Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT07532694Recruiting
Laser Treatment for Gum Disease in Kidney Transplant Patients
This study tests whether a special diode laser can safely and effectively treat gum disease (periodontitis) in people who have received a kidney transplant. Gum disease is common in transplant recipients and can affect overall health, so this treatment may help protect both oral and transplant health.
Hanoi, HadongAges Any age - NCT07533240Recruiting
Tooth Wear Treatment Effects on Bite and Jaw
This study looks at how a specific tooth-restoration treatment (called the One-Step No-Prep protocol) affects your bite alignment and jaw joint over time. Researchers want to understand if this treatment helps improve how your teeth fit together.
LiègeAges 18 years+ - NCT07534514Recruiting
Digital Implants for Older Adults Needing Tooth Extraction
This study tests a computer-guided approach to place dental implants immediately after tooth extraction in patients aged 65 and older. The goal is to see if this digital method helps older adults get stronger, longer-lasting implants with fewer complications.
Shibīn al Kawm, MenoufiaAges 60–80 - NCT07535177Recruiting
Gas6 and MerTK Protein Markers in Gum Disease
This study measures two proteins (Gas6 and MerTK) in the blood and gum tissue of people with and without gum disease to better understand how these proteins relate to periodontal health. Results may help doctors identify new ways to diagnose or treat gum disease in the future.
Bolu, BoluAges 18 years+ - NCT07536204Recruiting
Gum Inflammation Study: Understanding Immune Cell Activation
This research study investigates how certain immune proteins (JAK1 and JAK2) work in gum tissue, both in healthy gums and in gum disease. Understanding this may help develop better treatments for periodontal disease in the future.
Santiago, Metropolitan RegionAges 18 years+ - NCT07537426Recruiting
Acupuncture for Dry Eyes After Facial Paralysis
This trial tests whether tiny acupuncture needles placed under the skin can help relieve dry eyes and other eye discomfort that develops after long-lasting facial paralysis. The goal is to see if this treatment can improve symptoms when standard care hasn't worked well enough.
Hangzhou, ZhejiangAges 18–65 - NCT07544394Recruiting
Understanding Fatigue in Sjögren's Syndrome
This study explores why people with Sjögren's syndrome experience fatigue and what factors predict it. Researchers will follow you for 3 months to better understand your fatigue patterns and potentially improve treatment.
KahramanmaraşAges 18 years+ - NCT07546279Recruiting
Bone substitutes with gum graft for deep gum pockets
This trial tests two different bone-filling materials combined with a gum graft to repair deep pockets in your gums caused by gum disease. The goal is to help your gums heal and regain support around your teeth.
MilanAges Any age - NCT07547202Recruiting
Gum Disease Treatment Effects on Saliva in Smokers and Non-Smokers
This study tests whether a non-surgical cleaning procedure for gum disease changes markers in your saliva differently depending on whether you smoke. Researchers want to understand how smoking affects how your mouth heals.
Baghdad, Baghdad GovernorateAges 18 years+ - NCT07547371Recruiting
Aromatherapy and Digital Anesthesia for Dental Anxiety in Children
This study tests whether aromatherapy (calming scents) and digital anesthesia (numbing technology) can help reduce anxiety and pain when children need a baby molar removed. The goal is to find gentler ways to keep children comfortable during dental procedures.
Istanbul, IstanbulAges 6–12 - NCT07547904Recruiting
Bioactive filling material for back tooth cavities
This trial tests a newer type of tooth-filling material (bioactive bulk-fill) in back teeth that need repair. Researchers will compare how well it works compared to standard fillings, which may help improve how long fillings last.
IstanbulAges 18–50 - NCT07548268Recruiting
Ultrasound imaging for suspected throat cancer
This study tests a new ultrasound method to help doctors identify throat cancer earlier. You would undergo imaging scans to see if ultrasound can better detect cancer in the back of the throat.
AarhusAges 18 years+ - NCT07548502Recruiting
Night Guard Effect on Jaw Muscle Size in Children With Teeth Grinding
This study looks at whether wearing a night guard (a protective dental device) can help reduce jaw muscle thickness in children who grind their teeth at night. Researchers will measure changes in the masseter muscle, which is the main chewing muscle in your jaw.
NiğdeAges 10–12 - NCT07549347Recruiting
Smart Toothbrush vs. Professional Cleaning for Gum Disease
This study tests whether using an intelligent (electric) toothbrush with a smartphone app can manage early gum inflammation as effectively as professional dental cleaning. If you have mild gum disease, this trial may help you avoid or delay professional treatments.
Shanghai, Shanghai MunicipalityAges 18–64 - NCT07550127Recruiting
Managing Dental Implant Infection: Surgery and Follow-up Care
This study tests how to treat peri-implantitis—an infection around dental implants—using surgery, then tracks how well your implants heal and stay healthy over time. The research may help improve treatment for people with failing implants.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07551024Recruiting
Zygomatic Implant Placement Accuracy: Metallic vs Resin Guides
This study compares two types of surgical guides (metallic and resin-based) to help dentists place zygomatic implants—special dental anchors used when the upper jaw bone is severely worn down. The goal is to see which guide method places these implants more accurately.
New Cairo, Cairo GovernorateAges 18 years+ - NCT07551115Recruiting
Oral Parasites and Gum Health Study
This study examines whether certain microscopic parasites in the mouth are linked to gum disease. Researchers will compare people with healthy gums to those with gum inflammation or disease to understand this connection better.
Bolu, GölköyAges 18 years+ - NCT07555223Recruiting
Using 3D Scans to Better Detect Tooth Decay
This study tests whether special 3D imaging and intraoral scanning tools can help dentists better identify tooth decay and plaque buildup. Researchers want to see if these new methods work well and could improve how cavities are diagnosed.
Wondelgem, BotestraatAges 18–70 - NCT07557277Recruiting
Gum Recession and Quality of Life Study
This study looks at how gum recession (when gums pull back from teeth) affects your quality of life and oral health. Researchers will ask you questions and examine your teeth to understand this connection better.
Rohtak, HaryanaAges 18–45 - NCT07557875Recruiting
Laser Treatment for Tongue-Tie in Young Children
This study tests whether a special laser can safely and effectively treat tongue-tie (a condition where the tissue under the tongue is too tight) in children ages 3–6. The goal is to see if the laser helps the tongue move better and heals faster than other methods.
Ho Chi Minh CityAges 3–6 - NCT07560514Recruiting
Testing New Digital Tools to Detect Tooth Decay
This study tests new digital technologies—including a special camera called DIAGNOcam and AI software—to detect tooth decay early and accurately. If you have some cavities and healthy teeth in specific areas of your mouth, you may be eligible to help researchers improve how dentists find and diagnose tooth decay.
Martin, Žilina RegionAges 18–65 - NCT07562100Recruiting
AI-Powered Exercise Program for Oral Cancer Patients Returning to Work
This study tests a smartphone-based exercise and wellness program designed to help people recently diagnosed with oral cancer prepare their body and mind before treatment, with the goal of helping them return to work faster and more safely. Researchers will track whether the program improves recovery and reduces healthcare costs.
TaipeiAges 20–70 - NCT07566676Recruiting
Faster Upper Front Tooth Movement With Micro-holes
This study tests a new way to move upper front teeth into better position using braces combined with tiny holes made in the bone. The goal is to correct an overbite (when upper front teeth stick out too far) more quickly and effectively.
Cairo, Nasr CityAges 15–25 - NCT07567105Recruiting
Long-term stability of open-bite orthodontic treatment
This study looks at whether orthodontic treatment for anterior open bite (a gap between upper and lower front teeth when biting down) stays stable over time. The researchers want to understand what helps the correction last.
VantaaAges Any age
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
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Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.