Dentistry & oral health
Mouth & dental clinical trials
Conditions of the teeth, gums, mouth, and jaw. We’re tracking 1,962 recruiting studies in this area right now.
By phase
- Not applicable1,543
- Phase 2144
- Phase 385
- Phase 182
- Phase 460
- Phase 1/Phase 235
- Phase 2/Phase 313
Top conditions
- Periodontitis103
- Nasopharyngeal Carcinoma74
- Periodontal Diseases50
- Dental Caries46
- Gingivitis35
- Head and Neck Cancer35
- Oral Cancer32
- Periodontal Disease29
- Dental Implant28
- Gingival Recession25
- Alveolar Bone Loss24
- Nasopharyngeal Carcinoma (NPC)24
- Sjogren's Syndrome24
- Tooth Loss24
- Temporomandibular Disorders (TMD)22
- Oropharynx Cancer21
- Peri-Implantitis21
- Temporomandibular Joint Disorders20
Leading sponsors
- Cairo University77
- Sun Yat-sen University50
- Mansoura University25
- Ain Shams University24
- Postgraduate Institute of Dental Sciences Rohtak24
- Tanta University24
- Al-Azhar University23
- Universidad Complutense de Madrid16
- University of Baghdad16
- Assistance Publique - Hôpitaux de Paris14
Where studies are running
- California44
- Texas26
- Florida21
- Maryland21
- Massachusetts21
- New York19
- Pennsylvania19
- Ohio18
- Alabama17
- Michigan15
Recruiting studies1,962 total
- NCT04052373Recruiting
Treatment for gum inflammation around dental implants
This study tests a procedure (implantoplasty) to treat peri-implantitis, an infection/inflammation around dental implants. It may help improve the health of implants when there is exposed, changed implant surface.
Oslo, OsloAges 20 years+ - NCT04117360Recruiting
Speech therapy study for people after jaw alignment surgery
This study looks at how well people can make specific speech sounds before and after jaw alignment treatment. It may help researchers understand whether speech patterns improve with treatment in people with certain bite differences.
Chapel Hill, North CarolinaAges 15–40 - NCT04085900Recruiting
Screening test for nasopharyngeal cancer blood markers
This study screens people in certain cities to see whether signs in the blood related to a virus (EBV) can help find nasopharyngeal cancer earlier. It may help identify higher-risk people so they can be checked sooner.
Zhongshan, GuangdongAges 30–69 - NCT03991728Recruiting
TMJ implant registry for adults with a new jaw joint replacement
This registry is for adults getting an artificial (alloplastic) full replacement of the jaw joint (TMJ). It collects real-world information about your implant and care to help improve future outcomes.
São PauloAges 18 years+ - NCT03907826RecruitingPhase 3
PD-1 therapy plus chemoradiation for recurrent nasopharyngeal cancer
This trial studies whether adding a PD-1 antibody (an immunotherapy) to standard chemoradiation can better control recurrent nasopharyngeal cancer that can’t be removed with surgery. If you qualify, you’d receive the study treatment and be closely monitored for side effects and cancer response.
Guangzhou, GuangdongAges 18–70 - NCT03983369RecruitingPhase 3
Laser treatment to help prevent painful mouth sores from chemo
This trial tests whether low-level laser therapy (using special light on the mouth) can prevent or reduce mouth sores caused by chemotherapy in children and young adults. It may help you avoid painful inflammation that can affect eating, comfort, and treatment.
Villejuif, Val de MarneAges 4–25 - NCT03997552Recruiting
Gum surgery options to help regenerate damaged gum bone
This trial compares two dental gum surgery approaches to see which better helps the gum and bone heal in people with periodontitis. It may help by improving the depth of gum pockets and supporting regrowth of damaged areas around teeth.
MurciaAges 18 years+ - NCT03966014RecruitingPhase 3
Compare different amoxicillin schedules for Lyme rash
This trial tests which schedule of amoxicillin works best for people who have the early Lyme rash called erythema migrans. It may help you choose a treatment plan that clears infection with fewer issues.
LjubljanaAges 18 years+ - NCT03997578Recruiting
Gum surgery for deep periodontal bone defects
This trial studies a specific gum surgery technique plus a biologic product to help fill deep gum/bone defects from periodontitis (gum disease). It may help reduce gum pocket depth and improve healing around affected teeth.
MurciaAges 18 years+ - NCT03816345RecruitingPhase 1
Nivolumab for advanced cancer with autoimmune disease
This trial tests whether the immunotherapy drug nivolumab can safely treat advanced cancer in people who also have an autoimmune disease like rheumatoid arthritis, lupus, or multiple sclerosis. It aims to find out if the drug may help control cancer while managing their autoimmune condition.
Birmingham, AlabamaAges 18 years+ - NCT03740256RecruitingPhase 1
HER2-targeted oncolytic virus plus custom immune cells for solid cancers
This Phase 1 study tests a treatment plan that combines a virus designed to attack cancer with your own custom immune cells that target HER2. It aims to shrink advanced HER2-positive solid tumors (and make future options safer/more effective).
Houston, TexasAges 18 years+ - NCT03829033Recruiting
Photon vs proton radiation for early tonsil cancer
This trial compares two types of radiation—photon therapy and proton therapy—for early-stage tonsil cancer. The goal is to see which approach works well for cure while affecting surrounding tissues differently.
GävleAges 18 years+ - NCT02593565Recruiting
Pregnancy blood-vessel disease registry study
This is a pregnancy registry that collects information from people with certain blood-vessel inflammatory diseases during pregnancy. It helps researchers better understand these conditions in pregnancy and may guide future care.
Tampa, FloridaAges 18–50 - NCT03429036Recruiting
Collecting head and neck tissue samples for research
This study collects tissue and fluid samples from people with head and neck disorders to help researchers learn more about these conditions. By donating leftover samples from your regular medical care, you can help advance research without extra procedures.
Washington D.C., District of ColumbiaAges 3–120 - NCT03462329Recruiting
Study of expectations after Lyme disease symptoms
This study enrolls people diagnosed with early Lyme disease (erythema migrans) to learn how people’s expectations about symptoms may affect what happens after treatment. Your experience and beliefs will be compared to see if they relate to post-Lyme symptoms.
LjubljanaAges 18 years+ - NCT03384537RecruitingEarly Phase 1
Tropolone mouthwash test in healthy adults
This early trial compares a mouthwash that contains tropolone versus a mouthwash without tropolone to see how well each works against germs in the mouth. You may be asked to pause your usual mouth-cleaning routine for a few days beforehand.
CairoAges 18–45 - NCT03115203Recruiting
MRI muscle imaging study for facial paralysis
This study uses a stronger MRI machine (3 Tesla) to take detailed pictures of skin and face muscles in people with facial paralysis. It may help doctors better understand what changes happen in the face muscles over time.
Amiens, PicardieAges 18 years+ - NCT03050268Recruiting
Study of childhood cancer risk in families
This study looks at inherited (family) risk for childhood cancers, including families with early cancers or known cancer risk conditions. It may help researchers understand why some children get cancer and improve future risk detection and care.
Memphis, TennesseeAges Any age - NCT03083405Enrolling by invitation
Study of tooth grinding during sleep
This study is for adults who have been diagnosed with sleep bruxism (tooth grinding during sleep). Researchers want to understand it better using sleep testing, and it may help refine how this condition is evaluated.
WroclawAges 18–70 - NCT03065686Recruiting
Study genes in cleft lip or palate without a known cause
This study looks for genetic reasons behind cleft lip and/or cleft palate when the cause is not known. The results may help researchers understand risk factors and improve future care.
AmiensAges Any age - NCT03059420Recruiting
Genetic study of strabismus and certain birth eye-movement disorders
This study looks for genetic (inherited DNA) causes of strabismus (eyes that don’t line up) and certain birth conditions that affect eye movement and brainstem/cranial nerves. Your participation may help researchers better understand these conditions and guide future testing and care.
Boston, MassachusettsAges 1 day+ - NCT02734537RecruitingPhase 2
Radiation with or without cisplatin after head and neck surgery
This trial studies whether adding cisplatin (a chemotherapy medicine) to radiation therapy helps people with stage III–IVA squamous cell cancer of the head and neck after they’ve had surgery. It’s meant to lower the risk of the cancer coming back.
Birmingham, AlabamaAges 18 years+ - NCT03003572Recruiting
Test an immune marker in primary Sjögren’s disease activity
This study looks at an immune reaction (called anti-Ro/SSA IgE) to see how active primary Sjögren’s disease is. It may help doctors better understand what’s driving symptoms and activity levels over time.
BourgoinAges 18 years+ - NCT03010150Recruiting
Blood tests and swallowing exercise check-ins for head and neck cancer
This study looks at whether giving swallowing exercises and checking in with questionnaires can help people with metastatic (spreading to neck lymph nodes) head and neck cancers do the exercises correctly. It also uses blood tests to better understand adherence and progress over time.
Houston, TexasAges 18 years+
Common questions
- How many mouth & dental clinical trials are recruiting?
- Clin2 is tracking 1,962 recruiting dentistry & oral health studies from the U.S. registry right now, out of 3,756 we cover in this area in total.
- What does “Mouth & dental” cover here?
- Conditions of the teeth, gums, mouth, and jaw. We group each study into mouth & dental based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a mouth & dental trial near me?
- Use the search to filter mouth & dental studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.