Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT05183503Enrolling by invitation
Study of pain, stress, anxiety, and depression in jaw disorder
This study looks at how chronic jaw pain from temporomandibular disorder (TMD) relates to stress, anxiety, and depression in adults. Your results may help researchers better understand what affects symptoms and how people respond to care.
WroclawAges 18–80 - NCT05122897Recruiting
Study of plaque biofilm on temporary implant crown rings
This study looks at how plaque-biofilm (a thin layer of germs that can stick to surfaces) forms on temporary parts of dental implant crowns. If you have dental implants and are healthy and stable with gum health, your care team may use specific temporary rings to study biofilm buildup.
BaselAges 18 years+ - NCT05106608Recruiting
Mobile plus light therapy for dry mouth after head and neck cancer
This study tests whether “photobiomodulation” light therapy, guided by a phone app, can improve chronic dry mouth (xerostomia) in people who finished radiation for head and neck cancer. It may help reduce bothersome mouth dryness and support better day-to-day comfort after treatment.
GranadaAges 18 years+ - NCT05058638RecruitingPhase 2
Aquamin for bad breath
This study tests whether a dietary supplement called Aquamin (made from a marine mineral source) can help reduce bad breath (halitosis). Participants will take the supplement for a period and have their breath assessed at study visits.
Ann Arbor, MichiganAges 18–99 - NCT04613349Recruiting
MRI before first parotid tumor surgery
This study tests whether a special MRI scan (with a contrast dye) can help doctors better plan surgery for tumors in the salivary gland near the facial nerve. It may help surgical planning while avoiding unnecessary repeat imaging.
Paris, PARISAges 18 years+ - NCT04928352RecruitingPhase 3
Breathing numbing medicine during cleft palate surgery
This trial tests whether a breathing treatment (nebulized numbing medicine) can reduce pain during cleft palate repair in young children. It may help comfort your child after surgery when they are under general anesthesia.
Asyut, AssuitAges 1–7 - NCT04944914RecruitingPhase 3
Camrelizumab with targeted radiation for limited nasopharyngeal cancer spread
This trial tests whether combining camrelizumab (an immune medicine) with stereotactic body radiotherapy (high-precision radiation) works better than camrelizumab alone. It’s for people whose nasopharyngeal cancer has spread to a small number of spots in the body and may help control those metastases longer.
Guangzhou, GuangdongAges 18–70 - NCT04931160Recruiting
Study for suspected Sjögren’s disease diagnosis
This study follows people who may have Sjögren’s disease to better understand how to diagnose it. If you have symptoms like dry eyes or dry mouth, this could help researchers confirm the diagnosis and learn what tests best explain it.
BrestAges 18 years+ - NCT04930887RecruitingPhase 2
Numbing injection in the face to ease craniofacial pain
This trial tests whether an injection of a numbing medicine (bupivacaine) guided by an endoscope can reduce craniofacial pain. It may help people with certain headache or facial pain conditions by targeting the pain area more precisely.
Stanford, CaliforniaAges 18–80 - NCT03215719RecruitingPhase 2
De-escalating treatment for HPV-positive throat cancer with low-risk signals
This Phase 2 trial tests whether people with HPV-positive oropharyngeal (throat) cancer who look “lower risk” can safely receive less intensive treatment. It uses HPV blood test results and cancer staging scans to guide whether treatment can be de-escalated.
New York, New YorkAges 18 years+ - NCT04905745Recruiting
Integrative Korean medicine for new one-sided Bell’s palsy
This trial studies whether an integrative Korean medicine treatment can safely improve symptoms of Bell’s palsy. It’s meant for people whose facial weakness started recently, to see if treatment helps recovery.
Seoul, Gangnam-GuAges 19–69 - NCT04920136Recruiting
Tissue graft to strengthen gum around teeth or implants
This study tests a gum-repair approach that may help create more durable, firm gum tissue around teeth or dental implants. If your area lacks “keratinized” (firmer, protective) gum tissue, this could improve comfort and stability after dental work.
Birmingham, AlabamaAges 18–99 - NCT04860141RecruitingPhase 4
Gabapentin before wisdom tooth removal to reduce pain
This trial tests whether taking gabapentin before extracting a wisdom tooth helps with pain and comfort after the procedure. It may help people who need a third-molar removal, if they meet the safety and health requirements.
Loma Linda, CaliforniaAges 18–59 - NCT04901234RecruitingPhase 2
Adaptive radiation for advanced throat cancer
This study tests an approach called “adaptive radiotherapy,” where the radiation plan may be adjusted based on how your tumor and anatomy look during treatment. It is for adults with biopsy-proven oropharyngeal (throat) squamous cell carcinoma who are planning curative radiation, with or without chemotherapy.
MelbourneAges 18 years+ - NCT04900623RecruitingPhase 2
Using HPV blood test to guide treatment for HPV throat cancer
This Phase 2 study tests a “risk-adapted” treatment plan for HPV-related throat cancer, using an HPV DNA blood test to help decide how treatment is done. If your baseline blood test shows detectable HPV DNA, the study may help tailor therapy to your risk and potentially improve outcomes while limiting unnecessary treatment.
Boston, MassachusettsAges 22 years+ - NCT03286569Recruiting
Braces study for children to move the lower jaw forward
This study looks at whether a removable mouth “expansion appliance” can help the lower jaw grow forward in children whose bite is too far back. It may help improve the way the upper and lower teeth and jaws fit together.
Edmonton, AlbertaAges 9–11 - NCT03276923Recruiting
Pregnancy registry for women with autoimmune disease
This study is a pregnancy and health registry for women with autoimmune (immune system) conditions who are trying to become pregnant or are already pregnant. It helps researchers better understand pregnancy outcomes and health needs in autoimmune disease.
Durham, North CarolinaAges Any age - NCT04831060Recruiting
Study of inflammation in gum and implant disease
This trial studies people with advanced gum disease (periodontitis) or gum inflammation around dental implants (peri-implantitis), and compares them with people who have healthy gums. The goal is to understand inflammation and how it relates to these dental conditions.
Ivry-sur-SeineAges 18 years+ - NCT04847648Enrolling by invitation
Air polishing for gum infection around dental implants
This trial tests whether “air polishing” (a gentle cleaning method) can improve peri-implantitis, an infection and inflammation around dental implants. It may help by reducing deep gum pockets, bleeding, pus, and bone loss around the implant.
GothenburgAges 18 years+ - NCT04805320Recruiting
Study of gum inflammation after tooth removal
This study looks at how gum (periodontal) inflammation affects the body’s immune response during wound healing after a tooth is taken out. You might be considered because you need a molar or premolar extraction where the tooth cannot be repaired.
Lincoln, NebraskaAges 21–70 - NCT04771156RecruitingPhase 4
Ketorolac pain relief during cleft palate repair
This trial tests whether ketorolac (a pain medicine similar to other NSAIDs) helps control pain during palatoplasty, the surgery to repair a cleft palate. It may help make recovery more comfortable for people having their first palate repair.
Houston, TexasAges 6 months+ - NCT04693949Recruiting
A study on a new coating for dental bridges
This trial tests a special coating for dental bridges made from a strong white material (zirconia). It may help the bridge bond better to your tooth.
LjubljanaAges Any age - NCT04719026Recruiting
Teeth and heart attack link in people with or without heart attacks
This study compares dental health in people who were recently admitted for a heart attack with similar people who have not had a heart attack. It aims to see whether gum and dental health might be related to heart attack risk.
AberdeenAges 20–90 - NCT04605445Recruiting
One vs two dentist visits for infected root canals
This study compares whether treating an infected, dead tooth in one visit works as well as using two visits. It may help you and your dentist choose the simplest schedule while still clearing infection and supporting healing.
Vaxjo, Kronoberg CountyAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.