Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,575 recruiting studies in this area right now.
By phase
- Not applicable2,950
- Phase 4240
- Phase 2131
- Phase 3102
- Phase 193
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University59
- Beijing Tiantan Hospital34
- Tanta University33
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University20
Where studies are running
- California151
- New York79
- Massachusetts65
- Florida64
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,575 total
- NCT07809425Recruiting
Pain relief options for gastric bypass surgery
This study compares two ways to manage pain after gastric bypass surgery: a nerve block alone versus a nerve block plus a lidocaine drip. The goal is to see which approach provides better pain relief and fewer side effects.
AlexandriaAges 18–60 - NCT07815145Recruiting
Comparing two nerve blocks for pain after hip replacement
This study compares two types of nerve blocks to see which provides better pain relief after hip replacement surgery. The blocks are given during surgery to reduce pain and may help you recover more comfortably.
Tanta, El-GharbiaAges 18–75 - NCT07814729Recruiting
Sacral block for chronic sacroiliac joint pain
This study tests whether adding a nerve block near the sacrum to a standard sacroiliac joint injection gives more pain relief. It's for people with long-term sacroiliac joint pain that hasn't improved with other treatments.
Al FayyumAges 21–60 - NCT07809321Enrolling by invitation
Beta-alanine effects on performance in female rugby players
This study tests whether a daily supplement called beta-alanine can improve muscle performance and heart health in female rugby players. It might help you play better and recover faster.
Madrid, MadridAges 18–40 - NCT07812389Recruiting
Opioid-free anesthesia for sinus surgery
This trial tests whether avoiding opioid painkillers during and after sinus surgery helps patients recover faster and with fewer side effects, using a standard recovery plan called ERAS.
Ankara, ÇANKAYAAges 18–65 - NCT07813728Recruiting
Online therapy for young people with PTSD and chronic pain
This study tests an internet-based therapy that helps young people manage both post-traumatic stress and chronic pain. It aims to help you regain function in daily life by participating in weekly sessions online.
LundAges 15–24 - NCT07813455Recruiting
Ultrasound-guided injection for piriformis syndrome pain
This study tests whether adding a special fluid injection around the piriformis muscle to a standard ultrasound-guided injection provides better pain relief for people with piriformis syndrome. If you qualify, you'll receive the injection and be followed for a short time to see how well it works.
Istanbul, UskudarAges 18–70 - NCT07809542Recruiting
Brain scans in people with muscle pain
This study looks at how the brain processes pain in people with muscle pain. Researchers will use special brain scans (MEG and MRI) to see if there are any differences in brain activity. This may help improve future treatments for chronic pain.
Jinan, ShandongAges 18–70 - NCT07810218Recruiting
Personalized exercise for chronic pelvic pain
This study tests whether a smartphone app can give you personalized exercise recommendations to help reduce chronic pelvic pain, which may come from conditions like endometriosis or fibroids. You'll track your symptoms and activity daily, and the app will learn what works best for you.
New York, New YorkAges 18–55 - NCT06395428RecruitingPhase 4
Haloperidol for severe back pain in the ER
This study tests whether the medication haloperidol, given in the emergency room, can help relieve severe back pain that started on its own (not from an injury). It compares haloperidol to a common pain reliever called ketorolac.
Kalamazoo, MichiganAges 18–65 - NCT07804199Recruiting
Ear nerve stimulation for knee osteoarthritis pain in veterans
This study tests whether a small device that stimulates a nerve in your ear can help reduce knee pain caused by osteoarthritis. If you join, you'll be asked to stop taking your current knee pain medicines during the trial, but you can use a safe rescue medicine (acetaminophen/paracetamol) if needed.
Decatur, GeorgiaAges 45–75 - NCT07805928Recruiting
A guided pain plan after rib remodeling surgery
This study tests a step-by-step pain management plan guided by your pain scores after rib remodeling surgery. The plan uses a mix of medications to reduce pain safely and may help you recover with less discomfort.
BogotáAges 18–55 - NCT07804446Recruiting
Knee injection: comparing two needle angles for knee arthritis pain
This study compares two ways of giving a knee steroid injection to see which works better for pain and function in people with medial knee arthritis. You will get the injection as part of your normal care.
Bolingbrook, IllinoisAges 40 years+ - NCT07801586Recruiting
Pain education with pre-surgery physical therapy for spine surgery recovery
This study tests whether adding pain neuroscience education to standard physical therapy before spinal surgery helps reduce pain and disability after surgery. This could help you recover better by understanding how pain works and learning coping strategies before your operation.
IslamabadAges 35–60 - NCT07808684Recruiting
Comparing root canal file designs on debris removal
This study tests two different root canal file designs to see which one removes debris better from the end of the root. It may help people who need a root canal on a tooth with a single root canal.
Minya, Minya GovernorateAges 20–40 - NCT07807839Recruiting
Back pain study: testing a blood protein linked to MRI findings
This study looks at how a protein in your blood (called BDNF) relates to the severity of your lower back condition, as seen on MRI. It may help doctors better understand and treat back pain in the future.
Daegu, DaeguAges 20–80 - NCT07807943Recruiting
Knee arthritis pain relief procedure for cancer patients
This study tests a procedure called geniculate artery embolization (GAE) to reduce knee pain from osteoarthritis in people who also have cancer. It may help those who cannot or do not want to have knee surgery.
Houston, TexasAges 40 years+ - NCT07807020Enrolling by invitationPhase 1/Phase 2
Lower-dose pain medication for knee replacement surgery
This study tests whether a lower dose of a pain medication given through spinal anesthesia can provide good pain relief after knee replacement surgery with fewer side effects. It may help reduce risks like low blood pressure or slow heart rate.
Islamabad, FederalAges 18–60 - NCT07802951Recruiting
How doctors, physios, and patients view low back pain care
This study interviews general practitioners, physiotherapists, and patients with low back pain to understand how they make care decisions together. The goal is to improve teamwork and communication in primary care.
Woluwe-Saint-Lambert, Brussels CapitalAges 18–100 - NCT07807852Recruiting
Shock wave therapy for CRPS after wrist fracture
This trial tests whether sound wave therapy (ESWT) can reduce pain from a chronic pain condition called Complex Regional Pain Syndrome (CRPS) that started after a wrist fracture. It might help reduce pain and improve recovery.
Istanbul, IstanbulAges 18–75 - NCT07803601Recruiting
Magnesium through the vein to reduce inflammation after colon cancer surgery
This study tests whether giving magnesium through an IV during colon cancer surgery can lower the body's inflammation afterward, which may help you recover more smoothly. It is for people having open surgery for colon cancer.
Cairo, AbbassiaAges 35–75 - NCT07803926Recruiting
Lymphatic drainage and exercise for lipedema
This study tests whether a special massage technique (manual lymphatic drainage) combined with exercise can help women with lipedema. It may improve symptoms like swelling, pain, or discomfort and overall quality of life.
Istanbul, EyupsultanAges 18–65 - NCT06518421Recruiting
Emotions and Memory in Chronic Facial Nerve Pain
This study looks at how emotions and memory are affected in people with chronic trigeminal neuralgia (a type of facial nerve pain). Participants will have an MRI scan and fill out questionnaires to help researchers understand the link between chronic pain and cognitive changes.
Toronto, OntarioAges 35–60 - NCT07799857Recruiting
Light therapy for pelvic pain registry
This study tracks people getting light therapy inside the vagina for chronic pelvic pain. It helps doctors learn if this treatment works and who it helps most.
Melbourne, FloridaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,575 recruiting pain medicine studies from the U.S. registry right now, out of 6,452 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.