Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT05494190Recruiting
Treatment strategy for lymph node spread in hypopharyngeal cancer
This trial studies treatment choices for people with hypopharyngeal squamous cell cancer that has spread to certain neck lymph nodes. The goal is to help control the cancer in the neck and improve outcomes when the lymph node area can be surgically managed.
Harbin, HeilongjiangAges 18–75 - NCT05470023Recruiting
Imaging study of gum health and mouth biofilm
This study uses imaging to look at how healthy your gums are and how much “plaque/biofilm” is in your mouth. It may help researchers better understand gum health and how oral hygiene affects it.
Irvine, CaliforniaAges 18 years+ - NCT05492266Recruiting
Breathing muscle training for nasal speech in children
This trial tests whether strengthening the muscles you use to breathe out can help children ages 5–17 who have too much nasal sound in their speech. If it works, it could reduce the need for surgery.
Pittsburgh, PennsylvaniaAges 5–17 - NCT05384132Recruiting
Dental gel trial with deep cleaning for gum disease
This study tests whether a new dental gel used along with deep gum cleaning (scaling and root planing) can improve periodontitis. If you qualify, you would receive standard gum treatment plus the study gel, then be followed over time.
Birmingham, AlabamaAges 18–85 - NCT05451004RecruitingPhase 3
SPECT-CT test to target neck radiation on one side
This study tests whether using a special scan (SPECT-CT) can guide radiation treatment to only the safer/needed side of the neck in people with a one-sided oropharyngeal cancer. It aims to keep cancer control while potentially reducing side effects from unnecessary radiation.
Corona, CaliforniaAges 18 years+ - NCT05427006Recruiting
Dental implant follow-up registry for zirconia tooth implants
This registry study follows adults after getting specific zirconia dental implants to track how they do over time. It helps the company and doctors understand safety and real-world performance of these implant products.
BerlinAges 18 years+ - NCT05442034RecruitingPhase 1/Phase 2
Two gum treatments for deep bone defects in teeth
This study tests whether one of two treatments can improve healing of “intra-bony” gum/bone defects around teeth after deep cleaning. It may help some people with periodontal disease who have pockets deep enough to involve the bone but with certain health and dental conditions.
Davie, FloridaAges 18 years+ - NCT05439330Recruiting
Dental MRI to help diagnose jaw, gum, and tooth problems
This study tests whether a special dental MRI can give useful pictures to diagnose jaw joint problems, tooth-related tissue changes, and gum/inflammation issues, and to help plan some dental implant treatments. If you need imaging for these reasons, the trial may help doctors choose the best next treatment by using clearer, dedicated scans.
AarhusAges 18 years+ - NCT05441813RecruitingPhase 2
Coconut oil mouth rinse to prevent mouth sores during transplant
This study tests whether a coconut oil mouth rinse can help prevent mouth sores in children and young adults who are about to receive intense chemotherapy for a stem cell transplant. If mouth sores can be prevented, it may make treatment more comfortable and reduce complications.
Charlotte, North CarolinaAges 7–26 - NCT05429099Recruiting
Planning study for jaw reconstruction surgery
This study helps teams plan surgery for people who need part of the lower jaw removed and rebuilt using special tissue flaps. It mainly looks at whether having specific pre-surgery CT images is possible and useful for reconstruction planning.
Vancouver, British ColumbiaAges 18 years+ - NCT05449548Recruiting
Lenalidomide for severe mouth ulcers from Behçet’s
This trial studies lenalidomide to treat frequent, ongoing mouth ulcers caused by mucosal Behçet’s syndrome. It’s meant for people whose mouth sores keep coming back despite standard treatments like steroid medicines and other immune-suppressing drugs.
Beijing, Beijing MunicipalityAges 18–65 - NCT05414019Enrolling by invitation
Braces study for tooth root damage in teens
This study compares different orthodontic force plans to see how they affect “root resorption,” when the tooth root shortens over time. It’s meant to find safer ways to move front lower teeth in teens who have a deep bite.
CairoAges 12–16 - NCT05388773RecruitingPhase 2
Surgery then lower-dose radiation for p16+ throat cancer
This Phase 2 study tests whether removing the tumor through the mouth, followed by a reduced course of radiation, can control HPV-related (p16+) oropharynx throat cancer. It may help reduce treatment intensity after surgery, while still aiming to keep the cancer from coming back.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05408845RecruitingPhase 2
Study drug vs standard care for HER2 salivary gland cancer
This Phase 2 trial tests how well ado-trastuzumab emtansine (and compares to two standard treatment options) works for salivary gland cancers that are HER2-positive or HER2-low. It aims to see whether the study drug can control cancer better and with acceptable side effects.
Birmingham, AlabamaAges 18 years+ - NCT04281056Recruiting
Tooth loss and dentures: taste and food preferences
This study looks at how losing teeth and wearing dentures affects your mouth sensations and your food choices. It compares people who are fully without teeth (and use dentures) with people who still have their natural teeth.
ParisAges 18–79 - NCT05340491RecruitingPhase 3
Radiation plus immunotherapy for repeat nasopharyngeal cancer
This trial studies whether adding an anti–PD-1 immunotherapy to standard chemoradiotherapy can control nasopharyngeal cancer that has come back in the local area. It may help patients live longer or have the cancer respond better compared with chemoradiotherapy alone.
Guangzhou, GuangdongAges 18–70 - NCT05329558Enrolling by invitation
Testing changes in jawbone problems in adults
This study looks at what changes happen in the jawbone in people with osteonecrosis of the jaw (a damaged jawbone area), whether or not they take certain cancer/bone medicines. It may help doctors better understand the condition and how it behaves over time.
GrazAges 18 years+ - NCT05307939RecruitingPhase 2
Using tumor DNA tests to time treatment for HPV throat cancer
This study checks a blood test that looks for HPV tumor DNA to help doctors decide when to start routine treatment after surgery. It may help some people avoid starting treatment too early or too late based on how the test changes after the operation.
Miami, FloridaAges 18 years+ - NCT05296109Recruiting
3D MRI study of facial nerves in parotid tumors
This trial tests a special 3D MRI picture method to evaluate the facial nerves in people with parotid (salivary gland) tumors. It may help your care team see facial nerve involvement more clearly, which can guide treatment planning.
Hong KongAges 18 years+ - NCT05272488Recruiting
Manual therapy plus vagus nerve stimulation for jaw muscle pain
This trial tests whether combining hands-on jaw treatment with a vagus nerve stimulator can reduce jaw muscle pain and improve jaw movement. It may help people whose jaw pain has been present recently and who have not had recent physiotherapy.
Alcalá de Henares, MadridAges 18 years+ - NCT04863222RecruitingPhase 4
Compare MTA vs Biodentine for baby molar pulp care
This trial compares two tooth materials (MTA and Biodentine) used during pulpotomy or indirect pulp cap procedures for children with early decay in baby molars. It looks at how well the tooth heals over time using symptoms and follow-up dental X-rays.
Danville, PennsylvaniaAges 2–12 - NCT05214924Enrolling by invitationPhase 2/Phase 3
PRF injections for mild to moderate jaw joint wear
This study tests whether injecting iPRF (a therapy made from your blood growth factors) into the jaw joint can reduce symptoms from mild to moderate jaw joint degeneration. It’s being compared against standard care for people who currently are not on other jaw-joint treatments.
WroclawAges 18–80 - NCT05237570Recruiting
Less invasive sinus lift for upper back teeth
This trial tests a minimally invasive procedure to lift the sinus floor to help support an upper back tooth area when the tooth cannot be rebuilt. It may help people who need bone support for a future dental restoration or implant by using a specific, less invasive pathway.
MurciaAges 18 years+ - NCT05172245RecruitingPhase 1
Testing a new drug added to chemoradiation for head and neck cancer
This study tests whether adding a new targeted drug called ipatasertib to standard chemoradiation can improve treatment for people with locally advanced head and neck cancer. Ipatasertib may help block a protein that helps cancer grow, possibly making the standard therapy more effective.
Tampa, FloridaAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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- Genetic & congenital
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- Pain
- Injuries & trauma
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.