Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT04669717RecruitingPhase 4
Testing antibiotic dosing alongside periodontal treatment
This study tests how antibiotics should be added to standard gum (periodontal) treatment, including dosing and blood-level timing. It may help people whose gum disease is severe, by improving how antibiotics are used with routine dental care.
Geneva, Canton of GenevaAges 18–80 - NCT04630587Enrolling by invitation
3D-printed fillings for back teeth needing repairs
This study tests how long different types of dental fillings made with 3D printing last in back teeth (premolars and molars). It may help you by comparing filling types in a careful, structured way.
OuluAges 18 years+ - NCT04620187RecruitingPhase 2
Study medicine T-DM1 after surgery for HER2-positive salivary cancer
This Phase 2 trial studies T-DM1 given after surgery for salivary gland cancer that is HER2-positive. The goal is to reduce the risk of the cancer coming back by targeting HER2-positive tumor cells.
Atlanta, GeorgiaAges 18 years+ - NCT04528082RecruitingPhase 3
Apremilast for children with frequent mouth ulcers from Behçet’s disease
This study tests apremilast to help reduce active, recurring mouth (oral) ulcers in children with Behçet’s disease. It may help if your child has had repeated mouth ulcers despite at least one non-biologic treatment.
BronAges 2–17 - NCT04534127Recruiting
DaRT radiation device for skin and mouth or superficial tumors
This trial tests a targeted radiation device (DaRT seeds) to treat certain cancers on the skin, in the mouth, or in superficial soft tissue. It may help when standard treatment (like surgery or regular radiation/chemo) hasn’t worked, isn’t safe, or isn’t wanted.
JerusalemAges 18 years+ - NCT04544839Enrolling by invitation
Test two ways to attach dentures or implants
This trial compares two different attachment systems for people who have major problems with their upper and/or lower dentures, or who want implant-supported replacement teeth. It may help your smile and chewing by improving how the replacement teeth stay firmly in place.
PuneAges 18 years+ - NCT04436965RecruitingPhase 3
Standard nutrition support for malnourished nasopharyngeal cancer patients
This Phase 3 study tests whether giving a standard nutrition plan can improve nutritional status and outcomes in people with locally advanced nasopharyngeal cancer who are malnourished. It mainly checks whether nutrition support helps you tolerate treatment and do better over time.
Guangzhou, GuangdongAges 18–65 - NCT04392622RecruitingPhase 1
Limonene gelcaps with radiation and chemo to prevent dry mouth
This Phase 1 study tests whether a citrus-flavored supplement (d-limonene gelcaps) can help prevent or reduce dry mouth (xerostomia) in people getting radiation plus chemotherapy for certain head and neck cancers. It aims to see how well the approach is tolerated and whether it can protect saliva function during treatment.
Stanford, CaliforniaAges 18 years+ - NCT04402086Recruiting
Rheumatology patient and skin sample registry study at Yale
This study builds a health record and blood/skin sample collection for people with rheumatic autoimmune diseases who are getting care at Yale. It may help researchers understand these conditions and develop better tests or treatments over time.
New Haven, ConnecticutAges 18–99 - NCT04425265Recruiting
Low-temperature plasma treatment vs high-frequency cautery for recurring cancer
This trial compares two ways of surgically treating localized, recurrent nasopharyngeal cancer: a low-temperature plasma radiofrequency method versus a standard high-frequency cautery method. You might be eligible if your recurrence is limited and can be surgically removed, and you are within the allowed health and age ranges.
Guangzhou, GuangdongAges 18–70 - NCT04266093Enrolling by invitation
Gene therapy follow-up for adults previously treated at NCI
This study is a follow-up check for people who were previously enrolled in certain NCI gene therapy treatment studies. It helps the research team monitor long-term effects and outcomes after treatment.
Bethesda, MarylandAges 18–120 - NCT04265430RecruitingPhase 4
MRI scans to predict normal-tissue side effects after treatment
This trial uses repeated MRI scans to better predict which patients may develop painful jaw and mouth tissue problems after radiation and/or certain bone or blood-vessel medicines. It may help clinicians spot problems earlier and tailor follow-up care.
Houston, TexasAges 18 years+ - NCT04334031Recruiting
Hospital follow-up study for immune-related disease
This is a study that follows people with an immune-related illness at Lille University Hospital to better understand their care needs over time. By collecting information regularly, the study may help improve how future patients are monitored and treated.
LilleAges 18 years+ - NCT04319042Recruiting
Same-day versus 4-week dental implant crown placement study
This study compares placing a crown on a dental implant either the same day as the implant or 4 weeks later. It may help decide which timing leads to better healing and tooth function after an implant.
Bern, Canton of BernAges 20 years+ - NCT04254861Recruiting
Platelet treatment for deep gum bone defects
This trial studies an “autologous platelet concentrate” (a gel made from your own blood) to help heal deep bone defects caused by periodontitis. It’s meant for adults with specific measurements in one or more gum pockets and bone areas after recent non-surgical gum treatment.
LondonAges 25–80 - NCT04333537RecruitingPhase 2/Phase 3
Sentinel node biopsy versus standard neck surgery for early mouth cancer
This trial compares two ways of checking whether early oral cavity squamous cell cancer has spread to neck lymph nodes. It tests whether sentinel lymph node biopsy can find spread as well as standard neck dissection, while potentially reducing more extensive surgery for some people.
Birmingham, AlabamaAges 18 years+ - NCT04214561Enrolling by invitation
Studies how sleep measures relate to teeth grinding
This study looks at sleep testing results to understand what relates to sleep bruxism, which is teeth grinding or clenching during sleep. It may help researchers better understand the causes and patterns behind this condition.
WroclawAges 18–70 - NCT04227314RecruitingPhase 3
Apremilast vs placebo for severe recurrent mouth ulcers
This Phase 3 trial tests whether apremilast can reduce severe, recurring mouth ulcers compared with an inactive placebo. It aims to improve ulcer frequency and pain while carefully checking safety.
AmiensAges 18 years+ - NCT04151082RecruitingPhase 1/Phase 2
Steroid therapy for late nerve damage after throat cancer radiation
This trial tests whether high-dose steroids (prednisone or methylprednisolone) can improve symptoms of nerve damage that may occur years after radiation treatment for oropharyngeal cancer. It includes a registry for tracking similar nerve issues in head and neck cancer survivors.
Houston, TexasAges 18 years+ - NCT04190953Recruiting
Braces and expanders in kids to improve airflow space
This study looks at how jaw and palate treatments affect airflow through the upper airway in children with a specific bite and jaw shape. It may help researchers understand which treatments improve space for breathing and related pressure changes.
Edmonton, AlbertaAges 8–14 - NCT04234971RecruitingPhase 4
Compare costs of bone grafting for cleft jaw repair
This study looks at whether alveolar bone graft surgery is cost-effective for people with cleft lip and palate. It may help clinics choose the most practical approach for the best outcomes while managing overall costs.
Houston, TexasAges 6–15 - NCT04178174RecruitingPhase 3
Boost radiation for HPV throat cancer with shorter treatment
This trial studies whether adding a precise “extra boost” to radiation can work as well as (or better than) standard radiation for HPV-related oropharynx cancer, while keeping the overall treatment shorter. It may help improve tumor control while aiming for manageable side effects.
London, OntarioAges 18 years+ - NCT04198766RecruitingPhase 1/Phase 2
New OX40 immunotherapy for advanced solid tumors
This trial tests a new immunotherapy drug (INBRX-106) alone or with Keytruda (pembrolizumab) for adults with advanced solid tumors that have not responded to standard treatments. The goal is to see if the drug can help the immune system fight cancer.
Duarte, CaliforniaAges 18 years+ - NCT04068155Recruiting
Radiation device for certain skin cancers you can treat locally
This trial tests a radiation-emitting device placed near the tumor to treat certain malignant skin cancers that can be fully covered. It may help shrink or control the cancer at the skin site where the device is applied.
GrenobleAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.