Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,580 recruiting studies in this area right now.
By phase
- Not applicable2,955
- Phase 4240
- Phase 2129
- Phase 3103
- Phase 194
- Phase 2/Phase 337
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University84
- Cairo University61
- Beijing Tiantan Hospital34
- Tanta University34
- Ain Shams University28
- Foundation University Islamabad28
- Mayo Clinic25
- VA Office of Research and Development23
- Hacettepe University22
- Stanford University21
Where studies are running
- California151
- New York79
- Florida65
- Massachusetts65
- Texas51
- Illinois40
- North Carolina40
- Maryland39
- Ohio39
- Minnesota37
Recruiting studies3,580 total
- NCT06208267Recruiting
Tranexamic acid for pain and bleeding after hip or knee replacement
This study tests whether a medicine called tranexamic acid (TXA) can reduce pain, improve movement, and lessen bleeding after hip or knee replacement surgery. It is for adults having their first joint replacement at St. Mary's Hospital.
Montreal, QuebecAges 18 years+ - NCT06224829Recruiting
Massage therapy for long-term neck pain
This study tests whether massage can help people with neck pain that has lasted at least 3 months. You will receive massage sessions, and researchers will track how your pain changes.
Gainesville, FloridaAges 18–60 - NCT06228755Enrolling by invitation
Study on group integrative care for chronic pain
This study looks at how well group medical visits that combine different treatments (like mind-body approaches) work for people with chronic pain. It aims to make these visits more available and helpful.
Chapel Hill, North CarolinaAges 18 years+ - NCT06225817Recruiting
Can a placebo help with chronic jaw pain and sleep?
This study is testing whether a placebo (a pill with no medication) can help improve sleep and reduce pain for people with long-term jaw or face pain. Researchers want to see if just expecting relief can change how your body handles pain.
Baltimore, MarylandAges 18–88 - NCT06213233RecruitingPhase 2
CBD oil for veterans with chronic pain
This study tests whether CBD oil can help veterans manage chronic pain. You would take a daily dose of CBD and report your symptoms using a smartphone app.
Ann Arbor, MichiganAges 18 years+ - NCT06209645Recruiting
Personalized brain stimulation for stubborn nerve pain relief
This study tests a non-invasive, personalized brain stimulation technique to reduce nerve pain that has not responded to standard treatments. It may be a good option if you have had nerve pain for over a year and have already tried other pain medications without enough relief.
BronAges 18–80 - NCT06216717Recruiting
Study of electrode location for brain stimulation in chronic pain
This study looks at where electrodes are placed in the brain for people who have a device that stimulates the motor cortex to treat chronic nerve pain. The goal is to help improve how these devices are positioned for better pain relief.
Nice, Alpes MaritimesAges 18 years+ - NCT06214923Recruiting
Virtual reality for jaw pain caused by TMD
This study tests whether immersive virtual reality can reduce chronic jaw pain from Temporomandibular Disorder (TMD). It uses EEG to see how VR affects brain activity related to pain.
Baltimore, MarylandAges 18–88 - NCT06206486Recruiting
Gut germs and pain after kidney transplant
This study looks at whether the germs in your gut (microbiome) and certain chemicals in your blood affect pain after a kidney transplant. By joining, you may help doctors better understand and manage pain for future kidney transplant patients.
Chicago, IllinoisAges 18 years+ - NCT05269212Recruiting
Help people with ongoing back pain return to work
This study looks at how to help people with long-lasting spinal pain (PSPS-Type II) get back to work. It may help by testing a plan for managing persistent pain so work becomes more doable.
GhentAges 18–60 - NCT05896826Recruiting
Magnetocardiography to better spot heart attack patients
This study tests whether magnetocardiography—a scan that measures heart signals using magnets—can more accurately identify myocardial infarction (heart attack). It may help doctors detect heart attacks faster and more accurately using safer, non-invasive testing.
Jinan, ShandongAges 18–79 - NCT06015711Recruiting
Does a pre-surgery painkiller reduce strong IV pain meds needed?
This trial tests if taking Maxigesic® (a combination of two pain relievers) before surgery can lower the amount of a strong IV pain medicine called remifentanil needed during anesthesia. It may help patients have a smoother recovery with fewer side effects.
Suwon, Gyeonggi-doAges 19–60 - NCT06188923RecruitingPhase 2
Pregnenolone for anxiety and depression in veterans
This study tests whether a dietary supplement called pregnenolone can improve day-to-day function in veterans struggling with anxiety and depression. It is a 12-week program that combines the supplement with your usual care, and the goal is to help you feel better and do more of what matters to you.
Durham, North CarolinaAges 18–65 - NCT06200662Recruiting
Maternal Comfort for Pain Relief During Blood Draw in Preemies
This study tests whether a mother's comforting actions (like holding, talking, or breastfeeding) can reduce pain in very premature babies during a blood draw. It may help your baby feel less pain without extra medicine.
Strasbourg, Bas-RhinAges 7 months–8 months - NCT06206044Enrolling by invitation
Evaluating typical spinal blocks for cesarean delivery
This study looks at how well the standard spinal block works for cesarean sections. It aims to understand the typical effects to improve care for patients having a C-section.
Portland, OregonAges 15–55 - NCT06205342RecruitingEarly Phase 1
Stem cell treatment for chronic pancreatitis pain
This trial tests whether a new stem cell treatment can reduce the pain of chronic pancreatitis. It aims to improve your quality of life by easing long-term pain.
Charleston, South CarolinaAges 18–75 - NCT06188793Recruiting
Virtual reality for IBD pain during hospital stay
This study tests if using virtual reality can help manage pain for people with inflammatory bowel disease (IBD) while they are in the hospital. It may offer a drug-free way to feel better.
Ann Arbor, MichiganAges 18 years+ - NCT06186141RecruitingPhase 4
Comparing morphine and oxycodone for kids' pain after surgery
This study compares two common pain medicines—morphine and oxycodone—given through a PCA pump after surgery in children. The goal is to see which one causes less nausea and vomiting, so your child can recover more comfortably.
Melbourne, VictoriaAges 6–18 - NCT06185816RecruitingPhase 2/Phase 3
Non-invasive pulsed radiofrequency for nerve pain
This trial tests a non-invasive treatment called pulsed radiofrequency for people with chronic nerve pain after an injury. It uses a device that sends short bursts of energy to the painful area to help reduce pain without surgery.
Redwood City, CaliforniaAges 18 years+ - NCT06184126Recruiting
Virtual reality for sickle cell pain in the emergency room
This trial tests whether using a virtual reality (VR) headset, along with your usual pain treatment, can help reduce pain during a sickle cell crisis. It is for adults with sickle cell disease who are in the emergency department and receiving IV opioids for a vaso-occlusive crisis.
Baltimore, MarylandAges 18 years+ - NCT06185829Recruiting
Hypnosis versus sedation for hand surgery
This trial compares two ways to help you relax during hand surgery: hypnoanalgesia (using focused attention and suggestions) versus standard sedation. It aims to see which method provides better comfort and recovery.
Champigny-sur-MarneAges 18–80 - NCT06201676RecruitingPhase 4
Low-dose short-term ketorolac to cut opioid use after bone surgery
This study tests whether giving a low dose of a non-steroidal anti-inflammatory drug (NSAID) called ketorolac for a short time after orthopedic surgery can reduce the need for strong painkillers like opioids. It is for people who have broken bones that need surgery with metal plates, screws, or rods.
Boston, MassachusettsAges 18–70 - NCT06182059Recruiting
Pain after knee replacement study
This study looks at long-term pain after total knee replacement surgery. It may help understand why some people have persistent pain and find ways to prevent it.
Monza, Monza BrianzaAges 18–85 - NCT06183281Recruiting
Comparing two non-drug approaches for chronic pain
This study compares two different ways to help people manage chronic pain without using medications. Over 12 months, you'll use a smartphone app and learn strategies to feel better and have more control over your pain.
San Francisco, CaliforniaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,580 recruiting pain medicine studies from the U.S. registry right now, out of 6,510 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.