Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 2,053 recruiting studies in this area right now.
By phase
- Not applicable1,631
- Phase 2148
- Phase 183
- Phase 381
- Phase 458
- Phase 1/Phase 236
- Phase 2/Phase 316
Top conditions
- Periodontitis108
- Nasopharyngeal Carcinoma79
- Periodontal Diseases57
- Dental Caries49
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer35
- Dental Implant30
- Sjogren's Syndrome29
- Gingival Recession27
- Periodontal Disease27
- Alveolar Bone Loss23
- Nasopharyngeal Carcinoma (NPC)23
- Peri-Implantitis23
- Tooth Loss22
- Oropharynx Cancer21
- Temporomandibular Disorders (TMD)21
- Trigeminal Neuralgia21
Leading sponsors
- Cairo University91
- Sun Yat-sen University53
- Ain Shams University30
- Mansoura University30
- Postgraduate Institute of Dental Sciences Rohtak24
- Al-Azhar University23
- Tanta University23
- University of Baghdad19
- Universidad Complutense de Madrid18
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California40
- Texas27
- Massachusetts22
- Ohio22
- Pennsylvania22
- New York20
- Maryland19
- Florida18
- Alabama16
- Michigan15
Recruiting studies2,053 total
- NCT07619014Recruiting
Miswak vs. toothbrush for cleaning teeth with braces
This study compares how well a miswak (a natural chewing stick) and a regular toothbrush remove plaque buildup around orthodontic braces. If you wear braces, this trial tests whether miswak might be an equally effective cleaning option.
HomsAges 18–30 - NCT07620184Recruiting
Parotid Gland Surgery With or Without a Drain
This study compares two ways to do parotid gland surgery (removal of a gland in front of the ear). One method uses a drain tube to remove fluid after surgery, and the other does not. Researchers want to see if skipping the drain is safe and improves recovery.
StockholmAges 18 years+ - NCT07620353Recruiting
Study of OROSEDAL for sore throat and mouth sores
This study observes how well OROSEDAL, a topical oral medication, works for sore throats and minor mouth ulcers or sores that have lasted less than 15 days. You'll be asked to track your pain relief while using the product your doctor prescribes.
Multiple LocationsAges 8 years+ - NCT07625423RecruitingPhase 1
Gene therapy injection for advanced head and neck cancer
This trial tests a new treatment where a specially designed virus carrying an anti-cancer gene is injected directly into tumors in the head and neck area. It's for patients whose cancer has come back or spread after prior chemotherapy and who cannot have surgery or radiation.
Chengdu, ChinaAges 18–65 - NCT07626424Recruiting
Vibration therapy for drooling in children with cerebral palsy
This study tests whether gentle vibration applied to the chin and neck area can reduce drooling in children with cerebral palsy. Drooling affects many children with cerebral palsy and can cause skin irritation; this trial explores a non-surgical treatment option.
VanAges 2–18 - NCT07632443Recruiting
Testing temporary dental crowns and bridges made of PMMA
This study tests the safety and performance of ON DENT® temporary dental crowns and bridges made from a tooth-colored plastic material called PMMA. If you need a temporary crown or bridge while waiting for a permanent restoration, this trial may help determine how well these temporary options work.
IzmirAges 18 years+ - NCT07633665Recruiting
Safety and effectiveness study of dental implants
This study tests two types of dental implants (BIODENTOSS® and DWC®) to see how well they work and how safe they are in patients who need tooth replacement. If you have a missing tooth and want an implant, this study will track how your implant performs over time.
KonyaAges 18 years+ - NCT07636733Recruiting
Vitamin D for Gum and Bone Health in Periodontal Disease
This study tests whether vitamin D supplements can reduce inflammation and improve healing in people with gum disease, ranging from mild gingivitis to advanced periodontitis. Researchers will compare how vitamin D affects different stages of gum disease.
RizeAges 18–70 - NCT07637227Recruiting
Comparing two types of clear aligners for teeth straightening
This study tests two different ways of making clear aligners (custom plastic trays that move your teeth). Researchers want to see if 3D-printed aligners work as well as traditional heat-formed ones for mild crowding or spacing.
Baghdad, Bab Al-MuadhamAges 15–30 - NCT07638319RecruitingEarly Phase 1
Bone filler to preserve jawbone after tooth extraction
This early-stage trial tests a bone filler material (Neocement Inject P) placed in the socket after tooth removal to help preserve jawbone volume. This may help if you need a dental implant later.
Caparica, Monte Da CaparicaAges 18 years+ - NCT07638254Recruiting
Buffered vs. Standard Numbing for Dental Pain in Children
This study tests whether a specially prepared numbing medicine works better than standard numbing to reduce pain and anxiety during a dental procedure for children with a painful infected tooth. The goal is to find the gentlest way to numb the area before treatment.
San Luis Potosí City, San Luis PotosíAges 6–12 - NCT07638969Recruiting
Study of complications around dental implants
This study looks at problems that can happen around dental implants after they've been in place for over a year. Researchers want to understand what factors lead to these complications so they can help prevent them in the future.
BadajozAges Up to 90 years - NCT07639944Recruiting
REN Device Study for Jaw Pain and Headaches
This study tests whether a treatment called REN can help reduce headaches and jaw pain caused by temporomandibular disorders (TMD). You would use the REN device at home on your smartphone or tablet over several months.
Ridgeland, MississippiAges 12 years+ - NCT07641933RecruitingPhase 1
Root Canal Retreatment Dressing Comparison Study
This study compares different medicines placed inside root canals between appointments to help heal infections. You'll have a tooth retreated (cleaned and filled again) and help researchers find which dressing works best.
CairoAges 21–45 - NCT07643311Recruiting
Comparing two types of tooth caps for root-canal-treated molars
This study compares two ways to restore (cap) back teeth that have had root-canal treatment and lost a cusp or more. Researchers want to see which method—computer-milled or 3D-printed crowns—works better and lasts longer.
Santiago, Santiago MetropolitanAges 18–70 - NCT07643441Recruiting
Testing digital scanning accuracy for full-arch dental implants
This study tests how accurately a digital scanning method (photogrammetry) can measure and plan treatment for patients with implant-supported full-mouth dental replacements. If you have multiple dental implants supporting a complete denture or bridge, researchers want to see if this scanning technique gives reliable measurements to help design better-fitting prosthetics.
Shibīn al Kawm, MenoufiaAges 18–50 - NCT07654166Recruiting
Glue vs stitches for mouth growth removal
This trial compares using a skin glue (tissue adhesive) versus stitches (sutures) to close the small wound after removing a harmless growth inside your mouth. It may help reduce discomfort and healing time.
Damascus, MazzhAges 18–80 - NCT07661784Recruiting
Saliva tests to track gum disease
This study looks at whether substances in your saliva can show if gum disease is getting worse. It might help find a simple way to monitor gum health without needles or X-rays.
IspartaAges 18–65 - NCT07662603Recruiting
Breathing exercise program for teens with Behcet's after lung surgery
This trial is for teenagers with Behcet's disease who have had a specific lung surgery to remove a clot. It tests a breathing exercise program to help improve lung function after surgery.
Giza, DokkiAges 13–17 - NCT07664605Recruiting
Comparing two bone grafting methods for dental implants
This trial compares two surgical techniques for building up narrow jawbone before placing a dental implant. It may be an option if you have mild to moderate bone loss in your jaw.
CairoAges 20–75 - NCT07666126Recruiting
Uric acid and gum bone health study
This study looks at whether high uric acid levels affect the bone around your teeth. If you are between 18 and 65, have at least 20 natural teeth, and are either healthy or have high uric acid and gum disease, this trial may be for you.
RizeAges 18–65 - NCT07666360Recruiting
Jaw pain study: factors that predict TMD severity
This trial looks at how your head, neck, and jaw work together to understand why some people have more severe jaw joint (TMD) pain. If you have jaw pain, the findings may help researchers identify better treatments.
AnkaraAges 18–55 - NCT07667088Recruiting
Whitening mouthwash using oil pulling
This study tests a whitening mouthwash that uses an oil-pulling method. It lasts a few months and compares the mouthwash to not using any whitening product. If you have naturally darker front teeth and haven't whitened them recently, this might be an option for you.
San Antonio, TexasAges 18–60 - NCT07671274RecruitingEarly Phase 1
Comparing two ways to treat gum disease without surgery
This study compares a standard deep cleaning method with a newer, less invasive approach for treating advanced gum disease (periodontitis). It aims to see if one works better for patients with good oral hygiene and no other health issues.
Al Mansurah, DakhliaAges 20–40
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 2,053 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,969 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
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- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.