Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,764 recruiting studies in this area right now.
By phase
- Not applicable3,111
- Phase 4251
- Phase 2144
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University97
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad26
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- Illinois38
- North Carolina38
Recruiting studies3,763 total
- NCT04260854Enrolling by invitationPhase 1
Bupivacaine for pain control during skin surgery
This Phase 1 study tests bupivacaine, a numbing medicine, to see how well it controls pain during cutaneous (skin) surgery. It’s primarily looking at safety and how the medicine works for people undergoing the procedure.
Chicago, IllinoisAges 19 years+ - NCT07348419Recruiting
Pain blocks after single-level lumbar disc surgery
This study compares two types of pain-blocking injections (Quadro-Iliac vs Thoracolumbar Interfascial Plane Block) to see which provides better pain relief after a single-level lumbar disc surgery. If you are having this surgery, the trial may help you have less pain and use fewer pain medicines afterwards.
SamsunAges 18–70 - NCT07348523Recruiting
Comparing two types of back pain blocks after lumbar spine surgery
This trial compares two ways of delivering a pain-blocking injection (erector spinae plane block) after a single-level lower back surgery. The goal is to see which approach provides better pain relief after surgery.
SamsunAges 18–70 - NCT07349810RecruitingPhase 4
Post-surgery pain pump study
This trial tests a pain pump after specific shoulder or knee surgeries to see how well it controls pain. It may help you recover more comfortably after surgery.
Somerset, New JerseyAges 18 years+ - NCT07350148Recruiting
Text messages to support opioid medication adherence
This study tests whether daily supportive text messages help people stay on track with their methadone or buprenorphine treatment for opioid use disorder. It is designed for adults who recently started or resumed this medication and have a cellphone.
Albuquerque, New MexicoAges 18 years+ - NCT07350460Recruiting
Comparing two pain blocks for hemorrhoid surgery
This study tests two types of numbing injections (a pudendal block and a sacral ESP block) to see which works better for pain after hemorrhoid surgery. If you're scheduled for this surgery, you might qualify to help find a better way to manage pain.
BellinzonaAges 18–80 - NCT07351851Recruiting
Exercise for back pain and urine leakage in women
This study tests whether a special exercise program called PEMM (which combines pelvic floor and core exercises) can help women with both chronic low back pain and urinary incontinence. It is designed for women who have had back pain and urine leakage for at least 3 months.
Doha, Baladiyat ad DawhahAges 18–65 - NCT07352514Recruiting
Natural supplements and exercise for chemo nerve pain
This study tests if a combination of two natural supplements (PEA and Scutellaria) plus a specific exercise program can help reduce nerve pain caused by chemotherapy. It is for people who have had chemotherapy in the last 6 months and still have moderate to severe nerve pain.
Palermo, ItaliaAges 18 years+ - NCT07352813Recruiting
Comparing numbing methods for kids with MIH teeth
This study tests two ways to numb teeth—in the bone or in the gum—to see which works better for children with weak enamel on their back teeth and front teeth. It may help find a pain-free way to treat these teeth.
AnkaraAges 6–12 - NCT07353632Recruiting
What affects re-participation in Danish colorectal screening
This study looks at why some people come back for a second round of the Danish bowel cancer screening program after their first colonoscopy. It aims to learn what factors influence their decision to participate again.
AabenraaAges 50–75 - NCT07353996RecruitingPhase 4
Finding the right dose of a new IV painkiller after bone surgery
This trial tests a single dose of a new pain medicine called tegileridine fumarate given through a vein right after orthopedic surgery (like spine, hip, or knee surgery). The goal is to find the best dose that works well for pain without causing side effects.
Hanzhong, ZhejiangAges 18–75 - NCT07354542Recruiting
Relaxation therapy for pain and sleep after joint replacement
This trial tests if different relaxation methods, such as breathing exercises or virtual reality, can help reduce pain and improve sleep after hip or knee replacement surgery. It is designed for people who have had a joint replacement and are able to use a mobile phone or tablet.
Bartın, CenterAges 18 years+ - NCT07354581Recruiting
Pain blocks after lower back surgery
This trial compares two types of pain-block injections (erector spinae plane block versus quadro-iliac plane block) given during lower back surgery to see which controls pain better. It may help you have less pain and need fewer pain medicines after your operation.
BursaAges 18–65 - NCT07355790Recruiting
Does a foam pad make a back belt more comfortable?
This study tests whether adding an extra foam pad to a lumbar belt makes it more comfortable and how it affects your body. You will be asked to wear the belt, walk on a treadmill, and have an MRI.
Saint-EtienneAges 18–50 - NCT07356102Recruiting
Pulsed radiofrequency for pudendal nerve pain
This trial compares two types of a procedure called pulsed radiofrequency to treat chronic pain in the pudendal nerve (a nerve in the pelvic area). The goal is to find out if a higher-voltage, longer-duration treatment works better than the standard one.
AnkaraAges 18 years+ - NCT07356115Recruiting
Pain patterns and pain location in muscle and sports clinics
This study looks at whether people's pain patterns—measured by a simple questionnaire called PainDETECT—are linked to where their pain is and what caused it. It may help doctors better understand and treat different types of pain.
IstanbulAges 18 years+ - NCT07356206Recruiting
Dog-assisted therapy for fibromyalgia
This study tests whether spending time with a specially trained therapy dog can help people with fibromyalgia feel better and manage pain. You would attend 10 sessions and complete a few questionnaires.
GuimarãesAges 18 years+ - NCT07357233Recruiting
Comparing two methods for root canal pain relief in lower molars
This trial compares two different ways of cleaning and shaping the inside of a tooth (root canal) to see which one causes less pain afterward. It is for people with a specific type of tooth infection in a lower back molar.
AlexandriaAges 18–50 - NCT07357480Recruiting
Comparing two anesthesia methods for brain surgery
This trial compares two ways of giving anesthesia during planned brain surgery on the upper part of the brain. It tests if using a computer-controlled system to deliver the anesthesia drugs is better than manually adjusting them.
Istanbul, BakırköyAges 18–60 - NCT07359144Recruiting
Pilates for low back pain after childbirth
This study tests whether Pilates exercises can help relieve low back pain in women who have had a baby. It focuses on pain that started after childbirth and lasts for more than three months.
Kafr ash Shaykh, KafrelsheikhAges 20–30 - NCT07359287Recruiting
Study on antibiotic use for respiratory infections
This study tests a program to help doctors prescribe antibiotics more carefully for common respiratory infections like colds, flu, bronchitis, and sinusitis. It may lead to better treatment for you.
CaenAges Any age - NCT07360093Recruiting
Nerve block for chronic hip pain from osteoarthritis
This study tests a nerve block treatment for people with long-term hip pain from osteoarthritis who haven't gotten enough relief from other treatments. It aims to see if this procedure can help reduce pain.
AnkaraAges 18–80 - NCT07360392Recruiting
Nerve block comparison for knee replacement pain
This study compares two numbing techniques (nerve blocks) for pain relief after knee replacement surgery. The goal is to find which one works better and helps you recover with less pain.
AmasyaAges 18–80 - NCT07361692Recruiting
Electric brain stimulation for complex regional pain syndrome
This trial tests if a gentle electric current applied to the scalp (called tDCS) can reduce pain in people with Complex Regional Pain Syndrome (CRPS), a chronic pain condition. It aims to see if this treatment is effective and safe for managing symptoms.
Saint-NazaireAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,764 recruiting pain medicine studies from the U.S. registry right now, out of 6,842 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.