Pain medicine
Pain clinical trials
Chronic and acute pain, and the conditions that cause it. We’re tracking 3,764 recruiting studies in this area right now.
By phase
- Not applicable3,111
- Phase 4251
- Phase 2144
- Phase 3104
- Phase 197
- Phase 2/Phase 335
- Phase 1/Phase 222
Top conditions
Leading sponsors
- Riphah International University97
- Cairo University62
- Beijing Tiantan Hospital34
- Ain Shams University32
- Tanta University30
- Foundation University Islamabad26
- Mayo Clinic26
- Stanford University24
- VA Office of Research and Development22
- Hacettepe University20
Where studies are running
- California158
- New York80
- Massachusetts68
- Florida65
- Texas52
- Ohio48
- Maryland42
- Minnesota41
- Illinois38
- North Carolina38
Recruiting studies3,763 total
- NCT06534593Enrolling by invitation
Physical therapy for low back pain from disc herniation
This trial tests whether physical therapy can help people with a specific type of disc herniation (postero-lateral) by improving pain, stability, walking, and daily function. It may be a good fit if you have low back pain that spreads to your leg or stays in your back.
Islamabad, FederalAges 18–50 - NCT06507449Enrolling by invitation
Treating Heavily Calcified Heart Blockages to Improve Microcirculation
This study is testing a technique to treat heavily calcified (hard) blockages in heart arteries. The goal is to see if a special way of preparing the blockage before placing a stent helps improve blood flow to the tiny blood vessels in the heart muscle.
KatowiceAges 18 years+ - NCT06501859Enrolling by invitation
Shoulder pacemaker rehab study
This study tests a device called a shoulder pacemaker to help with recovery after shoulder replacement surgery. It may help you regain strength and movement faster.
Salt Lake City, UtahAges 18–80 - NCT06494670Enrolling by invitation
Trends in muscle and bone pain in U.S. adults
This study looks at how common different types of muscle and bone pain have been in U.S. adults over time. It uses data from a national health survey to understand trends, which may help improve pain care.
Ages Any age - NCT06484192Enrolling by invitationPhase 4
Pain control after lower back fusion surgery
This trial tests a new pain management plan for people having spinal fusion surgery on their lower back. It aims to find the best way to control pain while reducing side effects.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06478628Enrolling by invitation
Insomnia in pain rehabilitation patients
This trial looks at sleep problems in people going through pain rehabilitation. It aims to understand and possibly improve sleep in those with long-lasting pain.
RissaAges 18 years+ - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT06465992Enrolling by invitationPhase 4
Liposomal bupivacaine with dexamethasone for foot surgery pain relief
This trial tests whether adding dexamethasone to liposomal bupivacaine in a nerve block provides better pain relief after foot or ankle surgery. If you're having foot or ankle surgery and are willing to answer a few surveys, you may be able to join.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06460402Enrolling by invitation
Ice packs and warm baths after hemorrhoid surgery
This trial tests whether using ice packs and warm baths after hemorrhoid surgery helps wounds heal faster and reduces pain more than standard care. If you are having surgery to remove hemorrhoids, this study may offer a simple, gentle way to help you recover.
Kaohsiung CityAges 18–80 - NCT06455423Enrolling by invitation
ELDOA and adjustments for upper back pain and posture
This study tests whether adding a gentle stretching technique (ELDOA) to standard upper back adjustments can improve upper back pain, reduce hunching, and correct forward head posture. It is for adults with upper back discomfort and postural issues.
Islamabad, FederalAges 19–44 - NCT06443164Enrolling by invitation
Chronic Pain Treatment Before Gender-Affirming Surgery
This study tests a one-session pain management class called Empowered Relief for people with chronic pain who are planning gender-affirming surgery. The goal is to see if learning these skills before surgery helps with pain afterward.
Portland, OregonAges 18–100 - NCT06432452Enrolling by invitationPhase 2/Phase 3
Testing a new drug for coronary artery spasm
This trial tests a drug that blocks certain receptors to see if it reduces chest pain caused by coronary artery spasm. If you have frequent angina despite current treatments, this study may offer a new option.
Eindhoven, North BrabantAges 18 years+ - NCT06430918Enrolling by invitation
Nerve pain and sleep quality in knee osteoarthritis
This study looks at how nerve pain and sleep quality are related in people with knee osteoarthritis. It aims to help doctors better understand and treat pain.
IzmirAges 18–80 - NCT06424041Enrolling by invitationPhase 2
Fecal transplant for fibromyalgia pain relief
This study tests whether transferring healthy gut bacteria from a donor can reduce pain in women with fibromyalgia. You would first take antibiotics and laxatives to prepare your gut, then receive the transplant through a colonoscopy.
Haifa, NorthAges 18–75 - NCT06407115Enrolling by invitation
Pain care support for rural patients
This study tests a nurse-led program to help people living in rural areas manage chronic pain. You'll work with a care manager who can support your pain treatment goals.
Winston-Salem, North CarolinaAges 18 years+ - NCT06405646Enrolling by invitation
Cannabidiol and Cannabinol for Chronic Jaw Muscle Pain
This study tests whether certain compounds from the cannabis plant (CBD and CBN) can help relieve long-term pain in the jaw muscles. It is for adults with chronic orofacial pain who have not recently taken medications that affect the nerves or muscles.
WroclawAges 18–80 - NCT06402149Enrolling by invitation
Comparing two ways to numb the arm for surgery
This trial tests two different methods for numbing the arm (infraclavicular block) before upper extremity surgery. It aims to find out which approach works better to block pain.
AnkaraAges 18 years+ - NCT06350981Enrolling by invitationPhase 2/Phase 3
Pain control after lower back fusion surgery
This study is comparing different ways to manage pain after a specific type of lower back fusion surgery called TLIF. The goal is to find the best pain control plan to make recovery more comfortable.
Tampa, FloridaAges 18 years+ - NCT06337513Enrolling by invitation
Back pain study for early arthritis diagnosis
This trial looks at people with low back pain to find early signs of a spine arthritis condition. It may help diagnose the condition sooner and guide better treatment.
Sønderborg, Southern DenmarkAges 18–48 - NCT06306157Enrolling by invitationPhase 4
Low dose naltrexone for complex regional pain syndrome
This trial tests whether a low dose of naltrexone, a medication that may help calm overactive immune and pain signals, can reduce pain and improve daily life in people with complex regional pain syndrome (CRPS), a chronic condition that often causes severe pain and swelling.
New York, New YorkAges 18–85 - NCT06275191Enrolling by invitation
Testing non-opioid pain relief after tooth extraction
This trial tests whether alternative pain treatments can replace opioid painkillers after wisdom tooth or other tooth removal in teens and young adults. It aims to find safer ways to manage dental pain without relying on opioids.
Lexington, KentuckyAges 12–25 - NCT06228755Enrolling by invitation
Study on group integrative care for chronic pain
This study looks at how well group medical visits that combine different treatments (like mind-body approaches) work for people with chronic pain. It aims to make these visits more available and helpful.
Chapel Hill, North CarolinaAges 18 years+ - NCT06225388Enrolling by invitation
Do compression socks help runners feel less sore?
This study tests whether wearing a compression sock while running can reduce muscle soreness after a run. It may help distance runners recover faster.
Rio de JaneiroAges 18–50 - NCT06221280Enrolling by invitation
Nerve blocks for pain after cesarean and depression
This study tests whether a nerve block (extra numbing medicine) given during a cesarean section can help with pain after delivery and may reduce the risk of postpartum depression. The trial compares the nerve block to standard care.
Kahramanmaraş, KahramanmaraşAges 18 years+
Common questions
- How many pain clinical trials are recruiting?
- Clin2 is tracking 3,764 recruiting pain medicine studies from the U.S. registry right now, out of 6,842 we cover in this area in total.
- What does “Pain” cover here?
- Chronic and acute pain, and the conditions that cause it. We group each study into pain based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a pain trial near me?
- Use the search to filter pain studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Digestive system
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.