Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,764 recruiting studies in this area right now.
By phase
- Not applicable3,111
- Phase 4251
- Phase 2144
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University97
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad26
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- Illinois38
- North Carolina38
Recruiting studies3,763 total
- NCT06716359Enrolling by invitation
Comparing two pain medicines after C-section
This trial compares two pain relievers, hydromorphone and nalbuphine, given through a patient-controlled pump after cesarean section. It aims to find which provides better pain control with fewer side effects.
Wuhan, HubeiAges 20–50 - NCT06715969Enrolling by invitation
Comparing two treatments for low back pain
This study compares two different hands-on treatments for low back pain. It may be a good fit if you have ongoing back pain and haven't had recent therapy or medication.
Gaziantep, sehitkamilAges 35–60 - NCT06708000Enrolling by invitationPhase 3
Personalized testing for new chest pain
This trial compares a personalized evaluation approach to standard care for people with new chest pain who might have heart disease. It aims to see if tailoring tests can improve diagnosis and outcomes.
HerningAges 30–75 - NCT06699745Enrolling by invitation
Music vs. white noise for kids during endoscopy
This study compares playing music or white noise during a child's first endoscopy to see which helps them feel more comfortable. It might help your child relax during the procedure.
Istanbul, AvcilarAges 6–12 - NCT06689826Enrolling by invitation
Core Strength in Rotator Cuff Injury
This study looks at whether core muscle strength (the muscles in your belly and lower back) is affected in people with a partially torn rotator cuff in one shoulder. If you join, you will help researchers understand this connection, which might lead to better recovery programs.
Kırşehir, CentreAges 18–65 - NCT06689345Enrolling by invitation
Brain stimulation study for chronic pain including post-COVID
This study tests if a non-invasive brain stimulation technique can reduce pain in people with chronic pain conditions like fibromyalgia, headaches, or pain that started after COVID-19. It is looking for healthy people and people with ongoing pain to see if the treatment helps.
Sâo Bernardo Do Campo, São PauloAges 18–64 - NCT06686875Enrolling by invitation
Chronic belly pain after sleeve gastrectomy study
This study looks at long-term belly pain in people who had a sleeve gastrectomy 3 months to 5 years ago. It aims to understand the pain better to help future patients.
WarsawAges 18 years+ - NCT06684665Enrolling by invitation
How emotions and social factors affect low back pain
This study looks at how social, psychological, and emotional factors might cause problems with movement and daily life in people with back pain. It could help doctors better understand and treat your pain.
Wenzhou, ZhejiangAges 18–75 - NCT06677216Enrolling by invitation
Botox for jaw muscle pain study
This study tests if Botox injections can reduce pain in the jaw muscles caused by a jaw joint disorder (TMD). If you have this type of pain and are interested in Botox treatment, you may be able to join.
Utrecht, UtrechtAges 18 years+ - NCT06636331Enrolling by invitation
Pain relief after hip surgery: comparing two numbing methods
This trial compares two ways to numb the hip and thigh area after a specific type of hip surgery (cephalomedullary nailing). One method uses a continuous nerve block above the hip bone, and the other uses a continuous epidural. The goal is to find which offers better pain control.
Denpasar, BaliAges 18–65 - NCT06628180Enrolling by invitation
Low-intensity focused ultrasound for chronic pain
This study tests a noninvasive treatment called low-intensity focused ultrasound (LIFU) to help relieve chronic pain. It may be an option if you have had moderate to severe pain for at least 3 months.
Roanoke, VirginiaAges 18–65 - NCT06619340Enrolling by invitationPhase 4
Exparrel block for knee replacement pain relief
This trial tests a special numbing injection called an EXPAREL IPSA block to see how well it controls pain after knee replacement surgery. It is for people with knee arthritis who are having their first knee replacement under spinal anesthesia.
Germantown, TennesseeAges 18 years+ - NCT06619171Enrolling by invitation
Teens with chronic pain: a study on distress
This study looks at why some teenagers with long-lasting chronic pain feel more distressed than others. It asks you to fill out a short survey on your phone every day for a period of time, to help researchers understand who is most at risk and when.
BathAges 12–19 - NCT06611722Enrolling by invitation
Study on emotions in chronic hip pain
This study looks at how people feel emotionally when they have long-term hip pain. It aims to understand the differences in mental state among patients with chronic hip pain.
Beijing, Beijing MunicipalityAges 16–65 - NCT06603714Enrolling by invitation
Soft tissue massage at different muscle lengths study
This trial tests how soft tissue mobilization affects muscles when stretched compared to relaxed. It may help improve flexibility or recovery in healthy people.
Izola, PrimorskaAges 18–25 - NCT06601413Enrolling by invitation
Nerve block for pain after laparoscopic hysterectomy
This study tests a special type of nerve block (called M-TAPA) to manage pain after a laparoscopic hysterectomy. It aims to see if this block provides better pain relief than standard care.
AnkaraAges 18–65 - NCT06587919Enrolling by invitation
Brain training for pain after trauma
This trial tests a brain-training technique called EEG-neurofeedback to help people with ongoing pain after a traumatic event. It aims to retrain overactive brain networks to reduce pain and distress.
OdenseAges 18 years+ - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT06581185Enrolling by invitation
Long-term headache outcomes in childhood pseudotumor cerebri
This trial is studying how headaches from pseudotumor cerebri (a condition of increased pressure around the brain) change over 10 years in people who were diagnosed as children. It might help doctors understand the long-term effects of this condition.
HaifaAges Any age - NCT06576570Enrolling by invitation
Improving surgeon ergonomics with AI analytics
This trial uses AI to analyze surgeon posture and movements during acute care surgeries, with the goal of improving ergonomics and reducing physical strain. It may help identify better surgical practices for both surgeons and patients.
Gainesville, FloridaAges 18–99 - NCT06575010Enrolling by invitationPhase 4
Comparing pain relief methods for rotator cuff repair surgery
This trial tests two different pain relief methods for people having rotator cuff repair surgery. The goal is to see which one works better for managing pain after surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06571006Enrolling by invitation
Music therapy for pain relief during spinal tap in babies
This study tests whether playing gentle music during a lumbar puncture (a spinal tap) can help lower a baby's pain. It's for newborn infants who need this procedure and have normal hearing.
ErzurumAges 1 month–1 month - NCT06550323Enrolling by invitation
Virtual reality for pain during chest tube removal
This study tests if using virtual reality can reduce pain, anxiety, and discomfort when a chest tube is removed after heart bypass surgery. If you are between 18 and 65 and have a chest tube after coronary artery bypass surgery, you may be able to join.
ErzurumAges 18–65 - NCT06540456Enrolling by invitation
Capsaicin patch for nerve-related lower back pain
This study tests a medicated patch called Qutenza (capsaicin) to treat chronic lower back pain that involves nerve damage. The patch is placed on the skin to help reduce pain signals.
Summerville, South CarolinaAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,764 recruiting pain medicine studies from the U.S. registry right now, out of 6,842 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.