fatigue in jaw joint health
This study tests if chewing sugar-free gum for a while can affect how tired you feel and how your jaw muscles work. It compares people with and without jaw joint problems (TMJ disorders).
Milan, MilanAges 19–35 - NCT07274189Recruiting
Gum health and sodium bicarbonate toothpaste study
This trial tests whether a sodium bicarbonate (baking soda) toothpaste can improve gum health compared to a standard toothpaste. If you have some gum problems (but not too severe), it might help.
PlymouthAges 18 years+ - NCT07276087Recruiting
Physical and Mental Health in Takayasu Arteritis and Behçet's Disease
This study compares physical and mental health in people with Takayasu arteritis or Behçet's disease to healthy volunteers. It aims to better understand how these conditions affect day-to-day life and well-being.
Denizli, DenizliAges 18 years+ - NCT07277764RecruitingPhase 2
Radiation and immunotherapy for returning nasopharyngeal cancer
This trial tests a combination of high and low dose radiation plus an immunotherapy drug (PD-1 inhibitor) for people whose nasopharyngeal cancer has come back after previous treatment. The goal is to see if this approach can be more effective while reducing side effects.
Nanchang, JiangxiAges 18–75 - NCT07278999Recruiting
Light therapy and clobetasol for oral lichen planus
This trial tests two light-based treatments (photobiomodulation and photodynamic therapy) and a steroid cream (clobetasol) for painful oral lichen planus. The goal is to see which treatment works best to reduce mouth sores and discomfort.
Zabrze, Silesian VoivodeshipAges 20–70 - NCT07279883Recruiting
Nerve block for pain after cleft palate surgery in children
This study looks back at the medical records of children who had cleft palate surgery in 2017 or 2018. It compares how long they stayed in the hospital and their pain needs after surgery, between those who got standard pain medicine alone and those who also got a nerve block to help with pain.
StockholmAges 3 months–15 years - NCT07280260RecruitingPhase 4
Testing a new dental implant system for replacing a missing back tooth
This trial tests the Nobel N1 dental implant system in people missing a single back tooth. It aims to see how well the implant works when a replacement tooth is placed right away.
New Orleans, LouisianaAges 18 years+ - NCT07281456RecruitingPhase 2
Testing a new oral drug for Sjögren's disease safety
This study tests the safety of a daily pill called Tofacitinib for adults with mild-to-moderate Sjögren's disease. It aims to see if this drug helps manage symptoms when other treatments haven't worked well.
Bethesda, MarylandAges 18–75 - NCT07282756Recruiting
Lovastatin gel for gum disease treatment
This study tests whether a lovastatin gel applied to the gums (after a deep cleaning) helps treat gum disease better than cleaning alone. Participants must not have had previous gum treatment or antibiotics recently, and can be a smoker or non-smoker.
Bielsko-Biala, Silesian VoivodeshipAges 18–59 - NCT07284797RecruitingPhase 1
Safety study for autoimmune disease and healthy volunteers
This trial is testing an experimental drug for safety in people with certain autoimmune diseases—like myositis, scleroderma, or Sjögren's disease—as well as in healthy volunteers. It aims to find out if the drug is safe enough to study further.
MelbourneAges 18–75 - NCT07286344Recruiting
Fluoride varnish for tooth sensitivity
This trial tests whether a special fluoride varnish can reduce dentin hypersensitivity (tooth sensitivity). If you have sensitive teeth, this study may help find a better treatment.
Concepción, BiobioAges 18–40 - NCT07286916Recruiting
Guided biofilm therapy for gum disease
This study tests a new, guided gum cleaning method (biofilm therapy) to see how it affects certain markers of gum health and healing. It may help people with active gum disease that has not improved with standard care.
BaghdadAges 18 years+ - NCT07287293Recruiting
Suctioning vs no suctioning when waking from anesthesia
This trial compares two ways of managing your breathing tube when you wake up from general anesthesia: suctioning the tube or not. It aims to see which method is more comfortable and safer for you after surgery.
Samut SakhonAges 18 years+ - NCT07287540Recruiting
Anti-inflammatory diet for gum disease treatment
This trial tests whether an anti-inflammatory diet can improve the results of standard gum disease treatment. It is for people diagnosed with periodontitis who are otherwise healthy and do not smoke.
RizeAges 20–65 - NCT07287709Recruiting
Laser vs. standard treatment for painful adult molars
This study tests if using a laser is better than the usual method for treating painful, inflamed teeth that still have a live nerve. The goal is to save the tooth and reduce pain without removing the nerve entirely.
AlexandriaAges 16–50
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Lungs & breathing
- Immune system & allergy
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- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.