Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT07569432Recruiting
Understanding Immune Cells Around Dental Implants
This study examines how immune cells behave around dental implants that are failing or healthy. Researchers will take small tissue samples during your implant surgery to better understand why some implants develop problems and how to prevent or treat them in the future.
IstanbulAges 18 years+ - NCT07574606Recruiting
Soft Tissue Coverage for Zygomatic Implants in Jaw Bone Loss
This study compares two surgical methods to cover zygomatic implants (special anchor posts for teeth) in patients with severe jawbone loss. Researchers will measure how much soft tissue (gum and fat) builds up over the implants to see which method produces better, longer-lasting results.
Cairo, New CairoAges 18 years+ - NCT07574827Recruiting
Candida Fungus and Gum Disease in Syrian Patients
This study looks at whether a common fungus called Candida albicans is linked to chronic periodontitis (advanced gum disease). Researchers will examine gum samples from Syrian patients to understand this connection and may help improve gum disease treatment.
HomsAges 18 years+ - NCT07575347Recruiting
Gum Disease and Rare Kidney Disorders Study
This study explores whether people with certain rare kidney diseases or chronic kidney problems have more gum disease than others. Researchers will examine your teeth and gums to understand the connection and help improve care for people with kidney conditions.
BucharestAges 18 years+ - NCT07575997Recruiting
Testing Different Interdental Brushes for Gum Disease
This study compares different types of small brushes designed to clean between your teeth in adults with periodontal disease (a serious gum condition). The goal is to see which brush works best at improving gum health.
BrusselsAges 18–80 - NCT07577232Recruiting
Ultrasound imaging for diagnosing throat abscesses
This trial tests whether using ultrasound (sound wave imaging) through the mouth helps doctors better diagnose a throat abscess—a pocket of infection near the tonsil. The goal is to see if this imaging method improves diagnosis accuracy and treatment decisions.
CopenhagenAges 18 years+ - NCT07579416Recruiting
Teeth Grinding, Anxiety, and Gum Health in Dental Students
This study looks at the connection between teeth grinding (bruxism), anxiety, and gum health in dental students. Researchers want to understand how stress and grinding habits affect the teeth and gums of students in their final years of dental school.
HomsAges 18 years+ - NCT07580495Recruiting
Collagen Membrane to Preserve Jaw Bone After Tooth Extraction
This study tests whether a collagen membrane (a thin, natural material) placed after a tooth extraction helps preserve the jaw bone. Keeping bone healthy can make future tooth replacement easier and more successful.
Pittsburgh, PennsylvaniaAges 18–80 - NCT07581821RecruitingPhase 2
Immunotherapy plus targeted drugs for advanced nasopharyngeal cancer
This trial tests a combination of three drugs (sintilimab, anlotinib, and chemotherapy) for nasopharyngeal cancer that has returned or spread after initial treatment. The goal is to see if this combination helps slow or shrink the cancer.
Zhuhai, GuangdongAges 18–65 - NCT07584499RecruitingPhase 1
New drug test for children with EGFR-positive solid tumors
This study tests a new cancer drug called Becotatug Vedotin in children ages 2–18 with certain types of solid tumors (cancers that form in organs or tissues) that have an EGFR protein. The drug is designed to find tumors with this protein and attack cancer cells while sparing healthy ones.
Guangzhou, GuangdongAges 2–18 - NCT07590024RecruitingPhase 3
Personalized Cancer Treatment Guidance for Nasopharyngeal Cancer
This trial tests whether a special analysis of blood markers and imaging scans can help doctors choose the best combination of chemotherapy and radiation for nasopharyngeal cancer. The goal is to improve outcomes by tailoring treatment to each patient's specific cancer characteristics.
Beijing, Beijing MunicipalityAges 18–65 - NCT07593495Recruiting
Electric Nerve Stimulation to Treat Dry Mouth
This study tests whether a gentle electrical nerve stimulation treatment (called TENS) can help increase saliva production in people with dry mouth. Participants will receive this treatment along with standard care and answer questions about how the treatment affects their quality of life.
Toluca, State of MexicoAges 12–90 - NCT07594184Recruiting
Can hyaluronic acid injections help dry mouth?
This study tests whether injections of hyaluronic acid—a naturally occurring substance—can relieve chronic dry mouth (xerostomia). If it works, it could offer a new treatment option for people who have had dry mouth for at least a year.
Barcelona, BarcelonaAges 18 years+ - NCT07596485RecruitingPhase 1/Phase 2
RP-008 Plus Varenicline for Trigeminal Neuralgia Pain
This trial tests a new drug called RP-008 combined with varenicline (a quit-smoking medication) to relieve severe facial pain from trigeminal neuralgia. If you've already tried standard pain medications without enough relief, this combination might help reduce your pain attacks.
SherbrookeAges 18–80 - NCT07599254RecruitingPhase 4
Pain Relief After Root Canal Retreatment
This study tests two different ways of cleaning and treating a tooth that had a root canal treatment before. Researchers want to see which method causes less pain after the procedure.
KayseriAges 18–60 - NCT07599657Recruiting
Protein Levels in Gum Disease Before and After Minimally Invasive Surgery
This study measures a natural protein in your gums before and after a minimally invasive surgical treatment for moderate to advanced gum disease. Researchers want to understand how this protein changes with treatment, which may help improve gum disease care in the future.
CairoAges 18 years+ - NCT07604493Recruiting
Italian Doctors' Survey on Oral Health and General Wellness
This study asks Italian general practitioners (family doctors) about their views on how oral health—like teeth and gum health—affects overall body health. Your answers help researchers understand what doctors know and think about the connection between mouth and systemic diseases.
Roma, RMAges 18 years+ - NCT07607639Recruiting
Gum Health Markers in Children and Young Adults
This study looks at special proteins in the fluid around your gums to understand how gum disease develops in young people. By studying these markers, researchers hope to better understand and treat gum inflammation.
NiğdeAges 8–24 - NCT07609797Recruiting
Fluoride and Mouthwash Effects on Cavity Markers in Children
This study tests whether sodium fluoride and chlorhexidine (a prescription mouthwash) change certain markers in saliva that may relate to tooth decay in children with cavities. The goal is to understand if these common dental treatments affect the body's natural cavity-fighting substances.
Alanya, AntalyaAges 6–8 - NCT07611643Recruiting
Treating Jaw Clenching and Facial Pain With a Custom Bite Guard
This study tests whether a custom-made bite guard (called an occlusal splint) can help relieve jaw and facial pain caused by temporomandibular disorders—conditions affecting the jaw joint and muscles. Researchers will monitor how well the treatment works and how it affects your symptoms.
Roma, RomaAges 18 years+ - NCT07611942Recruiting
Plaque Removal in Children With Learning Disabilities
This study compares how well children with learning disabilities can remove plaque from their teeth compared to children without learning disabilities. It aims to understand if dental plaque removal is harder for children with specific learning challenges.
Alanya, AntalyaAges 7–12 - NCT07611981Recruiting
Tooth Decay and Oral Health in Children With Learning Disabilities
This study compares tooth decay and brushing habits between children with specific learning disabilities and healthy children. Researchers want to understand if children with learning disabilities need special dental care strategies.
Alanya, AntalyaAges 7–12 - NCT07614490RecruitingPhase 4
Dental plaque and gum health study
This research study examines how dental plaque relates to gum inflammation in people with different levels of gum health. Researchers will collect plaque samples and measure gum health to better understand these patterns, which may help improve oral care products.
Fort Wayne, IndianaAges 18 years+ - NCT07618078Recruiting
Personalized Cancer Risk Assessment for Nasopharyngeal Cancer
This study helps doctors predict which patients with nasopharyngeal cancer (a cancer of the upper throat) will benefit most from additional chemotherapy after radiation treatment. It uses a special blood test and imaging to create a personalized risk score for each patient.
Beijing, Beijing MunicipalityAges 18–75
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.